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Volumn 10, Issue 8, 2004, Pages 821-827

P2X7 receptor inhibition improves recovery after spinal cord injury

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; GLIAL FIBRILLARY ACIDIC PROTEIN; PURINE P2X7 RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; RECEPTOR BLOCKING AGENT;

EID: 4043079197     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1082     Document Type: Article
Times cited : (449)

References (52)
  • 1
    • 0036788971 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors
    • North, R.A. Molecular physiology of P2X receptors. Physiol. Rev. 82, 1013-1067 (2002).
    • (2002) Physiol. Rev. , vol.82 , pp. 1013-1067
    • North, R.A.1
  • 2
    • 0033366463 scopus 로고    scopus 로고
    • Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds
    • Khakh, B.S., Bao, X.R., Labarca, C. & Lester, H.A. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat. Neurosci. 2, 322-330 (1999).
    • (1999) Nat. Neurosci. , vol.2 , pp. 322-330
    • Khakh, B.S.1    Bao, X.R.2    Labarca, C.3    Lester, H.A.4
  • 3
    • 0031822940 scopus 로고    scopus 로고
    • Cytolytic P2X purinoceptors
    • Di Virgilio, F. et al. Cytolytic P2X purinoceptors. Cell Death Differ. 5, 191-199 (1998).
    • (1998) Cell Death Differ. , vol.5 , pp. 191-199
    • Di Virgilio, F.1
  • 4
    • 0035883160 scopus 로고    scopus 로고
    • Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems
    • Deuchars, S.A. et al. Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems. J. Neurosci. 21, 7143-7152 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 7143-7152
    • Deuchars, S.A.1
  • 5
    • 0032417621 scopus 로고    scopus 로고
    • Connexins regulate calcium signaling by controlling ATP release
    • Cotrina, M.L. et al. Connexins regulate calcium signaling by controlling ATP release. Proc. Natl. Acad. Sci. USA 95, 15735-15740 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15735-15740
    • Cotrina, M.L.1
  • 6
    • 0033555444 scopus 로고    scopus 로고
    • ATP released from astrocytes mediates glial calcium waves
    • Guthrie, P.B. et al. ATP released from astrocytes mediates glial calcium waves. J. Neurosci. 19, 520-528 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 520-528
    • Guthrie, P.B.1
  • 7
    • 0037162496 scopus 로고    scopus 로고
    • Intercellular calcium signaling mediated by point-source burst release of ATP
    • Arcuino, G. et al. Intercellular calcium signaling mediated by point-source burst release of ATP. Proc. Natl. Acad. Sci. USA 99, 9840-9845 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9840-9845
    • Arcuino, G.1
  • 8
    • 0037131025 scopus 로고    scopus 로고
    • New insights into neuron-glia communication
    • Fields, R.D. & Stevens-Graham, B. New insights into neuron-glia communication. Science 298, 556-562 (2002).
    • (2002) Science , vol.298 , pp. 556-562
    • Fields, R.D.1    Stevens-Graham, B.2
  • 9
    • 0035287432 scopus 로고    scopus 로고
    • Glia: Listening and talking to the synapse
    • Haydon, P.G. Glia: listening and talking to the synapse. Nat. Rev. Neurosci. 2, 185-193 (2001).
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 185-193
    • Haydon, P.G.1
  • 10
    • 0141533205 scopus 로고    scopus 로고
    • New roles for astrocytes: Redefining the functional architecture of the brain
    • Nedergaard, M., Ransom, B. & Goldman, S. New roles for astrocytes: Redefining the functional architecture of the brain. Trends Neurosci. 26, 523-530 (2003).
    • (2003) Trends Neurosci. , vol.26 , pp. 523-530
    • Nedergaard, M.1    Ransom, B.2    Goldman, S.3
  • 11
    • 0034652098 scopus 로고    scopus 로고
    • Intercellular communication in spinal cord astrocytes: Fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation
    • Scemes, E., Suadicani, S.O. & Spray, D.C. Intercellular communication in spinal cord astrocytes: fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation. J. Neurosci. 20, 1435-1445 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 1435-1445
    • Scemes, E.1    Suadicani, S.O.2    Spray, D.C.3
  • 13
    • 0036149221 scopus 로고    scopus 로고
    • Cell damage excites nociceptors through release of cytosolic ATP
    • Cook, S.P. & McCleskey, E.W. Cell damage excites nociceptors through release of cytosolic ATP. Pain 95, 41-47 (2002).
    • (2002) Pain , vol.95 , pp. 41-47
    • Cook, S.P.1    McCleskey, E.W.2
  • 14
    • 0037444676 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors
    • Neary, J.T., Kang, Y., Willoughby, K.A. & Ellis, E.F. Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J. Neurosci. 23, 2348-2356 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 2348-2356
    • Neary, J.T.1    Kang, Y.2    Willoughby, K.A.3    Ellis, E.F.4
  • 15
    • 0032911557 scopus 로고    scopus 로고
    • Calcium influx and activation of calpain I mediate acute reactive gliosis in injured spinal cord
    • Du, S. et al. Calcium influx and activation of calpain I mediate acute reactive gliosis in injured spinal cord. Exp. Neurol. 157, 96-105 (1999).
    • (1999) Exp. Neurol. , vol.157 , pp. 96-105
    • Du, S.1
  • 16
    • 0020622859 scopus 로고
    • Extracellular calcium activity in the injured spinal coid
    • Stokes, E.T., Fox, P. & Hollinden, G. Extracellular calcium activity in the injured spinal coid. Exp. Neurol. 80, 561-572 (1983).
    • (1983) Exp. Neurol. , vol.80 , pp. 561-572
    • Stokes, E.T.1    Fox, P.2    Hollinden, G.3
  • 18
    • 0042364995 scopus 로고    scopus 로고
    • Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesium
    • Stout, C. & Charles, A. Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesium. Glia 43, 265-273 (2003).
    • (2003) Glia , vol.43 , pp. 265-273
    • Stout, C.1    Charles, A.2
  • 19
    • 0032988572 scopus 로고    scopus 로고
    • Pharmacological characterization of recombinant human and rat P2X receptor subtypes
    • Bianchi, B.R. et al. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur. J. Pharmacol. 376, 127-138 (1999).
    • (1999) Eur. J. Pharmacol. , vol.376 , pp. 127-138
    • Bianchi, B.R.1
  • 20
    • 0030821471 scopus 로고    scopus 로고
    • Impact of cytoplasmic calcium buffering on the spatial and temporal characteristics of intercellular calcium signals in astrocytes
    • Wang, Z., Tymianski, M., Jones, O.T. & Nedergaard, M. Impact of cytoplasmic calcium buffering on the spatial and temporal characteristics of intercellular calcium signals in astrocytes. J. Neurosci. 17, 7359-7371 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 7359-7371
    • Wang, Z.1    Tymianski, M.2    Jones, O.T.3    Nedergaard, M.4
  • 21
    • 0034800265 scopus 로고    scopus 로고
    • Glutamate release promotes growth of malignant gliomas
    • Takano, T. et al. Glutamate release promotes growth of malignant gliomas. Nat. Med. 7, 1010-1015 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 1010-1015
    • Takano, T.1
  • 22
  • 24
    • 0031783714 scopus 로고    scopus 로고
    • Apoptosis after traumatic human spinal cord injury
    • Emery, E. et al. Apoptosis after traumatic human spinal cord injury. J. Neurosurg. 89, 911-920 (1998).
    • (1998) J. Neurosurg. , vol.89 , pp. 911-920
    • Emery, E.1
  • 25
    • 0034996673 scopus 로고    scopus 로고
    • Apoptotic and anti-apoptotic mechanisms following spinal cord injury
    • Keane, R.W. et al. Apoptotic and anti-apoptotic mechanisms following spinal cord injury. J. Neuropathol. Exp. Neurol. 60, 422-429 (2001).
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 422-429
    • Keane, R.W.1
  • 26
    • 0027530024 scopus 로고
    • Oxidized ATP An irreversible inhibitor of the macrophage purinergic P2Z receptor
    • Murgia, M., Hanau, S., Pizzo, P., Rippa, M. & Di Virgilio, F. Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J. Biol. Chem. 268, 8199-8203 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 8199-8203
    • Murgia, M.1    Hanau, S.2    Pizzo, P.3    Rippa, M.4    Di Virgilio, F.5
  • 27
    • 0034077280 scopus 로고    scopus 로고
    • Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1
    • Michel, A.D., Kaur, R., Chessell, I.P. & Humphrey, P.P. Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1. Br. J. Pharmacol. 130, 513-520 (2000).
    • (2000) Br. J. Pharmacol. , vol.130 , pp. 513-520
    • Michel, A.D.1    Kaur, R.2    Chessell, I.P.3    Humphrey, P.P.4
  • 28
    • 1842558753 scopus 로고    scopus 로고
    • Contribution of calcium ions to P2X channel responses
    • Egan, T.M. & Khakh, B.S. Contribution of calcium ions to P2X channel responses. J. Neurosci. 24, 3413-3420 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 3413-3420
    • Egan, T.M.1    Khakh, B.S.2
  • 29
    • 0030609068 scopus 로고    scopus 로고
    • Tissue distribution of the P2X7 receptor
    • Collo, G. et al. Tissue distribution of the P2X7 receptor. Neuropharmacology 36, 1277-1283 (1997).
    • (1997) Neuropharmacology , vol.36 , pp. 1277-1283
    • Collo, G.1
  • 30
    • 0037098856 scopus 로고    scopus 로고
    • Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase
    • Armstrong, J.N., Brust, T.B., Lewis, R.G. & MacVicar, B.A. Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase. J. Neurosci. 22, 5938-5945 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 5938-5945
    • Armstrong, J.N.1    Brust, T.B.2    Lewis, R.G.3    MacVicar, B.A.4
  • 31
    • 0037440567 scopus 로고    scopus 로고
    • P2X7 receptor-mediated release of excitatory amino acids from astrocytes
    • Duan, S., Anderson, C.M., Keung, E.C., Chen, Y. & Swanson, R.A. P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J. Neurosci. 23, 1320-1328 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 1320-1328
    • Duan, S.1    Anderson, C.M.2    Keung, E.C.3    Chen, Y.4    Swanson, R.A.5
  • 32
    • 0033105466 scopus 로고    scopus 로고
    • Confocal calcium imaging reveals an ionotropic P2 nucleotide receptor in the paranodal membrane of rat Schwann cells
    • Grafe, P., Mayer, C., Takigawa, T., Kamleiter, M. & Sanchez-Brandelik, R. Confocal calcium imaging reveals an ionotropic P2 nucleotide receptor in the paranodal membrane of rat Schwann cells. J. Physiol. 515 (Pt. 2), 377-383 (1999).
    • (1999) J. Physiol. , vol.515 , Issue.PART 2 , pp. 377-383
    • Grafe, P.1    Mayer, C.2    Takigawa, T.3    Kamleiter, M.4    Sanchez-Brandelik, R.5
  • 33
    • 0036788652 scopus 로고    scopus 로고
    • Molecular mechanisms in the pathogenesis of traumatic brain injury
    • Ray, S.K., Dixon, C.E. & Banik, N.L. Molecular mechanisms in the pathogenesis of traumatic brain injury. Histol. Histopathol. 17, 1137-1152 (2002).
    • (2002) Histol. Histopathol. , vol.17 , pp. 1137-1152
    • Ray, S.K.1    Dixon, C.E.2    Banik, N.L.3
  • 34
    • 0141867841 scopus 로고    scopus 로고
    • New roles for astrocytes: Regulation of synaptic transmission
    • Newman, E.A. New roles for astrocytes: regulation of synaptic transmission. Trends Neurosci. 26, 536-542 (2003).
    • (2003) Trends Neurosci. , vol.26 , pp. 536-542
    • Newman, E.A.1
  • 35
    • 0018825068 scopus 로고
    • 14C-antipyrine autoradiography in the measurement of spinal cord blood flow after severe impact injury
    • 14C-antipyrine autoradiography in the measurement of spinal cord blood flow after severe impact injury. J. Neurosurg. 52, 801-807 (1980).
    • (1980) J. Neurosurg. , vol.52 , pp. 801-807
    • Cawthon, D.F.1    Senter, H.J.2    Stewart, W.B.3
  • 36
    • 0029914112 scopus 로고    scopus 로고
    • Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: An experimental study in the rat using microdialysis
    • Farooque, M., Hillered, L., Holtz, A. & Olsson, Y. Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: an experimental study in the rat using microdialysis. J. Neurotrauma 13, 537-548 (1996).
    • (1996) J. Neurotrauma , vol.13 , pp. 537-548
    • Farooque, M.1    Hillered, L.2    Holtz, A.3    Olsson, Y.4
  • 37
    • 0035052896 scopus 로고    scopus 로고
    • ATP stimulates calcium-dependent glutamate release from cultured astrocytes
    • Jeremic, A., Jeftinija, K., Stevanovic, J., Glavaski, A. & Jeftinija, S. ATP stimulates calcium-dependent glutamate release from cultured astrocytes. J. Neurochem. 77, 664-675 (2001).
    • (2001) J. Neurochem. , vol.77 , pp. 664-675
    • Jeremic, A.1    Jeftinija, K.2    Stevanovic, J.3    Glavaski, A.4    Jeftinija, S.5
  • 38
    • 0036718797 scopus 로고    scopus 로고
    • Beyond the role of glutamate as a neurotransmitter
    • Nedergaard, M., Takano, T. & Hansen, A.J. Beyond the role of glutamate as a neurotransmitter. Nat. Rev. Neurosci. 3, 748-755 (2002).
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 748-755
    • Nedergaard, M.1    Takano, T.2    Hansen, A.J.3
  • 39
    • 0031020308 scopus 로고    scopus 로고
    • Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
    • Agrawal, S.K. & Fehlings, M.G. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J. Neurosci. 17, 1055-1063 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 1055-1063
    • Agrawal, S.K.1    Fehlings, M.G.2
  • 40
    • 0030474894 scopus 로고    scopus 로고
    • Pretreatment with NMDA receptor antagonist MK801 improves neurophysiological outcome after an acute spinal cord injury
    • Haghighi, S.S., Johnson, G.C., de Vergel, C.F. & Vergel Rivas, B.J. Pretreatment with NMDA receptor antagonist MK801 improves neurophysiological outcome after an acute spinal cord injury. Neurol. Res. 18, 509-515 (1996).
    • (1996) Neurol. Res. , vol.18 , pp. 509-515
    • Haghighi, S.S.1    Johnson, G.C.2    De Vergel, C.F.3    Vergel Rivas, B.J.4
  • 41
    • 0037025282 scopus 로고    scopus 로고
    • Extracellular ATP and P2X7 receptors in neurodegeneration
    • Le Feuvre, R., Brough, D. & Rothwell, N. Extracellular ATP and P2X7 receptors in neurodegeneration. Eur. J. Pharmacol. 447, 261-269 (2002).
    • (2002) Eur. J. Pharmacol. , vol.447 , pp. 261-269
    • Le Feuvre, R.1    Brough, D.2    Rothwell, N.3
  • 42
    • 0035808396 scopus 로고    scopus 로고
    • Altered cytokine production in mice lacking P2X(7) receptors
    • Solle, M. et al. Altered cytokine production in mice lacking P2X(7) receptors. J. Biol. Chem. 276, 125-132 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 125-132
    • Solle, M.1
  • 43
    • 0037096207 scopus 로고    scopus 로고
    • Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response
    • Labasi, J.M. et al. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168, 6436-6445 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 6436-6445
    • Labasi, J.M.1
  • 44
    • 0842322759 scopus 로고    scopus 로고
    • Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia
    • Suzuki, T. et al. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J. Neurosci. 24, 1-7 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 1-7
    • Suzuki, T.1
  • 45
    • 0038143359 scopus 로고    scopus 로고
    • P2X7 mediates Superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease
    • Parvathenani, L.K. et al. P2X7 mediates Superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J. Biol. Chem. 278, 13309-13317 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 13309-13317
    • Parvathenani, L.K.1
  • 46
    • 0036347208 scopus 로고    scopus 로고
    • Erythropoietin strikes a new cord
    • Goldman, S.A. & Nedergaard, M. Erythropoietin strikes a new cord. Nat. Med. 8, 785-787 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 785-787
    • Goldman, S.A.1    Nedergaard, M.2
  • 47
    • 1842419475 scopus 로고    scopus 로고
    • Degenerative and regenerative mechanisms governing spinal cord injury
    • Profyris, C. et al. Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol. Dis. 15, 415-436 (2004).
    • (2004) Neurobiol. Dis. , vol.15 , pp. 415-436
    • Profyris, C.1
  • 48
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso, D.M., Beattie, M.S. & Bresnahan, J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12, 1-21 (1995).
    • (1995) J. Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 49
    • 0027158001 scopus 로고
    • Characterization of cortical depolarization evoked in focal cerebral ischemia
    • Nedergaard, M. & Hansen, A.J. Characterization of cortical depolarization evoked in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 13, 568-574 (1993).
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 568-574
    • Nedergaard, M.1    Hansen, A.J.2
  • 50
    • 0032175749 scopus 로고    scopus 로고
    • Gap-junction-mediated propagation and amplification of cell injury
    • Lin, J.H. et al. Gap-junction-mediated propagation and amplification of cell injury. Nat. Neurosci. 1, 494-500 (1998).
    • (1998) Nat. Neurosci. , vol.1 , pp. 494-500
    • Lin, J.H.1
  • 51
    • 0037439761 scopus 로고    scopus 로고
    • Connexin mediates gap junction-independent resistance to cellular injury
    • Lin, J.H. et al. Connexin mediates gap junction-independent resistance to cellular injury. J. Neurosci. 23, 430-441 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 430-441
    • Lin, J.H.1
  • 52
    • 10744233012 scopus 로고    scopus 로고
    • Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord
    • Roy, N.S. et al. Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat. Biotechnol. 22, 297-305 (2004).
    • (2004) Nat. Biotechnol. , vol.22 , pp. 297-305
    • Roy, N.S.1


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