메뉴 건너뛰기




Volumn 35, Issue 7, 2014, Pages 1547-1555

Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ATORVASTATIN; CYCLINE; EHBP1 PROTEIN; GELATINASE A; GELATINASE B; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INSULIN; MEVALONIC ACID; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PREX1 PROTEIN; PROTEIN; PROTEIN KINASE B; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84903999475     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgu019     Document Type: Article
Times cited : (56)

References (46)
  • 1
    • 84866991538 scopus 로고    scopus 로고
    • Statin use and risk of prostate cancer: a meta-analysis of observational studies
    • Bansal, D. et al. (2012) Statin use and risk of prostate cancer: a meta-analysis of observational studies. PLoS One, 7, e46691.
    • (2012) PLoS One , vol.7
    • Bansal, D.1
  • 2
    • 33845864688 scopus 로고    scopus 로고
    • Statin drugs and risk of advanced prostate cancer
    • Platz, E.A. et al. (2006) Statin drugs and risk of advanced prostate cancer. J. Natl Cancer Inst., 98, 1819-1825.
    • (2006) J. Natl Cancer Inst. , vol.98 , pp. 1819-1825
    • Platz, E.A.1
  • 3
    • 79958848145 scopus 로고    scopus 로고
    • Statins and prostate cancer diagnosis and grade in a veterans population
    • Farwell, W.R. et al. (2011) Statins and prostate cancer diagnosis and grade in a veterans population. J. Natl Cancer Inst., 103, 885-892.
    • (2011) J. Natl Cancer Inst. , vol.103 , pp. 885-892
    • Farwell, W.R.1
  • 4
    • 84868550230 scopus 로고    scopus 로고
    • Statin use and reduced cancer-related mortality
    • Nielsen, S.F. et al. (2012) Statin use and reduced cancer-related mortality. N. Engl. J. Med., 367, 1792-1802.
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1792-1802
    • Nielsen, S.F.1
  • 5
    • 84860710342 scopus 로고    scopus 로고
    • Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins
    • Roy, M. et al. (2011) Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. Am. J. Cancer Res., 1, 542-561.
    • (2011) Am. J. Cancer Res. , vol.1 , pp. 542-561
    • Roy, M.1
  • 6
    • 84862908644 scopus 로고    scopus 로고
    • Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
    • Freed-Pastor, W.A. et al. (2012) Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell, 148, 244-258.
    • (2012) Cell , vol.148 , pp. 244-258
    • Freed-Pastor, W.A.1
  • 7
    • 81855207294 scopus 로고    scopus 로고
    • Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL
    • Murtola, T.J. et al. (2011) Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. Eur. J. Pharmacol., 673, 96-100.
    • (2011) Eur. J. Pharmacol. , vol.673 , pp. 96-100
    • Murtola, T.J.1
  • 8
    • 36049032742 scopus 로고    scopus 로고
    • Statins and ATP regulate nuclear pAkt via the P2X7 purinergic receptor in epithelial cells
    • Mistafa, O. et al. (2008) Statins and ATP regulate nuclear pAkt via the P2X7 purinergic receptor in epithelial cells. Biochem. Biophys. Res. Commun., 365, 131-136.
    • (2008) Biochem. Biophys. Res. Commun. , vol.365 , pp. 131-136
    • Mistafa, O.1
  • 9
    • 70249093582 scopus 로고    scopus 로고
    • Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells
    • Mistafa, O. et al. (2009) Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells. Biochem. Pharmacol., 78, 1115-1126.
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 1115-1126
    • Mistafa, O.1
  • 10
    • 77956236967 scopus 로고    scopus 로고
    • Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases
    • Mistafa, O. et al. (2010) Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J. Biol. Chem., 285, 27900-27910.
    • (2010) J. Biol. Chem. , vol.285 , pp. 27900-27910
    • Mistafa, O.1
  • 11
    • 77951887071 scopus 로고    scopus 로고
    • Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice
    • Mans, R.A. et al. (2010) Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice. Neuroscience, 166, 435-444.
    • (2010) Neuroscience , vol.166 , pp. 435-444
    • Mans, R.A.1
  • 12
    • 77954641960 scopus 로고    scopus 로고
    • A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice
    • Lee, S.H. et al. (2010) A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc. Natl Acad. Sci. USA, 107, 11002-11007.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 11002-11007
    • Lee, S.H.1
  • 13
    • 84867283425 scopus 로고    scopus 로고
    • The emerging multiple roles of nuclear Akt
    • Martelli, A.M. et al. (2012) The emerging multiple roles of nuclear Akt. Biochim. Biophys. Acta, 1823, 2168-2178.
    • (2012) Biochim. Biophys. Acta , vol.1823 , pp. 2168-2178
    • Martelli, A.M.1
  • 14
    • 33845977965 scopus 로고    scopus 로고
    • Ubiquitination regulates PTEN nuclear import and tumor suppression
    • Trotman, L.C. et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell, 128, 141-156.
    • (2007) Cell , vol.128 , pp. 141-156
    • Trotman, L.C.1
  • 15
    • 84862557061 scopus 로고    scopus 로고
    • Expression of P2X7 receptor increases in vivo tumor growth
    • Adinolfi, E. et al. (2012) Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res., 72, 2957-2969.
    • (2012) Cancer Res. , vol.72 , pp. 2957-2969
    • Adinolfi, E.1
  • 16
    • 79955579562 scopus 로고    scopus 로고
    • P2X(7) receptor activation enhances SK3 channelsand cystein cathepsin-dependent cancer cells invasiveness
    • Jelassi, B. et al. (2011) P2X(7) receptor activation enhances SK3 channelsand cystein cathepsin-dependent cancer cells invasiveness. Oncogene, 30, 2108-2122.
    • (2011) Oncogene , vol.30 , pp. 2108-2122
    • Jelassi, B.1
  • 17
    • 84855885805 scopus 로고    scopus 로고
    • Silencing p110β prevents rapid depletion of nuclear pAkt
    • Ye, Z.W. et al. (2011) Silencing p110β prevents rapid depletion of nuclear pAkt. Biochem. Biophys. Res. Commun., 415, 613-618.
    • (2011) Biochem. Biophys. Res. Commun. , vol.415 , pp. 613-618
    • Ye, Z.W.1
  • 18
    • 49649087385 scopus 로고    scopus 로고
    • Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
    • Jia, S. et al. (2008) Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature, 454, 776-779.
    • (2008) Nature , vol.454 , pp. 776-779
    • Jia, S.1
  • 19
    • 39749159112 scopus 로고    scopus 로고
    • Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
    • Gudmundsson, J. et al. (2008) Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat. Genet., 40, 281-283.
    • (2008) Nat. Genet. , vol.40 , pp. 281-283
    • Gudmundsson, J.1
  • 20
    • 4544290119 scopus 로고    scopus 로고
    • Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes
    • Guilherme, A. et al. (2004) Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J. Biol. Chem., 279, 40062-40075.
    • (2004) J. Biol. Chem. , vol.279 , pp. 40062-40075
    • Guilherme, A.1
  • 21
    • 77955593371 scopus 로고    scopus 로고
    • EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans
    • Shi, A. et al. (2010) EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans. Mol. Biol. Cell, 21, 2930-2943.
    • (2010) Mol. Biol. Cell , vol.21 , pp. 2930-2943
    • Shi, A.1
  • 22
    • 34047155597 scopus 로고    scopus 로고
    • EHD1 regulates beta1 integrin endosomal transport: effects on focal adhesions, cell spreading and migration
    • Jović, M. et al. (2007) EHD1 regulates beta1 integrin endosomal transport: effects on focal adhesions, cell spreading and migration. J. Cell Sci., 120(Pt 5), 802-814.
    • (2007) J. Cell Sci. , vol.120 , Issue.PART 5 , pp. 802-814
    • Jović, M.1
  • 23
    • 33947597433 scopus 로고    scopus 로고
    • MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway
    • Bravo-Cordero, J.J. et al. (2007) MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J., 26, 1499-1510.
    • (2007) EMBO J. , vol.26 , pp. 1499-1510
    • Bravo-Cordero, J.J.1
  • 24
    • 33845218255 scopus 로고    scopus 로고
    • Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs
    • Roudier, E. et al. (2006) Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs. Mol. Cancer Ther., 5, 2706-2715.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 2706-2715
    • Roudier, E.1
  • 25
    • 34247548755 scopus 로고    scopus 로고
    • Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
    • Yeager, M. et al. (2007) Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat. Genet., 39, 645-649.
    • (2007) Nat. Genet. , vol.39 , pp. 645-649
    • Yeager, M.1
  • 26
    • 23244460597 scopus 로고    scopus 로고
    • Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    • Chen, Z. et al. (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature, 436, 725-730.
    • (2005) Nature , vol.436 , pp. 725-730
    • Chen, Z.1
  • 27
    • 33644804885 scopus 로고    scopus 로고
    • Profiling of signaling molecules in four different human prostate carcinoma cell lines before and after induction of apoptosis
    • Skjøth, I.H. et al. (2006) Profiling of signaling molecules in four different human prostate carcinoma cell lines before and after induction of apoptosis. Int. J. Oncol., 28, 217-229.
    • (2006) Int. J. Oncol. , vol.28 , pp. 217-229
    • Skjøth, I.H.1
  • 28
    • 84860702956 scopus 로고    scopus 로고
    • The differential effects of statins on the metastatic behaviour of prostate cancer
    • Brown, M. et al. (2012) The differential effects of statins on the metastatic behaviour of prostate cancer. Br. J. Cancer, 106, 1689-1696.
    • (2012) Br. J. Cancer , vol.106 , pp. 1689-1696
    • Brown, M.1
  • 29
    • 67349167687 scopus 로고    scopus 로고
    • Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis
    • Qin, J. et al. (2009) Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene, 28, 1853-1863.
    • (2009) Oncogene , vol.28 , pp. 1853-1863
    • Qin, J.1
  • 30
    • 34447528690 scopus 로고    scopus 로고
    • EHD1 and Eps15 interact with phosphatidylinositols via their Eps15 homology domains
    • Naslavsky, N. et al. (2007) EHD1 and Eps15 interact with phosphatidylinositols via their Eps15 homology domains. J. Biol. Chem., 282, 16612-16622.
    • (2007) J. Biol. Chem. , vol.282 , pp. 16612-16622
    • Naslavsky, N.1
  • 31
    • 83355166914 scopus 로고    scopus 로고
    • Identification of P-Rex1 as a novel Rac1- guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes
    • Balamatsias, D. et al. (2011) Identification of P-Rex1 as a novel Rac1- guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes. J. Biol. Chem., 286, 43229-43240.
    • (2011) J. Biol. Chem. , vol.286 , pp. 43229-43240
    • Balamatsias, D.1
  • 32
    • 84903966212 scopus 로고    scopus 로고
    • P-REX1 is a novel PTEN-interacting protein that activates PI3K signaling in breast cancer
    • Abstarct # LB-37. AACR Annual Meeting 2013. AACR, Washington, DC, vol. Abstarct # LB-37
    • Dillon, L.M. et al. (2013) P-REX1 is a novel PTEN-interacting protein that activates PI3K signaling in breast cancer. Abstarct # LB-37. AACR Annual Meeting 2013. AACR, Washington, DC, vol. Abstarct # LB-37.
    • (2013)
    • Dillon, L.M.1
  • 33
    • 77952471484 scopus 로고    scopus 로고
    • Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression
    • Zhang, Y. et al. (2010) Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression. Cancer Lett., 293, 189-197.
    • (2010) Cancer Lett. , vol.293 , pp. 189-197
    • Zhang, Y.1
  • 34
    • 77953631796 scopus 로고    scopus 로고
    • P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages
    • Lees, M.P. et al. (2010) P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages. J. Immunol., 184, 7040-7046.
    • (2010) J. Immunol. , vol.184 , pp. 7040-7046
    • Lees, M.P.1
  • 35
    • 0035815630 scopus 로고    scopus 로고
    • A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor
    • Gu, B.J. et al. (2001) A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J. Biol. Chem., 276, 11135-11142.
    • (2001) J. Biol. Chem. , vol.276 , pp. 11135-11142
    • Gu, B.J.1
  • 36
    • 84867131849 scopus 로고    scopus 로고
    • Rho GEFs and cancer: linking gene expression and metastatic dissemination
    • Barrio-Real, L. et al. (2012) Rho GEFs and cancer: linking gene expression and metastatic dissemination. Sci. Signal., 5, pe43.
    • (2012) Sci. Signal. , vol.5
    • Barrio-Real, L.1
  • 37
    • 84883370460 scopus 로고    scopus 로고
    • Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition
    • Giagtzoglou, N. et al. (2013) Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. J. Cell Sci., 126(Pt 16), 3686-3696.
    • (2013) J. Cell Sci. , vol.126 , Issue.PART 16 , pp. 3686-3696
    • Giagtzoglou, N.1
  • 38
    • 84887154867 scopus 로고    scopus 로고
    • Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells
    • Espinoza, I. et al. (2013) Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells. Cancer Lett., 341, 41-45.
    • (2013) Cancer Lett. , vol.341 , pp. 41-45
    • Espinoza, I.1
  • 39
    • 84875913574 scopus 로고    scopus 로고
    • Genetic susceptibility loci, pesticide exposure and prostate cancer risk
    • Koutros, S. et al. (2013) Genetic susceptibility loci, pesticide exposure and prostate cancer risk. PLoS One, 8, e58195.
    • (2013) PLoS One , vol.8
    • Koutros, S.1
  • 40
    • 69949170092 scopus 로고    scopus 로고
    • Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
    • Fine, B. et al. (2009) Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science, 325, 1261-1265.
    • (2009) Science , vol.325 , pp. 1261-1265
    • Fine, B.1
  • 41
    • 84866495012 scopus 로고    scopus 로고
    • TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury
    • Yin, H.Z. et al. (2012) TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp. Neurol., 238, 93-102.
    • (2012) Exp. Neurol. , vol.238 , pp. 93-102
    • Yin, H.Z.1
  • 42
    • 78751484981 scopus 로고    scopus 로고
    • Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression
    • Kochuparambil, S.T. et al. (2011) Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression. J. Pharmacol. Exp. Ther., 336, 496-505.
    • (2011) J. Pharmacol. Exp. Ther. , vol.336 , pp. 496-505
    • Kochuparambil, S.T.1
  • 43
    • 79960384694 scopus 로고    scopus 로고
    • Epigenetic regulation of phosphatidylinositol 3, 4, 5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells
    • Wong, C.Y. et al. (2011) Epigenetic regulation of phosphatidylinositol 3, 4, 5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. J. Biol. Chem., 286, 25813-25822.
    • (2011) J. Biol. Chem. , vol.286 , pp. 25813-25822
    • Wong, C.Y.1
  • 44
    • 0035878944 scopus 로고    scopus 로고
    • Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathway
    • Yang, J. et al. (2001) Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathway. Cancer Res., 61, 5652-5659.
    • (2001) Cancer Res. , vol.61 , pp. 5652-5659
    • Yang, J.1
  • 45
    • 84883132550 scopus 로고    scopus 로고
    • lncRNA-dependent mechanisms of androgen-receptor- regulated gene activation programs
    • Yang, L. et al. (2013) lncRNA-dependent mechanisms of androgen-receptor- regulated gene activation programs. Nature, 500, 598-602.
    • (2013) Nature , vol.500 , pp. 598-602
    • Yang, L.1
  • 46
    • 84879421132 scopus 로고    scopus 로고
    • Statin use in relation to prostate cancer outcomes in a population-based patient cohort study
    • Geybels, M.S. et al. (2013) Statin use in relation to prostate cancer outcomes in a population-based patient cohort study. Prostate, 73, 1214-1222.
    • (2013) Prostate , vol.73 , pp. 1214-1222
    • Geybels, M.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.