Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells

Carcinogenesis

Volumn 35, Issue 7, 2014, Pages 1547-1555

  Ghalali, Aram ^a   Wiklund, Fredrik ^a   Zheng, Huiyuan ^a   Stenius, Ulla ^a   Högberg, Johan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ATORVASTATIN; CYCLINE; EHBP1 PROTEIN; GELATINASE A; GELATINASE B; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INSULIN; MEVALONIC ACID; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PREX1 PROTEIN; PROTEIN; PROTEIN KINASE B; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CANCER CELL; CANCER GROWTH; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENE TRANSLOCATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR INVASION;

ADENOSINE TRIPHOSPHATE; BLOTTING, WESTERN; CARRIER PROTEINS; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOENZYME TECHNIQUES; MALE; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; PYRROLES; RECEPTORS, PURINERGIC P2X7; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84903999475     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgu019     Document Type: Article

References (46)

1. Bansal, D. et al. (2012) Statin use and risk of prostate cancer: a meta-analysis of observational studies. PLoS One, 7, e46691.
2. Platz, E.A. et al. (2006) Statin drugs and risk of advanced prostate cancer. J. Natl Cancer Inst., 98, 1819-1825.
3. Farwell, W.R. et al. (2011) Statins and prostate cancer diagnosis and grade in a veterans population. J. Natl Cancer Inst., 103, 885-892.
4. Nielsen, S.F. et al. (2012) Statin use and reduced cancer-related mortality. N. Engl. J. Med., 367, 1792-1802.
5. Roy, M. et al. (2011) Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. Am. J. Cancer Res., 1, 542-561.
6. Freed-Pastor, W.A. et al. (2012) Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell, 148, 244-258.
7. Murtola, T.J. et al. (2011) Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. Eur. J. Pharmacol., 673, 96-100.
8. Mistafa, O. et al. (2008) Statins and ATP regulate nuclear pAkt via the P2X7 purinergic receptor in epithelial cells. Biochem. Biophys. Res. Commun., 365, 131-136.
9. Mistafa, O. et al. (2009) Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells. Biochem. Pharmacol., 78, 1115-1126.
10. Mistafa, O. et al. (2010) Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J. Biol. Chem., 285, 27900-27910.
11. Mans, R.A. et al. (2010) Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice. Neuroscience, 166, 435-444.
12. Lee, S.H. et al. (2010) A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc. Natl Acad. Sci. USA, 107, 11002-11007.
13. Martelli, A.M. et al. (2012) The emerging multiple roles of nuclear Akt. Biochim. Biophys. Acta, 1823, 2168-2178.
14. Trotman, L.C. et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell, 128, 141-156.
15. Adinolfi, E. et al. (2012) Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res., 72, 2957-2969.
16. Jelassi, B. et al. (2011) P2X(7) receptor activation enhances SK3 channelsand cystein cathepsin-dependent cancer cells invasiveness. Oncogene, 30, 2108-2122.
17. Ye, Z.W. et al. (2011) Silencing p110β prevents rapid depletion of nuclear pAkt. Biochem. Biophys. Res. Commun., 415, 613-618.
18. Jia, S. et al. (2008) Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature, 454, 776-779.
19. Gudmundsson, J. et al. (2008) Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat. Genet., 40, 281-283.
20. Guilherme, A. et al. (2004) Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J. Biol. Chem., 279, 40062-40075.
21. Shi, A. et al. (2010) EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans. Mol. Biol. Cell, 21, 2930-2943.
22. Jović, M. et al. (2007) EHD1 regulates beta1 integrin endosomal transport: effects on focal adhesions, cell spreading and migration. J. Cell Sci., 120(Pt 5), 802-814.
23. Bravo-Cordero, J.J. et al. (2007) MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J., 26, 1499-1510.
24. Roudier, E. et al. (2006) Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs. Mol. Cancer Ther., 5, 2706-2715.
25. Yeager, M. et al. (2007) Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat. Genet., 39, 645-649.
26. Chen, Z. et al. (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature, 436, 725-730.
27. Skjøth, I.H. et al. (2006) Profiling of signaling molecules in four different human prostate carcinoma cell lines before and after induction of apoptosis. Int. J. Oncol., 28, 217-229.
28. Brown, M. et al. (2012) The differential effects of statins on the metastatic behaviour of prostate cancer. Br. J. Cancer, 106, 1689-1696.
29. Qin, J. et al. (2009) Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene, 28, 1853-1863.
30. Naslavsky, N. et al. (2007) EHD1 and Eps15 interact with phosphatidylinositols via their Eps15 homology domains. J. Biol. Chem., 282, 16612-16622.
31. Balamatsias, D. et al. (2011) Identification of P-Rex1 as a novel Rac1- guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes. J. Biol. Chem., 286, 43229-43240.
32. Dillon, L.M. et al. (2013) P-REX1 is a novel PTEN-interacting protein that activates PI3K signaling in breast cancer. Abstarct # LB-37. AACR Annual Meeting 2013. AACR, Washington, DC, vol. Abstarct # LB-37.
33. Zhang, Y. et al. (2010) Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression. Cancer Lett., 293, 189-197.
34. Lees, M.P. et al. (2010) P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages. J. Immunol., 184, 7040-7046.
35. Gu, B.J. et al. (2001) A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J. Biol. Chem., 276, 11135-11142.
36. Barrio-Real, L. et al. (2012) Rho GEFs and cancer: linking gene expression and metastatic dissemination. Sci. Signal., 5, pe43.
37. Giagtzoglou, N. et al. (2013) Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. J. Cell Sci., 126(Pt 16), 3686-3696.
38. Espinoza, I. et al. (2013) Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells. Cancer Lett., 341, 41-45.
39. Koutros, S. et al. (2013) Genetic susceptibility loci, pesticide exposure and prostate cancer risk. PLoS One, 8, e58195.
40. Fine, B. et al. (2009) Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science, 325, 1261-1265.
41. Yin, H.Z. et al. (2012) TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp. Neurol., 238, 93-102.
42. Kochuparambil, S.T. et al. (2011) Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression. J. Pharmacol. Exp. Ther., 336, 496-505.
43. Wong, C.Y. et al. (2011) Epigenetic regulation of phosphatidylinositol 3, 4, 5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. J. Biol. Chem., 286, 25813-25822.
44. Yang, J. et al. (2001) Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathway. Cancer Res., 61, 5652-5659.
45. Yang, L. et al. (2013) lncRNA-dependent mechanisms of androgen-receptor- regulated gene activation programs. Nature, 500, 598-602.
46. Geybels, M.S. et al. (2013) Statin use in relation to prostate cancer outcomes in a population-based patient cohort study. Prostate, 73, 1214-1222.