Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Nature

Volumn 485, Issue 7397, 2012, Pages 207-212

  Hattori, Motoyuki ^a   Gouaux, Eric ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPROTEIN; PURINERGIC P2X4 RECEPTOR; ION CHANNEL; PURINERGIC P2X RECEPTOR;

ANIMAL; ARTICLE; BINDING SITE; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; METABOLISM; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ZEBRA FISH; BETA SHEET; BINDING AFFINITY; CRYSTAL STRUCTURE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; VESTIBULE; X RAY DIFFRACTION;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; ANIMALS; APOPROTEINS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ION CHANNEL GATING; MODELS, MOLECULAR; RECEPTORS, PURINERGIC P2X4; STRUCTURE-ACTIVITY RELATIONSHIP; ZEBRAFISH;

ALKALI METAL; CALCIUM; CRYSTAL STRUCTURE; DRUG; ION; MOLECULAR ANALYSIS; MUSCLE; THREE-DIMENSIONAL MODELING;

DANIO RERIO;

EID: 84860785529     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature11010     Document Type: Article

References (37)

1. Yuse, A. &Sano, M. Instabilities of quasi-static crack patterns in quenched glass plates. Physica D 108, 365-378 (1997).
2. 2 film stress measurements on thermally oxidized Si. J. Vac. Sci. Technol. B 5, 15-19 (1987).
3. Cotterell, B. &Rice, J. R. Slightly curved or kinked cracks. IntJ. Fract. 16, 155-169 (1980).
4. He, M.-Y. &Hutchison, J. W. Kinking of a crack out of an interface. J.Appl. Mech. 56, 270-278 (1989).
5. Choi, S. T. &Earmme, Y. Y. Elastic study on singularities interacting with interfaces using alternating technique: Part I. Anisotropic trimaterial. Int.J. Solids Struct 39, 943-957 (2002).
6. Choi, S. T. &Earmme, Y. Y. Elastic study on singularities interacting with interfaces using alternating technique: Part II. Isotropic trimaterial. Int. J. Solids Struct. 39, 1199-1211 (2002).
7. Faber, K. T. &Evans, A. G. Crack deflection processes - I. Theory. Acta Metall. 31, 565-576 (1983).
8. Green, D. J., Tandon, R. & Sglavo, V. M. Crack arrest and multiple cracking in glass through the use of designed residual stress profiles. Science 283, 1295-1297 (1999).
9. Rao, M. P., Sanchez-Herencia, A. J., Beltz, G. E., Mc Meeking, R. M. &Lange, F. F. Laminar ceramics that exhibit a threshold strength. Science 286, 102-105 (1999).
10. Clegg, W. J. Controlling cracks in ceramics. Science 286, 1097-1099 (1999).
11. Son, Y. etal. Nanoscale electronics: digital fabrication by direct femtosecond laser processing of metal nanoparticles. Adv. Mater. 23, 3176-3181 (2011).
12. Xia, Y. etal. One dimensional nanostructures: synthesis, characterization, and applications. Adv. Mater. 15, 353-389 (2003).
13. Nam, S. W. etal. Sub-10-nm nanochannels by self-sealing and self-limiting atomic layer deposition. Nano Lett. 10, 3324-3329 (2010).
14. Marder, M. Cracks takes a new turn. Nature 362, 295-296 (1993).
15. Buehler, M. J. &Gao, H. Dynamical fracture instabilities due to local hyperelasticity at crack tips. Nature 439, 307-310 (2006).
16. Buehler, M. J. &Gao, H. agonist binding and gating revealed using cysteine scanning mutagenesis. J. Neurochem. 109, 1042-1052 (2009).
17. Jiang, R. etal. Agonist trapped in ATP-binding sites of the P2X2 receptor. Proc. Natl Acad. Sci. USA 108, 9066-9071 (2011).
18. Bianchi, B. R. etal. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur. J. Pharmacol. 376, 127-138 (1999).
19. 2/3 receptors. Mol. Pharmacol. 53, 969-973 (1998).
20. Soto, F. etal. P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc. Natl Acad. Sci. USA 93, 3684-3688 (1996).
21. Garcia-Guzman, M., Soto, F., Gomez-Hernandez, J. M., Lund, P. E. &Stuhmer, W. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol. Pharmacol. 51, 109-118 (1997).
22. 2 receptors identified by the substituted cysteine accessibility method. J. Neurosci. 18, 2350-2359 (1998).
23. Rassendren, F., Buell, G., Newbolt, A., North, R. A. &Surprenant, A. Identification of amino acid residues contributing to the pore of a P2X receptor. EMBOJ. 16, 3446-3454(1997).
24. Li, M., Chang, T. H., Silberberg, S. D. &Swartz, K. J. Gating the pore of P2X receptor channels. Nature Neurosci. 11, 883-887 (2008).
25. Li, M., Kawate, T., Silberberg, S. D. &Swartz, K. J. Pore-opening mechanism in trimeric P2X receptor channels. Nature Commun. 1, 1-7 (2010).
26. Kracun, S., Chaptal, V., Abramson, J. &Khakh, B. S. Gated access to the pore of a P2X receptor: structural implications for closed-open transitions. J. Biol. Chem. 285, 10110-10121 (2010).
27. Evans, R. J. etal. Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. J. Physiol. (Lond.) 497, 413-422(1996).
28. Liu, D. M. &Adams, D. J. Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia. J. Physiol. (Lond.) 534, 423-435 (2001).
29. Villarroel, A., Burnashev, N. & Sakmann, B. Dimensions of the narrow portion of a recombinant NMDA receptorchannel. Biophys.J. 68, 866-875 (1995).
30. 2 receptor. J. Biol. Chem. 276, 30934-30941 (2001).
31. Browne, L. E. etal. P2X receptor channels show threefold symmetry in ionic charge selectivity and unitary conductance. Nature Neurosci. 14, 17-18 (2011).
32. Kawate, T., Robertson, J. L., Li, M., Silberberg, S. D. &Swartz, K. J. Ion access pathway to the transmembrane pore in P2X receptor channels. J. Gen. Physiol. 137, 579-590 (2011).
33. Samways, D. S., Khakh, B. S., Dutertre, S. &Egan, T. M. Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors). Proc. Natl Acad. Sci. USA 108, 13800-13805 (2011).
34. 2 ATP receptorchannel. J. Gen. Physiol. 133, 93-109 (2009).
35. Jelinkova, I. etal. Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel activation. Biochem. Biophys. Res. Commun. 349, 619-625 (2006).
36. Silberberg, S. D., Li, M. &Swartz, K. J. Ivermectin interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels. Neuron 54, 263-274 (2007).
37. Khakh, B. S., Proctor, W. R., Dunwiddie, T. V., Labarca, C. &Lester, H. A. Allosteric control of gating and kinetics at P2X4 receptor channels. J. Neurosci. 19, 7289-7299(1999).