Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of alzheimer's disease

Experimental and Molecular Medicine

Volumn 43, Issue 1, 2011, Pages 7-14

  Lee, Hwan Goo ^a,b,c   Won, Sun Mi ^a,e   Gwag, Byoung Joo ^a,d,e   Lee, Yong Beom ^a,b,c  

^a Brain Disease Research Center ^*

^b Ajou University   (South Korea)

^c Institute for Medical Science   (South Korea)

^d Ajou University School of Medicine   (South Korea)

^e Neurotech Pharmaceuticals Co Ltd   (South Korea)

Author keywords

Adenosine triphosphate; Alzheimer disease; Amyloid protein precursor; Dlgh4 protein; Microglia; Mouse; Purinergic P2X7; Reactive oxygen species; Receptors

Indexed keywords

AMYLOID BETA PROTEIN; CD11B ANTIGEN; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; IMMUNOGLOBULIN RECEPTOR; PIRB PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; CELL DAMAGE; CELL DENSITY; CELL LOSS; CONTROLLED STUDY; DENDRITE; FEMALE; MICROGLIA; MOUSE; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; AGING; AMYLOID PLAQUE; ANIMAL; DISEASE MODEL; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; NERVE CELL; PATHOLOGY; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALIA; MUS;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIGENS, CD11B; BLOTTING, WESTERN; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; GENE EXPRESSION; MICE; MICE, TRANSGENIC; MICROGLIA; NEURONS; PLAQUE, AMYLOID; REACTIVE OXYGEN SPECIES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PURINERGIC P2X7;

EID: 79251641533     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2011.43.1.001     Document Type: Article

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