Purinergic receptor P2X7: A novel target for anti-inflammatory therapy

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 54-88

  Mehta, Nisha ^a   Kaur, Maninder ^a   Singh, Manjinder ^a   Chand, Sukhvir ^a   Vyas, Bhawna ^a   Silakari, Pragati ^b   Bahia, Malkeet Singh ^a   Silakari, Om ^a  

^a PUNJABI UNIVERSITY   (India)

^b ADINA Institute of Pharmaceutical Sciences   (India)

Author keywords

Caspase 1; Inflammasome; Interleukin 1 ; P2X7 receptor antagonists; Pro inflammatory cytokines; Purinergic receptor; Toll like receptor (TLR)

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; AMANTADINE DERIVATIVE; BENZAMIDE DERIVATIVE; BENZYL DERIVATIVE; DIAZEPINE DERIVATIVE; DIHYDRODIBENZO [A,G] QUINOLIZINIUM DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2X7 RECEPTOR ANTAGONIST; PYRAZOLODIAZEPINE DERIVATIVE; PYROGLUTAMIC ACID DERIVATIVE; TETRAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; CYTOKINE RELEASE; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CASPASE-1; INFLAMMASOME; INTERLEUKIN-1Β; P2X(7) RECEPTOR ANTAGONISTS; PRO-INFLAMMATORY CYTOKINES; PURINERGIC RECEPTOR; TOLL LIKE RECEPTOR (TLR);

ANTI-INFLAMMATORY AGENTS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; RECEPTORS, PURINERGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84891483656     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.10.054     Document Type: Review

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