The purinergic receptor P2x7 triggers α-secretase-dependent processing of the amyloid precursor protein

Journal of Biological Chemistry

Volumn 286, Issue 4, 2011, Pages 2596-2606

  Delarasse, Cécile ^a,b,c,d   Auger, Rodolphe ^c,d   Gonnord, Pauline ^c,d   Fontaine, Bertrand ^a,b,e   Kanellopoulos, Jean M ^c,d  

^a INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PLAQUES; AMYLOID PRECURSOR PROTEINS; ECTODOMAIN; EXTRACELLULAR; GLIAL CELLS; HIPPOCAMPAL NEURONS; HUMAN NEUROBLASTOMA; HYDROXAMATE; METALLOPROTEASE INHIBITORS; METALLOPROTEINASE-9; MITOGEN ACTIVATED PROTEIN KINASE; NEURAL CELLS; NEURAL PROGENITOR CELLS; NEUROBLASTOMA CELLS; PEPTIDE SEQUENCES; PHARMACOLOGICAL INHIBITORS; PROTEOLYTIC CLEAVAGE; PURINERGIC RECEPTORS; SECRETASES; SMALL INTERFERING RNA (SIRNA); THERAPEUTIC TARGETS;

GLYCOPROTEINS; PEPTIDES; RNA;

ENZYME ACTIVITY;

ADAM10 ENDOPEPTIDASE; ADENOSINE TRIPHOSPHATE; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; DISINTEGRIN; GELATINASE B; ILOMASTAT; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR CALCIUM; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NEURAL STEM CELL; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; WESTERN BLOTTING;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASTROCYTES; CELL LINE, TUMOR; DIPEPTIDES; GENE KNOCKDOWN TECHNIQUES; HIPPOCAMPUS; HUMANS; HYDROXAMIC ACIDS; MAP KINASE KINASE 4; MICE; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, PURINERGIC P2X7; STEM CELLS;

MUS;

EID: 78951488216     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.200618     Document Type: Article

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