-
1
-
-
84951653316
-
A study of the adrenotropic receptors
-
Ahlquist RP (1948) A study of the adrenotropic receptors. Am J Physiol 153: 586-600.
-
(1948)
Am J Physiol
, vol.153
, pp. 586-600
-
-
Ahlquist, R.P.1
-
2
-
-
0019805670
-
Avermectins: Structure determination
-
Albers-Schönberg G, Arson BH, Chabala JC, Douglas AW, Eskola P, Fisher MH, Lusi A, Mrozik H, Smith JL, and Tolman RL (1981) Avermectins: structure determination. J Am Chem Soc 103:4216-4221.
-
(1981)
J Am Chem Soc
, vol.103
, pp. 4216-4221
-
-
Albers-Schönberg, G.1
Arson, B.H.2
Chabala, J.C.3
Douglas, A.W.4
Eskola, P.5
Fisher, M.H.6
Lusi, A.7
Mrozik, H.8
Smith, J.L.9
Tolman, R.L.10
-
4
-
-
84455161674
-
The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels
-
Allsopp RC and Evans RJ (2011) The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels. J Biol Chem 286: 44691-44701.
-
(2011)
J Biol Chem
, vol.286
, pp. 44691-44701
-
-
Allsopp, R.C.1
Evans, R.J.2
-
6
-
-
84866519244
-
Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes
-
Baconguis I and Gouaux E (2012) Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes. Nature 489:400-405.
-
(2012)
Nature
, vol.489
, pp. 400-405
-
-
Baconguis, I.1
Gouaux, E.2
-
7
-
-
79959709453
-
Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model
-
Ballini E, Virginio C, Medhurst SJ, Summerfield SG, Aldegheri L, Buson A, Carignani C, Chen YH, Giacometti A, and Lago I et al. (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br J Pharmacol 163:1315-1325.
-
(2011)
Br J Pharmacol
, vol.163
, pp. 1315-1325
-
-
Ballini, E.1
Virginio, C.2
Medhurst, S.J.3
Summerfield, S.G.4
Aldegheri, L.5
Buson, A.6
Carignani, C.7
Chen, Y.H.8
Giacometti, A.9
Lago, I.10
-
8
-
-
79851471254
-
Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor
-
Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, and Müller CE (2011) Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor. J Med Chem 54:817-830.
-
(2011)
J Med Chem
, vol.54
, pp. 817-830
-
-
Baqi, Y.1
Hausmann, R.2
Rosefort, C.3
Rettinger, J.4
Schmalzing, G.5
Müller, C.E.6
-
10
-
-
27144549227
-
Effects of aerosolized adenosine 59-triphosphate vs adenosine 59-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma
-
Basoglu OK, Pelleg A, Essilfie-Quaye S, Brindicci C, Barnes PJ, and Kharitonov SA (2005) Effects of aerosolized adenosine 59-triphosphate vs adenosine 59-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma. Chest 128:1905-1909.
-
(2005)
Chest
, vol.128
, pp. 1905-1909
-
-
Basoglu, O.K.1
Pelleg, A.2
Essilfie-Quaye, S.3
Brindicci, C.4
Barnes, P.J.5
Kharitonov, S.A.6
-
11
-
-
0030854414
-
Acute nociception mediated by hindpaw P2X receptor activation in the rat
-
Bland-Ward PA and Humphrey PPA (1997) Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br J Pharmacol 122:365-371.
-
(1997)
Br J Pharmacol
, vol.122
, pp. 365-371
-
-
Bland-Ward, P.A.1
Humphrey, P.P.A.2
-
12
-
-
0017682312
-
Observations on the algogenic actions of adenosine compounds on the human blister base preparation
-
Bleehen T and Keele CA (1977) Observations on the algogenic actions of adenosine compounds on the human blister base preparation. Pain 3:367-377.
-
(1977)
Pain
, vol.3
, pp. 367-377
-
-
Bleehen, T.1
Keele, C.A.2
-
13
-
-
48849113877
-
Ionotropic glutamate receptors & CNS disorders
-
Bowie D (2008) Ionotropic glutamate receptors & CNS disorders. CNS Neurol Disord Drug Targets 7:129-143.
-
(2008)
CNS Neurol Disord Drug Targets
, vol.7
, pp. 129-143
-
-
Bowie, D.1
-
14
-
-
0028025001
-
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
-
Brake AJ, Wagenbach MJ, and Julius D (1994) New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 371:519-523.
-
(1994)
Nature
, vol.371
, pp. 519-523
-
-
Brake, A.J.1
Wagenbach, M.J.2
Julius, D.3
-
15
-
-
46749136470
-
Homomeric and heteromeric P2X3 receptors in peripheral sensory neurons
-
Brederson JD and Jarvis MF (2008) Homomeric and heteromeric P2X3 receptors in peripheral sensory neurons. Curr Opin Investig Drugs 9:716-725.
-
(2008)
Curr Opin Investig Drugs
, vol.9
, pp. 716-725
-
-
Brederson, J.D.1
Jarvis, M.F.2
-
16
-
-
57349085122
-
Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1- yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation
-
Broom DC, Matson DJ, Bradshaw E, Buck ME, Meade R, Coombs S, Matchett M, Ford KK, Yu W, and Yuan J et al. (2008) Characterization of N-(adamantan-1- ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation. J Pharmacol Exp Ther 327: 620-633.
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 620-633
-
-
Broom, D.C.1
Matson, D.J.2
Bradshaw, E.3
Buck, M.E.4
Meade, R.5
Coombs, S.6
Matchett, M.7
Ford, K.K.8
Yu, W.9
Yuan, J.10
-
17
-
-
0028170406
-
Blockade of P2X-purinoceptors by trypan blue in rat vas deferens
-
Bültmann R, Trendelenburg M, and Starke K (1994) Blockade of P2X-purinoceptors by trypan blue in rat vas deferens. Br J Pharmacol 113:349-354.
-
(1994)
Br J Pharmacol
, vol.113
, pp. 349-354
-
-
Bültmann, R.1
Trendelenburg, M.2
Starke, K.3
-
18
-
-
0015393308
-
Purinergic nerves
-
Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24:509-581.
-
(1972)
Pharmacol Rev
, vol.24
, pp. 509-581
-
-
Burnstock, G.1
-
20
-
-
34248576759
-
Physiology and pathophysiology of purinergic neurotransmission
-
Burnstock G (2007) Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87:659-797.
-
(2007)
Physiol Rev
, vol.87
, pp. 659-797
-
-
Burnstock, G.1
-
21
-
-
0022178232
-
Is there a basis for distinguishing two types of P2-purinoceptor?
-
Burnstock G and Kennedy C (1985) Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol 16:433-440.
-
(1985)
Gen Pharmacol
, vol.16
, pp. 433-440
-
-
Burnstock, G.1
Kennedy, C.2
-
22
-
-
84875420867
-
-
ACS National Meeting, Boston, MA; August, MEDI-474
-
Cantin L, Bayrakdarian M, Buon C, Hu Y, Kennedy V, Laplante M, Leung C, Luo X, Popovic N, Rene O et al.(2010) Pyrrolopyrimidine-based P2X3 antagonists for the treatment of pain. ACS National Meeting, Boston, MA; August 24-26, MEDI-474.
-
(2010)
Pyrrolopyrimidine-based P2X3 Antagonists for the Treatment of Pain
, pp. 24-26
-
-
Cantin, L.1
Bayrakdarian, M.2
Buon, C.3
Hu, Y.4
Kennedy, V.5
Laplante, M.6
Leung, C.7
Luo, X.8
Popovic, N.9
Rene, O.10
-
23
-
-
84862829828
-
Discovery of P2X3 selective antagonists for the treatment of chronic pain
-
Cantin LD, Bayrakdarian M, Buon C, Grazzini E, Hu YJ, Labrecque J, Leung C, Luo X, Martino G, and Paré M et al. (2012) Discovery of P2X3 selective antagonists for the treatment of chronic pain. Bioorg Med Chem Lett 22:2565-2571.
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 2565-2571
-
-
Cantin, L.D.1
Bayrakdarian, M.2
Buon, C.3
Grazzini, E.4
Hu, Y.J.5
Labrecque, J.6
Leung, C.7
Luo, X.8
Martino, G.9
Paré, M.10
-
24
-
-
36348952111
-
Thr339-toserine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308
-
Cao L, Young MT, Broomhead HE, Fountain SJ, and North RA (2007) Thr339-toserine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308. J Neurosci 27: 12916-12923.
-
(2007)
J Neurosci
, vol.27
, pp. 12916-12923
-
-
Cao, L.1
Young, M.T.2
Broomhead, H.E.3
Fountain, S.J.4
North, R.A.5
-
25
-
-
61349100301
-
Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain
-
Carter DS, Alam M, Cai H, Dillon MP, Ford APDW, Gever JR, Jahangir A, Lin C, Moore AG, and Wagner PJ et al. (2009) Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett 19:1628-1631.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 1628-1631
-
-
Carter, D.S.1
Alam, M.2
Cai, H.3
Dillon, M.P.4
Ford, A.P.D.W.5
Gever, J.R.6
Jahangir, A.7
Lin, C.8
Moore, A.G.9
Wagner, P.J.10
-
26
-
-
58149237912
-
Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1
-
Chaumont S, Compan V, Toulme E, Richler E, Housley GD, Rassendren F, and Khakh BS (2008) Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1. Sci Signal 1:ra8.
-
(2008)
Sci Signal
, vol.1
-
-
Chaumont, S.1
Compan, V.2
Toulme, E.3
Richler, E.4
Housley, G.D.5
Rassendren, F.6
Khakh, B.S.7
-
27
-
-
20144375454
-
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
-
Chessell IP, Hatcher JP, Bountra C,Michel AD, Hughes JP, Green P, Egerton J,Murfin M, Richardson J, and Peck WL et al. (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114:386-396.
-
(2005)
Pain
, vol.114
, pp. 386-396
-
-
Chessell, I.P.1
Hatcher, J.P.2
Bountra, C.3
Michel, A.D.4
Hughes, J.P.5
Green, P.6
Egerton, J.7
Murfin, M.8
Richardson, J.9
Peck, W.L.10
-
28
-
-
0034807785
-
Selective agonism of group i P2X receptors by dinucleotides dependent on a single adenine moiety
-
Cinkilic O, King BF, van der Giet M, Schlüter H, Zidek W, and Burnstock G (2001) Selective agonism of group I P2X receptors by dinucleotides dependent on a single adenine moiety. J Pharmacol Exp Ther 299:131-136.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 131-136
-
-
Cinkilic, O.1
King, B.F.2
Van Der Giet, M.3
Schlüter, H.4
Zidek, W.5
Burnstock, G.6
-
30
-
-
0028036881
-
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans
-
Cully DF, Vassilatis DK, Liu KK, Paress PS, Van der Ploeg LH, Schaeffer JM, and Arena JP (1994) Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature 371:707-711.
-
(1994)
Nature
, vol.371
, pp. 707-711
-
-
Cully, D.F.1
Vassilatis, D.K.2
Liu, K.K.3
Paress, P.S.4
Van Der Ploeg, L.H.5
Schaeffer, J.M.6
Arena, J.P.7
-
31
-
-
0032577682
-
NF279: A novel potent and selective antagonist of P2X receptor-mediated responses
-
Damer S, Niebel B, Czeche S, Nickel P, Ardanuy U, Schmalzing G, Rettinger J, Mutschler E, and Lambrecht G (1998) NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur J Pharmacol 350:R5-R6.
-
(1998)
Eur J Pharmacol
, vol.350
-
-
Damer, S.1
Niebel, B.2
Czeche, S.3
Nickel, P.4
Ardanuy, U.5
Schmalzing, G.6
Rettinger, J.7
Mutschler, E.8
Lambrecht, G.9
-
33
-
-
34347333404
-
Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states
-
Donnelly-Roberts DL and Jarvis MF (2007) Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol 151:571-579.
-
(2007)
Br J Pharmacol
, vol.151
, pp. 571-579
-
-
Donnelly-Roberts, D.L.1
Jarvis, M.F.2
-
34
-
-
38749115790
-
Painful purinergic receptors
-
Donnelly-Roberts D, McGaraughty S, Shieh C-C, Honore P, and Jarvis MF (2008) Painful purinergic receptors. J Pharmacol Exp Ther 324:409-415.
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 409-415
-
-
Donnelly-Roberts, D.1
McGaraughty, S.2
Shieh, C.-C.3
Honore, P.4
Jarvis, M.F.5
-
35
-
-
70350339068
-
Mammalian P2X7 receptor pharmacology: Comparison of recombinant mouse, rat and human P2X7 receptors
-
Donnelly-Roberts DL, Namovic MT, Han P, and Jarvis MF (2009) Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol 157:1203-1214.
-
(2009)
Br J Pharmacol
, vol.157
, pp. 1203-1214
-
-
Donnelly-Roberts, D.L.1
Namovic, M.T.2
Han, P.3
Jarvis, M.F.4
-
36
-
-
84863249245
-
Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulations
-
Du J, Dong H, and Zhou HX (2012) Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulations. Proc Natl Acad Sci USA 109:4140-4145.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 4140-4145
-
-
Du, J.1
Dong, H.2
Zhou, H.X.3
-
37
-
-
0036023394
-
Control of P2X(2) channel permeability by the cytosolic domain
-
Eickhorst AN, Berson A, Cockayne D, Lester HA, and Khakh BS (2002) Control of P2X(2) channel permeability by the cytosolic domain. J Gen Physiol 120:119-131.
-
(2002)
J Gen Physiol
, vol.120
, pp. 119-131
-
-
Eickhorst, A.N.1
Berson, A.2
Cockayne, D.3
Lester, H.A.4
Khakh, B.S.5
-
38
-
-
33646072818
-
The P2X7 receptor: A key player in IL-1 processing and release
-
Ferrari D, Pizzirani C, Adinolfi E, Lemoli RM, Curti A, Idzko M, Panther E, and DiVirgilio F (2006) The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 176:3877-3883.
-
(2006)
J Immunol
, vol.176
, pp. 3877-3883
-
-
Ferrari, D.1
Pizzirani, C.2
Adinolfi, E.3
Lemoli, R.M.4
Curti, A.5
Idzko, M.6
Panther, E.7
Divirgilio, F.8
-
39
-
-
84856298187
-
In pursuit of P2X3 antagonists: Novel therapeutics for chronic pain and afferent sensitization
-
Ford AP (2012) In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. Purinergic Signal 8 (Suppl 1):3-26.
-
(2012)
Purinergic Signal
, vol.8
, Issue.SUPPL. 1
, pp. 3-26
-
-
Ford, A.P.1
-
40
-
-
0030977216
-
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes
-
Gargett CE and Wiley JS (1997) The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br J Pharmacol 120:1483-1490.
-
(1997)
Br J Pharmacol
, vol.120
, pp. 1483-1490
-
-
Gargett, C.E.1
Wiley, J.S.2
-
41
-
-
33745737686
-
Pharmacology of P2X channels
-
Gever JR, Cockayne DA, Dillon MP, Burnstock G, and Ford APDW (2006) Pharmacology of P2X channels. Pflugers Arch 452:513-537.
-
(2006)
Pflugers Arch
, vol.452
, pp. 513-537
-
-
Gever, J.R.1
Cockayne, D.A.2
Dillon, M.P.3
Burnstock, G.4
Ford, A.P.D.W.5
-
42
-
-
77954038361
-
AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
-
Gever JR, Soto R, Henningsen RA, Martin RS, Hackos DH, Panicker S, Rubas W, Oglesby IB, Dillon MP, and Milla ME et al. (2010) AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol 160: 1387-1398.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1387-1398
-
-
Gever, J.R.1
Soto, R.2
Henningsen, R.A.3
Martin, R.S.4
Hackos, D.H.5
Panicker, S.6
Rubas, W.7
Oglesby, I.B.8
Dillon, M.P.9
Milla, M.E.10
-
43
-
-
0022629214
-
Extracellular ATP: Effects, sources and fate
-
Gordon JL (1986) Extracellular ATP: effects, sources and fate. Biochem J 233: 309-319.
-
(1986)
Biochem J
, vol.233
, pp. 309-319
-
-
Gordon, J.L.1
-
44
-
-
66249138835
-
Antagonists of the P2X(7) receptor. from lead identification to drug development
-
Guile SD, Alcaraz L, Birkinshaw TN, Bowers KC, Ebden MR, Furber M, and Stocks MJ (2009) Antagonists of the P2X(7) receptor. From lead identification to drug development. J Med Chem 52:3123-3141.
-
(2009)
J Med Chem
, vol.52
, pp. 3123-3141
-
-
Guile, S.D.1
Alcaraz, L.2
Birkinshaw, T.N.3
Bowers, K.C.4
Ebden, M.R.5
Furber, M.6
Stocks, M.J.7
-
45
-
-
84856274262
-
P2X receptor antagonists for pain management: Examination of binding and physicochemical properties
-
Gum RJ, Wakefield B, and Jarvis MF (2012) P2X receptor antagonists for pain management: examination of binding and physicochemical properties. Purinergic Signal 8 (Suppl 1):41-56.
-
(2012)
Purinergic Signal
, vol.8
, Issue.SUPPL. 1
, pp. 41-56
-
-
Gum, R.J.1
Wakefield, B.2
Jarvis, M.F.3
-
46
-
-
84860785529
-
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
-
Hattori M and Gouaux E (2012) Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature 485:207-212.
-
(2012)
Nature
, vol.485
, pp. 207-212
-
-
Hattori, M.1
Gouaux, E.2
-
48
-
-
84871574635
-
Salt bridge switching from Arg290/Glu167 to Arg290/ATP promotes the closed-to-open transition of the P2X2 receptors
-
Hausmann R, Günther J, Kless A, Kuhlmann D, Kassack MU, Bahrenberg G, Markwardt F, and Schmalzing G (2013) Salt bridge switching from Arg290/Glu167 to Arg290/ATP promotes the closed-to-open transition of the P2X2 receptors. Mol Pharmacol 83:73-84.
-
(2013)
Mol Pharmacol
, vol.83
, pp. 73-84
-
-
Hausmann, R.1
Günther, J.2
Kless, A.3
Kuhlmann, D.4
Kassack, M.U.5
Bahrenberg, G.6
Markwardt, F.7
Schmalzing, G.8
-
49
-
-
84870001757
-
N-substituted phenoxazine and acridone derivatives: Structure-activity relationships of potent P2X4 receptor antagonists
-
Hernandez-Olmos V, Abdelrahman A, El-Tayeb A, Freudendahl D, Weinhausen S, and Müller CE (2012) N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. J Med Chem 55:9576-9588.
-
(2012)
J Med Chem
, vol.55
, pp. 9576-9588
-
-
Hernandez-Olmos, V.1
Abdelrahman, A.2
El-Tayeb, A.3
Freudendahl, D.4
Weinhausen, S.5
Müller, C.E.6
-
50
-
-
0035843178
-
Identification of the platelet ADP receptor targeted by antithrombotic drugs
-
Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, and Julius D et al. (2001) Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409:202-207.
-
(2001)
Nature
, vol.409
, pp. 202-207
-
-
Hollopeter, G.1
Jantzen, H.M.2
Vincent, D.3
Li, G.4
England, L.5
Ramakrishnan, V.6
Yang, R.B.7
Nurden, P.8
Nurden, A.9
Julius, D.10
-
51
-
-
33751165071
-
A-740003 [N-(1-[(cyanoimino)(5-quinolinylamino) methyl]amino-2,2- dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat
-
Honore P, Donnelly-Roberts D, Namovic MT, Hsieh G, Zhu CZ, Mikusa JP, Hernandez G, Zhong C, Gauvin DM, and Chandran P et al. (2006) A-740003 [N-(1-[(cyanoimino)(5-quinolinylamino) methyl]amino-2,2-dimethylpropyl)-2-(3,4- dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther 319:1376-1385.
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 1376-1385
-
-
Honore, P.1
Donnelly-Roberts, D.2
Namovic, M.T.3
Hsieh, G.4
Zhu, C.Z.5
Mikusa, J.P.6
Hernandez, G.7
Zhong, C.8
Gauvin, D.M.9
Chandran, P.10
-
52
-
-
67849099111
-
The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice
-
Honore P, Donnelly-Roberts D, Namovic M, Zhong C, Wade C, Chandran P, Zhu C, Carroll W, Perez-Medrano A, and Iwakura Y et al. (2009) The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice. Behav Brain Res 204:77-81.
-
(2009)
Behav Brain Res
, vol.204
, pp. 77-81
-
-
Honore, P.1
Donnelly-Roberts, D.2
Namovic, M.3
Zhong, C.4
Wade, C.5
Chandran, P.6
Zhu, C.7
Carroll, W.8
Perez-Medrano, A.9
Iwakura, Y.10
-
53
-
-
0031595744
-
Isoquinolines as antagonists of the P2X7 nucleotide receptor: High selectivity for the human versus rat receptor homologues
-
Humphreys BD, Virginio C, Surprenant A, Rice J, and Dubyak GR (1998) Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues. Mol Pharmacol 54:22-32.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 22-32
-
-
Humphreys, B.D.1
Virginio, C.2
Surprenant, A.3
Rice, J.4
Dubyak, G.R.5
-
54
-
-
84872295116
-
Nicotinic acetylcholine receptors: From basic science to therapeutics
-
DOI: 10.1016/j.pharmthera.2012.08.012
-
Hurst R, Rollema H, and Bertrand D(2012) Nicotinic acetylcholine receptors: from basic science to therapeutics. Pharmacol Ther DOI: 10.1016/j.pharmthera.2012.08.012.
-
(2012)
Pharmacol Ther
-
-
Hurst, R.1
Rollema, H.2
Bertrand, D.3
-
55
-
-
53449102024
-
P2X7 receptor-Pannexin1 complex: Pharmacology and signaling
-
Iglesias R, Locovei S, Roque A, Alberto AP, Dahl G, Spray DC, and Scemes E (2008) P2X7 receptor-Pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol 295:C752-C760.
-
(2008)
Am J Physiol Cell Physiol
, vol.295
-
-
Iglesias, R.1
Locovei, S.2
Roque, A.3
Alberto, A.P.4
Dahl, G.5
Spray, D.C.6
Scemes, E.7
-
56
-
-
28444486336
-
The function of microglia through purinergic receptors: Neuropathic pain and cytokine release
-
Inoue K (2006) The function of microglia through purinergic receptors: neuropathic pain and cytokine release. Pharmacol Ther 109:210-226.
-
(2006)
Pharmacol Ther
, vol.109
, pp. 210-226
-
-
Inoue, K.1
-
57
-
-
36249018328
-
Modification of neuropathic pain sensation through microglial ATP receptors
-
Inoue K, Tsuda M, and Tozaki-Saitoh H (2007) Modification of neuropathic pain sensation through microglial ATP receptors. Purinergic Signal 3:311-316.
-
(2007)
Purinergic Signal
, vol.3
, pp. 311-316
-
-
Inoue, K.1
Tsuda, M.2
Tozaki-Saitoh, H.3
-
58
-
-
77954308978
-
P2Y nucleotide receptors: Promise of therapeutic applications
-
Jacobson KA and Boeynaems J-M (2010) P2Y nucleotide receptors: promise of therapeutic applications. Drug Discov Today 15:570-578.
-
(2010)
Drug Discov Today
, vol.15
, pp. 570-578
-
-
Jacobson, K.A.1
Boeynaems, J.-M.2
-
59
-
-
33747431924
-
Agonists and antagonists for P2 receptors
-
discussion 68-72, 107 112275-281
-
Jacobson KA, Costanzi S, Joshi BV, Besada P, Shin DH, Ko H, Ivanov AA, and Mamedova L (2006) Agonists and antagonists for P2 receptors. Novartis Found Symp 276:58-68, discussion 68-72, 107-112, 275-281.
-
(2006)
Novartis Found Symp
, vol.276
, pp. 58-68
-
-
Jacobson, K.A.1
Costanzi, S.2
Joshi, B.V.3
Besada, P.4
Shin, D.H.5
Ko, H.6
Ivanov, A.A.7
Mamedova, L.8
-
60
-
-
0037068428
-
Purine and pyrimidine (P2) receptors as drug targets
-
Jacobson KA, Jarvis MF, and Williams M (2002) Purine and pyrimidine (P2) receptors as drug targets. J Med Chem 45:4057-4093.
-
(2002)
J Med Chem
, vol.45
, pp. 4057-4093
-
-
Jacobson, K.A.1
Jarvis, M.F.2
Williams, M.3
-
61
-
-
73449108381
-
The neural-glial purinergic receptor ensemble in chronic pain states
-
Jarvis MF (2010) The neural-glial purinergic receptor ensemble in chronic pain states. Trends Neurosci 33:48-57.
-
(2010)
Trends Neurosci
, vol.33
, pp. 48-57
-
-
Jarvis, M.F.1
-
62
-
-
0037168683
-
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
-
Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, and Bianchi B et al. (2002) A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci USA 99: 17179-17184.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 17179-17184
-
-
Jarvis, M.F.1
Burgard, E.C.2
McGaraughty, S.3
Honore, P.4
Lynch, K.5
Brennan, T.J.6
Subieta, A.7
Van Biesen, T.8
Cartmell, J.9
Bianchi, B.10
-
64
-
-
0035144599
-
Modulation of BzATP and formalin induced nociception: Attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue
-
Jarvis MF, Wismer CT, Schweitzer E, Yu H, van Biesen T, Lynch KJ, Burgard EC, Kowaluk EA, and Kowaluk EA (2001) Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue. Br J Pharmacol 132:259-269.
-
(2001)
Br J Pharmacol
, vol.132
, pp. 259-269
-
-
Jarvis, M.F.1
Wismer, C.T.2
Schweitzer, E.3
Yu, H.4
Van Biesen, T.5
Lynch, K.J.6
Burgard, E.C.7
Kowaluk, E.A.8
Kowaluk, E.A.9
-
65
-
-
45649083271
-
Identification of P2X(4) receptor transmembrane residues contributing to channel gating and interaction with ivermectin
-
Jelínkova I, Vávra V, Jindrichova M, Obsil T, Zemkova HW, Zemkova H, and Stojilkovic SS (2008) Identification of P2X(4) receptor transmembrane residues contributing to channel gating and interaction with ivermectin. Pflugers Arch 456: 939-950.
-
(2008)
Pflugers Arch
, vol.456
, pp. 939-950
-
-
Jelínkova, I.1
Vávra, V.2
Jindrichova, M.3
Obsil, T.4
Zemkova, H.W.5
Zemkova, H.6
Stojilkovic, S.S.7
-
67
-
-
84860540831
-
Tightening of the ATP-binding sites induces the opening of P2X receptor channels
-
Jiang R, Taly A, Lemoine D, Martz A, Cunrath O, and Grutter T (2012) Tightening of the ATP-binding sites induces the opening of P2X receptor channels. EMBO J 31: 2134-2143.
-
(2012)
EMBO J
, vol.31
, pp. 2134-2143
-
-
Jiang, R.1
Taly, A.2
Lemoine, D.3
Martz, A.4
Cunrath, O.5
Grutter, T.6
-
68
-
-
79960254731
-
Inhibition of neuronal voltage-gated sodium channels by brilliant blue G
-
Jo S and Bean BP (2011) Inhibition of neuronal voltage-gated sodium channels by brilliant blue G. Mol Pharmacol 80:247-257.
-
(2011)
Mol Pharmacol
, vol.80
, pp. 247-257
-
-
Jo, S.1
Bean, B.P.2
-
69
-
-
84861526394
-
Molecular and functional properties of P2X receptors-recent progress and persisting challenges
-
Kaczmarek-Hájek K, Lörinczi E, Hausmann R, and Nicke A (2012) Molecular and functional properties of P2X receptors-recent progress and persisting challenges. Purinergic Signal 8:375-417.
-
(2012)
Purinergic Signal
, vol.8
, pp. 375-417
-
-
Kaczmarek-Hájek, K.1
Lörinczi, E.2
Hausmann, R.3
Nicke, A.4
-
70
-
-
33748569819
-
Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs
-
Kamei J and Takahashi Y (2006) Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. Eur J Pharmacol 547:160-164.
-
(2006)
Eur J Pharmacol
, vol.547
, pp. 160-164
-
-
Kamei, J.1
Takahashi, Y.2
-
71
-
-
0031887759
-
Ivermectin: A positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor
-
Krause RM, Buisson B, Bertrand S, Corringer PJ, Galzi JL, Changeux JP, and Bertrand D (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 53:283-294.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 283-294
-
-
Krause, R.M.1
Buisson, B.2
Bertrand, S.3
Corringer, P.J.4
Galzi, J.L.5
Changeux, J.P.6
Bertrand, D.7
-
72
-
-
67949117176
-
Crystal structure of the ATP-gated P2X(4) ion channel in the closed state
-
Kawate T, Michel JC, Birdsong WT, and Gouaux E (2009) Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature 460:592-598.
-
(2009)
Nature
, vol.460
, pp. 592-598
-
-
Kawate, T.1
Michel, J.C.2
Birdsong, W.T.3
Gouaux, E.4
-
73
-
-
84866105881
-
Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
-
Keystone EC, Wang MM, Layton M, Hollis S, and McInnes IB; D1520C00001 Study Team (2012) Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine. Ann Rheum Dis 71:1630-1635.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1630-1635
-
-
Keystone, E.C.1
Wang, M.M.2
Layton, M.3
Hollis, S.4
McInnes, I.B.5
-
74
-
-
0033366463
-
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds
-
Khakh BS, Bao XR, Labarca C, and Lester HA (1999a) Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci 2:322-330.
-
(1999)
Nat Neurosci
, vol.2
, pp. 322-330
-
-
Khakh, B.S.1
Bao, X.R.2
Labarca, C.3
Lester, H.A.4
-
75
-
-
84867132775
-
Neuromodulation by extracellular ATP and P2X receptors in the CNS
-
Khakh BS and North RA (2012) Neuromodulation by extracellular ATP and P2X receptors in the CNS. Neuron 76:51-69.
-
(2012)
Neuron
, vol.76
, pp. 51-69
-
-
Khakh, B.S.1
North, R.A.2
-
76
-
-
0033198189
-
Allosteric control of gating and kinetics at P2X(4) receptor channels
-
Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, and Lester HA (1999b) Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci 19: 7289-7299.
-
(1999)
J Neurosci
, vol.19
, pp. 7289-7299
-
-
Khakh, B.S.1
Proctor, W.R.2
Dunwiddie, T.V.3
Labarca, C.4
Lester, H.A.5
-
77
-
-
0035890154
-
Proteomic and functional evidence for a P2X7 receptor signalling complex
-
Kim M, Jiang LH, Wilson HL, North RA, and Surprenant A (2001) Proteomic and functional evidence for a P2X7 receptor signalling complex. EMBO J 20:6347-6358.
-
(2001)
EMBO J
, vol.20
, pp. 6347-6358
-
-
Kim, M.1
Jiang, L.H.2
Wilson, H.L.3
North, R.A.4
Surprenant, A.5
-
78
-
-
0028268565
-
Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists
-
Kleene SJ (1994) Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists. Br J Pharmacol 111:469-472.
-
(1994)
Br J Pharmacol
, vol.111
, pp. 469-472
-
-
Kleene, S.J.1
-
79
-
-
0023600751
-
Calmodulin antagonists depress calcium and potassium currents in ventricular and vascular myocytes
-
Klöckner U and Isenberg G (1987) Calmodulin antagonists depress calcium and potassium currents in ventricular and vascular myocytes. Am J Physiol 253: H1601-H1611.
-
(1987)
Am J Physiol
, vol.253
-
-
Klöckner, U.1
Isenberg, G.2
-
80
-
-
0028174057
-
Effect of ivermectin on gamma-aminobutyric acidinduced chloride currents in mouse hippocampal embryonic neurones
-
Krüsek J and Zemková H (1994) Effect of ivermectin on gamma-aminobutyric acidinduced chloride currents in mouse hippocampal embryonic neurones. Eur J Pharmacol 259:121-128.
-
(1994)
Eur J Pharmacol
, vol.259
, pp. 121-128
-
-
Krüsek, J.1
Zemková, H.2
-
81
-
-
0037096207
-
Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response
-
Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, and Gabel CA (2002) Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 168:6436-6445.
-
(2002)
J Immunol
, vol.168
, pp. 6436-6445
-
-
Labasi, J.M.1
Petrushova, N.2
Donovan, C.3
McCurdy, S.4
Lira, P.5
Payette, M.M.6
Brissette, W.7
Wicks, J.R.8
Audoly, L.9
Gabel, C.A.10
-
82
-
-
0031877057
-
29,39-O-(2,4,6- trinitrophenyl) adenosine 59-triphosphate (TNP-ATP)-a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels
-
Lewis CJ, Surprenant A, and Evans RJ (1998) 29,39-O-(2,4,6- trinitrophenyl) adenosine 59-triphosphate (TNP-ATP)-a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br J Pharmacol 124:1463-1466.
-
(1998)
Br J Pharmacol
, vol.124
, pp. 1463-1466
-
-
Lewis, C.J.1
Surprenant, A.2
Evans, R.J.3
-
83
-
-
84863914041
-
Involvement of the cysteinerich head domain in activation and desensitization of the P2X1 receptor
-
Lörinczi É, Bhargava Y, Marino SF, Taly A, Kaczmarek-Hájek K, Barrantes-Freer A, Dutertre S, Grutter T, Rettinger J, and Nicke A (2012) Involvement of the cysteinerich head domain in activation and desensitization of the P2X1 receptor. Proc Natl Acad Sci USA 109:11396-11401.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 11396-11401
-
-
Lörinczi, E.1
Bhargava, Y.2
Marino, S.F.3
Taly, A.4
Kaczmarek-Hájek, K.5
Barrantes-Freer, A.6
Dutertre, S.7
Grutter, T.8
Rettinger, J.9
Nicke, A.10
-
84
-
-
36149001732
-
Evaluation of purinergic mechanism for the treatment of voiding dysfunction: A study in conscious spinal cord-injured rats
-
Lu SH, Groat WC, Lin AT, Chen KK, and Chang LS (2007) Evaluation of purinergic mechanism for the treatment of voiding dysfunction: a study in conscious spinal cord-injured rats. J Chin Med Assoc 70:439-444.
-
(2007)
J Chin Med Assoc
, vol.70
, pp. 439-444
-
-
Lu, S.H.1
Groat, W.C.2
Lin, A.T.3
Chen, K.K.4
Chang, L.S.5
-
85
-
-
0035655395
-
Rapid secretion of interleukin-1beta by microvesicle shedding
-
MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, and Surprenant A (2001) Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15: 825-835.
-
(2001)
Immunity
, vol.15
, pp. 825-835
-
-
Mackenzie, A.1
Wilson, H.L.2
Kiss-Toth, E.3
Dower, S.K.4
North, R.A.5
Surprenant, A.6
-
86
-
-
33645224991
-
Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function
-
Masin M, Kerschensteiner D, Dümke K, Rubio ME, and Soto F (2006) Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function. J Biol Chem 281:4100-4108.
-
(2006)
J Biol Chem
, vol.281
, pp. 4100-4108
-
-
Masin, M.1
Kerschensteiner, D.2
Dümke, K.3
Rubio, M.E.4
Soto, F.5
-
87
-
-
34249099764
-
P2X7-related modulation of pathological nociception in rats
-
McGaraughty S, Chu KL, Namovic MT, Donnelly-Roberts DL, Harris RR, Zhang X-F, Shieh C-C, Wismer CT, Zhu CZ, and Gauvin DM et al. (2007) P2X7-related modulation of pathological nociception in rats. Neuroscience 146:1817-1828.
-
(2007)
Neuroscience
, vol.146
, pp. 1817-1828
-
-
McGaraughty, S.1
Chu, K.L.2
Namovic, M.T.3
Donnelly-Roberts, D.L.4
Harris, R.R.5
Zhang, X.-F.6
Shieh, C.-C.7
Wismer, C.T.8
Zhu, C.Z.9
Gauvin, D.M.10
-
88
-
-
81755177800
-
The role of the P2X7 receptor in infectious diseases
-
Miller CM, Boulter NR, Fuller SJ, Zakrzewski AM, Lees MP, Saunders BM, Wiley JS, and Smith NC (2011) The role of the P2X7 receptor in infectious diseases. PLoS Pathog 7:e1002212.
-
(2011)
PLoS Pathog
, vol.7
-
-
Miller, C.M.1
Boulter, N.R.2
Fuller, S.J.3
Zakrzewski, A.M.4
Lees, M.P.5
Saunders, B.M.6
Wiley, J.S.7
Smith, N.C.8
-
89
-
-
77955171038
-
Emerging structures and ligands for P2X3 and P2X4 receptorstowards novel treatments of neuropathic pain
-
Müller CE (2010) Emerging structures and ligands for P2X3 and P2X4 receptorstowards novel treatments of neuropathic pain. Purinergic Signal 6:145-148.
-
(2010)
Purinergic Signal
, vol.6
, pp. 145-148
-
-
Müller, C.E.1
-
90
-
-
22544478846
-
An intersubunit zinc binding site in rat P2X2 receptors
-
Nagaya N, Tittle RK, Saar N, Dellal SS, and Hume RI (2005) An intersubunit zinc binding site in rat P2X2 receptors. J Biol Chem 280:25982-25993.
-
(2005)
J Biol Chem
, vol.280
, pp. 25982-25993
-
-
Nagaya, N.1
Tittle, R.K.2
Saar, N.3
Dellal, S.S.4
Hume, R.I.5
-
91
-
-
0036788971
-
Molecular physiology of P2X receptors
-
North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067.
-
(2002)
Physiol Rev
, vol.82
, pp. 1013-1067
-
-
North, R.A.1
-
92
-
-
33845737742
-
Ideas about pain, a historical view
-
Perl ER (2007) Ideas about pain, a historical view. Nat Rev Neurosci 8:71-80.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 71-80
-
-
Perl, E.R.1
-
93
-
-
0028175838
-
Interleukin-1 b maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity
-
Perregaux DG and Gabel CA (1994) Interleukin-1 b maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 269:15195-15203.
-
(1994)
J Biol Chem
, vol.269
, pp. 15195-15203
-
-
Perregaux, D.G.1
Gabel, C.A.2
-
94
-
-
1442309855
-
Mechanism of ivermectin facilitation of human P2X4 receptor channels
-
Priel A and Silberberg SD (2004) Mechanism of ivermectin facilitation of human P2X4 receptor channels. J Gen Physiol 123:281-293.
-
(2004)
J Gen Physiol
, vol.123
, pp. 281-293
-
-
Priel, A.1
Silberberg, S.D.2
-
95
-
-
13844294341
-
Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist
-
Rettinger J, Braun K, Hochmann H, Kassack MU, Ullmann H, Nickel P, Schmalzing G, and Lambrecht G (2005) Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology 48:461-468.
-
(2005)
Neuropharmacology
, vol.48
, pp. 461-468
-
-
Rettinger, J.1
Braun, K.2
Hochmann, H.3
Kassack, M.U.4
Ullmann, H.5
Nickel, P.6
Schmalzing, G.7
Lambrecht, G.8
-
96
-
-
33847345548
-
Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor family
-
Samways DS and Egan TM (2007) Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor family. J Gen Physiol 129:245-256.
-
(2007)
J Gen Physiol
, vol.129
, pp. 245-256
-
-
Samways, D.S.1
Egan, T.M.2
-
97
-
-
80051959810
-
Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)
-
Samways DS, Khakh BS, Dutertre S, and Egan TM (2011) Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors). Proc Natl Acad Sci USA 108:13800-13805.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 13800-13805
-
-
Samways, D.S.1
Khakh, B.S.2
Dutertre, S.3
Egan, T.M.4
-
98
-
-
84857718067
-
Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals
-
Samways DS, Khakh BS, and Egan TM (2012) Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals. J Biol Chem 287: 7594-7602.
-
(2012)
J Biol Chem
, vol.287
, pp. 7594-7602
-
-
Samways, D.S.1
Khakh, B.S.2
Egan, T.M.3
-
99
-
-
34147179943
-
Ivermectin Interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels
-
Silberberg SD, Li M, and Swartz KJ (2007) Ivermectin Interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels. Neuron 54:263-274.
-
(2007)
Neuron
, vol.54
, pp. 263-274
-
-
Silberberg, S.D.1
Li, M.2
Swartz, K.J.3
-
100
-
-
0024804742
-
Coomassie Brilliant Blue G is a more potent antagonist of P2 purinergic responses than Reactive Blue 2 (Cibacron Blue 3GA) in rat parotid acinar cells
-
Soltoff SP, McMillian MK, and Talamo BR (1989) Coomassie Brilliant Blue G is a more potent antagonist of P2 purinergic responses than Reactive Blue 2 (Cibacron Blue 3GA) in rat parotid acinar cells. Biochem Biophys Res Commun 165: 1279-1285.
-
(1989)
Biochem Biophys Res Commun
, vol.165
, pp. 1279-1285
-
-
Soltoff, S.P.1
McMillian, M.K.2
Talamo, B.R.3
-
101
-
-
84862777282
-
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
-
Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, and Costigan M et al. (2012) Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med 18:595-599.
-
(2012)
Nat Med
, vol.18
, pp. 595-599
-
-
Sorge, R.E.1
Trang, T.2
Dorfman, R.3
Smith, S.B.4
Beggs, S.5
Ritchie, J.6
Austin, J.S.7
Zaykin, D.V.8
Vander Meulen, H.9
Costigan, M.10
-
102
-
-
0029665112
-
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
-
Surprenant A, Rassendren F, Kawashima E, North RA, and Buell G (1996) The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272:735-738.
-
(1996)
Science
, vol.272
, pp. 735-738
-
-
Surprenant, A.1
Rassendren, F.2
Kawashima, E.3
North, R.A.4
Buell, G.5
-
103
-
-
34547120738
-
A histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding site
-
Tittle RK, Power JM, and Hume RI (2007) A histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding site. J Biol Chem 282:19526-19533.
-
(2007)
J Biol Chem
, vol.282
, pp. 19526-19533
-
-
Tittle, R.K.1
Power, J.M.2
Hume, R.I.3
-
104
-
-
79955956565
-
Role of purinergic receptors in CNS function and neuroprotection
-
Tozaki-Saitoh H, Tsuda M, and Inoue K (2011) Role of purinergic receptors in CNS function and neuroprotection. Adv Pharmacol 61:495-528.
-
(2011)
Adv Pharmacol
, vol.61
, pp. 495-528
-
-
Tozaki-Saitoh, H.1
Tsuda, M.2
Inoue, K.3
-
105
-
-
84861528073
-
P2X4 purinoceptor signaling in chronic pain
-
Trang T and Salter MW (2012) P2X4 purinoceptor signaling in chronic pain. Purinergic Signal 8:621-628.
-
(2012)
Purinergic Signal
, vol.8
, pp. 621-628
-
-
Trang, T.1
Salter, M.W.2
-
106
-
-
67349141925
-
Airway nerves and dyspnea associated with inflammatory airway disease
-
Undem BJ and Nassenstein C (2009) Airway nerves and dyspnea associated with inflammatory airway disease. Respir Physiol Neurobiol 167:36-44.
-
(2009)
Respir Physiol Neurobiol
, vol.167
, pp. 36-44
-
-
Undem, B.J.1
Nassenstein, C.2
-
107
-
-
0028030797
-
A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP
-
Valera S, Hussy N, Evans RJ, Adami N, North RA, Surprenant A, and Buell G (1994) A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP. Nature 371:516-519.
-
(1994)
Nature
, vol.371
, pp. 516-519
-
-
Valera, S.1
Hussy, N.2
Evans, R.J.3
Adami, N.4
North, R.A.5
Surprenant, A.6
Buell, G.7
-
108
-
-
0031866948
-
Trinitrophenylsubstituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors
-
Virginio C, Robertson G, Surprenant A, and North RA (1998) Trinitrophenylsubstituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol 53:969-973.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 969-973
-
-
Virginio, C.1
Robertson, G.2
Surprenant, A.3
North, R.A.4
-
109
-
-
0027310852
-
Cloning and functional expression of a brain G-protein-coupled ATP receptor
-
Webb TE, Simon J, Krishek BJ, Bateson AN, Smart TG, King BF, Burnstock G, and Barnard EA (1993) Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett 324:219-225.
-
(1993)
FEBS Lett
, vol.324
, pp. 219-225
-
-
Webb, T.E.1
Simon, J.2
Krishek, B.J.3
Bateson, A.N.4
Smart, T.G.5
King, B.F.6
Burnstock, G.7
Barnard, E.A.8
-
111
-
-
84859450561
-
Ion channel drug discovery: Challenges and future directions
-
Wickenden A, Priest B, and Erdemli G (2012) Ion channel drug discovery: challenges and future directions. Future Med Chem 4:661-679.
-
(2012)
Future Med Chem
, vol.4
, pp. 661-679
-
-
Wickenden, A.1
Priest, B.2
Erdemli, G.3
-
112
-
-
0037072748
-
Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus
-
Wilson HL, Wilson SA, Surprenant A, and North RA (2002) Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J Biol Chem 277:34017-34023.
-
(2002)
J Biol Chem
, vol.277
, pp. 34017-34023
-
-
Wilson, H.L.1
Wilson, S.A.2
Surprenant, A.3
North, R.A.4
-
113
-
-
79953023121
-
Molecular determinants of potent P2X2 antagonism identified by functional analysis, mutagenesis, and homology docking
-
Wolf C, Rosefort C, Fallah G, Kassack MU, Hamacher A, Bodnar M, Wang H, Illes P, Kless A, and Bahrenberg G et al. (2011) Molecular determinants of potent P2X2 antagonism identified by functional analysis, mutagenesis, and homology docking. Mol Pharmacol 79:649-661.
-
(2011)
Mol Pharmacol
, vol.79
, pp. 649-661
-
-
Wolf, C.1
Rosefort, C.2
Fallah, G.3
Kassack, M.U.4
Hamacher, A.5
Bodnar, M.6
Wang, H.7
Illes, P.8
Kless, A.9
Bahrenberg, G.10
-
114
-
-
79951579664
-
Central sensitization: Implications for the diagnosis and treatment of pain
-
Woolf CJ (2011) Central sensitization: implications for the diagnosis and treatment of pain. Pain 152(3, Suppl)S2-S15.
-
(2011)
Pain
, vol.152
, Issue.3 SUPPL.
-
-
Woolf, C.J.1
-
115
-
-
0030946034
-
Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery
-
Ziyal R, Ziganshin AU, Nickel P, Ardanuy U, Mutschler E, Lambrecht G, and Burnstock G (1997) Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery. Br J Pharmacol 120:954-960.
-
(1997)
Br J Pharmacol
, vol.120
, pp. 954-960
-
-
Ziyal, R.1
Ziganshin, A.U.2
Nickel, P.3
Ardanuy, U.4
Mutschler, E.5
Lambrecht, G.6
Burnstock, G.7
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