P2X7 purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability

Cellular Immunology

Volumn 244, Issue 1, 2006, Pages 10-18

  Placido, Roberta ^c   Auricchio, Giovanni ^a   Falzoni, Simonetta ^d   Battistini, Luca ^c   Colizzi, Vittorio ^b   Brunetti, Ercole ^a   Di Virgilio, Francesco ^d   Mancino, Giorgio ^a  

^a FATEBENEFRATELLI HOSPITAL   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^d UNIVERSITY OF FERRARA   (Italy)

Author keywords

Apoptosis anti mycobacterial activity; ATP; M. tuberculosis; Monocytes macrophages; P2X7; Purinergic receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; PURINE P2 RECEPTOR;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; BACTERIAL INFECTION; BACTERIAL VIABILITY; CELL PROTECTION; COLONY FORMING UNIT; CONTROLLED STUDY; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MYCOBACTERIUM TUBERCULOSIS; OXIDATION; PARACRINE SIGNALING; PRIORITY JOURNAL; RECEPTOR BLOCKING;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; EXTRACELLULAR FLUID; HUMANS; MICROBIAL VIABILITY; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; RECEPTORS, PURINERGIC P2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUBERCULOSIS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 34247641287     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2007.02.001     Document Type: Article

References (48)

1. Mc Donough K.A., Cress Y., and Bloom B.R. Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages. Infect. Immun. 61 (1993) 2763-2773
2. Douvas G.S., Berger E.M., Repine J.E., and Crowle A.J. Natural mycobacteriostatic activity in human monocyte-derived adherent cells. Am. Rev. Respir. Dis. 134 (1986) 44-48
3. Denis M. Killing of Mycobacterium tuberculosis within human monocytes: activation by cytokines and calcitriol. Clin. Exp. Immunol. 84 (1991) 200-206
4. Warwick-Davies J., Dhillon J., O'Brien L., Andrew P.W., and Lowrie D.B. Apparent killing of Mycobacterium tuberculosis by cytokine-activated human monocytes can be an artefact of a cytotoxic effect on the monocytes. Clin. Exp. Immunol. 96 (1994) 214-217
5. Molloy A., Laochumroonvorapong P., and Kaplan G. Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular Bacillus Calmette-Guerin. J. Exp. Med. 180 (1994) 1499-1509
6. 2 induces monocyte apoptosis and reduces viability of Mycobacterium Avium-Mycobacterium intracellulare within cultured human monocytes. Infect. Immun. 64 (1996) 452-459
7. Fratazzi C., Arbeit R.D., Carini C., and Remold H.G. Programmed cell death of Mycobacterium avium serovar 4-infected human macrophages prevents mycobacteria from spreading and induces mycobacterial growth inhibition by freshly added, uninfected macrophages. J. Immunol. 158 (1997) 4320-4327
8. Williams G.T. Programmed cell death: a fundamental protective response to pathogens. Trends Microbiol. 2 (1994) 463-464
9. Placido R., Mancino G., Amendola A., Mariani F., Vendetti S., Piacentini M., Sanduzzi A., Bocchino M.L., Zembala M., and Colizzi V. Apoptosis of human monocytes/macrophages in Mycobacterium tuberculosis infection. J. Pathol. 181 (1997) 31-38
10. Durrbaum-Landmann I., Gercken J., Flad H.D., and Ernst M. Effect of in vitro infection of human monocytes with low numbers of Mycobacterium tuberculosis bacteria on monocyte apoptosis. Infect. Immun. 64 (1996) 5384-5389
11. Cree I.A., Nurbhai S., Milne G., and Swanson Beck J. Cell death in granulomata: the role of apoptosis. J. Clin. Pathol. 40 (1987) 1314-1319
12. Di Virgilio F. The P2Z purinoreceptors: an intriguing role in immunity, inflammation and cell death. Immunol. Today 16 (1995) 524-528
13. North R.A. Families of ion channels with two hydrophobic segments. Curr. Opin. Cell Biol. 8 (1996) 474-483
14. Lepine S., Le Stunff H., Lakatos B., Sulpice J.B., and Giraud F. ATP-induced apoptosis of thymocytes is mediated by activation of P2X7 receptor and involves de novo ceramide synthesis and mitochondria. Biochim. Biophys. Acta 1761 (2005) 73-82
15. Ferrari D., Chiozzi P., Falzoni S., Hanau S., and Di Virgilio F. Purinergic modulation of interleukin-1β release from microglial cells stimulated with bacterial toxin. J. Exp. Med. 185 (1997) 579-582
16. Raymond M.N., and Le Stunff H. Involvement of de novo ceramide biosynthesis in macrophage death induced by activation of ATP-sensitive P2X7 receptor. FEBS Lett. 580 (2006) 131-136
17. 7) receptors. Immunity 7 (1997) 433-444
18. Kusner D.J., and Adams J. ATP-induced killing of virulent Mycobacterium tuberculosis within human macrophages requires phospholipase D. J. Immunol. 164 (2000) 379-388
19. Myers A.J., Eilertson B., Fulton S.A., Flynn J.L., and Canaday D.H. The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection. Infect. Immun. 73 (2005) 3192-3195
20. Chen Y., and Zychlinsky A. Apoptosis induced by bacterial pathogens. Microb. Pathog. 17 (1994) 203-212
21. Keane J., Balcewicz-Sablinska M.K., Remold H.G., Chupp G.L., Meek B.B., Fenton M.J., and Kornfeld H. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect. Immun. 65 (1997) 298-304
22. Moore K.I., and Matlashewski G. Intracellular infection by Leishmania donovani inhibits macrophage apoptosis. J. Immunol. 152 (1994) 2930-2937
23. Kremer L., Estaquier J., Brandt E., Ameisen J.C., and Locht C. Mycobacterium bovis bacillus Calmette Guerin infection prevents apoptosis of resting human monocytes. Eur. J. Immunol. 27 (1997) 2450-2456
24. Gan H., Newman G.W., and Remold H.G. Plasminogen activator inhibitor type 2 prevents programmed cell death of human macrophages infected with Mycobacterium avium, serovar 4. J. Immunol. 155 (1995) 1304-1315
25. Kornfeld H., Mancino G., and Colizzi V. The role of macrophage cell death in tuberculosis. Cell Death Differ. 6 (1999) 71-78
26. Hickman S.E., El Khoury J., Greenberg S., Schieren I., and Silverstein I. P2Z adenosine triphosphate receptor activity in cultured human monocyte-derived macrophages. Blood 84 (1994) 2452-2456
27. Murgia M., Pizzo P., Steinberg T.H., and Di Virgilio F. Characterization of the cytotoxic effect of extracellular ATP in J774 mouse macrophages. Biochem. J. 288 (1992) 897-901
28. 2+ fluxes in J774 macrophages by two distinct mechanisms. J. Biol. Chem. 263 (1988) 10337-10343
29. Rassendren F., Buell G., Virginio C., Collo G., North R.A., and Surprenant R.A. The permeabilising ATP receptor, P2X7. J. Biol. Chem. 272 (1997) 5482-5486
30. 7). Science 272 (1996) 735-738
31. Ferrari D., Chiozzi P., Falzoni S., Dal Susino M., Collo G., Buell G., and Di Virgilio F. ATP-mediated cytotoxicity in microglial cells. Neuropharmacology 36 (1997) 1295
32. Falzoni S., Munerati M., Ferrari D., Spisani S., Moretti S., and Di Virgilio F. The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J. Clin. Invest. 95 (1995) 1207-1216
33. Ferrari D., Villalba M., Chiozzi P., Falzoni S., Ricciardi-Castagnoli P., and Di Virgilio F. Mouse microglial cells express a plasma membrane pore gated by extracellular ATP. J. Immunol. 156 (1996) 1531-1539
34. 7 receptor. J. Cell Biol. 138 (1997) 697-706
35. Kahlenberg J.M., Lundberg K.C., Kertesy S.B., Qu Y., and Dubyak G.R. Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-κB-driven protein synthesis. J. Immunol. 175 (2005) 7611-7622
36. Ferrari D., Pizzirani C., Adinolfi E., Lemoli R.M., Curti A., Idzko M., Panther E., and Di Virgilio F. The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol. 176 (2006) 3877-3883
37. Moon H., Na H.Y., Chong K.H., and Kim T.J. P2X7 receptor-dependent ATP-induced shedding of CD27 in mouse lymphocytes. Immunol. Lett. 102 (2006) 98-105
38. Molloy A., Laochumroonvorapong P., and Kaplan G. Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guerin. J. Exp. Med. 180 (1994) 1499-1509
39. Oddo M., Renno T., Attinger A., Bakker T., Macdonal H.R., and Meylan P.A.R. Fas ligand-induced apoptosis of infected human alveolar macrophages reduces the viability of intracellular Mycobacterium tuberculosis. J. Immunol. 160 (1998) 5448-5454
40. Stenger S., Mazzaccaro R.J., Uyemura K., Cho S., Barnes P.F., Rosat J.P., Sette A., Brenner M.B., Porcelli S.A., Bloom B.R., and Modlin R.L. Differential effects of cytolytic T cell subsets on intracellular infection. Science 276 (1997) 1684-1687
41. Li C.M., Campbell S.J., Kumararatne D.S., Bellamy R., Ruwende C., McAdam K.P.W.J., Hill A.V.S., and Lammas D.A. Association of a polymorphism in the P2X7 gene with Tuberculosis in a Gambian population. J. Infect. Dis. 186 (2002) 1458-1462
42. Sanders B.M., Fernando S.L., Sluyter R., Britton W.J., and Wiley J.S. A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria. J. Immunol. 171 (2003) 5442-5446
43. Fernando S.L., Saunders B.M., Sluyter R., Skarratt K.K., Wiley J.S., and Britton W.J. Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages. J. Infect. Dis. 192 (2005) 145-149
44. Shemon A.N., Sluyter R., Fernando S.L., Clarke A.L., Dao-Ung L.P., Skarratt K.K., Saunders B.M., Tan K.S., Gu B.J., Fuller S.J., Britton W.J., Petrou S., and Wiley J.S. A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. J. Biol. Chem. 281 (2006) 2079-2086
45. Blanchard D.K., McMillen S., and Djeu J.Y. IFN-γ enhances sensitivity of human macrophages to extracellular ATP-mediated lysis. J. Immunol. 147 (1991) 2579-2585
46. 7 nucleotide receptor and associated phospholipase D activity by Lipopolysaccharide and IFNγ in the human THP-1 monocytic cell line. J. Immunol. 157 (1996) 5627-5637
47. Ojcius D.M., Degani H., Mispelter J., and Dautry-Varsat A. Enhancement of ATP levels and glucose metabolism during an infection by Chlamydia. NMR studies of living cells. J. Biol. Chem. 273 (1998) 7052-7058
48. Robson S.C., Kaczmarek E., Siegel J.B., Candinas D., Koziak K., Millan M., Hancock W.W., and Bach F.H. Loss of ATP diphosphohydrolase activity with endothelial cell activation. J. Exp. Med. 185 (1997) 153-163