Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling

Bone

Volumn 28, Issue 5, 2001, Pages 507-512

  Bowler, W B ^a   Buckley, K A ^a   Gartland, A ^a   Hipskind, R A ^b   Bilbe, G ^c   Gallagher, J A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b CNRS   (France)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Adenosine triphosphate (ATP); c fos; Osteoblast; P2 receptor; Parathyroid hormone (PTH); Remodeling

Indexed keywords

ADENOSINE TRIPHOSPHATE; PARATHYROID HORMONE; PROTEIN C FOS; PURINE P2Y RECEPTOR;

ANIMAL CELL; ARTICLE; BONE REMODELING; CELL ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; OSTEOBLAST; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BONE REMODELING; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; HUMANS; NUCLEOTIDES; OSTEOBLASTS; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION;

EID: 0035046976     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(01)00430-6     Document Type: Article

References (77)

1. Expression cloning of a common receptor for parathyroid-hormone and parathyroid hormone-related peptide from rat osteoblast-like cells-a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium
2. 2+, phospholipase C and mitogen-activated protein kinase
3. An intact N terminus is required for the anabolic action of parathyroid hormone on adult female rats
4. ATP as an osteoclast regulator?
5. Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase
6. Classification of P2 purinoceptors
7. Increased flow-induced ATP release from isolated vascular endothelial cells but not smooth muscle cells
8. ATP-stimulated release of ATP by human endothelial cells
9. G-protein coupled receptors in bone
10. Identification and cloning of human P-2U purinoceptor present in osteoclastoma, bone, and osteoblasts
11. 2+ mobilization is strongly potentiated by a parathyroid hormone/cAMP-dependent protein kinase pathway independently of mitogen-activated protein kinase
12. Release of ATP by osteoblasts; Modulation by fluid shear forces
13. Real time measurement of ATP release from human osteoblasts
14. Effects of extracellular ATP on resorption and transcription factor activation in co-culture and RANK ligand-derived human osteoclasts
15. Purinergic nerves
16. Physiological and pathological roles of purines-an update
17. Evidence that ectonucleoside triphosphate pyrophosphatase serves in the generation of inorganic pyrophosphate in human bone and articular cartilage
18. Anabolic actions of parathyroid-hormone on bone
19. Effects of extracellular nucleotides on single cells and populations of human osteoblasts; Contribution of cell heterogeneity to relative potencies
20. P2 purinergic receptors on osteoblasts and osteoclasts; Potential targets for drug development
21. PTH receptor coupling to phospholipase-C is an alternate pathway of signal transduction in bone and kidney
22. 2 osteoblast-like cells
23. Calcium activation of ras mediated by neuronal exchange factor ras-grf
24. Nomenclature and classification of purinoceptors
25. Structure-function relationship of parathyroid-hormone-activation of phospholipase-C, protein kinase-A and kinase-C in osteosarcoma cells
26. 2U signalling pathways
27. Cyclic-AMP stimulates somatostatin gene-transcription by phosphorylation of CREB at serine-133
28. Fos and bone cell-development-lessons from a nuclear oncogene
29. CFTR channels expressed in CHO cells do not have detectable ATP conductance
30. ATP transport and ABC proteins
31. Release, metabolism and interconversion of adenine and uridine nucleotides; Implications for G protein-coupled P2 receptor agonist selectivity
32. Blockade by glibenclamide of the flow-induced endothelial release of ATP that contributors to the vasodilation in the pulmonary vascular bed of the rat
33. MAP kinase signalling cascades and gene expression in osteoblasts
34. Expression of P2 receptors in bone
35. Extracellular ATP is a mitogen for 3T3 cell, 3T6-cell, and A-431 cell and acts synergistically with other growth factors
36. Real time calcium response of cultured bone cells to fluid flow
37. Potentiation of ATP calcium responses by A2B receptor stimulation and other signals coupled to Gs proteins in type-1 cerebellar astrocytes
38. Pleiotropic effects of a null mutation in the c-fos protooncogene
39. Purinergic transmitters inhibit bone formation by cultured osteoblasts
40. ATP- and gap junction-dependent intracellular calcium signaling in osteoblastic cells
41. 2+, but not cyclic adenosine 3′,5′-monophosphate response to parathyroid hormone in rat osteoblastic cells
42. Prostaglandin; Stimulation of bone resorption in tissue culture
43. Continuous bioluminescent monitoring of cytoplasmic ATP in single isolated rat hepatocytes during metabolic poisoning
44. Laminar flow stimulates ATP and shear stress-dependent nitric oxide production in cultured bovine endothelial cells
45. Purinergic regulation of cytosolic calcium and phosphoinositide metabolism in rat osteoblast-like osteosarcoma cells
46. Direct demonstration of mechanically-induced release of cellular UTP and its implication for uridine nucleotide receptor activation
47. Stimulation of cartilage resorption by extracellular ATP acting at P-2-purinoceptors
48. Regulated ATP release by cultured human articular chondrocytes
49. Cloning of P2Y6 cDNAs and identification of a pseudogene; Comparison of P2Y receptor subtype expression in bone and brain tissue
50. Down-regulation of P-2U-purinergic nucleotide receptor messenger RNA expression during in vitro differentiation of human myeloid leukocytes by phorbol esters or inflammatory activators
51. ATP is a potent stimulator of the activation and formation of rodent osteoclasts
52. 4 purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts
53. Nucleotide receptors
54. Cell-to-cell spread of calcium signals mediated by ATP receptors in mast-cells
55. Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways
56. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production
57. ABC transporter-facilitated ATP conductive transport
58. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP
59. ATP and adenosine act as a mitogen for osteoblast-like cells (MC3T3-E1)
60. Evidence for P2-receptors on human osteoblast-like cells
61. 2+ stores available to receptors linked to inositol triphosphate formation
62. Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P-2Y2 receptor
63. Activation of P-2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C
64. Removal of calcium from bone as influenced by the parathyroids
65. Functional expression and signaling properties of cloned human parathyroid hormone receptor in Xenopus oocytes-Evidence for a novel signaling pathway
66. Mechanotransduction in bone; Do bone cells act as sensors of fluid flow?
67. Extracellular ATP and ADP stimulate proliferation of porcine aortic smooth-muscle cells
68. Increased bone growth by local prostaglandin E2 in rats
69. Bone and haematopoietic defects in mice lacking c-fos
70. Arachidonic acid release induced by extracellular ATP in osteoblasts; Role of phospholipase D Prostagland
71. Calcium signalling via multiple P2 purinoceptor subtypes in rat osteoclasts
72. Inhibition of phospholipase A2-mediated arachidonic acid release by cyclic AMP defines a negative feedback loop for P2Y receptor activation in Madin-Darby canine kidney D1 cells
73. Osteoblast-like cells have a variable mixed population of purino/nucleotide receptors