P2X 7-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 302, Issue 5, 2012, Pages

  Grol, Matthew W ^a   Zelner, Irene ^b   Jeffrey Dixon, S ^b  

^a Department of Anatomy and Cell Biology ^*  (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

Adenosine 5' triphosphate; Metabolism; Microphysiometer; Phosphatidylinositol 3 kinase; Proton efflux

Indexed keywords

CALCIUM; GLUCOSE; PHOSPHATIDYLINOSITOL 3 KINASE; PURINERGIC P2X7 RECEPTOR;

APOPTOSIS; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLIC ACID PRODUCTION; METABOLIC PARAMETERS; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BONE REMODELING; CALCIUM SIGNALING; CELL LINE; CELL SURVIVAL; CLONE CELLS; ENZYME INHIBITORS; GLUCOSE; HYDROGEN-ION CONCENTRATION; KINETICS; LACTIC ACID; LIGANDS; MICE; OSTEOBLASTS; PHOSPHATIDYLINOSITOL 3-KINASES; PURINERGIC P2X RECEPTOR AGONISTS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7; URIDINE TRIPHOSPHATE;

EID: 84857241763     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00209.2011     Document Type: Article

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