Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Molecular Neurobiology

Volumn 53, Issue 1, 2016, Pages 518-531

  Apolloni, Savina ^a,b   Fabbrizio, Paola ^b   Parisi, Chiara ^a   Amadio, Susanna ^b   Volonté, Cinzia ^a,b  

^a CNR   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Histamine H1 receptor; M1 M2 phenotype; Microglia; Motor neuron; P2X7

Indexed keywords

ARGINASE 1; BRAIN DERIVED NEUROTROPHIC FACTOR; CD68 ANTIGEN; CLEMASTINE; COPPER ZINC SUPEROXIDE DISMUTASE; GLYCOPROTEIN GP 91; INTERLEUKIN 10; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PURINERGIC P2X7 RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; ANTIINFLAMMATORY AGENT; SOD1 G93A PROTEIN; SUPEROXIDE DISMUTASE;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; ENZYME ACTIVATION; FEMALE; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; MOTONEURON; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN CONTENT; PROTEIN EXPRESSION; TREATMENT DURATION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; PHENOTYPE; PHYSIOLOGY; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CLEMASTINE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; NEUROPROTECTION; PHENOTYPE; SUPEROXIDE DISMUTASE;

EID: 84953364910     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-9019-8     Document Type: Article

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