A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice

Journal of Biological Chemistry

Volumn 284, Issue 38, 2009, Pages 25813-25822

  Nicke, Annette ^a   Kuan, Yung Hui ^a   Masin, Marianela ^b,c   Rettinger, Jürgen ^d   Marquez Klaka, Benjamin ^a   Bender, Olaf ^a   Górecki, Dariusz C ^e   Murrell Lagnado, Ruth D ^c   Soto, Florentina ^b,f  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d MPI of Biophysics ^*  (Germany)

^e UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ANALYSIS; BN-PAGE; DEACTIVATION KINETICS; DRUG TARGETS; DYE UPTAKE; FUNCTIONAL PROPERTIES; GENE DELETION; GENE INACTIVATION; HEK293 CELLS; HIGH PERMEABILITY; IMMUNE FUNCTION; ISOFORMS; KNOCK OUTS; MEMBRANE BLEBBING; MICE STRAINS; N-METHYL-D-GLUCAMINE; PCR ANALYSIS; PERMEABILITY MEASUREMENTS; RECEPTOR CHANNELS; RECEPTOR SIGNALING; SDS-PAGE; SPLICE VARIANTS; TRANS-MEMBRANE DOMAINS; WHOLE CELL PATCH CLAMP; XENOPUS OOCYTE;

ACTIVATION ANALYSIS; CAPILLARITY; DIFFUSERS (OPTICAL);

CELL MEMBRANES;

MEGLUMINE; PURINERGIC P2X7 RECEPTOR; 3' O (4 BENZOYL)BENZOYLADENOSINE 5' TRIPHOSPHATE; 3'-O-(4-BENZOYL)BENZOYLADENOSINE 5'-TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTITHROMBOCYTIC AGENT; DRUG DERIVATIVE; GAMMA-GLUTAMYLMETHYLAMIDE; GLUTAMIC ACID DERIVATIVE; GLUTAMYLMETHYLAMIDE; ISOPROTEIN; PURINERGIC P2 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DNA LIBRARY; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; NONHUMAN; OOCYTE; PATCH CLAMP; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SIGNAL TRANSDUCTION; SPLEEN; ALTERNATIVE RNA SPLICING; ANIMAL; CELL LINE; DRUG EFFECT; EXON; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; WISTAR RAT; XENOPUS LAEVIS;

MUS; RATTUS; RODENTIA;

ADENOSINE TRIPHOSPHATE; ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CELL LINE; CELL MEMBRANE PERMEABILITY; EXONS; GLUTAMATES; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; OOCYTES; PLATELET AGGREGATION INHIBITORS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

EID: 70350012258     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.033134     Document Type: Article

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