메뉴 건너뛰기




Volumn 82, Issue 1, 2012, Pages 80-89

Effects of nucleotide analogs at the P2X3 receptor and its mutants identify the agonist binding pouch

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; AMINO ACID; NUCLEOTIDE DERIVATIVE; PURINERGIC P2X RECEPTOR AGONIST; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X4 RECEPTOR;

EID: 84862546166     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.077818     Document Type: Article
Times cited : (7)

References (43)
  • 2
    • 0025055702 scopus 로고
    • ATP-activated channels in rat and bullfrog sensory neurons: Concentration dependence and kinetics
    • Bean BP (1990) ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics. J Neurosci 10:1-10.
    • (1990) J Neurosci , vol.10 , pp. 1-10
    • Bean, B.P.1
  • 4
  • 6
    • 0032940264 scopus 로고    scopus 로고
    • Single channel properties of P2X2 purinoceptors
    • Ding S and Sachs F (1999) Single channel properties of P2X2 purinoceptors. J Gen Physiol 113:695-720.
    • (1999) J Gen Physiol , vol.113 , pp. 695-720
    • Ding, S.1    Sachs, F.2
  • 8
    • 0030593493 scopus 로고    scopus 로고
    • Single channel properties of ATP-gated cation channels (P2X receptors) heterologously expressed in Chinese hamster ovary cells
    • Evans RJ (1996) Single channel properties of ATP-gated cation channels (P2X receptors) heterologously expressed in Chinese hamster ovary cells. Neurosci Lett 212:212-214.
    • (1996) Neurosci Lett , vol.212 , pp. 212-214
    • Evans, R.J.1
  • 9
    • 77958610109 scopus 로고    scopus 로고
    • Structural interpretation of P2X receptor mutagenesis studies on drug action
    • Evans RJ (2010) Structural interpretation of P2X receptor mutagenesis studies on drug action. Br J Pharmacol 161:961-971.
    • (2010) Br J Pharmacol , vol.161 , pp. 961-971
    • Evans, R.J.1
  • 11
    • 0347383758 scopus 로고    scopus 로고
    • MODELLER: Generation and Refinement of Homology-Based Protein Structure Models
    • DOI 10.1016/S0076-6879(03)74020-8
    • Fiser A and Sali A (2003) Modeller: generation and refinement of homology-based protein structure models. Methods Enzymol 374:461-491. (Pubitemid 37531821)
    • (2003) Methods in Enzymology , vol.374 , pp. 461-491
    • Fiser, A.1    Sali, A.2
  • 12
    • 0031668776 scopus 로고    scopus 로고
    • ATP binding site of P2X channel proteins: Structural similarities with class II aminoacyl-tRNA synthetases
    • DOI 10.1016/S0014-5793(98)00958-2, PII S0014579398009582
    • Freist W, Verhey JF, Stühmer W, and Gauss DH (1998) ATP binding site of P2X channel proteins: structural similarities with class II aminoacyl-tRNA synthetases. FEBS Lett 434:61-65. (Pubitemid 28404663)
    • (1998) FEBS Letters , vol.434 , Issue.1-2 , pp. 61-65
    • Freist, W.1    Verhey, J.F.2    Stuhmer, W.3    Gauss, D.H.4
  • 14
    • 67949092829 scopus 로고    scopus 로고
    • Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
    • Gonzales EB, Kawate T, and Gouaux E (2009) Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature 460:599-604.
    • (2009) Nature , vol.460 , pp. 599-604
    • Gonzales, E.B.1    Kawate, T.2    Gouaux, E.3
  • 15
  • 17
    • 0030322783 scopus 로고    scopus 로고
    • Double-mutant cycles: A powerful tool for analyzing protein structure and function
    • Horovitz A (1996) Double-mutant cycles: a powerful tool for analyzing protein structure and function. Fold Des 1:R121-R126.
    • (1996) Fold des , vol.1
    • Horovitz, A.1
  • 19
    • 0034602169 scopus 로고    scopus 로고
    • Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor
    • Jiang LH, Rassendren F, Surprenant A, and North RA (2000) Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor. J Biol Chem 275:34190-34196.
    • (2000) J Biol Chem , vol.275 , pp. 34190-34196
    • Jiang, L.H.1    Rassendren, F.2    Surprenant, A.3    North, R.A.4
  • 21
    • 37349124729 scopus 로고    scopus 로고
    • 3 receptors can be explained by an allosteric two-open-state model
    • DOI 10.1124/mol.107.038901
    • Karoly R, Mike A, Illes P, and Gerevich Z (2008) The unusual state-dependent affinity of P2X3 receptors can be explained by an allosteric two-open-state model. Mol Pharmacol 73:224-234. (Pubitemid 350294213)
    • (2008) Molecular Pharmacology , vol.73 , Issue.1 , pp. 224-234
    • Karoly, R.1    Mike, A.2    Illes, P.3    Gerevich, Z.4
  • 22
    • 67949117176 scopus 로고    scopus 로고
    • Crystal structure of the ATP-gated P2X(4) ion channel in the closed state
    • Kawate T, Michel JC, Birdsong WT, and Gouaux E (2009) Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature 460:592-598.
    • (2009) Nature , vol.460 , pp. 592-598
    • Kawate, T.1    Michel, J.C.2    Birdsong, W.T.3    Gouaux, E.4
  • 23
    • 0035107660 scopus 로고    scopus 로고
    • International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits
    • Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Ségué la P, Voigt M, and Humphrey PP (2001) International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev 53:107-118. (Pubitemid 32173110)
    • (2001) Pharmacological Reviews , vol.53 , Issue.1 , pp. 107-118
    • Khakh, B.S.1    Buenstock, G.2    Kennedy, C.3    King, B.F.4    North, R.A.5    Seguela, P.6    Voigt, M.7    Humphrey, P.P.A.8
  • 24
    • 34548230005 scopus 로고    scopus 로고
    • Purine ionotropic (P2X) receptors
    • DOI 10.2174/138161207781368747
    • Köles L, Fürst S, and Illes P (2007) Purine ionotropic (P2X) receptors. Curr Pharm Des 13:2368-2384. (Pubitemid 47321570)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.23 , pp. 2368-2384
    • Koles, L.1    Furst, S.2    Illes, P.3
  • 25
    • 10644241979 scopus 로고    scopus 로고
    • Bridging the gap between structural bioinformatics and receptor research: The membrane-embedded, ligand-gated, P2X glycoprotein receptor
    • DOI 10.2174/1568026043387197
    • Mager PP, Weber A, and Illes P (2004) Bridging the gap between structural bioinformatics and receptor research: the membrane-embedded, ligand-gated, P2X glycoprotein receptor. Curr Top Med Chem 4:1657-1705. (Pubitemid 39654455)
    • (2004) Current Topics in Medicinal Chemistry , vol.4 , Issue.16 , pp. 1657-1705
    • Mager, P.P.1    Weber, A.2    Illes, P.3
  • 26
    • 60549095934 scopus 로고    scopus 로고
    • Inter-subunit disulfide cross-linking in homomeric and heteromeric P2X receptors
    • Marquez-Klaka B, Rettinger J, and Nicke A (2009) Inter-subunit disulfide cross-linking in homomeric and heteromeric P2X receptors. Eur Biophys J 38:329-338.
    • (2009) Eur Biophys J , vol.38 , pp. 329-338
    • Marquez-Klaka, B.1    Rettinger, J.2    Nicke, A.3
  • 27
    • 17844405808 scopus 로고    scopus 로고
    • Maximum likelihood estimation of ion channel kinetics from macroscopic currents
    • DOI 10.1529/biophysj.104.053256
    • Milescu LS, Akk G, and Sachs F (2005) Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophys J 88:2494-2515. (Pubitemid 40976119)
    • (2005) Biophysical Journal , vol.88 , Issue.4 , pp. 2494-2515
    • Milescu, L.S.1    Akk, G.2    Sachs, F.3
  • 28
    • 0032089620 scopus 로고    scopus 로고
    • 3 receptors form stable trimers: A novel structural motif of ligand-gated ion channels
    • DOI 10.1093/emboj/17.11.3016
    • Nicke A, Bäumert HG, Rettinger J, Eichele A, Lambrecht G, Mutschler E, and Schmalzing G (1998) P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J 17:3016-3028. (Pubitemid 28254374)
    • (1998) EMBO Journal , vol.17 , Issue.11 , pp. 3016-3028
    • Nicke, A.1    Baumert, H.G.2    Rettinger, J.3    Eichele, A.4    Lambrecht, G.5    Mutschler, E.6    Schmalzing, G.7
  • 29
    • 0036788971 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors
    • North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067.
    • (2002) Physiol Rev , vol.82 , pp. 1013-1067
    • North, R.A.1
  • 30
    • 34247120710 scopus 로고    scopus 로고
    • Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors
    • DOI 10.1523/JNEUROSCI.2310-06.2007
    • Roberts JA and Evans RJ (2007) Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors. J Neurosci 27:4072-4082. (Pubitemid 46597149)
    • (2007) Journal of Neuroscience , vol.27 , Issue.15 , pp. 4072-4082
    • Roberts, J.A.1    Evans, R.J.2
  • 33
    • 1942504717 scopus 로고    scopus 로고
    • 3 receptors provides a novel and sensitive approach for their rapid up or downregulation
    • DOI 10.1038/sj.bjp.0705701
    • Sokolova E, Skorinkin A, Fabbretti E, Masten L, Nistri A, and Giniatullin R (2004) Agonist-dependence of recovery from desensitization of P2X(3) receptors provides a novel and sensitive approach for their rapid up or downregulation. Br J Pharmacol 141:1048-1058. (Pubitemid 38510089)
    • (2004) British Journal of Pharmacology , vol.141 , Issue.6 , pp. 1048-1058
    • Sokolova, E.1    Skorinkin, A.2    Fabbretti, E.3    Masten, L.4    Nistri, A.5    Giniatullin, R.6
  • 35
    • 76149120388 scopus 로고    scopus 로고
    • AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
    • Trott O and Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31:455-461.
    • (2010) J Comput Chem , vol.31 , pp. 455-461
    • Trott, O.1    Olson, A.J.2
  • 37
    • 4344701877 scopus 로고    scopus 로고
    • Molecular properties of ATP-gated P2X receptor ion channels
    • DOI 10.1016/j.tips.2004.07.008, PII S0165614704002081
    • Vial C, Roberts JA, and Evans RJ (2004) Molecular properties of ATP-gated P2X receptor ion channels. Trends Pharmacol Sci 25:487-493. (Pubitemid 39149705)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.9 , pp. 487-493
    • Vial, C.1    Roberts, J.A.2    Evans, R.J.3
  • 39
    • 15744376891 scopus 로고    scopus 로고
    • Molecular determinants of the agonist binding domain of a P2X receptor channel
    • DOI 10.1124/mol.104.010108
    • Yan Z, Liang Z, Tomic M, Obsil T, and Stojilkovic SS (2005) Molecular determinants of the agonist binding domain of a P2X receptor channel. Mol Pharmacol 67:1078-1088. (Pubitemid 40410408)
    • (2005) Molecular Pharmacology , vol.67 , Issue.4 , pp. 1078-1088
    • Yan, Z.1    Liang, Z.2    Tomic, M.3    Obsil, T.4    Stojilkovic, S.S.5
  • 40
    • 75749112926 scopus 로고    scopus 로고
    • P2X receptors: Dawn of the post-structure era
    • Young MT (2010) P2X receptors: dawn of the post-structure era. Trends Biochem Sci 35:83-90.
    • (2010) Trends Biochem Sci , vol.35 , pp. 83-90
    • Young, M.T.1
  • 41
    • 54449086943 scopus 로고    scopus 로고
    • Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy
    • Young MT, Fisher JA, Fountain SJ, Ford RC, North RA, and Khakh BS (2008) Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy. J Biol Chem 283: 26241-26251.
    • (2008) J Biol Chem , vol.283 , pp. 26241-26251
    • Young, M.T.1    Fisher, J.A.2    Fountain, S.J.3    Ford, R.C.4    North, R.A.5    Khakh, B.S.6
  • 42
    • 33845891326 scopus 로고    scopus 로고
    • 7 receptor that mediate differential sensitivity to ATP and BzATP
    • DOI 10.1124/mol.106.030163
    • Young MT, Pelegrin P, and Surprenant A (2007) Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Mol Pharmacol 71:92-100. (Pubitemid 46020980)
    • (2007) Molecular Pharmacology , vol.71 , Issue.1 , pp. 92-100
    • Young, M.T.1    Pelegrin, P.2    Surprenant, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.