P2X7 receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis

Journal of Neuroscience

Volumn 27, Issue 35, 2007, Pages 9525-9533

  Matute, Carlos ^a   Torre, Iratxe ^a   Pérez Cerdá, Fernando ^a   Pérez Samartín, Alberto ^a   Alberdi, Elena ^a   Etxebarria, Estibaliz ^a   Arranz, Amaia M ^a   Ravid, Rivka ^b   Rodríguez Antigüedad, Alfredo ^c   Sánchez Gómez, María Victoria ^a   Domercq, María ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b NETHERLANDS BRAIN BANK   (Netherlands)

^c HOSPITAL DE BASURTO   (Spain)

Author keywords

ATP; Demyelination; EAE; Excitotoxicity; Multiple sclerosis; Oligodendrocytes

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PURINE P2X7 RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DEMYELINATION; ELECTROPHYSIOLOGY; EXCITOTOXICITY; IMMUNOGOLD ELECTRON MICROSCOPY; MICROGLIA; MULTIPLE SCLEROSIS; NERVE FIBER; NEUROLOGIC DISEASE; NONHUMAN; OLIGODENDROGLIA; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOPROTEINS; HUMANS; MEMBRANE POTENTIALS; MICE; MICROSCOPY, IMMUNOELECTRON; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; OPTIC NERVE; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2;

EID: 34548398189     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0579-07.2007     Document Type: Article

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