P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair

Calcified Tissue International

Volumn 84, Issue 5, 2009, Pages 405-412

  Li, Jiliang ^a   Meyer, Rachel ^b   Duncan, Randall L ^c   Turner, Charles H ^b  

^a INDIANA UNIVERSITY   (United States)

^b Indiana University Purdue University Indianapolis   (United States)

^c UNIVERSITY OF DELAWARE   (United States)

Author keywords

Biomechanics; Bone density; Bone remodeling; Fracture repair; Histomorphometry; P2X7 receptor

Indexed keywords

PURINERGIC P2X7 RECEPTOR; STAINLESS STEEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE RADIOGRAPHY; BONE REMODELING; CALLUS; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; FRACTURE TREATMENT; GENE MUTATION; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOTOMY; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

ANIMALS; BONE REGENERATION; BONE REMODELING; BONY CALLUS; CALCIFICATION, PHYSIOLOGIC; DISEASE MODELS, ANIMAL; FEMALE; FEMUR; FRACTURES, BONE; MICE; MICE, KNOCKOUT; RECEPTORS, PURINERGIC P2; RECOVERY OF FUNCTION; STRESS, MECHANICAL; WEIGHT-BEARING; WOUND HEALING;

EID: 67349241408     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-009-9237-7     Document Type: Article

References (24)

1. DC Genetos DJ Geist D Liu HJ Donahue RL Duncan 2005 Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts J Bone Miner Res 20 41 49 (Pubitemid 41716217)
2. J Li D Liu HZ Ke RL Duncan CH Turner 2005 The P2X7 nucleotide receptor mediates skeletal mechanotransduction J Biol Chem 280 42952 42959 (Pubitemid 43049258)
3. WB Bowler CJ Dixon C Halleux R Maier G Bilbe WD Fraser JA Gallagher RA Hipskind 1999 Signaling in human osteoblasts by extracellular nucleotides. Their weak induction of the c-fos proto-oncogene via Ca2+ mobilization is strongly potentiated by a parathyroid hormone/cAMP-dependent protein kinase pathway independently of mitogen-activated protein kinase J Biol Chem 274 14315 14324 (Pubitemid 129518743)
4. RA North 2002 Molecular physiology of P2X receptors Physiol Rev 82 1013 1067
5. A Surprenant F Rassendren E Kawashima RA North G Buell 1996 The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7) Science 272 735 738 (Pubitemid 26152784)
6. D Ferrari P Chiozzi S Falzoni M Dal Susino L Melchiorri OR Baricordi F Di Virgilio 1997 Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages J Immunol 159 1451 1458 (Pubitemid 127484125)
7. D Ferrari M Los MK Bauer P Vandenabeele S Wesselborg K Schulze-Osthoff 1999 P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death FEBS Lett 447 71 75 (Pubitemid 29134951)
8. M Kim LH Jiang HL Wilson RA North A Surprenant 2001 Proteomic and functional evidence for a P2X7 receptor signalling complex EMBO J 20 6347 6358 (Pubitemid 33078708)
9. HZ Ke H Qi AF Weidema Q Zhang N Panupinthu DT Crawford WA Grasser VM Paralkar M Li LP Audoly CA Gabel WS Jee SJ Dixon SM Sims DD Thompson 2003 Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption Mol Endocrinol 17 1356 1367 (Pubitemid 36819956)
10. L Cui YF Ma W Yao H Zhou RB Setterberg TC Liang WS Jee 2001 Cancellous bone of aged rats maintains its capacity to respond vigorously to the anabolic effects of prostaglandin E2 by modeling-dependent bone gain J Bone Miner Metab 19 29 37 (Pubitemid 32048195)
11. A Mo W Yao C Li X Tian M Su Y Ling Q Zhang RB Setterberg WS Jee 2002 Bipedal stance exercise and prostaglandin E2 (PGE2) and its synergistic effect in increasing bone mass and in lowering the PGE2 dose required to prevent ovariectomized-induced cancellous bone loss in aged rats Bone 31 402 406 (Pubitemid 35299620)
12. W Yao WS Jee H Zhou J Lu L Cui R Setterberg T Liang Y Ma 1999 Anabolic effect of prostaglandin E2 on cortical bone of aged male rats comes mainly from modeling-dependent bone gain Bone 25 697 702 (Pubitemid 29525436)
13. M Solle J Labasi DG Perregaux E Stam N Petrushova BH Koller RJ Griffiths CA Gabel 2001 Altered cytokine production in mice lacking P2X(7) receptors J Biol Chem 276 125 132 (Pubitemid 32050297)
14. F Bonnarens TA Einhorn 1984 Production of a standard closed fracture in laboratory animal bone J Orthop Res 2 97 101 (Pubitemid 14034681)
15. C Li S Mori J Li Y Kaji T Akiyama J Kawanishi H Norimatsu 2001 Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats J Bone Miner Res 16 429 436 (Pubitemid 32173356)
16. J Li S Mori Y Kaji J Kawanishi T Akiyama H Norimatsu 2000 Concentration of bisphosphonate (incadronate) in callus area and its effects on fracture healing in rats J Bone Miner Res 15 2042 2051
17. J Li S Mori Y Kaji T Mashiba J Kawanishi H Norimatsu 1999 Effect of bisphosphonate (incadronate) on fracture healing of long bones in rats J Bone Miner Res 14 969 979 (Pubitemid 29262892)
18. R Dimitriou E Tsiridis PV Giannoudis 2005 Current concepts of molecular aspects of bone healing Injury 36 1392 1404 (Pubitemid 41618169)
19. LC Gerstenfeld YM Alkhiary EA Krall FH Nicholls SN Stapleton JL Fitch M Bauer R Kayal DT Graves KJ Jepsen TA Einhorn 2006 Three-dimensional reconstruction of fracture callus morphogenesis J Histochem Cytochem 54 1215 1228 (Pubitemid 44623342)
20. ZS Ai-Aql AS Alagl DT Graves LC Gerstenfeld TA Einhorn 2008 Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis J Dent Res 87 107 118 (Pubitemid 350297623)
21. P Pelegrin C Barroso-Gutierrez A Surprenant 2008 P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage J Immunol 180 7147 7157
22. Y Shigemoto-Mogami S Koizumi M Tsuda K Ohsawa S Kohsaka K Inoue 2001 Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5 J Neurochem 78 1339 1349 (Pubitemid 32899765)
23. CM Wang YY Chang SH Sun 2003 Activation of P2X7 purinoceptor-stimulated TGF-beta 1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2 Cell Signal 15 1129 1137 (Pubitemid 37298024)
24. J Korcok LN Raimundo HZ Ke SM Sims SJ Dixon 2004 Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts J Bone Miner Res 19 642 651 (Pubitemid 41071225)