Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7

European Journal of Pharmacology

Volumn 695, Issue 1-3, 2012, Pages 20-26

  Hattori, Fumie ^a   Ohshima, Yasuhiro ^a   Seki, Shizuka ^a   Tsukimoto, Mitsutoshi ^a   Sato, Mitsuru ^b   Takenouchi, Takato ^b   Suzuki, Akina ^a   Takai, Erina ^a   Kitani, Hiroshi ^b   Harada, Hitoshi ^c   Kojima, Shuji ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^c SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Inhibition; Oxidized ATP; P2X7; Purinergic receptor; Tumor growth

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; OXIDIZED ADENOSINE 5' TRIPHOSPHATE; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME RELEASE; FEASIBILITY STUDY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL PROLIFERATION; FEASIBILITY STUDIES; GENE KNOCKDOWN TECHNIQUES; HYDROGEN-ION CONCENTRATION; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84867577653     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.09.001     Document Type: Article

References (44)

1. E. Adinolfi, L. Raffaghello, A.L. Giuliani, L. Cavazzini, M. Capece, P. Chiozzi, G. Bianchi, G. Kroemer, V. Pistoia, and F. Di Virgiilio Expression of P2X7 receptor increases in vivo tumor growth Cancer Res. 2012 10.1158/0008.CAN-11-1947
2. O.R. Baricordi, L. Melchiorri, E. Adinolfi, S. Falzoni, P. Chiozzi, G. Buell, and F. Di Virgilio Increased proliferation rate of lymphoid cells transfected with the P2X(7) ATP receptor J. Biol. Chem. 274 1999 33206 33208
3. F. Bianco, S. Ceruti, A. Colombo, M. Fumagalli, D. Ferrari, C. Pizzirani, M. Matteoli, F. Di Virgilio, M.P. Abbracchio, and C. Verderio A role for P2X7 in microglial proliferation J. Neurochem. 99 2006 745 758
4. J.M. Brown, and A. Giaccia The unique physiology of solid tumors: opportunities (and problems) for cancer therapy Cancer Res. 58 1998 1408 1416
5. G. Burnstock Purinergic signalling Br. J. Pharmacol. 147 2006 S172 S181
6. R.C. Calvert, M. Shabbir, C.S. Thompson, D.P. Mikihalidis, R.J. Morgan, and G. Burstock Immunocytochemical and pharmacological characterization of P2-purinoceptor mediated cell growth and death in PC-3 hormone refractory prostate cancer cells Anticancer Res. 24 2004 2853 2859
7. T. Deli, N. Varga, A. Adam, I. Kenessey, E. Raso, L.G. Puskas, J. Tovari, J. Fodor, M. Feher, G.P. Szigeti, L. Csernoch, and J. Timar Functional genomics of calcium channels in human melanoma cells Int. J. Cancer 121 2007 55 65
8. F. Di Virgilio, P. Chiozzi, S. Falzoni, D. Ferrari, J.M. Sanz, V. Venketaraman, and O.R. Baricordi Cytolytic P2X purinoceptors Cell Death Differ. 5 1998 191 199
9. F. Di Virgillio, D. Ferrari, and E. Adinolfi P2X7: a growth-promoting receptor - implications for cancer Purinergic Signalling 5 2009 251 256
10. C.J. Dixon, W.B. Bowler, A. Littlewood-Evans, J.P. Dillon, G. Bilbe, G.R. Sharpe, and J.A. Gallagher Regulation of epidermal homeostasis through P2Y2 receptors Br. J. Pharmacol. 127 1999 1680 1686
11. E.V. Gerasimovskaya, H.N. Woodward, D.A. Tucker, and K.R. Stenmark Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells Angiogenesis 11 2008 169 182
12. A.V. Greig, C. Linger, V. Healy, P. Lim, E. Clayton, M.H. Rustin, D.A. McGrouther, and G. Burstock Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells J. Invest. Dermatol. 121 2003 315 327
13. H. Harada, C.M. Chan, A. Loesch, R. Unwin, and G. Burnstock Induction of proliferation and apoptotic cell death via P2Y and P2X receptors, respectively, in rat glomerular mesangial cells Kidney Int. 57 2000 949 958
14. 2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation Nat. Med. 3 1997 177 182
15. K.A. Hillman, H. Harada, C.M. Chan, A. Townsend-Nicholson, S.E. Moss, K. Miyamoto, Y. Suketa, G. Burnstock, R.J. Unwin, and P.M. Dunn Chicken DT40 cells stably transfected with the rat P2X7 receptor ion channel: asystem suitable for the study of purine receptor-mediated cell death Biochem. Pharmacol. 66 2003 415 424
16. K. Hisadome, T. Koyama, C. Kimura, G. Droogmans, Y. Ito, and M. Oike Volume regulated anion channels serve as an auto/paracrine nucleotide release pathway in aortic endothelial cells J. Gen. Physiol. 119 2002 511 520
17. B.M. Künzli, M.I. Bernlochner, S. Rath, S. Käser, E. Csizmadia, K. Enjyoji, P. Cowan, A. d'Apice, K. Dwyer, R. Rosenberg, A. Perren, H. Friess, C.A. Maurer, and S.C. Robson Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer Purinergic Signalling 7 2011 231 241
18. S.J. Lunt, N. Chaundary, and R.P. Hill The tumor microenvironment and metastatic disease Clin. Exp. Metastasis 26 2009 19 34
19. - channel by closely of related arylaminobenzoates J. Gen. Physiol. 102 1993 1 23
20. M. Murgial, S. Hanaug, P. Pizzol, M. Rippag, and F. Di Virgio Oxidized ATP J. Biol. Chem. 266 1993 8199 8203
21. D.W. Nelson, R.J. Gregg, M.E. Kort, A. Perez-Medrano, E.A. Voight, Y. Wang, G. Grayson, M.T. Namovic, D.L. Donnelly-Roberts, W. Niforatos, P. Honore, M.F. Jarvis, C.R. Faltynek, and W.A. Carroll Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists J. Med. Chem. 49 2006 3659 3666
22. Y. Ohshima, M. Tsukimoto, T. Takenouchi, H. Harada, A. Suzuki, M. Sato, H. Kitani, and S. Kojima γ-Irradiation induces P2X7 receptor-dependent ATP release from B16 melanoma cells Biochim. Biophys. Acta 1800 2010 40 46
23. A. Ohta, E. Gorelik, S.J. Prasad, F. Ronchese, D. Lukashev, M.K. Wong, X. Huang, S. Caldwell, K. Liu, P. Smith, J.F. Chen, E.K. Jackson, S. Apasov, S. Abrams, and M. Sitkovsky A2A adenosine receptor protects tumors from antitumor T cells Proc. Natl. Acad. Sci. USA 103 2006 13132 13137
24. P. Pellegatti, S. Falzoni, P. Pinton, R. Rizzuto, and F. Di Virgilio A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion Mol. Biol. Cell 16 2005 3659 3665
25. L. Raffaghello, P. Chiozzi, S. Falzoni, F. Di Virgilio, and V. Pistoia The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism Cancer Res. 66 2006 907 914
26. 2channel function J. Neurochem. 83 2002 285 298
27. J.K. Ryu, N. Jantaratnotai, M.C. Serrano-Perez, P.L. McGeer, and J.G. McLarnon Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model J. Neuropathol. Exp. Neurol. 70 2011 13 22
28. R.Z. Sabirov, A.K. Dutta, and Y. Okada Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release J. Gen. Physiol. 118 2001 251 266
29. J. Stagg, and M.J. Smyth Extracellular adenosine triphosphate and adenosine in cancer Oncogene 29 2010 5346 5358
30. M. Slater, R.A. Scolyer, A. Gidley-Baird, J.F. Thompson, and J.A. Barden Increased expression of apoptotic markers in melanoma Melanoma Res. 13 2003 137 145
31. A. Solini, S. Cuccato, D. Ferrari, E. Santini, S. Gulinelli, M.G. Callegari, A. Dardano, P. Faviana, S. Madec, F. Di Virgilio, and F. Monzani Increased P2X7 receptor expression and function in thyroid papillary cancer: a new potential marker of the disease? Endocrinology 149 2008 389 396
32. M. Stubbs, P.M. McSheehy, and J.R. Griffiths Causes and consequences of acidic pH in tumors Adv. Enzyme Regul. 39 1999 13 39
33. R.M. Sutherland Tumor hypoxia and gene expression-implications for malignant progression and therapy Acta Oncol. 37 1998 567 574
34. A.L. Taylor, B.A. Kudlow, K.L. Marrs, D.C. Gruenert, W.B. Guggino, and E.M. Schwiebert Bioluminescence detection of ATP release mechanisms in epithelia Am. J. Physiol. 275 1998 C1391 C1406
35. T. Takenouchi, Y. Iwamaru, S. Sugama, M. Sato, M. Hashimoto, and H. Kitani Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway J. Immunol. 180 2008 7827 7839
36. T. Takenouchi, M. Nakai, Y. Iwamaru, S. Sugama, M. Tsukimoto, M. Fujita, J. Wei, A. Sekigawa, M. Sato, S. Kojima, H. Kitani, and H. Hashimoto The activation of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells J. Immunol. 182 2009 2051 2062
37. M. Tsukimoto, H. Harada, A. Ikari, and K. Takagi Involvement of chloride in apoptotic cell death induced by activation of ATP-sensitive P2X7 purinoceptor J. Biol. Chem. 280 2005 2653 2658
38. M. Tsukimoto, M. Maehata, H. Harada, A. Ikari, K. Takagi, and M. Degawa P2X7 receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathways J. Immunol. 177 2006 2842 2850
39. M. Tsukimoto, H. Harada, and M. Degawa Role of purinoceptors in immune-mediated disease (therapies targeting the P2X7 receptor) Drug Discovery Today: Ther. Strategies 1 2007 33 37
40. M.T. Tu, S.F. Luo, C.C. Wang, C.S. Chien, C.T. Chiu, C.C. Lin, and C.M. Yang P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway Br. J. Pharmacol. 129 2000 1481 1489
41. N. White, P.E. Butler, and G. Burnstock Human melanomas express functional P2 X(7) receptors Cell Tissue Res. 321 2005 411 418
42. J. Wike-Hooley, J. Haveman, and H.S. Rheinhold The relevance of tumor pH to treatment of malignant disease Radiother. Oncol. 2 1984 343 366
43. G.G. Yegutkin Nucleotide- and nucleoside-converting ectoenzymes: important modulator of purinergic signalling cascade Biochim. Biophys. Acta 1783 2008 673 694
44. H. Zimmermann, and N. Braun Ecto-nucleotidases - molecular structures, catalytic properties, and functional roles in the nervous system Prog. Brain Res. 120 1999 371 385