Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 1, 2015, Pages 120-130

  Braganhol, Elizandra ^a,b,c   Kukulski, Filip ^a,b   Lévesque, Sébastien A ^a,b   Fausther, Michel ^a,b   Lavoie, Elise G ^a,b   Zanotto Filho, Alfeu ^c   Bergamin, Leticia S ^c   Pelletier, Julie ^a,b   Bahrami, Fariborz ^a,b   Yebdri, Fethia Ben ^a,b   Fonseca Moreira, José Claudio ^c   Battastini, Ana Maria O ^c   Sévigny, Jean ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

ATP; Glioma; IL 8 CXCL8; MCP 1 CCL2; P2 receptor

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEOTIDE; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 5; CCL2 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; PRIMER DNA; PURINERGIC RECEPTOR;

ARTICLE; ASTROCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; GLIOMA CELL; GLIOMA CELL LINE; HUMAN; HUMAN CELL; MACROPHAGE; MICROENVIRONMENT; MONOCYTE; NUCLEOTIDE METABOLISM; TUMOR INVASION; BRAIN TUMOR; GENETICS; GLIOMA; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BASE SEQUENCE; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOKINE CCL2; DNA PRIMERS; GLIOMA; HUMANS; INTERLEUKIN-8; POLYMERASE CHAIN REACTION; RECEPTORS, PURINERGIC; SIGNAL TRANSDUCTION;

EID: 84913557717     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.10.014     Document Type: Article

References (61)

1. Holland E.C. Progenitor cells and glioma formation. Curr. Opin. Neurol. 2001, 14(6):683-688.
2. Konopka G., Bonni A. Signaling pathways regulating gliomagenesis. Curr. Mol. Med. 2003, 3(1):73-84.
3. Furnari F.B., Fenton T., Bachoo R.M., Mukasa A., Stommel J.M., Stegh A., Hahn W.C., Ligon K.L., Louis D.N., Brennan C., Chin L., DePinho R.A., Cavenee W.K. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007, 21(21):2683-2710.
4. Lin W.W., Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 2007, 117(5):1175-1183.
5. Mantovani A. Inflaming metastasis. Nature 2009, 457(7225):36-37.
6. Watters J.J., Schartner J.M., Badie B. Microglial function in brain tumors. J. Neurosci. Res. 2005, 81:447-455.
7. Kelly M.G., Alvero A.B., Chen R., Silasi D.A., Abrahams V.M., Chan S., Visintin I., Rutherfo T., Mor G. TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res. 2006, 66:3859-3868.
8. Chen R., Alvero A.B., Silasi D.A., Kelly M.G., Fest S., Visintin I., Leiser A., Schwartz P.E., Rutherford T., Mor G. Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Oncogene 2008, 27(34):4712-4723.
9. Mantovani A., Allavena P., Sica A., Balkwill F. Cancer-related inflammation. Nature 2008, 454(7203):436-444.
10. Hoelzinger D.B., Demuth T., Berens M.E. Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J. Natl. Cancer Inst. 2007, 99(21):1583-1593.
11. Gay N.J., Gangloff M. Structure and function of Toll receptors and their ligands. Annu. Rev. Biochem. 2007, 76:141-165.
12. Pineau, Lacroix S. Endogenous signals initiating inflammation in the injured nervous system. Glia 2009, 57(4):351-361.
13. Takeda K., Akira S. TLR signaling pathways. Semin. Immunol. 2004, 16:3-9.
14. Tazzyman S., Lewis C.E., Murdoch C. Neutrophils: key mediators of tumour angiogenesis. Int. J. Exp. Pathol. 2009, 90(3):222-231.
15. Solinas G., Germano G., Mantovani A., Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol. 2009, 86(5):1065-1073.
16. De la Iglesia N., Konopka G., Lim K.L., Nutt C.L., Bromberg J.F., Frank D.A., Mischel P.S., Louis D.N., Bonni A. Deregulation of a STAT3-interleukin-8 signaling pathway promotes human glioma cell proliferation and invasiveness. J. Neurosci. 2008, 28(23):5870-5878.
17. Magge S.N., Malik S.Z., Royo N.C., Chen H.I., Yu L., Snyder E.Y., O'Rourke D.M., Watson D.J. Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors. J. Neurosci. Res. 2009, 87(7):1547-1555.
18. Chen R., Alvero A.B., Silasi D., Steffensen K.D., Mor G. Cancers take their Toll - the function and regulation of Toll-like receptors in cancer cells. Oncogene 2008, 27:225-233.
19. Bours M.J., Swennen E.L., Di Virgilio F., Cronstein B.N., Dagnelie P.C. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol. Ther. 2006, 112(2):358-404.
20. Abbracchio M.P., Burnstock G., Boeynaems J.M., Barnard E.A., Boyer J.L., Kennedy C., Knight G.E., Fumagalli M., Gachet C., Jacobson K.A., Weisman G.A. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev. 2006, 58:281-341.
21. Erb L., Liao Z., Seye C.I., Weisman G.A. P2 receptors: intracellular signaling. Pflugers Arch. 2006, 452:552-562.
22. Davalos D., Grutzendler J., Yang G., Kim J.V., Zuo Y., Jung S., Littman D.R., Dustin M.L., Gan W.B. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 2005, 8(6):752-758.
23. 12 receptor regulates microglial activation by extracellular nucleotides. Nat. Neurosci. 2006, 9(12):1512-1519.
24. Kukulski F., Ben Yebdri F., Lefebvre J., Warny M., Tessier P.A., Sévigny J. Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J. Leukoc. Biol. 2007, 81:1269-1275.
25. 6 nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J. Biol. Chem. 2001, 276:26051-26056.
26. 6 receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion. Eur. J. Immunol. 2009, 39(10):2885-2894.
27. Wink M.R., Lenz G., Braganhol E., Tamajusuku A.S., Schwartsmann G., Sarkis J.J., Battastini A.M. Altered extracellular ATP, ADP and AMP catabolism in glioma cell lines. Cancer Lett. 2003, 198:211-218.
28. Braganhol E., Huppes D., Bernardi A., Wink M.R., Lenz G., Battastini A.M. A comparative study of ectonucleotidase and P2 receptor mRNA profiles in C6 cell line cultures and C6 ex vivo glioma model. Cell Tissue Res. 2009, 335(2):331-340.
29. Coward P., Wada H.G., Falk M.S., Chan S.D., Meng F., Akil H., Conklin B.R. Controlling signaling with a specifically designed Gi-coupled receptor. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(1):352-357.
30. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(2Delta Delta C(T)) Method. Methods 2001, 25:402-408.
31. Kukulski F., Bahrami F., Ben Yebdri F., Lecka J., Martín-Satué M., Lévesque S.A., Sévigny J. NTPDase1 controls IL-8 production by human neutrophils. J. Immunol. 2011, 187(2):644-653.
32. 6 receptor antibodies. Naunyn Schmiedebergs Arch. Pharmacol. 2013, 386(10):885-891.
33. Baykov A.A., Evtushenko O.A., Avaeva S.M. A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay. Anal. Biochem. 1988, 171:266-270.
34. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:218-241.
35. Piperi C., Samaras V., Levidou G., Kavantzas N., Boviatsis E., Petraki K., Grivas A., Barbatis C., Varsos V., Patsouris E., Korkolopoulou P. Prognostic significance of IL-8-STAT-3 pathway in astrocytomas: correlation with IL-6, VEGF and microvessel morphometry. Cytokine 2011, 55(3):387-395.
36. Panenka W., Jijon H., Herx L.M., Armstrong J.N., Feighan D., Wei T., Yong V.W., Ransohoff R.M., MacVicar B.A. P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J. Neurosci. 2001, 21(18):7135-7142.
37. Lévesque S.A., Kukulski F., Enjyoji K., Robson S.C., Sévigny J. NTPDase1 governs P2X7-dependent functions in murine macrophages. Eur. J. Immunol. 2010, 40(5):1473-1485.
38. Ergüven M., Bilir A., Altug T., Aktar F., Akev N. Suramin increased telomerase activity in the C6 glioma/Wistar experimental brain tumor model. Int. J. Biomed. Sci. 2007, 3(2):104-111.
39. 6 mediates cellular response to γ-ray-induced DNA damage. J. Toxicol. Sci. 2014, 39(1):15-23.
40. Vuaden F.C., de Paula Cognato G., Bonorino C., Bogo M.R., Sarkis J.J., Bonan C.D. Lipopolysaccharide alters nucleotidase activities from lymphocytes and serum of rats. Life Sci. 2007, 80(19):1784-1791.
41. Yu L., Chen S. Toll-like receptors expressed in tumor cells: targets for therapy. Cancer Immunol. Immunother. 2008, 57(9):1271-1278.
42. North A. Molecular physiology of P2X receptors. Physiol. Rev. 2002, 82:1013-1067.
43. Michel A.D., Kaur R., Chessell I.P., Humphrey P.P.A. Antagonist effects on human P2X receptor-mediated cellular accumulation of YO-PRO-1. Br. J. Pharmacol. 2000, 130:513-520.
44. Donnelly-Roberts D.L., Jarvis M.F. Discovery of P2X receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br. J. Pharmacol. 2007, 151:571-579.
45. Pellegatti P., Raffaghello L., Bianchi G., Piccardi F., Pistoia V., Di Virgilio F. Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. PLoS ONE 2008, 3(7):e2599.
46. Morrone F.B., Oliveira D.L., Gamermann P., Stella J., Wofchuk S., Wink M.R., Meurer L., Edelweiss M.I., Lenz G., Battastini A.M. In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model. BMC Cancer 2006, 6:226.
47. Di Virgilio F., Ferrari D., Adinolfi E. P2X7: a growth-promoting receptor-implications for cancer. Purinergic Signal 2009, 5(2):251-256.
48. White N., Burnstock G. P2 receptors and cancer. Trends Pharmacol. Sci. 2006, 27(4):211-217.
49. Morrone F.B., Horn A.P., Stella J., Spiller F., Sarkis J.J., Salbego C.G., Lenz G., Battastini A.M. Increased resistance of glioma cell lines to extracellular ATP cytotoxicity. J. Neurooncol. 2005, 71:135-140.
50. Adinolfi E., Callegari M.G., Ferrari D., Bolognesi C., Minelli M., Wieckowski M.R., Pinton P., Rizzuto R., Di Virgilio F. Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol. Biol. Cell 2005, 16(7):3260-3272.
51. Adinolfi E., Raffaghello L., Giuliani A.L., Cavazzini L., Capece M., Chiozzi P., Bianchi G., Kroemer G., Pistoia V., Di Virgilio F. Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res. 2012, 72(12):2957-2969. (15).
52. Jelassi B., ChantÔme A., Alcaraz-Pérez F., Baroja-Mazo A., Cayuela M.L., Pelegrin P., Surprenant A., Roger S. P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness. Oncogene 2011, 30(18):2108-2122.
53. Sun S.H. Roles of P2X7 receptor in glial and neuroblastoma cells: the therapeutic potential of P2X7 receptor antagonists. Mol. Neurobiol. 2010, 41(2-3):351-355.
54. Tafani M., Schito L., Pellegrini L., Villanova L., Marfe G., Anwar T., Rosa R., Indelicato M., Fini M., Pucci B., Russo M.A. Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-kB. Carcinogenesis 2011, 32(8):1167-1175.
55. White J.R., Lee J.M., Young P.R., Hertzberg R.P., Jurewicz A.J., Chaikin M.A., Widdowson K., Foley J.J., Martin L.D., Griswold D.E., Sarau H.M. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J. Biol. Chem. 1998, 273(17):10095-10098.
56. Burnstock G. Purinergic signalling and disorders of the central nervous system. Nat. Rev. Drug Discov. 2008, 7(7):575-590.
57. 1 receptor with strong antithrombotic activity in mice. J. Pharmacol. Exp. Ther. 2006, 316(2):556-563.
58. 6 nucleotide receptors. Biochem. Pharmacol. 2004, 67(9):1763-1770.
59. 11 receptor antagonists with nanomolar potency. J. Med. Chem. 2005, 48(22):7040-7048.
60. 7 receptor. Br. J. Pharmacol. 1998, 124(6):1314-1320.
61. 7 antagonists. J. Med. Chem. 2006, 49(12):3659-3666.