Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats

Epilepsy and Behavior

Volumn 48, Issue , 2015, Pages 4-14

  Soni, Neha ^a   Koushal, Prashant ^a   Reddy, B V K ^a   Deshmukh, Rahul ^a   Kumar, Puneet ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Brilliant Blue G; Ceftriaxone; GLT 1; P2X7; Pentylenetetrazole

Indexed keywords

ACETYLCHOLINESTERASE; BRILLIANT BLUE G; CEFTRIAXONE; DIAZEPAM; GLUTATHIONE; NITRITE; PENTETRAZOLE; PROTEIN; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; SODIUM GLUCOSE COTRANSPORTER 1; UNCLASSIFIED DRUG; CONVULSANT AGENT; COOMASSIE BRILLIANT BLUE; EXCITATORY AMINO ACID TRANSPORTER 2; FUCHSINE; PURINERGIC P2X RECEPTOR ANTAGONIST; SLC1A2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVITY; GLUTAMATERGIC SYNAPSE; KINDLING; LEARNING; LIPID PEROXIDATION; LONG TERM MEMORY; LOW DRUG DOSE; MORRIS WATER MAZE TEST; MOTOR COORDINATION; MOTOR DYSFUNCTION; NERVE CELL STIMULATION; NEUROPROTECTION; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OXIDATIVE STRESS; PENTYLENETETRAZOLE-INDUCED SEIZURE; PROTEIN BLOOD LEVEL; PROTEIN CROSS LINKING; RAT; ROTAROD TEST; SUBCORTEX; TONIC CLONIC SEIZURE; TREATMENT DURATION; ANIMAL; BRAIN; CHEMICALLY INDUCED; COGNITION DISORDERS; DOSE RESPONSE; DRUG EFFECTS; EPILEPSY; MALE; SEIZURE;

ANIMALS; BRAIN; CEFTRIAXONE; COGNITION DISORDERS; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; EXCITATORY AMINO ACID TRANSPORTER 2; KINDLING, NEUROLOGIC; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PENTYLENETETRAZOLE; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; ROSANILINE DYES; SEIZURES;

EID: 84930616412     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2015.04.056     Document Type: Article

References (50)

1. de Almeida R.N., Agra Mde F., Maior F.N., de Sousa D.P. Essential oils and their constituents: anticonvulsant activity. Molecules 2011, 16:2726-2742.
2. Koutroumanidou E., Kimbaris A., Kortsaris A., Bezirtzoglou E., Polissiou M., Charalabopoulos K., et al. Increased seizure latency and decreased severity of pentylenetetrazol-induced seizures in mice after essential oil administration. Epilepsy Res Treat 2013, 2013:532657.
3. Kaila K., Ruusuvuori E., Seja P., Voipio J., Puskarjov M. GABA actions and ionic plasticity in epilepsy. Curr Opin Neurobiol 2014, 26:34-41.
4. Mehta A., Prabhakar M., Kumar P., Deshmukh R., Sharma P.L. Excitotoxicity: bridge to various triggers in neurodegenerative disorders. Eur J Pharmacol 2013, 698(1-3):6-18.
5. Kanai Y., Hediger M.A. The glutamate and neutral amino acid transporter family: physiological and pharmacological implications. Eur J Pharmacol 2003, 479(1-3):237-247.
6. Soni N., Reddy B.V., Kumar P. GLT-1 transporter: an effective pharmacological target for various neurological disorders. Pharmacol Biochem Behav 2014, 127:70-81.
7. Mookherjee P., Green P.S., Watson G.S., Marques M.A., Tanaka K., Meeker K.D., et al. GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model. J Alzheimers Dis 2011, 26(3):447-455.
8. Chen W., Mahadomrongkul V., Berger U.V., Bassan M., DeSilva T., Tanaka K., et al. The glutamate transporter GLT-1a is expressed in excitatory axon terminals of mature hippocampal neurons. J Neurosci 2004, 24:1136-1148.
9. Coulter D.A., Eid T. Astrocytic regulation of glutamate homeostasis in epilepsy. Glia 2012, 60(8):1215-1226.
10. Sun H.L., Zhang S.H., Zhong K., Xu Z.H., Feng B., Yu J., et al. A transient upregulation of glutamine synthetase in the dentate gyrus is involved in epileptogenesis induced by amygdala kindling in the rat. PLoS One 2013, 8(6):e66885.
11. Hammer J., Alvestad S., Osen K.K., Skare O., Sonnewald U., Ottersen O.P. Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy. Glia 2008, 56:856-868.
12. Kong Q., Takahashi K., Schulte D., Stouffer N., Lin Y., Lin C.L. Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. Neurobiol Dis 2012, 47(2):145-154.
13. Lopes M.W., Soares F.M., de Mello N., Nunes J.C., Cajado A.G., de Brito D., et al. Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy. Exp Brain Res 2013, 226(2):153-163.
14. Karaman I., Kizilay-Ozfidan G., Karadag C.H., Ulugol A. Lack of effect of ceftriaxone, a GLT-1 transporter activator, on spatial memory in mice. Pharmacol Biochem Behav 2013, 108:61-65.
15. Matos-Ocasio F., Hernandez-Lopez A., Thompson K.J. Ceftriaxone, a GLT-1 transporter activator, disrupts hippocampal learning in rats. Pharmacol Biochem Behav 2014, 122:118-121.
16. Borzelleca J.F., Depukat K., Hallagan J.B. Lifetime toxicity/carcinogenicity studies of FD & C Blue No. 1 (brilliant blue FCF) in rats and mice. Food Chem Toxicol 1990, 28(4):221-234.
17. Chen S., Zhu Z., Klebe D., Bian H., Krafft P.R., Tang J., et al. Role of P2X purinoceptor 7 in neurogenic pulmonary edema after subarachnoid hemorrhage in rats. PLoS One 2014, 9(2):e89042.
18. Vianna E.P., Ferreira A.T., Naffah-Mazzacoratti M.G., Sanabria E.R., Funke M., Cavalheiro E.A., et al. Evidence that ATP participates in the pathophysiology of pilocarpine-induced temporal lobe epilepsy: fluorimetric, immunohistochemical, and Western blot studies. Epilepsia 2002, 43(Suppl. 5):227-229.
19. Engel T., Jimenez-Pacheco A., Miras-Portugal M.T., Diaz-Hernandez M., Henshall D.C. P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. Int J Physiol Pathophysiol Pharmacol 2012, 4(4):174-187.
20. Morioka N., Abdin M.J., Kitayama T., Morita K., Nakata Y., Dohi T. P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport. Glia 2008, 56:528-538.
21. Akula K.K., Dhir A., Kulkarni S.K. Systemic administration of adenosine ameliorates pentylenetetrazol-induced chemical kindling and secondary behavioural and biochemical changes in mice. Fundam Clin Pharmacol 2007, 21(6):583-594.
22. Chen S., Ma Q., Krafft P.R., Hu Q., Rolland W., Sherchan P., et al. Zhang JH.P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH. Neurobiol Dis 2013, 58296-58307.
23. Kulkarni S.K., Singh K., Bishnoi M. Comparative behavioural profile of newer antianxiety drugs on different mazes. Indian J Exp Biol 2008, 46(9):633-638.
24. Kumar P., Kalonia H., Kumar A. Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone. Br J Pharmacol 2011, 164(2b):644-654.
25. Meng X.J., Wang F., Li C.K. Resveratrol is neuroprotective and improves cognition in pentylenetetrazole-kindling model of epilepsy in rats. Indian J Pharm Sci 2014, 76:125-131.
26. Deshmukh R., Sharma V., Mehan S., Sharma N., Bedi K.L. Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine - a PDE1 inhibitor. Eur J Pharmacol 2009, 620:49-56.
27. Wills E.D. Mechanisms of lipid peroxide formation in animal tissues. Biochem J 1966, 99:667-676.
28. Ellman G.L. Tissuesulfhydryl groups. Arch Biochem Biophys 1959, 82:70-77.
29. Sastry K., Moudgal R., Mohan J., Tyagi J., Rao G. Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Analytical biochemistry 2002, 306(1):79-82.
30. Gornall A.G., Bardawill C.J., David M.M. Determination of serum protein by means of the biuret reaction. J Biol Chem 1949, 177:751-766.
31. Ellman G.L., Courtney K.D., Andres V., Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology 1961, 7(2):88-95.
32. Dhir A. Pentylenetetrazol (PTZ) Kindling Model of Epilepsy. Current Protocols in Neuroscience 2012, 58:9.37:9.37.1-9.37.12.
33. Doi T., Ueda Y., Nagatomo K., Willmore L.J. Role of glutamate and GABA transporters in development of pentylenetetrazol-kindling. Neurochem Res 2009, 34(7):1324-1331.
34. Yu Y.H., Xie W., Zhao Y.Y. Effects of heterotherapy for homopathy on the metabolism path of glutamate in the pentylenetetrazol-kindled seizure rats' hippocampus. Zhongguo Zhong Xi Yi Jie He Za Zhi 2013, 33(1):95-99.
35. Fukamachi S., Furuta A., Ikeda T., Ikenoue T., Kaneoka T., Rothstein J.D., et al. Altered expressions of glutamate transporter subtypes in rat model of neonatal cerebral hypoxia-ischemia. Brain Res Dev Brain Res 2001, 132(2):131-139.
36. James G., Butt A.M. P2X and P2Y purinoreceptors mediate ATP-evoked calcium signalling in optic nerve glia in situ. Cell Calcium 2001, 30(4):251-259.
37. Arulkumaran N., Unwin R.J., Tam F.W. A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases. Expert Opin Investig Drugs 2011, 20(7):897-915.
38. Kumaria A., Tolias C.M., Burnstock G. ATP signalling in epilepsy. Purinergic Signal 2008, 4(4):339-346.
39. Gupta Y.K., Veerendra Kumar M.H., Srivastava A.K. Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats. Pharmacol Biochem Behav 2003, 74(3):579-585.
40. Ramos J.M. Long-term spatial memory in rats with hippocampal lesions. Eur J Neurosci 2000, 12:3375-3384.
41. Szyndler J., Piechal A., Blecharz-Klin K., Skorzewska A., Maciejak P., Walkowiak J., et al. Effect of kindled seizures on rat behavior in water Morris maze test and amino acid concentrations in brain structures. Pharmacol Rep 2006, 58(1):75-82.
42. Aguiar C.C., Almeida A.B., Araujo P.V., de Abreu R.N., Chaves E.M., do Vale O.C., et al. Oxidative stress and epilepsy: literature review. Oxid Med Cell Longev 2012, 2012:795259.
43. Shin E.J., Jeong J.H., Chung Y.H., Kim W.K., Ko K.H., Bach J.H., et al. Role of oxidative stress in epileptic seizures. Neurochem Int 2011, 59(2):122-137.
44. Zhao R.R., Xu X.C., Xu F., Zhang W.L., Liu L.M., Wang W.P. Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. Biochem Biophys Res Commun 2014, 448(4):414-417.
45. Lee E., Sidoryk-Wegrzynowicz M., Yin Z., Webb A., Son D.S., Aschner M. Transforming growth factor-alpha mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia 2012, 60(7):1024-1036.
46. Salles A., Romano A., Freudenthal R. Synaptic NF-kappa B pathway in neuronal plasticity and memory. J Physiol Paris 2014, 108:256-262.
47. Koomhin P., Tilokskulchai K., Tapechum S. Ceftriaxone improves spatial learning and memory in chronic cerebral hypoperfused rats. ScienceAsia 2012, 38:356-363.
48. Lewerenz J., Albrecht P., Tien M.L.T., Henke N., Karumbayaram S., Kornblum H.I., et al. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. Journal of neurochemistry 2009, 111(2):332-343.
49. Jiang L.H., Mackenzie A.B., North R.A., Surprenant A. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol 2000, 58(1):82-88.
50. Jiang R., Taly A., Grutter T. Moving through the gate in ATP-activated P2X receptors. Trends Biochem Sci 2013, 38:20-29.