메뉴 건너뛰기




Volumn 18, Issue 9, 2013, Pages 10953-10972

Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain

Author keywords

Antagonists and pharmacological target; Inflammatory response; P2X7R

Indexed keywords

ANTIINFLAMMATORY AGENT; AUTACOID; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR;

EID: 84885103040     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules180910953     Document Type: Review
Times cited : (82)

References (125)
  • 2
    • 41949093659 scopus 로고    scopus 로고
    • Hemodynamic regulation of inflammation at the endothelialneutrophil interface
    • Ji, J.Y.; Jing, H.; Diamond, S.L. Hemodynamic regulation of inflammation at the endothelialneutrophil interface. Ann. Biomed. Eng. 2008, 36, 586-595.
    • (2008) Ann. Biomed. Eng. , vol.36 , pp. 586-595
    • Ji, J.Y.1    Jing, H.2    Diamond, S.L.3
  • 6
    • 0015393308 scopus 로고
    • Purinergic nerves
    • Burnstock, G. Purinergic nerves. Pharmacol.Rev. 1972, 24, 509-581.
    • (1972) Pharmacol.Rev. , vol.24 , pp. 509-581
    • Burnstock, G.1
  • 7
    • 0017085138 scopus 로고
    • Purinergic receptors
    • Burnstock, G. Purinergic receptors. J. Theor. Biol. 1976, 62, 491-503.
    • (1976) J. Theor. Biol. , vol.62 , pp. 491-503
    • Burnstock, G.1
  • 8
    • 0022178232 scopus 로고
    • 2- purinoceptor?
    • DOI 10.1016/0306-3623(85)90001-1
    • Burnstock, G.; Kennedy, C. Is there a basis for distinguishing two types of P2-purinoceptor? Gen. Pharmacol. 1985, 16, 433-440. (Pubitemid 16250911)
    • (1985) General Pharmacology: Vascular System , vol.16 , Issue.5 , pp. 433-440
    • Burnstock, G.1    Kennedy, C.2
  • 9
    • 0036788971 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors
    • North, R.A. Molecular physiology of P2X receptors. Physiol. Rev. 2002, 82, 1013-1067.
    • (2002) Physiol. Rev. , vol.82 , pp. 1013-1067
    • North, R.A.1
  • 10
    • 0026572722 scopus 로고
    • ATP activates a cation-permeable pathway in rat parotid acinar cells
    • Soltoff, S.P.; McMillian, M.K.; Talamo, B.R. ATP activates a cation-permeable pathway in rat parotid acinar cells. Am. J. Physiol. 1992, 262, C934-C940.
    • (1992) Am. J. Physiol. , vol.262
    • Soltoff, S.P.1    McMillian, M.K.2    Talamo, B.R.3
  • 11
    • 0027753929 scopus 로고
    • 2+ by autonomic agonists in rat submandibular gland acini
    • Hurley, T.W.; Shoemaker, D.D.; Ryan, M.P. Extracellular ATP prevents the release of stored Ca2+ by autonomic agonists in rat submandibular gland acini. Am. J. Physiol. 1993, 265, C1472-C1478.
    • (1993) Am. J. Physiol. , vol.265
    • Hurley, T.W.1    Shoemaker, D.D.2    Ryan, M.P.3
  • 12
    • 0024605039 scopus 로고
    • Permeabilization of transformed mouse fibroblasts by 3'-O-(4-benzoyl) benzoyl adenosine 5'-triphosphate and the desensitization of the process
    • DOI 10.1002/jcp.1041390116
    • Gonzalez, F.A.; Ahmed, A.H.; Lustig, K.D.; Erb, L.; Weisman, G.A. Permeabilization of transformed mouse fibroblasts by 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate and the desensitization of the process. J. Cell Physiol. 1989, 139, 109-115. (Pubitemid 19120277)
    • (1989) Journal of Cellular Physiology , vol.139 , Issue.1 , pp. 109-115
    • Gonzalez, F.A.1    Ahmed, A.H.2    Lustig, K.D.3    Erb, L.4    Weisman, G.A.5
  • 13
    • 0025344435 scopus 로고
    • Covalent incorporation of 3'-O-(4-benzoyl)benzoyl-ATP into a P2 purinoceptor in transformed mouse fibroblasts
    • Erb, L.; Lustig, K.D.; Ahmed, A.H.; Gonzalez, F.A.; Weisman, G.A. Covalent incorporation of 3'-O-(4-benzoyl)benzoyl-ATP into a P2 purinoceptor in transformed mouse fibroblasts. J. Biol. Chem. 1990, 265, 7424-31.
    • (1990) J. Biol. Chem. , vol.265 , pp. 7424-7431
    • Erb, L.1    Lustig, K.D.2    Ahmed, A.H.3    Gonzalez, F.A.4    Weisman, G.A.5
  • 14
    • 9144269934 scopus 로고    scopus 로고
    • Cellular distribution and functions of P2 receptor subtypes in different systems
    • DOI 10.1016/S0074-7696(04)40002-3, PII S0074769604400023
    • Burnstock, G.; Knight, G.E. Cellular distribution and functions of P2 receptor subtypes in different systems. Int. Rev. Cytol. 2004, 240, 31-304. (Pubitemid 39539202)
    • (2004) International Review of Cytology , vol.240 , Issue.SPEC.ISS. , pp. 31-304
    • Burnstock, G.1    Knight, G.E.2
  • 15
    • 0029088454 scopus 로고
    • Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors)
    • Evans, R.J.; Lewis, C.; Buell, G.; Valera, S.; North, R.A.; Surprenant, A. Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors). Mol. Pharmacol. 1995, 48, 178-183.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 178-183
    • Evans, R.J.1    Lewis, C.2    Buell, G.3    Valera, S.4    North, R.A.5    Surprenant, A.6
  • 16
    • 0032756504 scopus 로고    scopus 로고
    • Pharmacological characterization of the human P2Y11 receptor
    • Communi, D.; Robaye, B.; Boeynaems, J.M. Pharmacological characterization of the human P2Y11 receptor. Br. J. Pharmacol. 1999, 128, 1199-206.
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 1199-1206
    • Communi, D.1    Robaye, B.2    Boeynaems, J.M.3
  • 17
    • 0029665112 scopus 로고    scopus 로고
    • The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
    • Surprenant, A.; Rassendren, F.; Kawashima, E.; North, R.A.; Buell, G. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science. 1996, 272, 735-738.
    • (1996) Science , vol.272 , pp. 735-738
    • Surprenant, A.1    Rassendren, F.2    Kawashima, E.3    North, R.A.4    Buell, G.5
  • 18
    • 0027323982 scopus 로고
    • + RNA from murine macrophages
    • Nuttle, L.C.; el-Moatassim, C.; Dubyak, G.R. Expression of the pore-forming P2Z purinoreceptor in Xenopus oocytes injected with poly(A)+ RNA from murine macrophages. Mol. Pharmacol. 1993, 44, 93-101. (Pubitemid 23230464)
    • (1993) Molecular Pharmacology , vol.44 , Issue.1 , pp. 93-101
    • Nuttle, L.C.1    El-Moatassim, C.2    Dubyak, G.R.3
  • 19
    • 70350339068 scopus 로고    scopus 로고
    • Mammalian P2X7 receptor pharmacology: Comparison of recombinant mouse, rat and human P2X7 receptors
    • Donnelly-Roberts, D.L.; Namovic, M.T.; Han, P.; Jarvis, M.F. Mammalian P2X7 receptor pharmacology: Comparison of recombinant mouse, rat and human P2X7 receptors. Br. J. Pharmacol. 2009, 157, 1203-1214.
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 1203-1214
    • Donnelly-Roberts, D.L.1    Namovic, M.T.2    Han, P.3    Jarvis, M.F.4
  • 22
    • 0030661885 scopus 로고    scopus 로고
    • 7 receptor
    • DOI 10.1016/S0028-3908(97)00141-X, PII S002839089700141X
    • Virginio, C.; Church, D.; North, R.A.; Surprenant, A. Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor. Neuropharmacology 1997, 36, 1285-94. (Pubitemid 27465616)
    • (1997) Neuropharmacology , vol.36 , Issue.9 , pp. 1285-1294
    • Virginio, C.1    Church, D.2    North, R.A.3    Surprenant, A.4
  • 23
    • 33947253242 scopus 로고    scopus 로고
    • 7 purinergic receptor
    • DOI 10.1111/j.1471-4159.2006.04343.x
    • Acuña-Castillo, C.C.C.; Bull, P.; Brito, J.; Huidobro-Toro, J.P. Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7purinergic receptor. J. Neurochem. 2007, 101, 17-26. (Pubitemid 46426467)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.1 , pp. 17-26
    • Acuna-Castillo, C.1    Coddou, C.2    Bull, P.3    Brito, J.4    Huidobro-Toro, J.P.5
  • 26
    • 0037068428 scopus 로고    scopus 로고
    • Purine and pyrimidine (P2) receptors as drug targets
    • DOI 10.1021/jm020046y
    • Jacobson, K.A.; Michael, F.J.; Michael, W. Purine and pyrimidine (P2) receptors as drug targets. J. Med. Chem. 2002, 45, 4057-4093. (Pubitemid 35025559)
    • (2002) Journal of Medicinal Chemistry , vol.45 , Issue.19 , pp. 4057-4093
    • Jacobson, K.A.1    Jarvis, M.F.2    Williams, M.3
  • 28
    • 79957615177 scopus 로고    scopus 로고
    • Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse
    • Jo, Y.H.; Donier, E.; Martinez, A.; Garret, M.; Toulme, E.; Boue-Grabot, E. Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse. J. Biol. Chem. 2011, 286, 19993-20004.
    • (2011) J. Biol. Chem. , vol.286 , pp. 19993-20004
    • Jo, Y.H.1    Donier, E.2    Martinez, A.3    Garret, M.4    Toulme, E.5    Boue-Grabot, E.6
  • 29
    • 0028303241 scopus 로고
    • Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes
    • Nuttle, L.C.; Dubyak, G.R. Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes. J. Biol. Chem. 1994, 269, 13988-13996.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13988-13996
    • Nuttle, L.C.1    Dubyak, G.R.2
  • 30
    • 0030977216 scopus 로고    scopus 로고
    • The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes
    • Gargett, C.E.; Wiley, J.S. The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br. J. Pharmacol. 1997, 120, 1483-1490. (Pubitemid 27192439)
    • (1997) British Journal of Pharmacology , vol.120 , Issue.8 , pp. 1483-1490
    • Gargett, C.E.1    Wiley, J.S.2
  • 31
    • 0027530024 scopus 로고
    • Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P(2Z) receptor
    • Murgia, M.; Hanau, S.; Pizzo, P.; Rippa, M.; Di, V.F. Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J. Biol. Chem. 1993, 268, 8199-8203. (Pubitemid 23120407)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.11 , pp. 8199-8203
    • Murgia, M.1    Hanau, S.2    Pizzo, P.3    Rippa, M.4    Di Virgilio, F.5
  • 34
    • 0031595744 scopus 로고    scopus 로고
    • 7 nucleotide receptor: High selectivity for the human versus rat receptor homologues
    • Humphreys, B.D.; Virginio, C.; Surprenant, A.; Rice, J.; Dubyak, G.R. Isoquinolines as antagonists of the P2X7 nucleotide receptor: High selectivity for the human versus rat receptor homologues. Mol. Pharmacol. 1998, 54, 22-32. (Pubitemid 28337583)
    • (1998) Molecular Pharmacology , vol.54 , Issue.1 , pp. 22-32
    • Humphreys, B.D.1    Virginio, C.2    Surprenant, A.3    Rice, J.4    Dubyak, G.R.5
  • 37
    • 38449084890 scopus 로고    scopus 로고
    • Benefits and side effects of different vegetable oil vectors on apoptosis, oxidative stress, and P2X7 cell death receptor activation
    • DOI 10.1167/iovs.07-0229
    • Said, T.; Dutot, M.; Christon, R.; Beaudeux, J.L.; Martin, C.; Warnet, J.M.; Rat, P. Benefits and side effects of different vegetable oil vectors on apoptosis, oxidative stress, and P2X7 cell death receptor activation. Invest. Ophthalmol. Vis. Sci. 2007, 48, 5000-5006. (Pubitemid 351260909)
    • (2007) Investigative Ophthalmology and Visual Science , vol.48 , Issue.11 , pp. 5000-5006
    • Said, T.1    Dutot, M.2    Christon, R.3    Beaudeux, J.-L.4    Martin, C.5    Warnet, J.-M.6    Rat, P.7
  • 38
    • 77953809988 scopus 로고    scopus 로고
    • Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor
    • Liu, L.; Zou, J.; Liu, X.; Jiang, L.H.; Li, J. Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor. Eur. J. Pharmacol.2010, 640, 15-19.
    • (2010) Eur. J. Pharmacol. , vol.640 , pp. 15-19
    • Liu, L.1    Zou, J.2    Liu, X.3    Jiang, L.H.4    Li, J.5
  • 40
    • 79958836059 scopus 로고    scopus 로고
    • Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: Implications for its therapeutic action
    • Marques-da-Silva, C.; Chaves, M.M.; Castro, N.G.; Coutinho-Silva, R.; Guimaraes, M.Z. Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action. Br. J. Pharmacol. 2011, 163, 912-926.
    • (2011) Br. J. Pharmacol. , vol.163 , pp. 912-926
    • Marques-Da-Silva, C.1    Chaves, M.M.2    Castro, N.G.3    Coutinho-Silva, R.4    Guimaraes, M.Z.5
  • 41
    • 84870195450 scopus 로고    scopus 로고
    • Action of natural products on p2 receptors: A reinvented era for drug discovery
    • Faria, R.; Ferreira, L.; Bezerra, R.; Frutuoso, V.; Alves, L. Action of natural products on p2 receptors: A reinvented era for drug discovery. Molecules 2012, 17, 13009-13025.
    • (2012) Molecules , vol.17 , pp. 13009-13025
    • Faria, R.1    Ferreira, L.2    Bezerra, R.3    Frutuoso, V.4    Alves, L.5
  • 42
    • 84876952708 scopus 로고    scopus 로고
    • Natural products as a source for new anti-inflammatory and analgesic compounds through the inhibition of purinergic P2X receptors
    • Soares-Bezerra, R.J.; Calheiros, A.S.; Ferreira, N.C.S.; Frutuoso, V.S.; Alves, L.A. Natural products as a source for new anti-inflammatory and analgesic compounds through the inhibition of purinergic P2X receptors. Pharmaceuticals 2013, 6, 650-658.
    • (2013) Pharmaceuticals , vol.6 , pp. 650-658
    • Soares-Bezerra, R.J.1    Calheiros, A.S.2    Ferreira, N.C.S.3    Frutuoso, V.S.4    Alves, L.A.5
  • 44
    • 0035890154 scopus 로고    scopus 로고
    • 7 receptor signalling complex
    • DOI 10.1093/emboj/20.22.6347
    • Kim, M.; Jiang, L.H.; Wilson, H.L.; North, R.A.; Surprenant, A. Proteomic and functional evidence for a P2X7 receptor signalling complex. EMBO J. 2001, 20, 6347-6358. (Pubitemid 33078708)
    • (2001) EMBO Journal , vol.20 , Issue.22 , pp. 6347-6358
    • Kim, M.1    Jiang, L.-H.2    Wilson, H.L.3    North, R.A.4    Surprenant, A.5
  • 45
    • 77952106771 scopus 로고    scopus 로고
    • Discovery of 2-chloro-N- ((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5- fluoropyrimidin-2-yl)b enzamide as a potent and CNS penetrable P2X7 receptor antagonist
    • Chen, X.; Pierce, B.; Naing, W.; Grapperhaus, M.L.; Phillion, D.P. Discovery of 2-chloro-N- ((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5- fluoropyrimidin-2-yl)b enzamide as a potent and CNS penetrable P2X7 receptor antagonist. Bioorg. Med. Chem. Lett. 2010, 20, 3107-3111.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3107-3111
    • Chen, X.1    Pierce, B.2    Naing, W.3    Grapperhaus, M.L.4    Phillion, D.P.5
  • 49
    • 78349284376 scopus 로고    scopus 로고
    • The P2X7-Egr pathway regulates nucleotide-dependent inflammatory gene expression in microglia
    • Friedle, S.A.; Brautigam, V.M.; Nikodemova, M.; Wright, M.L.; Watters, J.J. The P2X7-Egr pathway regulates nucleotide-dependent inflammatory gene expression in microglia. Glia 2011, 59, 1-13.
    • (2011) Glia , vol.59 , pp. 1-13
    • Friedle, S.A.1    Brautigam, V.M.2    Nikodemova, M.3    Wright, M.L.4    Watters, J.J.5
  • 50
    • 77951590103 scopus 로고    scopus 로고
    • P2X purinergic receptor ligands: Recently patented compounds
    • Gunosewoyo, H.; Kassiou, M. P2X purinergic receptor ligands: Recently patented compounds. Expert Opin. Ther. Pat. 2010, 20, 625-646.
    • (2010) Expert Opin. Ther. Pat. , vol.20 , pp. 625-646
    • Gunosewoyo, H.1    Kassiou, M.2
  • 51
    • 84875426837 scopus 로고    scopus 로고
    • P2X receptors as drug targets
    • North, R.A.; Jarvis, M.F. P2X receptors as drug targets. Mol. Pharmacol. 2012, 83, 759-769.
    • (2012) Mol. Pharmacol. , vol.83 , pp. 759-769
    • North, R.A.1    Jarvis, M.F.2
  • 52
    • 33751165071 scopus 로고    scopus 로고
    • A-740003 [N-(1-{[(cyanoimino)(5- quinolinylamino)methyl]amino}-2,2- dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat
    • Honore, P.; Donnelly-Roberts, D.; Namovic, M.T.; Hsieh, G.; Zhu, C.Z.; Mikusa, J.P.; Hernandez, G.; Zhong, C.; Gauvin, D.M.; Chandran, P.; et al. A-740003 [N-(1-{[(cyanoimino)(5- quinolinylamino)methyl]amino}-2,2- dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J. Pharmacol. Exp. Ther. 2006, 319, 1376-1385.
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 1376-1385
    • Honore, P.1    Donnelly-Roberts, D.2    Namovic, M.T.3    Hsieh, G.4    Zhu, C.Z.5    Mikusa, J.P.6    Hernandez, G.7    Zhong, C.8    Gauvin, D.M.9    Chandran, P.10
  • 54
    • 77958530854 scopus 로고    scopus 로고
    • Experimental characterization and mathematical modeling of P2X7 receptor channel gating
    • Yan, Z.; Khadra, A.; Li, S.; Tomic, M.; Sherman, A.; Stojilkovic, S.S. Experimental characterization and mathematical modeling of P2X7 receptor channel gating. J. Neurosci 2010, 30, 14213-14224.
    • (2010) J. Neurosci , vol.30 , pp. 14213-14224
    • Yan, Z.1    Khadra, A.2    Li, S.3    Tomic, M.4    Sherman, A.5    Stojilkovic, S.S.6
  • 55
    • 60449100436 scopus 로고    scopus 로고
    • Selective P2X(7) receptor antagonists for chronic inflammation and pain
    • Carroll, W.A.; Donnelly-Roberts, D.; Jarvis, M.F. Selective P2X(7) receptor antagonists for chronic inflammation and pain. Purinergic Signal. 2009, 5, 63-73.
    • (2009) Purinergic Signal. , vol.5 , pp. 63-73
    • Carroll, W.A.1    Donnelly-Roberts, D.2    Jarvis, M.F.3
  • 56
    • 77449148016 scopus 로고    scopus 로고
    • Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation
    • Friedle, S.A.; Curet, M.A.; Watters, J.J. Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation. Recent Pat. CNS Drug Discov. 2010, 5, 35-45.
    • (2010) Recent Pat. CNS Drug Discov. , vol.5 , pp. 35-45
    • Friedle, S.A.1    Curet, M.A.2    Watters, J.J.3
  • 58
    • 84883458893 scopus 로고    scopus 로고
    • Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses
    • doi:10.1007/s11302-013-9357-4
    • Jacob, F.; Novo, C.P.; Bachert, C.; Van Crombruggen, K. Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal. 2013, doi:10.1007/s11302-013-9357-4.
    • (2013) Purinergic Signal.
    • Jacob, F.1    Novo, C.P.2    Bachert, C.3    Van Crombruggen, K.4
  • 60
    • 0035086358 scopus 로고    scopus 로고
    • The P2X7 purinergic receptor on bovine macrophages mediates mycobacterial death
    • DOI 10.1016/S0165-2427(01)00245-8, PII S0165242701002458
    • Smith, R.A.; Alvarez, A.J.; Estes, D.M. The P2X7 purinergic receptor on bovine macrophages mediates mycobacterial death. Vet. Immunol. Immunopathol. 2001, 78, 249-262. (Pubitemid 32243945)
    • (2001) Veterinary Immunology and Immunopathology , vol.78 , Issue.3-4 , pp. 249-262
    • Smith, R.A.1    Alvarez, A.J.2    Estes D.Mark3
  • 61
    • 0038475924 scopus 로고    scopus 로고
    • Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation
    • DOI 10.1074/jbc.M207868200
    • Loomis, W.H.; Namiki, S.; Ostrom, R.S.; Insel, P.A. Hypertonic stress increases T cells interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J. Biol. Chem. 2003, 278, 4590-4596. (Pubitemid 36800956)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.7 , pp. 4590-4596
    • Loomis, W.H.1    Namiki, S.2    Ostrom, R.S.3    Insel, P.A.4    Junger, W.G.5
  • 62
    • 0035830853 scopus 로고    scopus 로고
    • ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage
    • Mehta, V.B.; Hart, J.; Wewers, M.D. ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J. Biol. Chem. 2001, 276, 3820-3826.
    • (2001) J. Biol. Chem. , vol.276 , pp. 3820-3826
    • Mehta, V.B.1    Hart, J.2    Wewers, M.D.3
  • 63
    • 0035031568 scopus 로고    scopus 로고
    • Detection of P2X purinergic receptors on human B lymphocytes
    • DOI 10.1007/s004410100372
    • Sluyter, R.; Barden, J.A.; Wiley, J.S. Detection of P2X purinergic receptors on human B lymphocytes. Cell. Tissue Res. 2001, 304, 231-236. (Pubitemid 32448989)
    • (2001) Cell and Tissue Research , vol.304 , Issue.2 , pp. 231-236
    • Sluyter, R.1    Barden, J.A.2    Wiley, J.S.3
  • 66
    • 33947675761 scopus 로고    scopus 로고
    • P2 purinergic receptor modulation of cytokine production
    • doi:10.1007/s11302-006-9034-y
    • Gabel, C.A. P2 purinergic receptor modulation of cytokine production. Purinergic Signal. 2007, doi:10.1007/s11302-006-9034-y.
    • (2007) Purinergic Signal.
    • Gabel, C.A.1
  • 67
    • 37449011204 scopus 로고    scopus 로고
    • In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain
    • Mingam, R.; De Smedt, V.; Amedee, T.; Bluthe, R.M.; Kelley, K.W.; Dantzer, R.; Laye, S. In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain. Brain Behav. Immun. 2008, 22, 234-244.
    • (2008) Brain Behav. Immun. , vol.22 , pp. 234-244
    • Mingam, R.1    De Smedt, V.2    Amedee, T.3    Bluthe, R.M.4    Kelley, K.W.5    Dantzer, R.6    Laye, S.7
  • 68
    • 49949084743 scopus 로고    scopus 로고
    • P2X7 receptor activation amplifies lipopolysaccharideinduced vascular hyporeactivity via interleukin-1 beta release
    • Chiao, C.W.; Tostes, R.C.; Webb, R.C. P2X7 receptor activation amplifies lipopolysaccharideinduced vascular hyporeactivity via interleukin-1 beta release. J. Pharmacol. Exp. Ther. 2008, 326, 864-870.
    • (2008) J. Pharmacol. Exp. Ther. , vol.326 , pp. 864-870
    • Chiao, C.W.1    Tostes, R.C.2    Webb, R.C.3
  • 69
    • 77249119641 scopus 로고    scopus 로고
    • Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X(7) receptors
    • Csolle, C.; Sperlagh, B. Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X(7) receptors. J. Neuroimmunol. 2010, 219, 38-46.
    • (2010) J. Neuroimmunol. , vol.219 , pp. 38-46
    • Csolle, C.1    Sperlagh, B.2
  • 70
    • 78649498799 scopus 로고    scopus 로고
    • Immunobiology purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages
    • Marques-da-silva, C.; Burnstock, G.; Ojcius, D.M.; Coutinho-silva, R. Immunobiology purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages. Auton Neurosci. 2011, 216, 1-11.
    • (2011) Auton Neurosci. , vol.216 , pp. 1-11
    • Marques-Da-Silva, C.1    Burnstock, G.2    Ojcius, D.M.3    Coutinho-Silva, R.4
  • 72
    • 79960019927 scopus 로고    scopus 로고
    • P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice
    • Furlan-Freguia, C.; Marchese, P.; Gruber, A.; Ruggeri, Z.M.; Ruf, W. P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. J. Clin. Invest.2011, 121, 2932-2944.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2932-2944
    • Furlan-Freguia, C.1    Marchese, P.2    Gruber, A.3    Ruggeri, Z.M.4    Ruf, W.5
  • 74
    • 2642512455 scopus 로고    scopus 로고
    • The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho
    • DOI 10.1189/jlb.1203648
    • Pfeiffer, Z.A.; Aga, M.; Prabhu, U.; Watters, J.J.; Hall, D.J.; Bertics, P.J. The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho. J. Leukoc. Biol. 2004, 75, 1173-1182. (Pubitemid 38720662)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.6 , pp. 1173-1182
    • Pfeiffer, Z.A.1    Aga, M.2    Prabhu, U.3    Watters, J.J.4    Hall, D.J.5    Bertics, P.J.6
  • 75
    • 20644448584 scopus 로고    scopus 로고
    • 7 nucleotide receptor: Modulation of LPS-induced macrophage signaling and mediator production
    • DOI 10.1002/ddr.1176
    • Watters, J.J.; Sommer, J.A.; Fisette, P.L.; Pfeiffer, A.Z.; Aga, M.; Prabhu, U.; Guerra, A.N.; Denlinger, L.C.; Bertics, P.J. P2X7 nucleotide receptor: Modulation of LPS-induced macrophage signaling and mediator production. Drug Develop. Res. 2001, 53, 91-104. (Pubitemid 32845848)
    • (2001) Drug Development Research , vol.53 , Issue.2-3 , pp. 91-104
    • Bertics, P.J.1
  • 77
    • 84876987954 scopus 로고    scopus 로고
    • On the role of ATP-Gated P2X receptors in acute, inflammatory and neuropathic pain
    • L., Light, A.R., Eds.; CRC Press: Boca Raton, FL, USA
    • Toulme, E.; Tsuda, M.; Khakh, B.S.; Inoue, K. On the role of ATP-Gated P2X receptors in acute, inflammatory and neuropathic pain. In Translational Pain Research: From Mouse to Man; Kruger, L., Light, A.R., Eds.; CRC Press: Boca Raton, FL, USA, 2010.
    • (2010) Translational Pain Research: From Mouse to Man; Kruger
    • Toulme, E.1    Tsuda, M.2    Khakh, B.S.3    Inoue, K.4
  • 78
    • 79958798010 scopus 로고    scopus 로고
    • A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases
    • Arulkumaran, N.; Unwin, R.J.; Tam, F.W. A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases. Expert. Opin. Investig. Drugs 2011, 20, 897-915.
    • (2011) Expert. Opin. Investig. Drugs , vol.20 , pp. 897-915
    • Arulkumaran, N.1    Unwin, R.J.2    Tam, F.W.3
  • 79
    • 40749157181 scopus 로고    scopus 로고
    • 7 expression after Atp stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls
    • DOI 10.1007/s10753-007-9052-0
    • Al-Shukaili, A.; Al-Kaabi, J.; Hassan, B. A comparative study of interleukin-1beta production and p2x7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls. Inflammation 2008, 31, 84-90. (Pubitemid 351388891)
    • (2008) Inflammation , vol.31 , Issue.2 , pp. 84-90
    • Al-Shukaili, A.1    Al-Kaabi, J.2    Hassan, B.3
  • 83
    • 84859456520 scopus 로고    scopus 로고
    • Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate
    • Stock, T.C.; Bloom, B.J.; Wei, N.; Ishaq, S.; Park, W.; Wang, X.; Gupta, P.; Mebus, C.A. Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J. Rheumatol.2012, 39, 720-727.
    • (2012) J. Rheumatol. , vol.39 , pp. 720-727
    • Stock, T.C.1    Bloom, B.J.2    Wei, N.3    Ishaq, S.4    Park, W.5    Wang, X.6    Gupta, P.7    Mebus, C.A.8
  • 84
    • 84866105881 scopus 로고    scopus 로고
    • Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
    • Keystone, E.C.; Wang, M.M.; Layton, M.; Hollis, S.; McInnes, I.B.; Team, D.C.S. Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine. Ann. Rheum. Dis. 2012, 71, 1630-1635.
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 1630-1635
    • Keystone, E.C.1    Wang, M.M.2    Layton, M.3    Hollis, S.4    McInnes, I.B.5
  • 85
  • 86
    • 79959951279 scopus 로고    scopus 로고
    • P2X(7) receptors in neurological and cardiovascular disorders
    • Skaper, S.D.; Debetto, P.; Giusti, P. P2X(7) Receptors in Neurological and Cardiovascular Disorders. Cardiovasc. Psychiatry Neurol. 2009, 2009, 861324-861324.
    • (2009) Cardiovasc. Psychiatry Neurol. , vol.2009 , pp. 861324-861324
    • Skaper, S.D.1    Debetto, P.2    Giusti, P.3
  • 88
    • 0014096549 scopus 로고
    • Myelinated afferent fibres responding specifically to noxious stimulation of the skin
    • Burgess, P.R.; Perl, E.R. Myelinated afferent fibres responding specifically to noxious stimulation of the skin. J. Physiol.1967, 190, 541-562.
    • (1967) J. Physiol. , vol.190 , pp. 541-562
    • Burgess, P.R.1    Perl, E.R.2
  • 89
    • 0032890162 scopus 로고    scopus 로고
    • The induction of pain: An integrative review
    • DOI 10.1016/S0301-0082(98)00048-3, PII S0301008298000483
    • Millan, M.J. The induction of pain: an integrative review. Prog. Neurobiol. 1999, 57, 1-164. (Pubitemid 28551764)
    • (1999) Progress in Neurobiology , vol.57 , Issue.1 , pp. 1-164
    • Millan, M.J.1
  • 90
    • 10044265537 scopus 로고    scopus 로고
    • Musculoskeletal pain in patients with myotonic dystrophy type 2
    • DOI 10.1001/archneur.61.12.1938
    • George, A.; Schneider-Gold, C.; Zier, S.; Reiners, K.; Sommer, C. Musculoskeletal pain in patients with myotonic dystrophy type 2. Arch. Neurol. 2004, 61, 1938-1942. (Pubitemid 39612956)
    • (2004) Archives of Neurology , vol.61 , Issue.12 , pp. 1938-1942
    • George, A.1    Schneider-Gold, C.2    Zier, S.3    Reiners, K.4    Sommer, C.5
  • 92
    • 0014025239 scopus 로고
    • Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'-triphosphate
    • Collier, H.O.; James, G.W.; Schneider, C. Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'- triphosphate. Nature 1966, 212, 411-412.
    • (1966) Nature , vol.212 , pp. 411-412
    • Collier, H.O.1    James, G.W.2    Schneider, C.3
  • 93
    • 0017190556 scopus 로고
    • Identification of algogenic substances in human erythrocytes
    • Bleehen, T.; Hobbiger, F.; Keele, C.A. Identification of algogenic substances in human erythrocytes. J. Physiol. 1976, 262, 131-149.
    • (1976) J. Physiol. , vol.262 , pp. 131-149
    • Bleehen, T.1    Hobbiger, F.2    Keele, C.A.3
  • 94
    • 33745738972 scopus 로고    scopus 로고
    • Purinergic signalling in neuron-glia interactions
    • DOI 10.1038/nrn1928, PII NRN1928
    • Fields, R.D.; Burnstock, G. Purinergic signalling in neuron-glia interactions. Nat. Rev. Neurosci. 2006, 7, 423-436. (Pubitemid 44012283)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.6 , pp. 423-436
    • Fields, R.D.1    Burnstock, G.2
  • 95
    • 28244493488 scopus 로고
    • Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut
    • Burnstock, G.; Campbell, G.; Satchell, D.; Smythe, A. Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. 1970. Br. J. Pharmacol. 1997, 120, 337-57.
    • (1970) Br. J. Pharmacol. , vol.120 , pp. 337-357
    • Burnstock, G.1    Campbell, G.2    Satchell, D.3    Smythe, A.4
  • 96
    • 84857045446 scopus 로고    scopus 로고
    • Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future
    • Burnstock, G. Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future. Bioessays 2012, 34, 218-225.
    • (2012) Bioessays , vol.34 , pp. 218-225
    • Burnstock, G.1
  • 97
    • 84870443538 scopus 로고    scopus 로고
    • Contribution of the spinal P2X7 receptors to bee venom-induced nociception and inflammation in conscious rats
    • Zhou, Z.H.; Wang, J.X.; Liu, B.J.; Li, M.; Lu, Y.; Chen, H.S. Contribution of the spinal P2X7 receptors to bee venom-induced nociception and inflammation in conscious rats. Neurosci. Lett. 2012, 531, 145-148.
    • (2012) Neurosci. Lett. , vol.531 , pp. 145-148
    • Zhou, Z.H.1    Wang, J.X.2    Liu, B.J.3    Li, M.4    Lu, Y.5    Chen, H.S.6
  • 98
    • 33750368810 scopus 로고    scopus 로고
    • Astrocyte calcium waves: What they are and what they do
    • DOI 10.1002/glia.20374
    • Scemes, E.; Giaume, C. Astrocyte calcium waves: What they are and what they do. Glia 2006, 54, 716-725. (Pubitemid 44629634)
    • (2006) GLIA , vol.54 , Issue.7 , pp. 716-725
    • Scemes, E.1    Giaume, C.2
  • 99
    • 79960008253 scopus 로고    scopus 로고
    • Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: A calcium imaging study
    • Kushnir, R.; Cherkas, P.S.; Hanani, M. Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: A calcium imaging study. Neuropharmacology 2011, 61, 739-746.
    • (2011) Neuropharmacology , vol.61 , pp. 739-746
    • Kushnir, R.1    Cherkas, P.S.2    Hanani, M.3
  • 100
    • 77957323601 scopus 로고    scopus 로고
    • Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors
    • Khakpay, R.; Polster, D.; Koles, L.; Skorinkin, A.; Szabo, B.; Wirkner, K.; Illes, P. Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors. Purinergic signal. 2010, 6, 349-359.
    • (2010) Purinergic Signal. , vol.6 , pp. 349-359
    • Khakpay, R.1    Polster, D.2    Koles, L.3    Skorinkin, A.4    Szabo, B.5    Wirkner, K.6    Illes, P.7
  • 101
    • 21744433587 scopus 로고    scopus 로고
    • Role of the immune system in chronic pain
    • DOI 10.1038/nrn1700
    • Marchand, F.; Perretti, M.; McMahon, S.B. Role of the immune system in chronic pain. Nat. Rev. Neurosci. 2005, 6, 521-532. (Pubitemid 40942819)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.7 , pp. 521-532
    • Marchand, F.1    Perretti, M.2    McMahon, S.B.3
  • 102
    • 84860647699 scopus 로고    scopus 로고
    • Tests and models of nociception and pain in rodents
    • Barrot, M. Tests and models of nociception and pain in rodents. Neuroscience 2012, 211, 39-50.
    • (2012) Neuroscience , vol.211 , pp. 39-50
    • Barrot, M.1
  • 103
    • 80052258918 scopus 로고    scopus 로고
    • Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors
    • Itoh, K.; Chiang, C.Y.; Li, Z.; Lee, J.C.; Dostrovsky, J.O.; Sessle, B.J. Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors. Neuroscience 2011, 192, 721-731.
    • (2011) Neuroscience , vol.192 , pp. 721-731
    • Itoh, K.1    Chiang, C.Y.2    Li, Z.3    Lee, J.C.4    Dostrovsky, J.O.5    Sessle, B.J.6
  • 104
    • 33646439133 scopus 로고    scopus 로고
    • Activated microglia contribute to the maintenance of chronic pain after spinal cord injury
    • DOI 10.1523/JNEUROSCI.0003-06.2006
    • Hains, B.C.; Waxman, S.G. Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J. Neurosci. 2006, 26, 4308-4317. (Pubitemid 44315390)
    • (2006) Journal of Neuroscience , vol.26 , Issue.16 , pp. 4308-4317
    • Hains, B.C.1    Waxman, S.G.2
  • 105
    • 78149281987 scopus 로고    scopus 로고
    • Minocycline attenuates mechanical allodynia and central sensitization following peripheral second-degree burn injury
    • Chang, Y.W.; Waxman, S.G. Minocycline attenuates mechanical allodynia and central sensitization following peripheral second-degree burn injury. J. Pain Relief. 2010, 11, 1146-1154.
    • (2010) J. Pain Relief. , vol.11 , pp. 1146-1154
    • Chang, Y.W.1    Waxman, S.G.2
  • 106
    • 23944447053 scopus 로고    scopus 로고
    • Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn)
    • DOI 10.1152/jn.00223.2005
    • Chiang, C.Y.; Zhang, S.; Xie, Y.F.; Hu, J.W.; Dostrovsky, J.O.; Salter, M.W.; Sessle, B.J. Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn). J. Neurophysiol. 2005, 94, 1751-1760. (Pubitemid 41192847)
    • (2005) Journal of Neurophysiology , vol.94 , Issue.3 , pp. 1751-1760
    • Chiang, C.Y.1    Zhang, S.2    Xie, Y.F.3    Hu, J.W.4    Dostrovsky, J.O.5    Salter, M.W.6    Sessle, B.J.7
  • 107
    • 0036899591 scopus 로고    scopus 로고
    • Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP
    • DOI 10.1002/art.10678
    • Dell'Antonio, G.; Quattrini, A.; Cin, E.D.; Fulgenzi, A.; Ferrero, M.E. Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP. Arthritis Rheum. 2002, 46, 3378-3385. (Pubitemid 35453550)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.12 , pp. 3378-3385
    • Dell'Antonio, G.1    Quattrini, A.2    Dal Cin, E.3    Fulgenzi, A.4    Ferrero, M.E.5
  • 108
    • 33745153343 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms in neuropathic pain
    • DOI 10.1016/j.brainresrev.2005.11.004, PII S0165017305001700
    • Moalem, G.; Tracey, D.J. Immune and inflammatory mechanisms in neuropathic pain. Brain Res. Rev. 2006, 51, 240-264. (Pubitemid 43902971)
    • (2006) Brain Research Reviews , vol.51 , Issue.2 , pp. 240-264
    • Moalem, G.1    Tracey, D.J.2
  • 110
    • 34548444551 scopus 로고    scopus 로고
    • Liaisons dangereuses: P2X(7) and the inflammasome
    • Di Virgilio, F. Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol. Sci. 2007, 28, 465-472.
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 465-472
    • Di Virgilio, F.1
  • 111
    • 56749085777 scopus 로고    scopus 로고
    • Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease
    • Ryu, J.K.; McLarnon, J.G. Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease. Neuroreport 2008, 19, 1715-1719.
    • (2008) Neuroreport , vol.19 , pp. 1715-1719
    • Ryu, J.K.1    McLarnon, J.G.2
  • 112
    • 84868094788 scopus 로고    scopus 로고
    • P2 receptors for extracellular nucleotides in the central nervous system: Role of P2X7 and P2Y(2) receptor interactions in neuroinflammation
    • Weisman, G.A.; Camden, J.M.; Peterson, T.S.; Ajit, D.; Woods, L.T.; Erb, L. P2 receptors for extracellular nucleotides in the central nervous system: Role of P2X7 and P2Y(2) receptor interactions in neuroinflammation. Mol. Neurobiol. 2012, 46, 96-113.
    • (2012) Mol. Neurobiol. , vol.46 , pp. 96-113
    • Weisman, G.A.1    Camden, J.M.2    Peterson, T.S.3    Ajit, D.4    Woods, L.T.5    Erb, L.6
  • 115
    • 23644441500 scopus 로고    scopus 로고
    • 7 receptors in non-neuronal cells of rat dorsal root ganglia
    • DOI 10.1016/j.brainres.2005.06.022, PII S0006899305008589
    • Zhang, X.F.; Han, P.; Faltynek, C.R.; Jarvis, M.F.; Shieh, C.C. Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia. Brain Res. 2005, 1052, 63-70. (Pubitemid 41116288)
    • (2005) Brain Research , vol.1052 , Issue.1 , pp. 63-70
    • Zhang, X.-F.1    Han, P.2    Faltynek, C.R.3    Jarvis, M.F.4    Shieh, C.-C.5
  • 120
    • 67650222417 scopus 로고    scopus 로고
    • Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays
    • Tsuda, M.; Kuboyama, K.; Inoue, T.; Nagata, K.; Tozaki-Saitoh, H.; Inoue, K. Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays. Mol. Pain 2009, 5, 28-34.
    • (2009) Mol. Pain , vol.5 , pp. 28-34
    • Tsuda, M.1    Kuboyama, K.2    Inoue, T.3    Nagata, K.4    Tozaki-Saitoh, H.5    Inoue, K.6
  • 121
    • 18044378766 scopus 로고    scopus 로고
    • 12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis
    • DOI 10.1055/s-2005-869523
    • Savi, P.; Herbert, J.M. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin. Thromb. Hemost. 2005, 31, 174-183. (Pubitemid 40605192)
    • (2005) Seminars in Thrombosis and Hemostasis , vol.31 , Issue.2 , pp. 174-183
    • Savi, P.1    Herbert, J.-M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.