Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

Gene

Volumn 573, Issue 1, 2015, Pages 1-32

  Ivanov, Igor ^a   Kuhn, Hartmut ^a   Heydeck, Dagmar ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Eicosanoids; Enzymology; Evolution; Leukotrienes; Lipid metabolism; Lipoxygenase

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; CHOLESTEROL ESTER; FATTY ACID; ISOENZYME; LEUKOTRIENE SYNTHASE; LIPOHYDROPEROXIDASE; MEMBRANE PHOSPHOLIPID; MESSENGER RNA; PEROXIDASE; PHOSPHOLIPID; SYNTHETASE; UNCLASSIFIED DRUG;

AUTOPHAGY; CARCINOGENESIS; CARDIOVASCULAR DISEASE; DIMERIZATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; LIPID METABOLISM; METABOLIC DISORDER; METASTASIS; MITOCHONDRION; MOLECULAR INTERACTION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TRANSLATION REGULATION; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; PROTEIN CONFORMATION;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; HUMANS; ISOENZYMES; PROTEIN CONFORMATION;

EID: 84941939717     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2015.07.073     Document Type: Review

References (404)

1. Adel S., Hofheinz K., Heydeck D., Kuhn H., Häfner A.K. Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes. Biochim. Biophys. Acta 2014, 1841:1460-1466.
2. Adel S., Kakularam K.R., Horn T., Reddanna P., Kuhn H., Heydeck D. Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens. Arch. Biochem. Biophys. 2015, 565:17-24.
3. Aggarwal N.T., Pfister S.L., Campbell W.B. Hypercholesterolemia enhances 15-lipoxygenase-mediated vasorelaxation and acetylcholine-induced hypotension. Arterioscler. Thromb. Vasc. Biol. 2008, 28:2209-2215.
4. Aggarwal N.T., Pfister S.L., Gauthier K.M., Chawengsub Y., Baker J.E., Campbell W.B. Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:H678-H688.
5. Alber T. Structure of the leucine zipper. Curr. Opin. Genet. Dev. 1992, 2:205-210.
6. Altmann R., Hausmann M., Spottl T., Gruber M., Bull A.W., Menzel K., Vogl D., Herfarth H., Scholmerich J., Falk W., Rogler G. 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. Biochem. Pharmacol. 2007, 74:612-622.
7. Bazan N.G. Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease. J. Lipid Res. 2009, 50:S400-S405. (Suppl.).
8. Belayev L., Khoutorova L., Atkins K.D., Eady T.N., Hong S., Lu Y., Obenaus A., Bazan N.G. Docosahexaenoic acid therapy of experimental ischemic stroke. Transl. Stroke Res. 2011, 2:33-41.
9. Belkner J., Wiesner R., Kuhn H., Lankin V.Z. The oxygenation of cholesterol esters by the reticulocyte lipoxygenase. FEBS Lett. 1991, 279:110-114.
10. Belkner J., Wiesner R., Rathman J., Barnett J., Sigal E., Kuhn H. Oxygenation of lipoproteins by mammalian lipoxygenases. Eur. J. Biochem. 1993, 213:251-261.
11. Belkner J., Stender H., Kuhn H. The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E. J. Biol. Chem. 1998, 273:23225-23232.
12. Ben-Nasr S., Aazza S., Mnif W., Miguel Mda G. Antioxidant and anti-lipoxygenase activities of extracts from different parts of Lavatera cretica L. grown in Algarve (Portugal). Pharmacogn. Mag. 2015, 11:48-54.
13. Berger M., Schwarz K., Thiele H., Reimann I., Huth A., Borngraber S., Kuhn H., Thiele B.J. Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits. J. Mol. Biol. 1998, 278:935-948.
14. Berger W., De Chandt M.T., Cairns C.B. Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease. Int. J. Clin. Pract. 2007, 61:663-676.
15. Bhattacharjee A., Shukla M., Yakubenko V.P., Mulya A., Kundu S., Cathcart M.K. IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages. Free Radic. Biol. Med. 2013, 54:1-16.
16. Bindu P.H., Sastry G.M., Sastry G.N. Characterization of calcium and magnesium binding domains of human 5-lipoxygenase. Biochem. Biophys. Res. Commun. 2004, 320:461-467.
17. Blanc L., Barres C., Bette-Bobillo P., Vidal M. Reticulocyte-secreted exosomes bind natural IgM antibodies: involvement of a ROS-activatable endosomal phospholipase iPLA2. Blood 2007, 110:3407-3416.
18. Bleich D., Chen S., Gu J.L., Nadler J.L. The role of 12-lipoxygenase in pancreatic -cells (Review). Int. J. Mol. Med. 1998, 1:265-272.
19. Bleich D., Chen S., Zipser B., Sun D., Funk C.D., Nadler J.L. Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. J. Clin. Invest. 1999, 103:1431-1436.
20. Borngraber S., Kuban R.J., Anton M., Kuhn H. Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases. J. Mol. Biol. 1996, 264:1145-1153.
21. Borngraber S., Browner M., Gillmor S., Gerth C., Anton M., Fletterick R., Kuhn H. Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity. J. Biol. Chem. 1999, 274:37345-37350.
22. Boudina S., Abel E.D. Diabetic cardiomyopathy revisited. Circulation 2007, 115:3213-3223.
23. Boyer R.F., Litts D., Kostishak J., Wijesundera R.C., Gunstone F.D. The action of lipoxygenase-1 on furan derivatives. Chem. Phys. Lipids 1979, 25:237-246.
24. Brash A.R. Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J. Biol. Chem. 1999, 274:23679-23682.
25. Brash A.R., Ingram C.D., Harris T.M. Analysis of a specific oxygenation reaction of soybean lipoxygenase-1 with fatty acids esterified in phospholipids. Biochemistry 1987, 26:5465-5471.
26. Brash A.R., Yokoyama C., Oates J.A., Yamamoto S. Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase. Arch. Biochem. Biophys. 1989, 273:414-422.
27. Brash A.R., Boeglin W.E., Chang M.S., Shieh B.H. Purification and molecular cloning of an 8R-lipoxygenase from the coral Plexaura homomalla reveal the related primary structures of R- and S-lipoxygenases. J. Biol. Chem. 1996, 271:20949-20957.
28. Brash A.R., Boeglin W.E., Chang M.S. Discovery of a second 15S-lipoxygenase in humans. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:6148-6152.
29. Brinckmann R., Topp M.S., Zalan I., Heydeck D., Ludwig P., Kuhn H., Berdel W.E., Habenicht J.R. Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4. Biochem. J. 1996, 318(Pt 1):305-312.
30. Brinckmann R., Schnurr K., Heydeck D., Rosenbach T., Kolde G., Kuhn H. Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme. Blood 1998, 91:64-74.
31. Brune B., Dehne N., Grossmann N., Jung M., Namgaladze D., Schmid T., von Knethen A., Weigert A. Redox control of inflammation in macrophages. Antioxid. Redox Signal. 2013, 19:595-637.
32. Bryant R.W., Bailey J.M., Schewe T., Rapoport S.M. Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid. J. Biol. Chem. 1982, 257:6050-6055.
33. Bryant R.W., Schewe T., Rapoport S.M., Bailey J.M. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4. J. Biol. Chem. 1985, 260:3548-3555.
34. Bürger F., Krieg P., Marks F., Fürstenberger G. Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes. Biochem. J. 2000, 348(Pt 2):329-335.
35. Calhoun D.B., Vanderkooi J.M., Woodrow G.V., Englander S.W. Penetration of dioxygen into proteins studied by quenching of phosphorescence and fluorescence. Biochemistry 1983, 22:1526-1532.
36. Canals S., Casarejos M.J., de Bernardo S., Rodriguez-Martin E., Mena M.A. Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. J. Biol. Chem. 2003, 278:21542-21549.
37. Chaitidis P., O'Donnell V., Kuban R.J., Bermudez-Fajardo A., Ungethuem U., Kuhn H. Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13. Cytokine 2005, 30:366-377.
38. Chaitidis P., Adel S., Anton M., Heydeck D., Kuhn H., Horn T. Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms. J. Lipid Res. 2013, 54:1397-1409.
39. Chakrabarti S.K., Wen Y., Dobrian A.D., Cole B.K., Ma Q., Pei H., Williams M.D., Bevard M.H., Vandenhoff G.E., Keller S.R., Gu J., Nadler J.L. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am. J. Physiol. Endocrinol. Metab. 2011, 300:E175-E187.
40. Chan P.H., Fishman R.A. Brain edema: induction in cortical slices by polyunsaturated fatty acids. Science 1978, 201:358-360.
41. Chan P.H., Fishman R.A., Caronna J., Schmidley J.W., Prioleau G., Lee J. Induction of brain edema following intracerebral injection of arachidonic acid. Ann. Neurol. 1983, 13:625-632.
42. Chattopadhyay R., Dyukova E., Singh N.K., Ohba M., Mobley J.A., Rao G.N. Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C epsilon-mediated zona occludens-1 phosphorylation at threonine 770/772. J. Biol. Chem. 2014, 289:3148-3163.
43. Chattopadhyay R., Tinnikov A., Dyukova E., Singh N.K., Kotla S., Mobley J.A., Rao G.N. 12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction. J. Lipid Res. 2015, 56:562-577.
44. Chawengsub Y., Gauthier K.M., Campbell W.B. Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone. Am. J. Physiol. Heart Circ. Physiol. 2009, 297:H495-H507.
45. Chen M., Yang Z.D., Smith K.M., Carter J.D., Nadler J.L. Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity. Diabetologia 2005, 48:486-495.
46. Chen B., Tsui S., Boeglin W.E., Douglas R.S., Brash A.R., Smith T.J. Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines. J. Biol. Chem. 2006, 281:18296-18306.
47. Chisolm G.M., Steinberg D. The oxidative modification hypothesis of atherogenesis: an overview. Free Radic. Biol. Med. 2000, 28:1815-1826.
48. Chiu J., Dawes I.W. Redox control of cell proliferation. Trends Cell Biol. 2012, 22:592-601.
49. Choi J., Chon J.K., Kim S., Shin W. Conformational flexibility in mammalian 15S-lipoxygenase: reinterpretation of the crystallographic data. Proteins 2008, 70:1023-1032.
50. Chu K., Vojtchovsky J., McMahon B.H., Sweet R.M., Berendzen J., Schlichting I. Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin. Nature 2000, 403:921-923.
51. Cimen I., Tuncay S., Banerjee S. 15-Lipoxygenase-1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT-116 and HT-29. Cancer Sci. 2009, 100:2283-2291.
52. Cimen I., Astarci E., Banerjee S. 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma. J. Cell. Biochem. 2011, 112:2490-2501.
53. Claesson H.E. On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. Prostaglandins Other Lipid Mediat. 2009, 89:120-125.
54. Coffa G., Brash A.R. A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:15579-15584.
55. Coffa G., Hill E.M. Discovery of an 11 (R)- and 12(S)-lipoxygenase activity in ovaries of the mussel Mytilus edulis. Lipids 2000, 35:1195-1204.
56. Coffa G., Imber A.N., Maguire B.C., Laxmikanthan G., Schneider C., Gaffney B.J., Brash A.R. On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant. J. Biol. Chem. 2005, 280:38756-38766.
57. Coffa G., Schneider C., Brash A.R. A comprehensive model of positional and stereo control in lipoxygenases. Biochem. Biophys. Res. Commun. 2005, 338:87-92.
58. 2, CO, NO, and Xe inside myoglobin. Biophys. J. 2006, 91:1844-1857.
59. Cole B.K., Morris M.A., Grzesik W.J., Leone K.A., Nadler J.L. Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet. Mediat. Inflamm. 2012, 2012:851798.
60. Cole B.K., Lieb D.C., Dobrian A.D., Nadler J.L. 12- and 15-lipoxygenases in adipose tissue inflammation. Prostaglandins Other Lipid Mediat. 2013, 104-105:84-92.
61. Conrad D.J., Lu M. Regulation of human 12/15-lipoxygenase by Stat6-dependent transcription. Am. J. Respir. Cell Mol. Biol. 2000, 22:226-234.
62. Conrad D.J., Kuhn H., Mulkins M., Highland E., Sigal E. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:217-221.
63. Conte D., Falaschi P., Proietti A., D'Urso R., Citarella F., Nordio M., Romanelli F., Maggi R., Motta M., Isidori A. Role of arachidonate metabolism on the in vitro release of luteinizing hormone and prolactin from the anterior pituitary gland: possible involvement of lipoxygenase pathway. Neuroendocrinology 1986, 43:428-434.
64. Cooke B.A., Dix C.J., Habberfield A.D., Sullivan M.H. Control of steroidogenesis in Leydig cells: roles of Ca2+ and lipoxygenase products in LH and LHRH agonist action. Ann. N. Y. Acad. Sci. 1984, 438:269-282.
65. Cretu E., Trifan A., Aprotosoaie A.C., Miron A. 15-lipoxygenase inhibition, superoxide and hydroxyl radicals scavenging activities of Cedrus brevifolia bark extracts. Rev. Med. Chir. Soc. Med. Nat. Iasi 2013, 117:250-256.
66. Cutuli L., Pirillo A., Uboldi P., Kuehn H., Catapano A.L. 15-lipoxygenase-mediated modification of HDL3 impairs eNOS activation in human endothelial cells. Lipids 2014, 49:317-326.
67. Cyrus T., Witztum J.L., Rader D.J., Tangirala R., Fazio S., Linton M.F., Funk C.D. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice. J. Clin. Invest. 1999, 103:1597-1604.
68. Cyrus T., Pratico D., Zhao L., Witztum J.L., Rader D.J., Rokach J., FitzGerald G.A., Funk C.D. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation 2001, 103:2277-2282.
69. Dainese E., Sabatucci A., van Zadelhoff G., Angelucci C.B., Vachette P., Veldink G.A., Agro A.F., Maccarrone M. Structural stability of soybean lipoxygenase-1 in solution as probed by small angle X-ray scattering. J. Mol. Biol. 2005, 349:143-152.
70. Dalli J., Colas R.A., Serhan C.N. Novel n-3 immunoresolvents: structures and actions. Sci. Rep. 2013, 3:1940.
71. de Groot J.J., Garssen G.J., Vliegenthart J.F., Boldingh J. The detection of linoleic acid radicals in the anaerobic reaction of lipoxygenase. Biochim. Biophys. Acta 1973, 326:279-284.
72. de La Houssaye B.A., Mikule K., Nikolic D., Pfenninger K.H. Thrombin-induced growth cone collapse: involvement of phospholipase A(2) and eicosanoid generation. J. Neurosci. 1999, 19:10843-10855.
73. De Marzo N., Sloane D.L., Dicharry S., Highland E., Sigal E. Cloning and expression of an airway epithelial 12-lipoxygenase. Am. J. Physiol. 1992, 262:L198-L207.
74. DeCostanzo A.J., Voloshyna I., Rosen Z.B., Feinmark S.J., Siegelbaum S.A. 12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels. J. Neurosci. 2010, 30:1822-1831.
75. Di Giovanni S., Knoblach S.M., Brandoli C., Aden S.A., Hoffman E.P., Faden A.I. Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Ann. Neurol. 2003, 53:454-468.
76. Di Venere A., Horn T., Stehling S., Mei G., Masgrau L., Gonzalez-Lafont A., Kuhn H., Ivanov I. Role of Arg403 for thermostability and catalytic activity of rabbit 12/15-lipoxygenase. Biochim. Biophys. Acta 2013, 1831:1079-1088.
77. Dix C.J., Habberfield A.D., Sullivan M.H., Cooke B.A. Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis. Biochem. J. 1984, 219:529-537.
78. Dix C.J., Habberfield A.D., Sullivan M.H., Cooke B.A. Evidence for the involvement of lipoxygenase products in steroidogenesis. Biochem. Soc. Trans. 1985, 13:60-63.
79. Dobrian A.D., Lieb D.C., Ma Q., Lindsay J.W., Cole B.K., Ma K., Chakrabarti S.K., Kuhn N.S., Wohlgemuth S.D., Fontana M., Nadler J.L. Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. Biochem. Biophys. Res. Commun. 2010, 403:485-490.
80. Dobrian A.D., Lieb D.C., Cole B.K., Taylor-Fishwick D.A., Chakrabarti S.K., Nadler J.L. Functional and pathological roles of the 12- and 15-lipoxygenases. Prog. Lipid Res. 2011, 50:115-131.
81. Downey B.R., Mootoo J.E., Doyle S.E. A role for lipoxygenase metabolites of arachidonic acid in porcine ovulation. Anim. Reprod. Sci. 1998, 49:269-279.
82. El Kebir D., Filep J.G. Modulation of neutrophil apoptosis and the resolution of inflammation through beta2 integrins. Front. Immunol. 2013, 4:60.
83. Emerson M.R., LeVine S.M. Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. Brain Res. 2004, 1021:140-145.
84. Epp N., Furstenberger G., Muller K., de Juanes S., Leitges M., Hausser I., Thieme F., Liebisch G., Schmitz G., Krieg P. 12R-lipoxygenase deficiency disrupts epidermal barrier function. J. Cell Biol. 2007, 177:173-182.
85. Ereso A.Q., Cureton E.L., Cripps M.W., Sadjadi J., Dua M.M., Curran B., Victorino G.P. Lipoxin a(4) attenuates microvascular fluid leak during inflammation. J. Surg. Res. 2009, 156:183-188.
86. Ezcurra D., Humaidan P. A review of luteinising hormone and human chorionic gonadotropin when used in assisted reproductive technology. Reprod. Biol. Endocrinol. 2014, 12:95.
87. Feinmark S.J., Begum R., Tsvetkov E., Goussakov I., Funk C.D., Siegelbaum S.A., Bolshakov V.Y. 12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses. J. Neurosci. 2003, 23:11427-11435.
88. Feltenmark S., Gautam N., Brunnstrom A., Griffiths W., Backman L., Edenius C., Lindbom L., Bjorkholm M., Claesson H.E. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:680-685.
89. Ferre N., Martinez-Clemente M., Lopez-Parra M., Gonzalez-Periz A., Horrillo R., Planaguma A., Camps J., Joven J., Tres A., Guardiola F., Bataller R., Arroyo V., Claria J. Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 296:G553-G562.
90. Fierro I.M., Colgan S.P., Bernasconi G., Petasis N.A., Clish C.B., Arita M., Serhan C.N. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. J. Immunol. 2003, 170:2688-2694.
91. Fischer K.A., Van Leyen K., Lovercamp K.W., Manandhar G., Sutovsky M., Feng D., Safranski T., Sutovsky P. 15-Lipoxygenase is a component of the mammalian sperm cytoplasmic droplet. Reproduction 2005, 130:213-222.
92. Fleming J., Thiele B.J., Chester J., O'Prey J., Janetzki S., Aitken A., Anton I.A., Rapoport S.M., Harrison P.R. The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases. Gene 1989, 79:181-188.
93. Folcik V.A., Nivar-Aristy R.A., Krajewski L.P., Cathcart M.K. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques. J. Clin. Invest. 1995, 96:504-510.
94. Freire M.O., Van Dyke T.E. Natural resolution of inflammation. Periodontol. 2013, 2000(63):149-164.
95. Funk C.D., Chen X.S., Johnson E.N., Zhao L. Lipoxygenase genes and their targeted disruption. Prostaglandins Other Lipid Mediat. 2002, 68-69:303-312.
96. Gan Q.F., Witkop G.L., Sloane D.L., Straub K.M., Sigal E. Identification of a specific methionine in mammalian 15-lipoxygenase which is oxygenated by the enzyme product 13-HPODE: dissociation of sulfoxide formation from self-inactivation. Biochemistry 1995, 34:7069-7079.
97. Gan Q.F., Browner M.F., Sloane D.L., Sigal E. Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis. J. Biol. Chem. 1996, 271:25412-25418.
98. Garreta A., Val-Moraes S.P., Garcia-Fernandez Q., Busquets M., Juan C., Oliver A., Ortiz A., Gaffney B.J., Fita I., Manresa A., Carpena X. Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa. FASEB J. 2013, 27:4811-4821.
99. Garscha U., Jernerén F., Chung D., Keller N.P., Hamberg M., Oliw E.H. Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism. J. Biol. Chem. 2007, 282:34707-34718.
100. Garssen G.J., Vliegenthart J.F., Boldingh J. An anaerobic reaction between lipoxygenase, linoleic acid and its hydroperoxides. Biochem. J. 1971, 122:327-332.
101. Garssen G.J., Vliegenthart J.F., Boldingh J. The origin and structures of dimeric fatty acids from the anaerobic reaction between soya-bean lipoxygenase, linoleic acid and its hydroperoxide. Biochem. J. 1972, 130:435-442.
102. George J., Afek A., Shaish A., Levkovitz H., Bloom N., Cyrus T., Zhao L., Funk C.D., Sigal E., Harats D. 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice. Circulation 2001, 104:1646-1650.
103. Gertow K., Nobili E., Folkersen L., Newman J.W., Pedersen T.L., Ekstrand J., Swedenborg J., Kühn H., Wheelock C.E., Hansson G.K., Hedin U., Haeggström J.Z., Gabrielsen A. 12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms. Atherosclerosis 2011, 215:411-416.
104. Gilbert N.C., Rui Z., Neau D.B., Waight M.T., Bartlett S.G., Boeglin W.E., Brash A.R., Newcomer M.E. Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. FASEB J. 2012, 26:3222-3229.
105. Gillmor S.A., Villasenor A., Fletterick R., Sigal E., Browner M.F. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat. Struct. Biol. 1997, 4:1003-1009.
106. Glick D., Barth S., Macleod K.F. Autophagy: cellular and molecular mechanisms. J. Pathol. 2010, 221:3-12.
107. Goswami S.K. Cellular redox, epigenetics and diseases. Subcell. Biochem. 2013, 61:527-542.
108. Green-Mitchell S.M., Tersey S.A., Cole B.K., Ma K., Kuhn N.S., Cunningham T.D., Maybee N.A., Chakrabarti S.K., McDuffie M., Taylor-Fishwick D.A., Mirmira R.G., Nadler J.L., Morris M.A. Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One 2013, 8:e56763.
109. Gregus A.M., Dumlao D.S., Wei S.C., Norris P.C., Catella L.C., Meyerstein F.G., Buczynski M.W., Steinauer J.J., Fitzsimmons B.L., Yaksh T.L., Dennis E.A. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013, 27:1939-1949.
110. Griffiths R.E., Kupzig S., Cogan N., Mankelow T.J., Betin V.M., Trakarnsanga K., Massey E.J., Parsons S.F., Anstee D.J., Lane J.D. The ins and outs of human reticulocyte maturation: autophagy and the endosome/exosome pathway. Autophagy 2012, 8:1150-1151.
111. Gronowicz G., Swift H., Steck T.L. Maturation of the reticulocyte in vitro. J. Cell Sci. 1984, 71:177-197.
112. Grossman S., Shahin I., Sredni B. Rat testis lipoxygenase-like enzyme. Characterization of products from linoleic acid. Biochim. Biophys. Acta 1979, 572:293-297.
113. Grullich C., Duvoisin R.M., Wiedmann M., van Leyen K. Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte. FEBS Lett. 2001, 489:51-54.
114. Gustafson B., Hedjazifar S., Gogg S., Hammarstedt A., Smith U. Insulin resistance and impaired adipogenesis. Trends Endocrinol. Metab. 2015, 26:193-200.
115. Haas U., Raschperger E., Hamberg M., Samuelsson B., Tryggvason K., Haeggstrom J.Z. Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:20479-20484.
116. Hada T., Swift L.L., Brash A.R. Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. Biochim. Biophys. Acta 1997, 1346:109-119.
117. Haeggstrom J.Z., Funk C.D. Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease. Chem. Rev. 2011, 111:5866-5898.
118. Hallenborg P., Jorgensen C., Petersen R.K., Feddersen S., Araujo P., Markt P., Langer T., Furstenberger G., Krieg P., Koppen A., Kalkhoven E., Madsen L., Kristiansen K. Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity. Mol. Cell. Biol. 2010, 30:4077-4091.
119. Hamberg M., Samuelsson B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Natl. Acad. Sci. U. S. A. 1974, 71:3400-3404.
120. Hammel M., Walther M., Prassl R., Kuhn H. Structural flexibility of the N-terminal beta-barrel domain of 15-lipoxygenase-1 probed by small angle X-ray scattering. Functional consequences for activity regulation and membrane binding. J. Mol. Biol. 2004, 343:917-929.
121. Han H., Xu D., Liu C., Claesson H.E., Bjorkholm M., Sjoberg J. Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells. PLoS One 2014, 9:e85085.
122. Han J., Sun L., Xu Y., Liang H., Cheng Y. Activation of PPARgamma by 12/15-lipoxygenase during cerebral ischemia-reperfusion injury. Int. J. Mol. Med. 2015, 35:195-201.
123. Hansen J., Garreta A., Benincasa M., Fuste M.C., Busquets M., Manresa A. Bacterial lipoxygenases, a new subfamily of enzymes? A phylogenetic approach. Appl. Microbiol. Biotechnol. 2013, 97:4737-4747.
124. Harats D., Ben-Shushan D., Cohen H., Gonen A., Barshack I., Goldberg I., Greenberger S., Hodish I., Harari A., Varda-Bloom N., Levanon K., Grossman E., Chaitidis P., Kuhn H., Shaish A. Inhibition of carcinogenesis in transgenic mouse models over-expressing 15-lipoxygenase in the vascular wall under the control of murine preproendothelin-1 promoter. Cancer Lett. 2005, 229:127-134.
125. Hartel B., Ludwig P., Schewe T., Rapoport S.M. Self-inactivation by 13-hydroperoxylinoleic acid and lipohydroperoxidase activity of the reticulocyte lipoxygenase. Eur. J. Biochem. 1982, 126:353-357.
126. Hawkins D.J., Brash A.R. Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity. J. Biol. Chem. 1987, 262:7629-7634.
127. Hawkins K.E., DeMars K.M., Singh J., Yang C., Cho H.S., Frankowski J.C., Dore S., Candelario-Jalil E. Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke. J. Neurochem. 2014, 129:130-142.
128. Haynes R.L., van Leyen K. 12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. Dev. Neurosci. 2013, 35:140-154.
129. Henricks P.A., Engels F., van der Vliet H., Nijkamp F.P. 9- and 13-hydroxy-linoleic acid possess chemotactic activity for bovine and human polymorphonuclear leukocytes. Prostaglandins 1991, 41:21-27.
130. Hersberger M. Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins. Clin. Chem. Lab. Med. 2010, 48:1063-1073.
131. Heydeck D., Thomas L., Schnurr K., Trebus F., Thierfelder W.E., Ihle J.N., Kuhn H. Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6. Blood 1998, 92:2503-2510.
132. Heydeck D., Upston J.M., Viita H., Yla-Herttuala S., Stocker R. Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions. J. Lipid Res. 2001, 42:1082-1088.
133. Higgs G.A., Salmon J.A., Spayne J.A. The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin. Br. J. Pharmacol. 1981, 74:429-433.
134. Hofmann B., Steinhilber D. 5-Lipoxygenase inhibitors: a review of recent patents (2010-2012). Expert Opin. Ther. Pat. 2013, 23:895-909.
135. Hohne M., Bayer D., Prehn S., Schewe T., Rapoport S.M. In vitro maturation of rabbit reticulocytes. III. Response of lipoxygenase. Biomed. Biochim. Acta 1983, 42:1129-1134.
136. Horn T., Reddy Kakularam K., Anton M., Richter C., Reddanna P., Kuhn H. Functional characterization of genetic enzyme variations in human lipoxygenases. Redox Biol. 2013, 1:566-577.
137. Horn T., Adel S., Schumann R., Sur S., Kakularam K.R., Polamarasetty A., Redanna P., Kuhn H., Heydeck D. Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling. Prog. Lipid Res. 2014, 57C:13-39.
138. Hu S., Mao-Ying Q.L., Wang J., Wang Z.F., Mi W.L., Wang X.W., Jiang J.W., Huang Y.L., Wu G.C., Wang Y.Q. Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines. J. Neuroinflammation 2012, 9:278.
139. Huang J.T., Welch J.S., Ricote M., Binder C.J., Willson T.M., Kelly C., Witztum J.L., Funk C.D., Conrad D., Glass C.K. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature 1999, 400:378-382.
140. Huo Y., Zhao L., Hyman M.C., Shashkin P., Harry B.L., Burcin T., Forlow S.B., Stark M.A., Smith D.F., Clarke S., Srinivasan S., Hedrick C.C., Pratico D., Witztum J.L., Nadler J.L., Funk C.D., Ley K. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004, 110:2024-2031.
141. Ikawa H., Yamamoto K., Takahashi Y., Ueda N., Hayashi Y., Yamamoto S., Ishimura K., Irahara M., Aono T. Arachidonate 12-lipoxygenase in porcine anterior pituitary cells: its localization and possible function in gonadotrophs. J. Endocrinol. 1996, 148:33-41.
142. Ivanov I., Schwarz K., Holzhutter H.G., Myagkova G., Kuhn H. Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the active site. Biochem. J. 1998, 336(Pt 2):345-352.
143. Ivanov I., Romanov S., Ozdoba C., Holzhutter H.G., Myagkova G., Kuhn H. Enantioselective substrate specificity of 15-lipoxygenase 1. Biochemistry 2004, 43:15720-15728.
144. Ivanov I., Saam J., Kuhn H., Holzhutter H.G. Dual role of oxygen during lipoxygenase reactions. FEBS J. 2005, 272:2523-2535.
145. Ivanov I., Heydeck D., Hofheinz K., Roffeis J., O'Donnell V.B., Kuhn H., Walther M. Molecular enzymology of lipoxygenases. Arch. Biochem. Biophys. 2010, 503:161-174.
146. Ivanov I., Shang W., Toledo L., Masgrau L., Svergun D.I., Stehling S., Gomez H., Di Venere A., Mei G., Lluch J.M., Skrzypczak-Jankun E., Gonzalez-Lafont A., Kuhn H. Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?. Proteins 2012, 80:703-712.
147. Janakiram N.B., Rao C.V. The role of inflammation in colon cancer. Adv. Exp. Med. Biol. 2014, 816:25-52.
148. Janakiram N.B., Mohammed A., Rao C.V. Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer. Cancer Metastasis Rev. 2011, 30:507-523.
149. Jansen C., Hofheinz K., Vogel R., Roffeis J., Anton M., Reddanna P., Kuhn H., Walther M. Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept. J. Biol. Chem. 2011, 286:37804-37812.
150. Jin G., Arai K., Murata Y., Wang S., Stins M.F., Lo E.H., van Leyen K. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke 2008, 39:2538-2543.
151. Jisaka M., Kim R.B., Boeglin W.E., Brash A.R. Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. J. Biol. Chem. 2000, 275:1287-1293.
152. Johannesson M., Backman L., Claesson H.E., Forsell P.K. Cloning, purification and characterization of non-human primate 12/15-lipoxygenases. Prostaglandins Leukot. Essent. Fatty Acids 2010, 82:121-129.
153. Keber R., Rozman D., Horvat S. Sterols in spermatogenesis and sperm maturation. J. Lipid Res. 2013, 54:20-33.
154. Kelavkar U., Wang S., Montero A., Murtagh J., Shah K., Badr K. Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes. Mol. Biol. Rep. 1998, 25:173-182.
155. Kelavkar U.P., Wang S., Badr K.F. Ku autoantigen (DNA helicase) is required for interleukins-13/-4-induction of 15-lipoxygenase-1 gene expression in human epithelial cells. Genes Immun. 2000, 1:237-250.
156. Kent G., Minick O.T., Volini F.I., Orfei E. Autophagic vacuoles in human red cells. Am. J. Pathol. 1966, 48:831-857.
157. Kenyon V., Rai G., Jadhav A., Schultz L., Armstrong M., Jameson J.B., Perry S., Joshi N., Bougie J.M., Leister W., Taylor-Fishwick D.A., Nadler J.L., Holinstat M., Simeonov A., Maloney D.J., Holman T.R. Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase. J. Med. Chem. 2011, 54:5485-5497.
158. Khanna S., Roy S., Ryu H., Bahadduri P., Swaan P.W., Ratan R.R., Sen C.K. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J. Biol. Chem. 2003, 278:43508-43515.
159. Khanna S., Roy S., Slivka A., Craft T.K., Chaki S., Rink C., Notestine M.A., DeVries A.C., Parinandi N.L., Sen C.K. Neuroprotective properties of the natural vitamin E alpha-tocotrienol. Stroke 2005, 36:2258-2264.
160. Kiesel L., Przylipiak A., Rabe T., Przylipiak M., Runnebaum B. Arachidonic acid and its lipoxygenase metabolites stimulate prolactin release in superfused pituitary cells. Hum. Reprod. 1987, 2:281-285.
161. Kim G.H., Ryan J.J., Archer S.L. The role of redox signaling in epigenetics and cardiovascular disease. Antioxid. Redox Signal. 2013, 18:1920-1936.
162. Klil-Drori A.J., Ariel A. 15-Lipoxygenases in cancer: a double-edged sword?. Prostaglandins Other Lipid Mediat. 2013, 106:16-22.
163. Knapp M.J., Klinman J.P. Kinetic studies of oxygen reactivity in soybean lipoxygenase-1. Biochemistry 2003, 42:11466-11475.
164. Knapp M.J., Seebeck F.P., Klinman J.P. Steric control of oxygenation regiochemistry in soybean lipoxygenase-1. J. Am. Chem. Soc. 2001, 123:2931-2932.
165. Krieg P., Rosenberger S., de Juanes S., Latzko S., Hou J., Dick A., Kloz U., van der Hoeven F., Hausser I., Esposito I., Rauh M., Schneider H. Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J. Investig. Dermatol. 2013, 133:172-180.
166. Kriska T., Cepura C., Magier D., Siangjong L., Gauthier K.M., Campbell W.B. Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension. Am. J. Physiol. Heart Circ. Physiol. 2012, 302:H2428-H2438.
167. Kronke G., Katzenbeisser J., Uderhardt S., Zaiss M.M., Scholtysek C., Schabbauer G., Zarbock A., Koenders M.I., Axmann R., Zwerina J., Baenckler H.W., van den Berg W., Voll R.E., Kuhn H., Joosten L.A., Schett G. 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J. Immunol. 2009, 183:3383-3389.
168. Kronke G., Uderhardt S., Katzenbeisser J., Schett G. The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation. Autoimmunity 2009, 42:383-385.
169. Kroschwald P., Kroschwald A., Kuhn H., Ludwig P., Thiele B.J., Hohne M., Schewe T., Rapoport S.M. Occurrence of the erythroid cell specific arachidonate 15-lipoxygenase in human reticulocytes. Biochem. Biophys. Res. Commun. 1989, 160:954-960.
170. Kuban R.J., Wiesner R., Rathman J., Veldink G., Nolting H., Solé V.A., Kühn H. The iron ligand sphere geometry of mammalian 15-lipoxygenases. Biochem. J. 1998, 332(Pt 1):237-242.
171. Kuhn H. Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)XY-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)XY-9Z,11E-octadecadienoic acid. Prog. Lipid Res. 1996, 35:203-226.
172. Kuhn H., Brash A.R. Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells. J. Biol. Chem. 1990, 265:1454-1458.
173. Kuhn H., O'Donnell V.B. Inflammation and immune regulation by 12/15-lipoxygenases. Prog. Lipid Res. 2006, 45:334-356.
174. Kuhn H., Salzmann-Reinhardt U., Ludwig P., Ponicke K., Schewe T., Rapoport S. The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. Biochim. Biophys. Acta 1986, 876:187-193.
175. Kuhn H., Schewe T., Rapoport S.M. The stereochemistry of the reactions of lipoxygenases and their metabolites. Proposed nomenclature of lipoxygenases and related enzymes. Adv. Enzymol. Relat. Areas Mol. Biol. 1986, 58:273-311.
176. Kuhn H., Wiesner R., Stender H., Schewe T., Lankin V.Z., Nekrasov A., Rapoport S.M. Requirement of monohydroperoxy fatty acids for the oxygenation of 15LS-HETE by reticulocyte lipoxygenase. FEBS Lett. 1986, 203:247-252.
177. Kuhn H., Belkner J., Wiesner R. Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes. Eur. J. Biochem. 1990, 191:221-227.
178. Kuhn H., Belkner J., Wiesner R., Brash A.R. Oxygenation of biological membranes by the pure reticulocyte lipoxygenase. J. Biol. Chem. 1990, 265:18351-18361.
179. Kuhn H., Sprecher H., Brash A.R. On singular or dual positional specificity of lipoxygenases. The number of chiral products varies with alignment of methylene groups at the active site of the enzyme. J. Biol. Chem. 1990, 265:16300-16305.
180. Kuhn H., Heydeck D., Sprecher H. On the mechanistic reasons for the dual positional specificity of the reticulocyte lipoxygenase. Biochim. Biophys. Acta 1991, 1081:129-134.
181. Kühn H., Barnett J., Grunberger D., Baecker P., Chow J., Nguyen B., Bursztyn-Pettegrew H., Chan H., Sigal E. Overexpression, purification and characterization of human recombinant 15-lipoxygenase. Biochim. Biophys. Acta 1993, 1169:80-89.
182. Kuhn H., Belkner J., Zaiss S., Fahrenklemper T., Wohlfeil S. Involvement of 15-lipoxygenase in early stages of atherogenesis. J. Exp. Med. 1994, 179:1903-1911.
183. Kuhn H., Heydeck D., Hugou I., Gniwotta C. In vivo action of 15-lipoxygenase in early stages of human atherogenesis. J. Clin. Invest. 1997, 99:888-893.
184. Kuhn H., Romisch I., Belkner J. The role of lipoxygenase-isoforms in atherogenesis. Mol. Nutr. Food Res. 2005, 49:1014-1029.
185. Kuhn H., Saam J., Eibach S., Holzhutter H.G., Ivanov I., Walther M. Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure. Biochem. Biophys. Res. Commun. 2005, 338:93-101.
186. Kuhn H., Banthiya S., van Leyen K. Mammalian lipoxygenases and their biological relevance. Biochim. Biophys. Acta 2015, 1851(4):308-330.
187. Kumar P., Kalonia H., Kumar A. Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone. Br. J. Pharmacol. 2011, 164:644-654.
188. Kundumani-Sridharan V., Dyukova E., Hansen D.E., Rao G.N. 12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction. J. Biol. Chem. 2013, 288:15830-15842.
189. Lankin V.Z., Kuhn H., Hiebsch C., Schewe T., Rapoport S.M., Tikhaze A.K., Gordeeva N.T. On the nature of the stimulation of the lipoxygenase from rabbit reticulocytes by biological membranes. Biomed. Biochim. Acta 1985, 44:655-664.
190. Lax Y., Grossman S., Rubinstein S., Magid N., Breitbart H. Role of lipoxygenase in the mechanism of acrosome reaction in mammalian spermatozoa. Biochim. Biophys. Acta 1990, 1043:12-18.
191. Laybutt D.R., Sharma A., Sgroi D.C., Gaudet J., Bonner-Weir S., Weir G.C. Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J. Biol. Chem. 2002, 277:10912-10921.
192. Lebeau A., Esclaire F., Rostene W., Pelaprat D. Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity. Neuroreport 2001, 12:2199-2202.
193. Lebeau A., Terro F., Rostene W., Pelaprat D. Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide. Cell Death Differ. 2004, 11:875-884.
194. Lee H.N., Surh Y.J. Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders. Biochem. Pharmacol. 2012, 84:1340-1350.
195. Lee Y.W., Kuhn H., Kaiser S., Hennig B., Daugherty A., Toborek M. Interleukin 4 induces transcription of the 15-lipoxygenase I gene in human endothelial cells. J. Lipid Res. 2001, 42:783-791.
196. Lee J., Kosaras B., Del Signore S.J., Cormier K., McKee A., Ratan R.R., Kowall N.W., Ryu H. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice. Acta Neuropathol. 2011, 121:487-498.
197. Lefterova M.I., Haakonsson A.K., Lazar M.A., Mandrup S. PPARgamma and the global map of adipogenesis and beyond. Trends Endocrinol. Metab. 2014, 25:293-302.
198. Lehnert N., Solomon E.I. Density-functional investigation on the mechanism of H-atom abstraction by lipoxygenase. J. Biol. Inorg. Chem. 2003, 8:294-305.
199. Lei Z.M., Rao C.V. The expression of 15-lipoxygenase gene and the presence of functional enzyme in cytoplasm and nuclei of pregnancy human myometria. Endocrinology 1992, 130:861-870.
200. Lemasters J.J. Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3). Redox Biol. 2014, 2:749-754.
201. Levy B.D., Romano M., Chapman H.A., Reilly J.J., Drazen J., Serhan C.N. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. J. Clin. Invest. 1993, 92:1572-1579.
202. Libby P. Inflammation in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2012, 32:2045-2051.
203. Lieb D.C., Brotman J.J., Hatcher M.A., Aye M.S., Cole B.K., Haynes B.A., Wohlgemuth S.D., Fontana M.A., Beydoun H., Nadler J.L., Dobrian A.D. Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes. J. Clin. Endocrinol. Metab. 2014, 99:E1713-E1720.
204. Liepelt A., Mossanen J.C., Denecke B., Heymann F., De Santis R., Tacke F., Marx G., Ostareck D.H., Ostareck-Lederer A. Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation. RNA 2014, 20:899-911.
205. Limor R., Sharon O., Knoll E., Many A., Weisinger G., Stern N. Lipoxygenase-derived metabolites are regulators of peroxisome proliferator-activated receptor gamma-2 expression in human vascular smooth muscle cells. Am. J. Hypertens. 2008, 21:219-223.
206. Liu M., Yokomizo T. The role of leukotrienes in allergic diseases. Allergol. Int. 2015, 64:17-26.
207. Liu C., Schain F., Han H., Xu D., Andersson-Sand H., Forsell P., Claesson H.E., Bjorkholm M., Sjoberg J. Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line. Exp. Cell Res. 2012, 318:169-176.
208. Lovat P.E., Oliverio S., Ranalli M., Corazzari M., Rodolfo C., Bernassola F., Aughton K., Maccarrone M., Hewson Q.D., Pearson A.D., Melino G., Piacentini M., Redfern C.P. GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Res. 2002, 62:5158-5167.
209. Lovat P.E., Ranalli M., Corazzari M., Raffaghello L., Pearson A.D., Ponzoni M., Piacentini M., Melino G., Redfern C.P. Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma. J. Cell. Biochem. 2003, 89:698-708.
210. Lovercamp K.W., Safranski T.J., Fischer K.A., Manandhar G., Sutovsky M., Herring W., Sutovsky P. Arachidonate 15-lipoxygenase and ubiquitin as fertility markers in boars. Theriogenology 2007, 67:704-718.
211. Lu X., Zhang J., Liu S., Zhang D., Xu Z., Wu J., Li J., Du G., Chen J. Overproduction, purification, and characterization of extracellular lipoxygenase of Pseudomonas aeruginosa in Escherichia coli. Appl. Microbiol. Biotechnol. 2013, 97:5793-5800.
212. Ludwig P., Holzhutter H.G., Colosimo A., Silvestrini M.C., Schewe T., Rapoport S.M. A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes. Eur. J. Biochem. 1987, 168:325-337.
213. Ludwig P., Hohne M., Kuhn H., Schewe T., Rapoport S.M. The biological dynamics of lipoxygenase in rabbit red cells in the course of an experimental bleeding anaemia. Unexpected effects of the calcium ionophore A 23187. Biomed. Biochim. Acta 1988, 47:593-608.
214. Lukiw W.J., Cui J.G., Marcheselli V.L., Bodker M., Botkjaer A., Gotlinger K., Serhan C.N., Bazan N.G. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J. Clin. Invest. 2005, 115:2774-2783.
215. Ma K., Nunemaker C.S., Wu R., Chakrabarti S.K., Taylor-Fishwick D.A., Nadler J.L. 12-Lipoxygenase products reduce insulin secretion and {beta}-cell viability in human islets. J. Clin. Endocrinol. Metab. 2010, 95:887-893.
216. Maas R.L., Brash A.R. Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes. Proc. Natl. Acad. Sci. U. S. A. 1983, 80:2884-2888.
217. Mack S.R., Han H.L., De Jonge J., Anderson R.A., Zaneveld L.J. The human sperm acrosome reaction does not depend on arachidonic acid metabolism via the cyclooxygenase and lipoxygenase pathways. J. Androl. 1992, 13:551-559.
218. Madsen L., Petersen R.K., Sorensen M.B., Jorgensen C., Hallenborg P., Pridal L., Fleckner J., Amri E.Z., Krieg P., Furstenberger G., Berge R.K., Kristiansen K. Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process. Biochem. J. 2003, 375:539-549.
219. Mancini A.D., Di Battista J.A. The cardinal role of the phospholipase A(2)/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E(2) (PCPP) axis in inflammostasis. Inflamm. Res. 2011, 60:1083-1092.
220. Mangino M.J., Brounts L., Harms B., Heise C. Lipoxin biosynthesis in inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2006, 79:84-92.
221. Martin H. Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. Mutat. Res. 2010, 690:57-63.
222. Martinez-Clemente M., Ferre N., Titos E., Horrillo R., Gonzalez-Periz A., Moran-Salvador E., Lopez-Vicario C., Miquel R., Arroyo V., Funk C.D., Claria J. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Hepatology 2010, 52:1980-1991.
223. Matsumoto T., Funk C.D., Radmark O., Hoog J.O., Jornvall H., Samuelsson B. Molecular cloning and amino acid sequence of human 5-lipoxygenase. Proc. Natl. Acad. Sci. U. S. A. 1988, 85:26-30.
224. May C., Hohne M., Gnau P., Schwennesen K., Kindl H. The N-terminal beta-barrel structure of lipid body lipoxygenase mediates its binding to liposomes and lipid bodies. Eur. J. Biochem. 2000, 267:1100-1109.
225. McDuffie M., Maybee N.A., Keller S.R., Stevens B.K., Garmey J.C., Morris M.A., Kropf E., Rival C., Ma K., Carter J.D., Tersey S.A., Nunemaker C.S., Nadler J.L. Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes 2008, 57:199-208.
226. Mei G., Di Venere A., Nicolai E., Angelucci C.B., Ivanov I., Sabatucci A., Dainese E., Kuhn H., Maccarrone M. Structural properties of plant and mammalian lipoxygenases. Temperature-dependent conformational alterations and membrane binding ability. Biochemistry 2008, 47:9234-9242.
227. Mele P.G., Dada L.A., Paz C., Neuman I., Cymeryng C.B., Mendez C.F., Finkielstein C.V., Cornejo Maciel F., Podesta E.J. Involvement of arachidonic acid and the lipoxygenase pathway in mediating luteinizing hormone-induced testosterone synthesis in rat Leydig cells. Endocr. Res. 1997, 23:15-26.
228. Merched A.J., Ko K., Gotlinger K.H., Serhan C.N., Chan L. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. 2008, 22:3595-3606.
229. Messias A.C., Harnisch C., Ostareck-Lederer A., Sattler M., Ostareck D.H. The DICE-binding activity of KH domain 3 of hnRNP K is affected by c-Src-mediated tyrosine phosphorylation. J. Mol. Biol. 2006, 361:470-481.
230. Mhatre M., Floyd R.A., Hensley K. Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets. J. Alzheimers Dis. 2004, 6:147-157.
231. Mikule K., Gatlin J.C., de la Houssaye B.A., Pfenninger K.H. Growth cone collapse induced by semaphorin 3A requires 12/15-lipoxygenase. J. Neurosci. 2002, 22:4932-4941.
232. Minor W., Steczko J., Stec B., Otwinowski Z., Bolin J.T., Walter R., Axelrod B. Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution. Biochemistry 1996, 35:10687-10701.
233. Moin S.T., Hofer T.S., Sattar R., Ul-Haq Z. Molecular dynamics simulation of mammalian 15S-lipoxygenase with AMBER force field. Eur. Biophys. J. 2011, 40:715-726.
234. Moore K., Lovercamp K., Feng D., Antelman J., Sutovsky M., Manandhar G., van Leyen K., Safranski T., Sutovsky P. Altered epididymal sperm maturation and cytoplasmic droplet migration in subfertile male Alox15 mice. Cell Tissue Res. 2010, 340:569-581.
235. Morgan A.H., Hammond V.J., Sakoh-Nakatogawa M., Ohsumi Y., Thomas C.P., Blanchet F., Piguet V., Kiselyov K., O'Donnell V.B. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biol. 2015, 4:40-47.
236. Moritz B., Lilie H., Naarmann-de Vries I.S., Urlaub H., Wahle E., Ostareck-Lederer A., Ostareck D.H. Biophysical and biochemical analysis of hnRNP K: arginine methylation, reversible aggregation and combinatorial binding to nucleic acids. Biol. Chem. 2014, 395:837-853.
237. Munger K.A., Montero A., Fukunaga M., Uda S., Yura T., Imai E., Kaneda Y., Valdivielso J.M., Badr K.F. Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:13375-13380.
238. Munoz-Garcia A., Thomas C.P., Keeney D.S., Zheng Y., Brash A.R. The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier. Biochim. Biophys. Acta 2014, 1841:401-408.
239. Naarmann I.S., Harnisch C., Flach N., Kremmer E., Kuhn H., Ostareck D.H., Ostareck-Lederer A. mRNA silencing in human erythroid cell maturation: heterogeneous nuclear ribonucleoprotein K controls the expression of its regulator c-Src. J. Biol. Chem. 2008, 283:18461-18472.
240. Naarmann I.S., Harnisch C., Muller-Newen G., Urlaub H., Ostareck-Lederer A., Ostareck D.H. DDX6 recruits translational silenced human reticulocyte 15-lipoxygenase mRNA to RNP granules. RNA 2010, 16:2189-2204.
241. Nadel J.A., Conrad D.J., Ueki I.F., Schuster A., Sigal E. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J. Clin. Invest. 1991, 87:1139-1145.
242. Nagelin M.H., Srinivasan S., Lee J., Nadler J.L., Hedrick C.C. 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. Arterioscler. Thromb. Vasc. Biol. 2008, 28:1811-1819.
243. Narumiya S., Salmon J.A., Flower R.J., Vane J.R. Purification and properties of arachidonate-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Adv. Prostaglandin Thromboxane Leukot. Res. 1982, 9:77-82.
244. Nasjletti A. Arthur C. Corcoran Memorial Lecture. The role of eicosanoids in angiotensin-dependent hypertension. Hypertension 1998, 31:194-200.
245. Nassar G.M., Morrow J.D., Roberts L.J., Lakkis F.G., Badr K.F. Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J. Biol. Chem. 1994, 269:27631-27634.
246. Natarajan R., Gu J.L., Rossi J., Gonzales N., Lanting L., Xu L., Nadler J. Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:4947-4951.
247. Neau D.B., Bender G., Boeglin W.E., Bartlett S.G., Brash A.R., Newcomer M.E. Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. J. Biol. Chem. 2014, 289:31905-31913.
248. Newcomer M.E., Brash A.R. The structural basis for specificity in lipoxygenase catalysis. Protein Sci. 2015, 24:298-309.
249. Nigam S., Zafiriou M.P., Deva R., Ciccoli R., Roux-Van der Merwe R. Structure, biochemistry and biology of hepoxilins: an update. FEBS J. 2007, 274:3503-3512.
250. Nishiyama M., Okamoto H., Watanabe T., Hori T., Hada T., Ueda N., Yamamoto S., Tsukamoto H., Watanabe K., Kirino T. Localization of arachidonate 12-lipoxygenase in canine brain tissues. J. Neurochem. 1992, 58:1395-1400.
251. Nishiyama M., Hoshino A., Tsai L., Henley J.R., Goshima Y., Tessier-Lavigne M., Poo M.M., Hong K. Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning. Nature 2003, 423:990-995.
252. Normandin M., Gagne J., Bernard J., Elie R., Miceli D., Baudry M., Massicotte G. Involvement of the 12-lipoxygenase pathway of arachidonic acid metabolism in homosynaptic long-term depression of the rat hippocampus. Brain Res. 1996, 730:40-46.
253. Nunemaker C.S., Chen M., Pei H., Kimble S.D., Keller S.R., Carter J.D., Yang Z., Smith K.M., Wu R., Bevard M.H., Garmey J.C., Nadler J.L. 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E1065-E1075.
254. Ohira T., Arita M., Omori K., Recchiuti A., Van Dyke T.E., Serhan C.N. Resolvin E1 receptor activation signals phosphorylation and phagocytosis. J. Biol. Chem. 2010, 285:3451-3461.
255. Oskolkova O.V., Afonyushkin T., Preinerstorfer B., Bicker W., von Schlieffen E., Hainzl E., Demyanets S., Schabbauer G., Lindner W., Tselepis A.D., Wojta J., Binder B.R., Bochkov V.N. Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation. J. Immunol. 2010, 185:7706-7712.
256. Ostareck D.H., Ostareck-Lederer A., Wilm M., Thiele B.J., Mann M., Hentze M.W. mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end. Cell 1997, 89:597-606.
257. Ostareck-Lederer A., Ostareck D.H., Standart N., Thiele B.J. Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3' untranslated region. EMBO J. 1994, 13:1476-1481.
258. Ostermann A., Waschipky R., Parak F.G., Nienhaus G.U. Ligand binding and conformational motions in myoglobin. Nature 2000, 404:205-208.
259. Othman A., Ahmad S., Megyerdi S., Mussell R., Choksi K., Maddipati K.R., Elmarakby A., Rizk N., Al-Shabrawey M. 12/15-Lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: contribution of NADPH oxidase. PLoS One 2013, 8:e57254.
260. Pace-Asciak C.R. The hepoxilins and some analogues: a review of their biology. Br. J. Pharmacol. 2009, 158:972-981.
261. Pace-Asciak C.R. Pathophysiology of the hepoxilins. Biochim. Biophys. Acta 2015, 1851:383-396.
262. Pallast S., Arai K., Wang X., Lo E.H., van Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J. Neurochem. 2009, 111:882-889.
263. Pallast S., Arai K., Pekcec A., Yigitkanli K., Yu Z., Wang X., Lo E.H., van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J. Cereb. Blood Flow Metab. 2010, 30:1157-1167.
264. Pekarova M., Kuhn H., Bezakova L., Ufer C., Heydeck D. Mutagenesis of triad determinants of rat Alox15 alters the specificity of fatty acid and phospholipid oxygenation. Arch. Biochem. Biophys. 2015, 571:50-57.
265. Pekcec A., Yigitkanli K., Jung J.E., Pallast S., Xing C., Antipenko A., Minchenko M., Nikolov D.B., Holman T.R., Lo E.H., van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013, 27:437-445.
266. Perrotta I. Ultrastructural features of human atherosclerosis. Ultrastruct. Pathol. 2013, 37:43-51.
267. Pfister S.L., Campbell W.B. Arachidonic acid- and acetylcholine-induced relaxations of rabbit aorta. Hypertension 1992, 20:682-689.
268. Pfister S.L., Spitzbarth N., Nithipatikom K., Edgemond W.S., Falck J.R., Campbell W.B. Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta. J. Biol. Chem. 1998, 273:30879-30887.
269. Pidgeon G.P., Lysaght J., Krishnamoorthy S., Reynolds J.V., O'Byrne K., Nie D., Honn K.V. Lipoxygenase metabolism: roles in tumor progression and survival. Cancer Metastasis Rev. 2007, 26:503-524.
270. Piomelli D. Metabolism of arachidonic acid in nervous system of marine mollusk Aplysia californica. Am. J. Physiol. 1991, 260:R844-R848.
271. Piomelli D., Shapiro E., Feinmark S.J., Schwartz J.H. Metabolites of arachidonic acid in the nervous system of Aplysia: possible mediators of synaptic modulation. J. Neurosci. 1987, 7:3675-3686.
272. Piomelli D., Volterra A., Dale N., Siegelbaum S.A., Kandel E.R., Schwartz J.H., Belardetti F. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature 1987, 328:38-43.
273. Pirillo A., Uboldi P., Kuhn H., Catapano A.L. 15-Lipoxygenase-mediated modification of high-density lipoproteins impairs SR-BI- and ABCA1-dependent cholesterol efflux from macrophages. Biochim. Biophys. Acta 2006, 1761:292-300.
274. Pirillo A., Uboldi P., Bolego C., Kuhn H., Catapano A.L. The 15-lipoxygenase-modified high density lipoproteins 3 fail to inhibit the TNF-alpha-induced inflammatory response in human endothelial cells. J. Immunol. 2008, 181:2821-2830.
275. Pirillo A., Uboldi P., Ferri N., Corsini A., Kuhn H., Catapano A.L. Upregulation of lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human endothelial cells by modified high density lipoproteins. Biochem. Biophys. Res. Commun. 2012, 428:230-233.
276. Poeckel D., Zemski Berry K.A., Murphy R.C., Funk C.D. Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice. J. Biol. Chem. 2009, 284:21077-21089.
277. Pontiki E., Hadjipavlou-Litina D. Synthesis of phenyl-substituted amides with antioxidant and anti-inflammatory activity as novel lipoxygenase inhibitors. Med. Chem. 2007, 3:175-186.
278. Powell W.S., Rokach J. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid. Biochim. Biophys. Acta 2015, 1851:340-355.
279. Pratico D., Zhukareva V., Yao Y., Uryu K., Funk C.D., Lawson J.A., Trojanowski J.Q., Lee V.M. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Am. J. Pathol. 2004, 164:1655-1662.
280. Putnam C.D., Hammel M., Hura G.L., Tainer J.A. X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution. Q. Rev. Biophys. 2007, 40:191-285.
281. Rabier M., Chavis C., Crastes de Paulet A., Damon M. Arachidonic acid metabolism in a cloned strain of rat pituitary tumor cells: correlation between 15 hydroxyeicosatetraenoic acid release and the prolactin secretory process. Prostaglandins Leukot. Med. 1987, 27:27-42.
282. Rabier M., Chavis C., Crastes de Paulet A., Damon M. 15-Lipoxygenase products stimulate prolactin secretion from a cloned strain of rat pituitary cells. Neuroendocrinology 1988, 47:323-328.
283. Radmark O., Werz O., Steinhilber D., Samuelsson B. 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease. Biochim. Biophys. Acta 2015, 1851:331-339.
284. Rai G., Kenyon V., Jadhav A., Schultz L., Armstrong M., Jameson J.B., Hoobler E., Leister W., Simeonov A., Holman T.R., Maloney D.J. Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. J. Med. Chem. 2010, 53:7392-7404.
285. Rai G., Joshi N., Jung J.E., Liu Y., Schultz L., Yasgar A., Perry S., Diaz G., Zhang Q., Kenyon V., Jadhav A., Simeonov A., Lo E.H., van Leyen K., Maloney D.J., Holman T.R. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J. Med. Chem. 2014, 57:4035-4048.
286. Ramis I., Catafau J.R., Serra J., Bulbena O., Picado C., Gelpi E. In vivo release of 15-HETE and other arachidonic acid metabolites in nasal secretions during early allergic reactions. Prostaglandins 1991, 42:411-420.
287. Rao J.S., Rapoport S.I., Kim H.W. Altered neuroinflammatory, arachidonic acid cascade and synaptic markers in postmortem Alzheimer's disease brain. Transl. Psychiatry 2011, 1:e31.
288. Rapoport S.M., Schewe T. The maturational breakdown of mitochondria in reticulocytes. Biochim. Biophys. Acta 1986, 864:471-495.
289. Rapoport S.M., Schewe T., Wiesner R., Halangk W., Ludwig P., Janicke-Hohne M., Tannert C., Hiebsch C., Klatt D. The lipoxygenase of reticulocytes. Purification, characterization and biological dynamics of the lipoxygenase; its identity with the respiratory inhibitors of the reticulocyte. Eur. J. Biochem. 1979, 96:545-561.
290. Rapoport S., Hartel B., Hausdorf G. Methionine sulfoxide formation: the cause of self-inactivation of reticulocyte lipoxygenase. Eur. J. Biochem. 1984, 139:573-576.
291. Reimann I., Huth A., Thiele H., Thiele B.J. Suppression of 15-lipoxygenase synthesis by hnRNP E1 is dependent on repetitive nature of LOX mRNA 3'-UTR control element DICE. J. Mol. Biol. 2002, 315:965-974.
292. Richter C., Wendel A., Weser U., Azzi A. Inhibition by superoxide dismutase of linoleic acid peroxidation induced by lipoxidase. FEBS Lett. 1975, 51:300-303.
293. Rickert K.W., Klinman J.P. Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. Biochemistry 1999, 38:12218-12228.
294. Romano M. Lipoxin and aspirin-triggered lipoxins. ScientificWorldJournal 2010, 10:1048-1064.
295. Romanov S., Wiesner R., Myagkova G., Kuhn H., Ivanov I. Affinity labeling of the rabbit 12/15-lipoxygenase using azido derivatives of arachidonic acid. Biochemistry 2006, 45:3554-3562.
296. Rosolowsky M., Campbell W.B. Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. Am. J. Physiol. 1993, 264:H327-H335.
297. Ross S., Essary B., de la Houssaye B.A., Pan Z., Mikule K., Mubarak O., Pfenninger K.H. Thrombin causes pseudopod detachment via a pathway involving cytosolic phospholipase A2 and 12/15-lipoxygenase products. Cell Growth Differ. 2000, 11:19-30.
298. Roy B., Cathcart M.K. Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes. J. Biol. Chem. 1998, 273:32023-32029.
299. Roy P., Sajan M.P., Kulkarni A.P. Lipoxygenase-mediated glutathione oxidation and superoxide generation. J. Biochem. Toxicol. 1995, 10:111-120.
300. Ryan A., Godson C. Lipoxins: regulators of resolution. Curr. Opin. Pharmacol. 2010, 10:166-172.
301. Saam J., Ivanov I., Walther M., Holzhutter H.G., Kuhn H. Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:13319-13324.
302. Sachs-Olsen C., Sanak M., Lang A.M., Gielicz A., Mowinckel P., Lodrup Carlsen K.C., Carlsen K.H., Szczeklik A. Eoxins: a new inflammatory pathway in childhood asthma. J. Allergy Clin. Immunol. 2010, 126(859-867):e9.
303. Sala A., Folco G., Murphy R.C. Transcellular biosynthesis of eicosanoids. Pharmacol. Rep. 2010, 62:503-510.
304. Salzmann U., Kuhn H., Schewe T., Rapoport S.M. Pentane formation during the anaerobic reactions of reticulocyte lipoxygenase. Comparison with lipoxygenases from soybeans and green pea seeds. Biochim. Biophys. Acta 1984, 795:535-542.
305. Sato H., Taketomi Y., Isogai Y., Miki Y., Yamamoto K., Masuda S., Hosono T., Arata S., Ishikawa Y., Ishii T., Kobayashi T., Nakanishi H., Ikeda K., Taguchi R., Hara S., Kudo I., Murakami M. Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J. Clin. Invest. 2010, 120:1400-1414.
306. Savari S., Vinnakota K., Zhang Y., Sjolander A. Cysteinyl leukotrienes and their receptors: bridging inflammation and colorectal cancer. World J. Gastroenterol. 2014, 20:968-977.
307. Schewe T. 15-lipoxygenase-1: a prooxidant enzyme. Biol. Chem. 2002, 383:365-374.
308. Schewe T., Halangk W., Hiebsch C., Rapoport S.M. A lipoxygenase in rabbit reticulocytes which attacks phospholipids and intact mitochondria. FEBS Lett. 1975, 60:149-152.
309. Schewe T., Halangk W., Hiebsch C., Rapoport S. Degradation of mitochondria by cytosolic factors in reticulocytes. Acta Biol. Med. Ger. 1977, 36:563-572.
310. Schewe T., Rapoport S.M., Kuhn H. Enzymology and physiology of reticulocyte lipoxygenase: comparison with other lipoxygenases. Adv. Enzymol. Relat. Areas Mol. Biol. 1986, 58:191-272.
311. Schewe T., Kroschwald P., Kroschwald A., Ludwig P., Kuhn H. The erythroid arachidonate 15-lipoxygenase in rat reticulocytes. Biomed. Biochim. Acta 1990, 49:S42-S46.
312. Schilstra M.J., Veldink G.A., Vliegenthart J.F. The dioxygenation rate in lipoxygenase catalysis is determined by the amount of iron (III) lipoxygenase in solution. Biochemistry 1994, 33:3974-3979.
313. Schneider C., Pratt D.A., Porter N.A., Brash A.R. Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. Chem. Biol. 2007, 14:473-488.
314. Schneider M., Wortmann M., Mandal P.K., Arpornchayanon W., Jannasch K., Alves F., Strieth S., Conrad M., Beck H. Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. Neoplasia 2010, 12:254-263.
315. Schnurr K., Belkner J., Ursini F., Schewe T., Kuhn H. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products. J. Biol. Chem. 1996, 271:4653-4658.
316. Schnurr K., Borchert A., Kuhn H. Inverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13. FASEB J. 1999, 13:143-154.
317. Schroder M., Hafner A.K., Hofmann B., Radmark O., Tumulka F., Abele R., Dotsch V., Steinhilber D. Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase. Biochim. Biophys. Acta 2014, 1842:1538-1547.
318. Schwarz K., Borngraber S., Anton M., Kuhn H. Probing the substrate alignment at the active site of 15-lipoxygenases by targeted substrate modification and site-directed mutagenesis. Evidence for an inverse substrate orientation. Biochemistry 1998, 37:15327-15335.
319. Schwenk U., Morita E., Engel R., Schroder J.M. Identification of 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid as a novel and potent human eosinophil chemotactic eicosanoid. J. Biol. Chem. 1992, 267:12482-12488.
320. Scott E.E., Gibson Q.H. Ligand migration in sperm whale myoglobin. Biochemistry 1997, 36:11909-11917.
321. Sears D.D., Miles P.D., Chapman J., Ofrecio J.M., Almazan F., Thapar D., Miller Y.I. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One 2009, 4:e7250.
322. Segraves E.N., Holman T.R. Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase. Biochemistry 2003, 42:5236-5243.
323. Sendobry S.M., Cornicelli J.A., Welch K., Bocan T., Tait B., Trivedi B.K., Colbry N., Dyer R.D., Feinmark S.J., Daugherty A. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br. J. Pharmacol. 1997, 120:1199-1206.
324. Serhan C.N., Petasis N.A. Resolvins and protectins in inflammation resolution. Chem. Rev. 2011, 111:5922-5943.
325. Serhan C.N., Dalli J., Karamnov S., Choi A., Park C.K., Xu Z.Z., Ji R.R., Zhu M., Petasis N.A. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J. 2012, 26:1755-1765.
326. Serhan C.N., Dalli J., Colas R.A., Winkler J.W., Chiang N. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim. Biophys. Acta 2015, 1851:397-413.
327. Shahin I., Grossman S., Sredni B. Lipoxygenase-like enzyme in rat testis microsomes. Biochim. Biophys. Acta 1978, 529:300-308.
328. Shang W., Ivanov I., Svergun D.I., Borbulevych O.Y., Aleem A.M., Stehling S., Jankun J., Kuhn H., Skrzypczak-Jankun E. Probing dimerization and structural flexibility of mammalian lipoxygenases by small-angle X-ray scattering. J. Mol. Biol. 2011, 409:654-668.
329. Shankaranarayanan P., Chaitidis P., Kuhn H., Nigam S. Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J. Biol. Chem. 2001, 276:42753-42760.
330. Shappell S.B., Gupta R.A., Manning S., Whitehead R., Boeglin W.E., Schneider C., Case T., Price J., Jack G.S., Wheeler T.M., Matusik R.J., Brash A.R., Dubois R.N. 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. Cancer Res. 2001, 61:497-503.
331. Shen J., Herderick E., Cornhill J.F., Zsigmond E., Kim H.S., Kuhn H., Guevara N.V., Chan L. Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development. J. Clin. Invest. 1996, 98:2201-2208.
332. Shillabeer G., Kumar V., Tibbo E., Lau D.C. Arachidonic acid metabolites of the lipoxygenase as well as the cyclooxygenase pathway may be involved in regulating preadipocyte differentiation. Metabolism 1998, 47:461-466.
333. Sloane D.L., Browner M.F., Dauter Z., Wilson K., Fletterick R.J., Sigal E. Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes. Biochem. Biophys. Res. Commun. 1990, 173:507-513.
334. Sloane D.L., Dixon R.A., Craik C.S., Sigal E. Expression of cloned human 15-lipoxygenase in eukaryotic and prokaryotic systems. Adv. Prostaglandin Thromboxane Leukot. Res. 1991, 21A:25-28.
335. Sloane D.L., Leung R., Craik C.S., Sigal E. A primary determinant for lipoxygenase positional specificity. Nature 1991, 354:149-152.
336. Sloane D.L., Leung R., Barnett J., Craik C.S., Sigal E. Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity. Protein Eng. 1995, 8:275-282.
337. Sobrado M., Pereira M.P., Ballesteros I., Hurtado O., Fernandez-Lopez D., Pradillo J.M., Caso J.R., Vivancos J., Nombela F., Serena J., Lizasoain I., Moro M.A. Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke. J. Neurosci. 2009, 29:3875-3884.
338. Soumya S.J., Binu S., Helen A., Reddanna P., Sudhakaran P.R. 15(S)-HETE-induced angiogenesis in adipose tissue is mediated through activation of PI3K/Akt/mTOR signaling pathway. Biochem. Cell Biol. 2013, 91:498-505.
339. Spanbroek R., Grabner R., Lotzer K., Hildner M., Urbach A., Ruhling K., Moos M.P., Kaiser B., Cohnert T.U., Wahlers T., Zieske A., Plenz G., Robenek H., Salbach P., Kuhn H., Radmark O., Samuelsson B., Habenicht A.J. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:1238-1243.
340. Spite M., Claria J., Serhan C.N. Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014, 19:21-36.
341. Steinberg D. The LDL modification hypothesis of atherogenesis: an update. J. Lipid Res. 2009, 50:S376-S381. (Suppl.).
342. Streckert G., Stan H.J. Conversion of linoleic acid hydroperoxide by soybean lipoxygenase in the presence of guaiacol: identification of the reaction products. Lipids 1975, 10:847-854.
343. Suardiaz R., Masgrau L., Lluch J.M., Gonzalez-Lafont A. An insight into the regiospecificity of linoleic acid peroxidation catalyzed by mammalian 15-lipoxygenases. J. Phys. Chem. B 2013, 117:3747-3754.
344. Suardiaz R., Masgrau L., Lluch J.M., Gonzalez-Lafont A. Introducing mutations to modify the C13/C9 ratio in linoleic acid oxygenations catalyzed by rabbit 15-lipoxygenase: a QM/MM and MD study. ChemPhysChem 2014, 15:4049-4054.
345. Suardiaz R., Masgrau L., Lluch J.M., Gonzalez-Lafont A. Regio- and stereospecificity in the oxygenation of arachidonic acid catalyzed by Leu597 mutants of rabbit 15-lipoxygenase: a QM/MM study. ChemPhysChem 2014, 15:2303-2310.
346. Sun D., Funk C.D. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J. Biol. Chem. 1996, 271:24055-24062.
347. Sutovsky P., Van Leyen K., McCauley T., Day B.N., Sutovsky M. Degradation of paternal mitochondria after fertilization: implications for heteroplasmy, assisted reproductive technologies and mtDNA inheritance. Reprod. Biomed. Online 2004, 8:24-33.
348. Suzuki H., Kishimoto K., Yoshimoto T., Yamamoto S., Kanai F., Ebina Y., Miyatake A., Tanabe T. Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase. Biochim. Biophys. Acta 1994, 1210:308-316.
349. Svensson-Ek M., Abramson J., Larsson G., Tornroth S., Brzezinski P., Iwata S. The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides. J. Mol. Biol. 2002, 321:329-339.
350. Takahashi Y., Glasgow W.C., Suzuki H., Taketani Y., Yamamoto S., Anton M., Kuhn H., Brash A.R. Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases. Eur. J. Biochem. 1993, 218:165-171.
351. Takayama H., Gimbrone M.A., Schafer A.I. Vascular lipoxygenase activity: synthesis of 15-hydroxyeicosatetraenoic acid from arachidonic acid by blood vessels and cultured vascular endothelial cells. Thromb. Res. 1987, 45:803-816.
352. Thiele B.J., Andree H., Hohne M., Rapoport S.M. Lipoxygenase mRNA in rabbit reticulocytes. Its isolation, characterization and translational repression. Eur. J. Biochem. 1982, 129:133-141.
353. Thiele B.J., Fleming J., Kasturi K., O'Prey J., Black E., Chester J., Rapoport S.M., Harrison P.R. Cloning of a rabbit erythroid-cell-specific lipoxygenase mRNA. Gene 1987, 57:111-119.
354. Toledo L., Masgrau L., Maréchal J.D., Lluch J.M., González-Lafont A. Insights into the mechanism of binding of arachidonic acid to mammalian 15-lipoxygenases. J. Phys. Chem. B 2010, 114:7037-7046.
355. Toledo L., Masgrau L., Lluch J.M., Gonzalez-Lafont A. Substrate binding to mammalian 15-lipoxygenase. J. Comput. Aided Mol. Des. 2011, 25:825-835.
356. Trebus F., Heydeck D., Schimke I., Gerth C., Kuhn H. Transient experimental anemia in cholesterol-fed rabbits induces systemic overexpression of the reticulocyte-type 15-lipoxygenase and protects from aortic lipid deposition. Prostaglandins Leukot. Essent. Fatty Acids 2002, 67:419-428.
357. Tsao C.H., Shiau M.Y., Chuang P.H., Chang Y.H., Hwang J. Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis. J. Lipid Res. 2014, 55:385-397.
358. Ueda N., Yamamoto S., Oates J.A., Brash A.R. Stereoselective hydrogen abstraction in leukotriene A4 synthesis by purified 5-lipoxygenase of porcine leukocytes. Prostaglandins 1986, 32:43-48.
359. Upston J.M., Neuzil J., Stocker R. Oxidation of LDL by recombinant human 15-lipoxygenase: evidence for alpha-tocopherol-dependent oxidation of esterified core and surface lipids. J. Lipid Res. 1996, 37:2650-2661.
360. Upston J.M., Neuzil J., Witting P.K., Alleva R., Stocker R. Oxidation of free fatty acids in low density lipoprotein by 15-lipoxygenase stimulates nonenzymic, alpha-tocopherol-mediated peroxidation of cholesteryl esters. J. Biol. Chem. 1997, 272:30067-30074.
361. van Leyen K. Lipoxygenase: an emerging target for stroke therapy. CNS Neurol. Disord. Drug Targets 2013, 12:191-199.
362. van Leyen K., Duvoisin R.M., Engelhardt H., Wiedmann M. A function for lipoxygenase in programmed organelle degradation. Nature 1998, 395:392-395.
363. van Leyen K., Kim H.Y., Lee S.R., Jin G., Arai K., Lo E.H. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke 2006, 37:3014-3018.
364. van Leyen K., Arai K., Jin G., Kenyon V., Gerstner B., Rosenberg P.A., Holman T.R., Lo E.H. Novel lipoxygenase inhibitors as neuroprotective reagents. J. Neurosci. Res. 2008, 86:904-909.
365. Van Os C.P., Rijke-Schilder G.P., Van Halbeek H., Verhagen J., Vliegenthart J.F. Double dioxygenation of arachidonic acid by soybean lipoxygenase-1. Kinetics and regio-stereo specificities of the reaction steps. Biochim. Biophys. Acta 1981, 663:177-193.
366. Vanderhoek J.Y., Bailey J.M. Activation of a 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes by the anti-inflammatory agent ibuprofen. J. Biol. Chem. 1984, 259:6752-6756.
367. Vogel R., Jansen C., Roffeis J., Reddanna P., Forsell P., Claesson H.E., Kuhn H., Walther M. Applicability of the triad concept for the positional specificity of mammalian lipoxygenases. J. Biol. Chem. 2010, 285:5369-5376.
368. Walther M., Ivanov I., Myagkova G., Kuhn H. Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis. Chem. Biol. 2001, 8:779-790.
369. Walther M., Anton M., Wiedmann M., Fletterick R., Kuhn H. The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding. J. Biol. Chem. 2002, 277:27360-27366.
370. Walther M., Wiesner R., Kuhn H. Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium. J. Biol. Chem. 2004, 279:3717-3725.
371. Walther M., Hofheinz K., Vogel R., Roffeis J., Kühn H. The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions. Arch. Biochem. Biophys. 2011, 516:1-9.
372. Wang H., Li J., Follett P.L., Zhang Y., Cotanche D.A., Jensen F.E., Volpe J.J., Rosenberg P.A. 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Eur. J. Neurosci. 2004, 20:2049-2058.
373. Watanabe T., Haeggstrom J.Z. Rat 12-lipoxygenase: mutations of amino acids implicated in the positional specificity of 15- and 12-lipoxygenases. Biochem. Biophys. Res. Commun. 1993, 192:1023-1029.
374. Watanabe T., Medina J.F., Haeggstrom J.Z., Radmark O., Samuelsson B. Molecular cloning of a 12-lipoxygenase cDNA from rat brain. Eur. J. Biochem. 1993, 212:605-612.
375. Weibel G.L., Joshi M.R., Alexander E.T., Zhu P., Blair I.A., Rothblat G.H. Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport. Arterioscler. Thromb. Vasc. Biol. 2009, 29:837-842.
376. Wendel M., Heller A.R. Anticancer actions of omega-3 fatty acids-current state and future perspectives. Anti Cancer Agents Med. Chem. 2009, 9:457-470.
377. Wennman A., Karkehabadi S., Oliw E.H. Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. Arch. Biochem. Biophys. 2014, 555-556:9-15.
378. Wiesner R., Suzuki H., Walther M., Yamamoto S., Kuhn H. Suicidal inactivation of the rabbit 15-lipoxygenase by 15S-HpETE is paralleled by covalent modification of active site peptides. Free Radic. Biol. Med. 2003, 34:304-315.
379. Winkler F.K., D'Arcy A., Hunziker W. Structure of human pancreatic lipase. Nature 1990, 343:771-774.
380. Wittwer J., Hersberger M. The two faces of the 15-lipoxygenase in atherosclerosis. Prostaglandins Leukot. Essent. Fat. Acids 2007, 77:67-77.
381. Witztum J.L., Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 1991, 88:1785-1792.
382. Xu B., Bhattacharjee A., Roy B., Xu H.M., Anthony D., Frank D.A., Feldman G.M., Cathcart M.K. Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3. Mol. Cell. Biol. 2003, 23:3918-3928.
383. Xu B., Bhattacharjee A., Roy B., Feldman G.M., Cathcart M.K. Role of protein kinase C isoforms in the regulation of interleukin-13-induced 15-lipoxygenase gene expression in human monocytes. J. Biol. Chem. 2004, 279:15954-15960.
384. Xu J., Zhang Y., Xiao Y., Ma S., Liu Q., Dang S., Jin M., Shi Y., Wan B., Zhang Y. Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARbeta/delta: a potential therapeutic role for CNS autoimmune disease. Cell Death Dis. 2013, 4:e569.
385. Yang H., Zhuo J.M., Chu J., Chinnici C., Pratico D. Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Biol. Psychiatry 2010, 68:922-929.
386. Yao Y., Clark C.M., Trojanowski J.Q., Lee V.M., Pratico D. Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment. Ann. Neurol. 2005, 58:623-626.
387. Yigitkanli K., Pekcec A., Karatas H., Pallast S., Mandeville E., Joshi N., Smirnova N., Gazaryan I., Ratan R.R., Witztum J.L., Montaner J., Holman T.R., Lo E.H., van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann. Neurol. 2013, 73:129-135.
388. Yla-Herttuala S., Rosenfeld M.E., Parthasarathy S., Glass C.K., Sigal E., Witztum J.L., Steinberg D. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:6959-6963.
389. Yoo S., Lim J.Y., Hwang S.W. Resolvins: endogenously-generated potent painkilling substances and their therapeutic perspectives. Curr. Neuropharmacol. 2013, 11:664-676.
390. Yoshimoto T., Suzuki H., Yamamoto S., Takai T., Yokoyama C., Tanabe T. Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:2142-2146.
391. Yoshinaga M., Buchanan F.G., DuBois R.N. 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. Prostaglandins Other Lipid Mediat. 2004, 73:111-122.
392. Zafiriou M.P., Zelarayan L.C., Noack C., Renger A., Nigam S., Siafaka-Kapadai A. Hepoxilin A(3) protects beta-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid. Biochim. Biophys. Acta 2011, 1811:361-369.
393. Zhang J. Autophagy and Mitophagy in Cellular Damage Control. Redox Biol. 2013, 1:19-23.
394. Zhang Y., Wang H., Li J., Jimenez D.A., Levitan E.S., Aizenman E., Rosenberg P.A. Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. J. Neurosci. 2004, 24:10616-10627.
395. Zhang B., Jia H., Liu J., Yang Z., Jiang T., Tang K., Li D., Huang C., Ma J., Shen G.X., Ye D., Huang B. Depletion of regulatory T cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. J. Immunol. 2010, 185:7199-7206.
396. Zhang H.P., Jia C.E., Lv Y., Gibson P.G., Wang G. Montelukast for prevention and treatment of asthma exacerbations in adults: systematic review and meta-analysis. Allergy Asthma Proc. 2014, 35:278-287.
397. Zhang H.J., Sun C.H., Kuang H.Y., Jiang X.Y., Liu H.L., Hua W.F., Liu Z.J., Zhou H., Sui H., Qi R. 12(S)-hydroxyeicosatetraenoic acid levels link to coronary artery disease in type 2 diabetic patients. J. Endocrinol. Invest. 2013, 36(6):385-389.
398. Zhao L., Pratico D., Rader D.J., Funk C.D. 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway. Prostaglandins Other Lipid Mediat. 2005, 78:185-193.
399. Zhao Y., Bhattacharjee S., Jones B.M., Hill J., Dua P., Lukiw W.J. Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b in Alzheimer's Disease (AD) and in Primary Human Neuronal-Glial (HNG) Cells. Mol. Neurobiol. 2014, 50(1):97-106.
400. Zheng Y., Brash A.R. Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids. J. Biol. Chem. 2010, 285:39866-39875.
401. Zheng Y., Brash A.R. On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1. J. Biol. Chem. 2010, 285:39876-39887.
402. Zhu D., Ran Y. Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension. J. Physiol. Sci. 2012, 62:163-172.
403. Zuo X., Shen L., Issa J.P., Moy O., Morris J.S., Lippman S.M., Shureiqi I. 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation. FASEB J. 2008, 22:1981-1992.
404. Zuo X., Morris J.S., Broaddus R., Shureiqi I. 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells. Oncogene 2009, 28:1496-1505.