The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation

Autoimmunity

Volumn 42, Issue 4, 2009, Pages 383-385

  Krönke, Gerhard ^a   Uderhardt, Stefan ^a   Katzenbeisser, Julia ^a   Schett, Georg ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

12 15 LO; HETE; OC

Indexed keywords

12 15 LIPOXYGENASE; 12 HYDROXYICOSATETRAENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; ICOSANOID; LIPOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME INHIBITION; GENE SILENCING; GROWTH STIMULATION; MOUSE; NONHUMAN; OSTEOCLAST; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; CELL DIFFERENTIATION; ENZYME INHIBITORS; MICE; MICE, KNOCKOUT; OSTEOCLASTS; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 70749147559     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930902832488     Document Type: Article

References (9)

1. Conrad DJ. The arachidonate 12/15-LO. A review of tissue expression and biologic function. Clin Rev Allergy Immunol 1999;17(1-2):71-89, Review.
2. CyrusT,WitztumJL,Rader DJ,TangiralaR,Fazio S,LintonMF, Funk CD. Disruption of the 12/15-LO gene diminishes atherosclerosis in apo E-deficient mice. J Clin Invest 1999; 103(11):1597-1604.
3. Cyrus T, Praticò D, Zhao L, Witztum JL, Rader DJ, Rokach J, FitzGerald GA, Funk CD. Absence of 12/15-LO expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice. Circulation 2001;103(18):2277-2282.
4. KleinRF,Allard J,Avnur Z, NikolchevaT,RotsteinD,CarlosAS, SheaM,WatersRV,BelknapJK,PeltzG,OrwollES.Regulationof bone mass in mice by the LO gene Alox15. Science 2004; 303(5655):229-232.
5. Urano T, Shiraki M, Fujita M, Hosoi T, Orimo H, Ouchi Y, Inoue S. Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 50-flanking region (-5229G/A) with bone mineral density. J Bone Miner Metab 2005;23(3): 226-230. (Pubitemid 40603205)
6. Cheung CL, Chan V, Kung AW. A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women. Hum Hered 2008;65(1):1-8, Epub 2007 Jul 25.
7. Sun D, Funk CD. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem 1996;271(39):24055-24062.
8. Bolick DT, Orr AW, Whetzel A, Srinivasan S, Hatley ME, Schwartz MA, Hedrick CC. 12/15-LO regulates intercellular adhesion molecule-1 expression and Mo adhesion to endothelium through activation of RhoA and NFkB. Arterioscler Thromb Vasc Biol 2005;25(11):2301-2307, Epub 2005 Sep 15.
9. Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C, Witztum JL, Funk CD, Conrad D, Glass CK. Interleukin-4-dependent production of PPAR-g ligands in macrophages by 12/15-LO. Nature 1999;400(6742):378-382.