Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation

Journal of Neuroscience

Volumn 24, Issue 47, 2004, Pages 10616-10627

  Zhang, Yumin ^a   Wang, Hong ^a   Li, Jianrong ^a   Jimenez, Daniel A ^b   Levitan, Edwin S ^b   Aizenman, Elias ^b   Rosenberg, Paul A ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

12 lipoxygenase; Apoptosis; Caspase; Peroxynitrite; Reactive oxygen species; Zinc

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; CASPASE 3; DIETHYLENETRIAMINE; MITOGEN ACTIVATED PROTEIN KINASE P38; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; NITRIC OXIDE DONOR; PEROXYNITRITE; ZINC;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; ENZYME INHIBITION; FETUS; HOMEOSTASIS; INFLAMMATION; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NERVE INJURY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; ARACHIDONATE 12-LIPOXYGENASE; CASPASE 3; CASPASES; CELLS, CULTURED; CHELATING AGENTS; ENZYME ACTIVATION; ETHYLENEDIAMINES; FREE RADICALS; GLUTATHIONE; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MOLSIDOMINE; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXYNITROUS ACID; RATS; SPECTROMETRY, FLUORESCENCE; ZINC;

EID: 9344268817     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2469-04.2004     Document Type: Article

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