Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase

Journal of Medicinal Chemistry

Volumn 54, Issue 15, 2011, Pages 5485-5497

  Kenyon, Victor ^d,e   Rai, Ganesha ^a   Jadhav, Ajit ^a   Schultz, Lena ^a   Armstrong, Michelle ^d   Jameson, J Brian ^d   Perry, Steven ^d   Joshi, Netra ^d   Bougie, James M ^a   Leister, William ^a   Taylor Fishwick, David A ^b   Nadler, Jerry L ^b   Holinstat, Michael ^c   Simeonov, Anton ^a   Maloney, David J ^a   Holman, Theodore R ^d  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IRON; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; THROMBOCYTE ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANALYSIS; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MOLECULE; MOUSE; NONHUMAN; THROMBOCYTE;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; BLOOD PLATELETS; HUMANS; ISLETS OF LANGERHANS; KINETICS; LIPOXYGENASE INHIBITORS; MICE; SHEEP; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79961219253     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2005089     Document Type: Article

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