Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet

Mediators of Inflammation

Volumn 2012, Issue , 2012, Pages

  Cole, Banumathi K ^a   Morris, Margaret A ^a   Grzesik, Wojciech J ^a   Leone, Kendall A ^a   Nadler, Jerry L ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 15 LIPOXYGENASE; GLUCOSE; LIPOXYGENASE; UNCLASSIFIED DRUG; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; LIPID;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDIDYMIS FAT; GENE DELETION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; INFLAMMATION; INSULIN RESISTANCE; LIPID DIET; MACROPHAGE MIGRATION; MALE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET; PRIORITY JOURNAL; WHITE ADIPOSE TISSUE; ANIMAL; BLOOD; C57BL MOUSE; ENZYMOLOGY; GENETICS; MACROPHAGE; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY;

MUS;

ADIPOSE TISSUE; ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; DIET, HIGH-FAT; GLUCOSE; INFLAMMATION; INSULIN-SECRETING CELLS; LIPIDS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL;

MLCS; MLOWN;

EID: 84872779944     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2012/851798     Document Type: Article

References (42)

1. Zhang H., Zhang C., Adipose talks to distant organs to regulate insulin sensitivity and vascular function. Obesity 2010 18 11 2071 2076 2-s2.0-78049252707 10.1038/oby.2010.91
2. Guilherme A., Virbasius J. V., Puri V., Czech M. P., Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nature Reviews Molecular Cell Biology 2008 9 5 367 377 2-s2.0-42449097289 10.1038/nrm2391 (Pubitemid 351574198)
3. Hotamisligil G. S., Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010 140 6 900 917 2-s2.0-77950343252 10.1016/j.cell.2010.02.034
4. Dobrian A. D., Lieb D. C., Cole B. K., Taylor-Fishwick D. A., Chakrabarti S. K., Nadler J. L., Functional and pathological roles of the 12- and 15-lipoxygenases. Progress in Lipid Research 2011 50 1 115 131 2-s2.0-78650698895 10.1016/j.plipres.2010.10.005
5. Chakrabarti S. K., Cole B. K., Wen Y., Keller S. R., Nadler J. L., 12/15-Lipoxygenase products induce inflammation and impair insulin signaling in 3T3-l1 adipocytes. Obesity 2009 17 9 1657 1663 2-s2.0-69749102190 10.1038/oby.2009.192
6. Chakrabarti S. K., Wen Y., Dobrian A. D., Cole B. K., Ma Q., Pei H., Williams M. D., Bevard M. H., Vandenhoff G. E., Keller S. R., Gu J., Nadler J. L., Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. American Journal of Physiology 2011 300 1 E175 E187 2-s2.0-78650788269 10.1152/ajpendo.00203.2010
7. Dobrian A. D., Lieb D. C., Ma Q., Lindsay J. W., Cole B. K., Ma K., Chakrabarti S. K., Kuhn N. S., Wohlgemuth S. D., Fontana M., Nadler J. L., Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. Biochemical and Biophysical Research Communications 2010 403 3-4 485 490 2-s2.0-78650173914 10.1016/j.bbrc.2010.11. 065
8. Cole B. K., Kuhn N. S., Green-Mitchell S. M., 12/15-lipoxygenase signaling in the endoplasmic reticulum stress response. American Journal of Physiology 2012 302 6 E654 E665
9. Nunemaker C. S., Chen M., Pei H., 12-lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by western diet. American Journal of Physiology 2008 295 5 E1065 E1075
10. Sears D. D., Miles P. D., Chapman J., Ofrecio J. M., Almazan F., Thapar D., Miller Y. I., 12/15-Lipoxygenase is equired for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS ONE 2009 4 9 2-s2.0-70349639659 10.1371/journal.pone.0007250 e7250
11. Mori M. A., Liu M., Bezy O., Almind K., Shapiro H., Kasif S., Kahn C. R., A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease. Diabetes 2010 59 11 2960 2971 2-s2.0-78049251400 10.2337/db10-0367
12. Furuhashi M., Hotamisligil G. S., Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nature Reviews Drug Discovery 2008 7 6 489 503 2-s2.0-44449118921 10.1038/nrd2589 (Pubitemid 351767117)
13. He W., Barak Y., Hevener A., Olson P., Liao D., Le J., Nelson M., Ong E., Olefsky J. M., Evans R. M., Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proceedings of the National Academy of Sciences of the United States of America 2003 100 26 15712 15717 2-s2.0-9144229185 10.1073/pnas.2536828100 (Pubitemid 38021055)
14. Yang Z., Chen M., Ellett J. D., Fialkow L. B., Carter J. D., McDuffie M., Nadler J. L., Autoimmune diabetes is blocked in Stat4-deficient mice. Journal of Autoimmunity 2004 22 3 191 200 2-s2.0-1642412663 10.1016/j.jaut.2003.08.006 (Pubitemid 38369180)
15. Carter J. D., Dula S. B., Corbin K. L., Wu R., Nunemaker C. S., A practical guide to rodent islet isolation and assessment. Biological Procedures Online 2009 11 1 3 31 2-s2.0-77649275237 10.1007/s12575-009-9021-0
16. Cefalu W. T., Fractalkine: a cellular link between adipose tissue inflammation and vascular pathologies. Diabetes 2011 60 5 1380 1382 2-s2.0-79959427550 10.2337/db11-0239
17. Shah R., Hinkle C. C., Ferguson J. F., Mehta N. N., Li M., Qu L., Lu Y., Putt M. E., Ahima R. S., Reilly M. P., Fractalkine is a novel human adipochemokine associated with type 2 diabetes. Diabetes 2011 60 5 1512 1518 2-s2.0-79959445914 10.2337/db10-0956
18. Middleton M. K., Rubinstein T., Puré E., Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase. Journal of Immunology 2006 176 1 265 274 2-s2.0-29644436198 (Pubitemid 43023271)
19. Trinchieri G., Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nature Reviews Immunology 2003 3 2 133 146 2-s2.0-0037313578 10.1038/nri1001 (Pubitemid 37328691)
20. Wen Y., Gu J., Chakrabarti S. K., Aylor K., Marshall J., Takahashi Y., Yoshimoto T., Nadler J. L., The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor- α in macrophages. Endocrinology 2007 148 3 1313 1322 2-s2.0-33847025363 10.1210/en.2006-0665
21. Saraiva M., O'Garra A., The regulation of IL-10 production by immune cells. Nature Reviews Immunology 2010 10 3 170 181 2-s2.0-77649184739 10.1038/nri2711
22. Pettersson A. T., Mejhert N., Jernås M., Twist1 in human white adipose tissue and obesity. Journal of Clinical Endocrinology & Metabolism 2011 96 1 133 141
23. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K., Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Journal of Clinical Investigation 2006 116 7 1784 1792 2-s2.0-33745834319 10.1172/JCI29126 (Pubitemid 44033298)
24. Khan T., Muise E. S., Iyengar P., Wang Z. V., Chandalia M., Abate N., Zhang B. B., Bonaldo P., Chua S., Scherer P. E., Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Molecular and Cellular Biology 2009 29 6 1575 1591 2-s2.0-62849107819 10.1128/MCB.01300-08
25. Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W., Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003 112 12 1796 1808 2-s2.0-0348230958 10.1172/JCI200319246 (Pubitemid 38063703)
26. Cristancho A. G., Lazar M. A., Forming functional fat: a growing understanding of adipocyte differentiation. Nature Reviews Molecular Cell Biology 2011 12 11 722 734
27. Chang B. H. J., Chan L., Regulation of triglyceride metabolism. III. Emerging role of lipid droplet protein ADFP in health and disease. American Journal of Physiology 2007 292 6 G1465 G1468 2-s2.0-34447500677 10.1152/ajpgi.00566.2006 (Pubitemid 47080580)
28. Lodhi I. J., Wei X., Semenkovich C. F., Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter. Trends in Endocrinology and Metabolism 2011 22 1 1 8 2-s2.0-78650520909 10.1016/j.tem.2010.09.002
29. Yen C. L. E., Stone S. J., Koliwad S., Harris C., Farese R. V., Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. Journal of Lipid Research 2008 49 11 2283 2301 2-s2.0-58149457426 10.1194/jlr.R800018-JLR200
30. Stanton M. C., Chen S. C., Jackson J. V., Rojas-Triana A., Kinsley D., Cui L., Fine J. S., Greenfeder S., Bober L. A., Jenh C. H., Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice. Journal of Inflammation 2011 8, article 8 2-s2.0-79952698689 10.1186/1476-9255-8-8
31. Niesner U., Albrecht I., Janke M., Autoregulation of Th1-mediated inflammation by twist1. Journal of Experimental Medicine 2008 205 8 1889 1901
32. Hong E. G., Ko H. J., Cho Y. R., Kim H. J., Ma Z., Yu T. Y., Friedline R. H., Kurt-Jones E., Finberg R., Fischer M. A., Granger E. L., Norbury C. C., Hauschka S. D., Philbrick W. M., Lee C. G., Elias J. A., Kim J. K., Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes 2009 58 11 2525 2535 2-s2.0-70350561703 10.2337/db08-1261
33. Suganami T., Ogawa Y., Adipose tissue macrophages: their role in adipose tissue remodeling. Journal of Leukocyte Biology 2010 88 1 33 39 2-s2.0-77954672503 10.1189/jlb.0210072
34. Inouye K. E., Shi H., Howard J. K., Daly C. H., Lord G. M., Rollins B. J., Flier J. S., Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes 2007 56 9 2242 2250 2-s2.0-34548434020 10.2337/db07-0425 (Pubitemid 47358231)
35. Bolick D. T., Orr A. W., Whetzel A., Srinivasan S., Hatley M. E., Schwartz M. A., Hedrick C. C., 12/15-Lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor- B. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 11 2301 2307 2-s2.0-27644571486 10.1161/01.ATV. 0000186181.19909.a6 (Pubitemid 41552646)
36. Kosteli A., Sugaru E., Haemmerle G., Martin J. F., Lei J., Zechner R., Ferrante A. W., Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. Journal of Clinical Investigation 2010 120 10 3466 3479 2-s2.0-77957838795 10.1172/JCI42845
37. Fischer-Posovszky P., Wang Q. A., Asterholm I. W., Rutkowski J. M., Scherer P. E., Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology 2011 152 8 3074 3081 2-s2.0-79960735393 10.1210/en.2011-1031
38. Puri V., Ranjit S., Konda S., Nicoloro S. M. C., Straubhaar J., Chawla A., Chouinard M., Lin C., Burkart A., Corvera S., Perugini R. A., Czech M. P., Cidea is associated with lipid droplets and insulin sensitivity in humans. Proceedings of the National Academy of Sciences of the United States of America 2008 105 22 7833 7838 2-s2.0-45549093204 10.1073/pnas.0802063105 (Pubitemid 351872724)
39. Koliwad S. K., Streeper R. S., Monetti M., Cornelissen I., Chan L., Terayama K., Naylor S., Rao M., Hubbard B., Farese R. V., DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. Journal of Clinical Investigation 2010 120 3 756 767 2-s2.0-77949690002 10.1172/JCI36066
40. Guri A. J., Bassaganya-Riera J., Systemic effects of white adipose tissue dysregulation and obesity-related inflammation. Obesity 2011 19 4 689 700 2-s2.0-79953166392 10.1038/oby.2010.230
41. Prentki M., Nolan C. J., Islet β cell failure in type 2 diabetes. Journal of Clinical Investigation 2006 116 7 1802 1812 2-s2.0-33745863033 10.1172/JCI29103 (Pubitemid 44033300)
42. Zhao L., Cuff C. A., Moss E., Wille U., Cyrus T., Klein E. A., Praticò D., Rader D. J., Hunter C. A., Puré E., Funk C. D., Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. Journal of Biological Chemistry 2002 277 38 35350 35356 2-s2.0-0037144594 10.1074/jbc.M205738200