Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis

Chemistry and Biology

Volumn 8, Issue 8, 2001, Pages 779-790

  Walther, Matthias ^a   Ivanov, Igor ^b   Myagkova, Galina ^b   Kuhn, Hartmut ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MIREA RUSSIAN TECHNOLOGICAL UNIVERSITY   (Russian Federation)

Author keywords

Atherosclerosis; Eicosanoid; Inflammation; Lipid peroxidation; Mutagenesis

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; ISOENZYME; LIPOXYGENASE; OXYGEN; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS FRAGMENTOGRAPHY; METABOLISM; MUTATION; RABBIT; SITE DIRECTED MUTAGENESIS;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; BINDING SITES; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; ISOENZYMES; LIPOXYGENASE; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXYGEN; RABBITS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0034873471     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00050-3     Document Type: Article

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