Interleukin 4 induces transcription of the 15-lipoxygenase I gene in human endothelial cells

Journal of Lipid Research

Volumn 42, Issue 5, 2001, Pages 783-791

  Lee, Yong Woo ^a   Kühn, Hartmut ^b   Kaiser, Simone ^a,c   Hennig, Bernhard ^a   Daugherty, Alan ^a   Toborek, Michal ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF POTSDAM   (Germany)

Author keywords

Atherosclerosis; Cytokines; Oxidation; Transcriptional regulation

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE 1; INTERLEUKIN 4; MESSENGER RNA; NUCLEAR FACTOR I; STAT6 PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FLANKING REGION; ELECTROPHORETIC MOBILITY; ENDOTHELIUM CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OXIDATION; PRIORITY JOURNAL; TIME; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UMBILICAL VEIN;

ARACHIDONATE 15-LIPOXYGENASE; ARTERIOSCLEROSIS; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXIMIDE; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-4; NFI TRANSCRIPTION FACTORS; PROTEIN SYNTHESIS INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; Y-BOX-BINDING PROTEIN 1;

EID: 0034984679     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Mammalian lipoxygenases: Structure, function, and evolutionary aspects
2. Is there a role for 15-lipoxygenase in atherogenesis?
3. The role of 15-lipoxygenase in atherogenesis: Pro- and antiatherogenic actions
4. 2 mimics cell-mediated oxidative modification
5. The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E
6. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions
7. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant anti-oxidant properties
8. Disruption of the 12/15-LO-IX gene diminishes atherosclerosis in apolipoprotein E deficient mice
9. Regulation of cellular 15-lipoxygenase activity on pre-translational, translational and post-translational levels
10. Lipoxygenase mRNA in rabbit reticulocytes. Its isolation, characterization and translational depression
11. Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region
12. mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3′ end
13. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase
14. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-trans-eicosatetraenoic acid and lipoxins
15. Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation
16. Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15(S)-HETE into cellular phospholipids in cultured pulmonary epithelial cells
17. Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4
18. Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes
19. Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: Evidence for the involvement of transcription factor STAT6
20. Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes
21. Interleukin-4 induces tissue eosinophilia in mice: Correlation with its in vitro capacity to stimulate the endothelial cell-dependent selective transmigration of human eosinophils
22. Interleukin-4: A prototypic immunoregulatory lymphokine
23. IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
24. Distinct immunohistochemical localization of IL-4 in human inflamed air-way tissues. IL-4 is localized to eosinophils in vivo and is released by peripheral blood eosinophils
25. A role for interleukin 4 in production of matrix metalloproteinase 1 by human aortic smooth muscle cells
26. TNF-alpha and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells
27. Effect of linoleic acid on endothelial cell inflammatory mediators
28. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: A mechanism for NF-kappa B activation
29. Nicotine attenuates arachidonic acid-induced overexpression of nitric oxide synthase in cultured spinal cord neurons
30. Modification of the Lowry procedure for the analysis of proteolipid protein
31. Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions
32. Involvement of 15-lipoxygenase in early stages of atherogenesis
33. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques
34. Biosynthesis and metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid by human umbilical vein endothelial cells
35. Cultured bovine coronary arterial endothelial cells synthesize HETEs and prostacyclin
36. Induction of monocyte binding to endothelial cells by MM-LDL: Role of lipoxygenase metabolites
37. Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells
38. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid
39. A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein
40. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX
41. Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblast and endothelial cells in culture
42. Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages
43. COX-1 and COX-2 tissue expression: Implications and predictions
44. Interleukin-1 increases 15-hydroxyeicosatetraenoic acid formation in cultured human endothelial cells
45. Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors
46. Human 15-lipoxygenase gene promoter: Analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes
47. Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene
48. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
49. c chain
50. Tumor necrosis factor α enhances the expression of the interleukin (IL)-4 receptor α-chain on endothelial cells increasing IL-4 or IL-13-induced Stat6 activation
51. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements
52. Cloning and characterization of a second AP-2 transcription factor: AP-2β
53. DNA-binding specificities of the GATA transcription factor family
54. The proline-rich transcriptional activator of CTF/NF-1 is distinct from the replication and DNA binding domain
55. A family of human CCAAT-box binding proteins active in transcription and DNA replication: Cloning and expression of multiple cDNAs
56. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter
57. GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase