15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells

Oncogene

Volumn 28, Issue 12, 2009, Pages 1496-1505

  Zuo, X ^a   Morris, J S ^a   Broaddus, R ^a   Shureiqi, I ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

15 lipoxygenase 1; Colon cancer; MTA1; NuRD

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE 1; CALVASCULIN; DEPSIPEPTIDE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; LUCIFERASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER PATIENT; CELL ACTIVATION; COLON CANCER; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GENE CONSTRUCT; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM MUCOSA; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

AGED; AGED, 80 AND OVER; ARACHIDONATE 15-LIPOXYGENASE; CELL LINE, TUMOR; COLONIC NEOPLASMS; FEMALE; HISTONE DEACETYLASES; HUMANS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 63449120098     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.494     Document Type: Article

References (49)

1. Ariel A, Serhan CN. (2007). Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28: 176-183.
2. Baer AN, Costello PB, Green FA. (1991). In vivo activation of an omega-6 oxygenase in human skin. Biochem Biophys Res Commun 180: 98-104.
3. Balasenthil S, Broaddus RR, Kumar R. (2006). Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas. Hum Pathol 37: 656-661.
4. Bolden JE, Peart MJ, Johnstone RW. (2006). Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5: 769-784.
5. Brash AR, Boeglin WE, Chang MS. (1997). Discovery of a second 15-Slipoxygenase in humans. Proc Natl Acad Sci USA 94: 6148-6152.
6. Brehm A, Nielsen SJ, Miska EA, McCance DJ, Reid JL, Bannister AJ et al. (1999). The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. EMBO J 18: 2449-2458.
7. Chen GG, Xu H, Lee JF, Subramaniam M, Leung KL, Wang SH et al. (2003). 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gammadependent pathway. Int J Cancer 107: 837-843.
8. Conrad DJ, Lu M. (2000). Regulation of Human 12/15-Lipoxygenase by Stat6-Dependent Transcription. Am J Respir Cell Mol Biol 22: 226-234.
9. Deguchi A, Xing SW, Shureiqi I, Yang P, Newman RA, Lippman SM et al. (2005). Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. Cancer Res 65:8 4428-447.
10. Furumai R, Matsuyama A, Kobashi N, Lee KH, Nishiyama M, Nakajima H et al. (2002). FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res 62: 4916-4921.
11. Giannini R, Cavallini A. (2005). Expression analysis of a subset of coregulators and three nuclear receptors in human colorectal carcinoma. Anticancer Res 25: 4287-4292.
12. Gibbs JB. (2000). Mechanism-based target identification and drug discovery in cancer research. Science 287: 1969-1973.
13. Gleason MM, Rojas CJ, Learn KS, Perrone MH, Bilder GE. (1995). Characterization and inhibition of 15-lipoxygenase in human monocytes: comparison with soybean 15-lipoxygenase. Am J Physiol 268: C1301-C1307.
14. Hennig R, Kehl T, Noor S, Ding XZ, Rao SM, Bergmann F et al. (2007). 15-Lipoxygenase-1 Production is Lost in Pancreatic Cancer and Overexpression of the Gene Inhibits Tumor Cell Growth. Neoplasia 9: 917-926.
15. Heslin MJ, Hawkins A, Boedefeld W, Arnoletti JP, Frolov A, Soong R et al. (2005). Tumor-associated down-regulation of 15-lipoxygenasel is reversed by celecoxib in colorectal cancer. Ann Surg 241: 941-946, (Discussion 946-947).
16. Hsi LC, Xi X, Lotan R, Shureiqi I, Lippman SM. (2004). The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells. Cancer Res 64: 8778-8781.
17. Hsi LC, Xi X, Wu Y, Lippman SM. (2005). The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells. Mol Cancer Ther 4: 17401746.
18. Huang BH, Laban M, Leung CHW, Lee L, Lee CK, Salto-Tellez M et al. (2005). Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1//WAF1 expression, independent of histone deacetylase 1. Cell Death Differ 12: 395-404.
19. Jiang WG, Watkins G, Douglas-Jones A, Mansel RE. (2006). Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer. Prostaglandins Leukot Essent Fatty Acids 74: 235-245.
20. Kamitani H, Geller M, Eling T. (1998). Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation. J Biol Chem 273: 21569-21577.
21. Kamitani H, Kameda H, Kelavkar UP, Eling TE. (2000). A GATA binding site is involved in the regulation of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line, caco-2. FEBS Lett 467: 341-347.
22. Kamitani H, Taniura S, Ikawa H, Watanabe T, Kelavkar UP, Eling TE. (2001). Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma. Carcinogenesis 22: 187-191.
23. Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J et al. (2000). Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J 19: 4342-4350.
24. Liu C, Xu D, Sjoberg J, Forsell P, Bjorkholm M, Claesson HE. (2004). Transcriptional regulation of 15-lipoxygenase expression by promoter methylation. Exp Cell Res 297: 61-67.
25. Manavathi B, Kumar R. (2007). Metastasis tumor antigens, an emerging family of multifaceted master coregulators. J Biol Chem 282: 1529-1533.
26. Marks PA, Richon VM, Miller T, Kelly WK. (2004). Histone Deacetylase Inhibitors. Adv Cancer Res 91: 137-168.
27. Nixon JB, Kim KS, Lamb PW, Bottone FG, Eling TE. (2004). 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. Prostaglandins Leukot Essent Fatty Acids 70: 7-15.
28. Ostareck DH, Ostareck-Lederer A, Wilm M, Thiele BJ, Mann M, Hentze MW. (1997). mRNA Silencing in Erythroid Differentiation: hnRNP K and hnRNP E1 Regulate 15-Lipoxygenase Translation from the 3' End. Cell 89: 597-606.
29. Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B et al. (2003). Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol 171: 6856-6865.
30. Shankaranarayanan P, Chaitidis P, Kuhn H, Nigam S. (2001). Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J Biol Chem 276: 42753-42760.
31. Sharma D, Saxena NK, Davidson NE, Vertino PM. (2006). Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res 66: 6370-6378.
32. Shureiqi I, Chen D, Lee JJ, Yang P, Newman RA, Brenner DE et al. (2000a). 15-LOX-1: a novel molecular target of nonsteroidal antiinflammatory drug-induced apoptosis in colorectal cancer cells. J Natl Cancer Inst 92: 1136-1142.
33. Shureiqi I, Chen D, Lotan R, Yang P, Newman RA, Fischer SM et al. (2000b). 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. Cancer Res 60: 6846-6850.
34. Shureiqi I, Jiang W, Fischer SM, Xu X, Chen D, Lee JJ et al. (2002). GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells. Cancer Res 62: 1178-1183.
35. Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM et al. (2003). The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci USA 100: 9968-9973.
36. Shureiqi I, Wojno KJ, Poore JA, Reddy RG, Moussalli MJ, Spindler SA et al. (1999). Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers. Carcinogenesis 20: 1985-1995.
37. Shureiqi I, Wu Y, Chen D, Yang XL, Guan B, Morris JS et al. (2005). The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis. Cancer Res 65: 11486-11492.
38. Shureiqi I, Xu X, Chen D, Lotan R, Morris JS, Fischer SM et al. (2001). Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. Cancer Res 61: 4879-4884.
39. Shureiqi I, Zuo X, Broaddus R, Wu Y, Guan B, Morris JS et al. (2007). The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer. FASEB J 21: 743-753.
40. Takamitsu S, Kiyomu F, Kazuhiro Y, Hideo S, Tomonori S, Hitoshi O et al. (2006). Peritoneal metastasis inhibition by linoleic acid with activation of PPARã in human gastrointestinal cancer cells. Virchows Archiv 448: 422-427.
41. Takata S, Matsubara M, Allen PG, Janmey PA, Serhan CN, Brady HR. (1994). Remodeling of neutrophil phospholipids with 15(S)- hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium. J Clin Invest 93: 499508.
42. Wu J, Xia HH, Tu SP, Fan DM, Lin MC, Kung HF et al. (2003). 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. Carcinogenesis 24: 243-247.
43. Wu Y, Fang B, Yang XQ, Wang L, Chen D, Krasnykh V et al. (2008). Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer. Mol Ther 16: 886-892.
44. Xue Y, Wong J, Moreno GT, Young MK, Cote J, Wang W. (1998). NURD, a novel complex with both ATP-dependent chromatinremodeling and histone deacetylase activities. Mol Cell 2: 851-861.
45. Zhang C, Richon V, Ni X, Talpur R, Duvic M. (2005a). Selective induction of apoptosis by Histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. J Investig Dermatol 125: 1045-1052.
46. Zhang X-y, DeSalle LM, Patel JH, Capobianco AJ, Yu D, Thomas-Tikhonenko A et al. (2005b). Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. PNAS 102: 13968-13973.
47. Zhu P, Martin E, Mengwasser J, Schlag P, Janssen KP, Gottlicher M. (2004). Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell 5: 455-463.
48. Zuo X, Shen L, Issa J-P, Moy O, Morris JS, Lippman SM et al. (2008). 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation. FASEB J 22: 1981-1992.
49. Zuo X, Wu Y, Morris JS, Stimmel JB, Leesnitzer LM, Fischer SM et al. (2006). Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. Oncogene 25: 1225-1241.