15S-hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor γ and inhibits proliferation in PC3 prostate carcinoma cells

Cancer Research

Volumn 61, Issue 2, 2001, Pages 497-503

  Shappell, Scott B ^a,b   Gupta, Rajnish A ^a,c   Manning, Suzanne ^a,b,c   Whitehead, Robert ^a,b   Boeglin, William E ^a   Schneider, Claus ^a   Case, Tom ^a   Price, James ^a   Jack, Gregory S ^a   Wheeler, Thomas M ^d   Matusik, Robert J ^a,b,c   Brash, Alan R ^a,b   DuBois, Raymond N ^a,b,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; FATTY ACID BINDING PROTEIN; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE;

ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; GENE ACTIVATION; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION;

AGAR; ARACHIDONATE 15-LIPOXYGENASE; BLOTTING, NORTHERN; CATALYSIS; CELL DIVISION; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; ISOENZYMES; LUCIFERASES; MALE; PROSTATIC NEOPLASMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035863307     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. 5-Lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death
2. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells
3. 2in human prostatic carcinoma cells
4. NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis-down-regulates bcl-2 expression in LNCaP cells
5. Overexpression of cyclooxygenase-2 in human prostate adenocarcinoma
6. Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer
7. Discovery of a second 15S-lipoxygenase in humans
8. 15-Lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma
9. Fresh tissue harvest for research from prostatectomy specimens
10. Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: Correlation with grade and expression in high grade prostatic intraepithelial neoplasia
11. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
12. Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
13. Activation of PPARγ leads to inhibition of anchorage independent growth of human colorectal cancer cells
14. Detection, assay, and isolation of allene-oxide synthase
15. Expression of peroxisome proliferator-activated receptor gamma (PPARγ) in human transitional bladder cancerand its role in inducing cell death
16. The organization, promoter analysis, and expression of the human PPARγ gene
17. 2
18. Real-time homogeneous assay of rapid cycle polymerase chain reaction product for identification of Leptonema illini
19. Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors
20. Analysis of gene expression in single oocytes and embryos by real-time rapid cycle fluorescence monitored RT-PCR
21. Fluorescence melting curve-based analysis for the detection of the bc1-1/JH translocation in mantle cell lymphoma
22. A rapid and sensitive approach for mutation detection using real-time polymerase chain reaction and melting curve analysis, using BRCA 1 as an example
23. High-speed prothrombin G A 20210 and methylenetetrahydrofolate reductase C T 677 mutation detection using real-time fluorescence PCR and melting curves
24. A human whole-blood assay for analysis of T-cell function by quantification of cytokine mRNA
25. Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
26. Adipogenesis and obesity: Rounding out the big picture
27. Terminal differentiation of human breast cancer through PPARγ
28. Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer
29. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma
30. PPARγ induces cell cycle withdrawal: Inhibition of E2F/DP DNA binding activity via downregulation of PP2A
31. Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase
32. Regulation of cellular 15-lipoxygenase activity on pretranslational, translational, and posttranslational levels
33. Differential activation of peroxisome proliferator-activated receptors by eicosanoids
34. Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas
35. Tumor suppressor activity of the gene encoding mammary-derived growth inhibitor
36. Mechanisms of androgen induction of sebocyte differentiation