Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice

Acta Neuropathologica

Volumn 121, Issue 4, 2011, Pages 487-498

  Lee, Junghee ^a,b   Kosaras, Bela ^c   Del Signore, Steve J ^a,d   Cormier, Kerry ^a,d   McKee, Ann ^a,d   Ratan, Rajiv R ^e   Kowall, Neil W ^a,b   Ryu, Hoon ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA BOSTON HEALTHCARE SYSTEM   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

4 Hydroxy 2 nonenal (4 HNE); Huntington's disease; Lipid peroxidation; Mitochondria; Neuronal survival

Indexed keywords

4 HYDROXYNONENAL; ADENOSINE TRIPHOSPHATE; HUNTINGTIN; LIPID; NORDIHYDROGUAIARETIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN REGION; CELL DEATH; CELL NUCLEUS INCLUSION BODY; CELL PROTECTION; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; IMMUNOREACTIVITY; LIFESPAN; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NERVE CELL CULTURE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STRIATE CORTEX; SYNAPSE;

ADENOSINE TRIPHOSPHATE; AGE FACTORS; ALDEHYDES; ANALYSIS OF VARIANCE; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; GLUTAMIC ACID; HUMANS; HUNTINGTON DISEASE; IMAGING, THREE-DIMENSIONAL; IN SITU NICK-END LABELING; INDOLES; LIPID PEROXIDATION; LIPOXYGENASE INHIBITORS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; NEOSTRIATUM; NERVE TISSUE PROTEINS; NEURONS; NORDIHYDROGUAIARETIC ACID; NUCLEAR PROTEINS; OXIDATIVE STRESS; SYNAPSES; TETRAZOLIUM SALTS; THIAZOLES; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 79954575043     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0788-5     Document Type: Article

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