Molecular Basis of Vitamin E Action: Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration

Journal of Biological Chemistry

Volumn 278, Issue 44, 2003, Pages 43508-43515

  Khanna, Savita ^a   Roy, Sashwati ^a   Ryu, Hoon ^c   Bahadduri, Praveen ^b   Swaan, Peter W ^b   Ratan, Rajiv R ^c   Sent, Chandan K ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHEMICAL BONDS; ENZYME INHIBITION; METABOLISM; NEUROLOGY; PATHOLOGY; TOXICITY;

NEURODEGENERATION;

VITAMINS;

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ARACHIDONATE 12 LIPOXYGENASE; BAICALEIN; BL 15; BUTHIONINE SULFOXIMINE; GLUTAMIC ACID; HOMOCYSTEINE; TOCOMIN;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL DEATH; CONTROLLED STUDY; DENDRITE; ENZYME ACTIVITY; MOUSE; NERVE CELL; NERVE DEGENERATION; NERVE FIBER; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; BINDING SITES; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CYTOSOL; GLUTAMIC ACID; GLUTATHIONE; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; NEURODEGENERATIVE DISEASES; NEURONS; NEUROTOXINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VITAMIN E;

ANIMALIA;

EID: 0242290274     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307075200     Document Type: Article

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