Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1

Journal of Medicinal Chemistry

Volumn 53, Issue 20, 2010, Pages 7392-7404

  Rai, Ganesha ^a   Kenyon, Victor ^b   Jadhav, Ajit ^a   Schultz, Lena ^a   Armstrong, Michelle ^b   Jameson, J Brian ^b   Hoobler, Eric ^b   Leister, William ^a   Simeonov, Anton ^a   Holman, Theodore R ^b   Maloney, David J ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 NAPHTHYL) 5 AMINO 1,3,4 OXADIAOLE; 2 (1 NAPHTHYL) 5 MERCAPTO 1,3,4 THIADIAZOLE; 4 (5 PHENYL 1,3,4 OXADIAZOL 2 YLTHIO)BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (1H INDOL 2 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (2 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (2 METHOXYPHENYL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROENZOATE; 4 [5 (3 FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (3 HYDROXYNAPHTHALEN 2 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (4 FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (FURAN 2 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLAMINO)BUT 2 YNYLTHIOPHENE 2 CARBOXYLATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLHIO]BUTYL 4 FLUOROBENZOATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 1H INDOLE 4 CARBOXYLATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 CHLOROBENZOATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 METHOXYBENZOATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYLBENZOFURAN 2 CARBOXYLATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYLTHIOPHENE 2 CARBOXYLATE; 4 [5 (NAPHTHALEN 1 YL) 1,3,4 THIADIAZOL 2 YLTHIO]BUT 2 YNYLTHIOPHENE 2 CARBOXYLATE; 4 [5 (QUINOLIN 5 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [5 (THIOPHEN 2 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL 4 FLUOROBENZOATE; 4 [[5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLTHIO]METHYL] BENZYL 4 FLUOROBENZOATE; HUMAN RETICULOCYTE 15 LIPOXYGENASE 1 INHIBITOR; ISOENZYME; LIPOXYGENASE INHIBITOR; N [4 [5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOL 2 YLTHIO]BUT 2 YNYL]THIOPHENE 2 CARBOXAMIDE; NORDIHYDROGUAIARETIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; ALKYNE; ALOX15 PROTEIN, HUMAN; ARACHIDONATE 15 LIPOXYGENASE; BENZOIC ACID DERIVATIVE; ESTER; MOLECULAR LIBRARY; NAPHTHALENE DERIVATIVE; OXADIAZOLE DERIVATIVE; SULFIDE; THIOPHENE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; STRUCTURE ACTIVITY RELATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; KINETICS; MOLECULAR LIBRARY; RETICULOCYTE; SYNTHESIS;

ALKYNES; ARACHIDONATE 15-LIPOXYGENASE; BENZOATES; BINDING SITES; ESTERS; HUMANS; KINETICS; LIPOXYGENASE INHIBITORS; MODELS, MOLECULAR; NAPHTHALENES; OXADIAZOLES; RETICULOCYTES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; THIOPHENES;

EID: 77958464748     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1008852     Document Type: Article

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