Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice

Journal of Biological Chemistry

Volumn 284, Issue 31, 2009, Pages 21077-21089

  Poeckel, Daniel ^a   Berry, Karin A Zemski ^b   Murphy, Robert C ^b   Funk, Colin D ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AORTIC ROOT; APOLIPOPROTEIN E (APOE); ARACHIDONIC ACIDS; ATHEROGENESIS; ATHEROSCLEROTIC LESIONS; CELL TYPES; CYCLOOXYGENASES; INCONSISTENT DATA; INFLAMMATORY RESPONSE; KNOCK OUTS; LIPID MEDIATORS; LIPOXYGENASES; PERITONEAL MACROPHAGE; PHORBOL MYRISTATE ACETATES; POTENTIAL THERAPIES; PROSTAGLANDINE; SPECIFIC ATTENUATION; STRIKING PATTERNS; SUBSTRATE UTILIZATION; VASCULAR PERMEABILITY; ZYMOSAN;

ACIDS; BIOCHEMISTRY; BLOOD VESSELS; CATALYSTS; CELL MEMBRANES; ENZYMES; METABOLISM; PATHOLOGY;

MACROPHAGES;

11 HYDROXYICOSATETRAENOIC ACID; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; APOLIPOPROTEIN E; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 1; HYDROXYICOSATETRAENOIC ACID; ICOSANOID; MESSENGER RNA; PHORBOL MYRISTATE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; THROMBOXANE B2; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ROOT; ARACHIDONIC ACID METABOLISM; ARTICLE; ATHEROMA; ATHEROSCLEROSIS; CELL ACTIVATION; CELL POPULATION; CONTROLLED STUDY; ENZYME SUBSTRATE; FACE INJURY; FEMALE; HUMAN; MALE; MOUSE; NONHUMAN; PERITONEUM LAVAGE; PERITONEUM MACROPHAGE; PERITONITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN WEIGHT;

ANIMALS; AORTA; APOLIPOPROTEINS E; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; ATHEROSCLEROSIS; EICOSANOIDS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; ORGAN SIZE; PERITONEAL LAVAGE; PERITONITIS; RNA, MESSENGER; SPLEEN;

MUS;

EID: 68949116297     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.000901     Document Type: Article

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