Structural flexibility of the N-terminal β-barrel domain of 15-Lipoxygenase-1 probed by small angle x-ray scattering. Functional consequences for activity regulation and membrane binding

Journal of Molecular Biology

Volumn 343, Issue 4, 2004, Pages 917-929

  Hammel, Michal ^a   Walther, Matthias ^b   Prassl, Ruth ^a   Kuhn, Hartmut ^b  

^a Institute of Biophysics and X ray S   (Austria)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

cell differentiation; eicosanoids; inflammation; reaction mechanism; structural flexibility

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ISOENZYME; LIGAND; MONOMER;

AB INITIO CALCULATION; AMINO TERMINAL SEQUENCE; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; EXPERIMENT; HYDRATION; MEMBRANE BINDING; MODEL; MOLECULE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; RABBIT; STRUCTURE ANALYSIS; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 5144223918     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.08.076     Document Type: Article

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