Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies

Journal of Medicinal Chemistry

Volumn 57, Issue 10, 2014, Pages 4035-4048

  Rai, Ganesha ^b   Joshi, Netra ^c   Jung, Joo Eun ^a   Liu, Yu ^a   Schultz, Lena ^b   Yasgar, Adam ^b   Perry, Steve ^c   Diaz, Giovanni ^c   Zhang, Qiangli ^c   Kenyon, Victor ^c   Jadhav, Ajit ^b   Simeonov, Anton ^b   Lo, Eng H ^a   Van Leyen, Klaus ^a   Maloney, David J ^b   Holman, Theodore R ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (METHYLAMINO) 2 (NAPHTHALEN 1 YL)OXAZOLE 4 CARBONITRILE; FERRIC ION; GLUTAMIC ACID; ISOENZYME; LIPOXYGENASE INHIBITOR; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL ACTIVITY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; RETICULOCYTE;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIPOXYGENASE INHIBITORS; MICE; RETICULOCYTES; STROKE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901267782     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401915r     Document Type: Article

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