12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: A new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction

Journal of Biological Chemistry

Volumn 288, Issue 22, 2013, Pages 15830-15842

  Kundumani Sridharan, Venkatesh ^a   Dyukova, Elena ^a   Hansen III, Dale E ^a   Rao, Gadiparthi N ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; AMINO ACIDS; ASCORBIC ACID; DISEASES; GENE EXPRESSION; MACROPHAGES; MAMMALS; METABOLITES; PHOSPHORYLATION;

15-LIPOXYGENASE; ARACHIDONIC ACIDS; CELL DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL-CELLS; HIGH-FAT-DIET; MACROPHAGE ADHESION; TIGHT JUNCTIONS; TYROSINE PHOSPHORYLATION; ZONULA OCCLUDENS;

ENDOTHELIAL CELLS;

15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; FOCAL ADHESION KINASE 2; PROTEIN ZO2; STEROID RECEPTOR COACTIVATOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY; ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CELL DISRUPTION; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; EX VIVO STUDY; GENE DELETION; LIPID ANALYSIS; LIPID DIET; LIPOGENESIS; MACROPHAGE MIGRATION; MOLECULAR MECHANICS; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TIGHT JUNCTION; VASCULITIS;

MUS;

EID: 84878385578     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.453290     Document Type: Article

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