Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1841, Issue 10, 2014, Pages 1538-1547

  Schröder, Mirjam ^a   Häfner, Ann Kathrin ^a   Hofmann, Bettina ^a   Rådmark, Olof ^b   Tumulka, Franz ^a   Abele, Rupert ^a   Dötsch, Volker ^a   Steinhilber, Dieter ^a  

^a GOETHE UNIVERSITY   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Aggregation; Coactosin like protein; Dicer; Differential scanning fluorimetry; Lipoxygenase; PLAT

Indexed keywords

ALPHA TOXIN; ARACHIDONATE 5 LIPOXYGENASE; CALCIUM; DICER; GLYCINE; LEUKOTRIENE; LIPOXYGENASE; POLYCYSTIN 1; TRYPTOPHAN; HYBRID PROTEIN; MICRORNA;

ARTICLE; CALCIUM BINDING; CROSS LINKING; ENZYME ANALYSIS; ENZYME ISOLATION; FLUOROMETRY; HUMAN; MEMBRANE BINDING; PRIORITY JOURNAL; THERMOSTABILITY; CATALYSIS; CELL NUCLEUS MEMBRANE; CYTOSOL; DIFFERENTIAL SCANNING CALORIMETRY; DRUG TARGETING; ENZYME ASSAY; MUTANT; NONHUMAN; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN METABOLISM; PROTEIN PURIFICATION;

EID: 84910089517     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2014.07.022     Document Type: Article

References (54)

1. O. Werz 5-Lipoxygenase: regulation and pharmacology Med. Chem. Rev. Online 1 2004 201 223
2. O. Rådmark, and B. Samuelsson Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis Biochem. Biophys. Res. Commun. 396 2010 105 110
3. S.E. Dahlén, P. Hedqvist, S. Hammarström, and B. Samuelsson Leukotrienes are potent constrictors of human bronchi Nature 288 1980 484 486 (Pubitemid 11163960)
4. M. Mehrabian, H. Allayee, J. Wong, W. Shi, X.-P. Wang, Z. Shaposhnik, C.D. Funk, A.J. Lusis, and W. Shih Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice Circ. Res. 91 2002 120 126 (Pubitemid 34827222)
5. M.P. Wasilewicz, B. Kołodziej, T. Bojułko, M. Kaczmarczyk, V. Sulzyc-Bielicka, D. Bielicki, and K. Ciepiela Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis Int. J. Colorectal Dis. 25 2010 1079 1085
6. K. Metzger, G. Angres, H. Maier, and W.D. Lehmann Lipoxygenase products in human saliva: patients with oral cancer compared to controls Free Radic. Biol. Med. 18 1995 185 194
7. Y. Chen, Y. Hu, H. Zhang, C. Peng, and S. Li Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia Nat. Genet. 41 2009 783 792
8. D. Steinhilber, and B. Hofmann Recent advances in the search for novel 5-lipoxygenase inhibitors Basic Clin. Pharmacol. Toxicol. 114 2014 70 77
9. C. Feisst, C. Pergola, M. Rakonjac, A. Rossi, A. Koeberle, G. Dodt, M. Hoffmann, C. Hoernig, L. Fischer, D. Steinhilber, L. Franke, G. Schneider, O. Rådmark, L. Sautebin, and O. Werz Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo Cell. Mol. Life Sci. 66 2009 2759 2771
10. J.M. Wisniewska, C.B. Rödl, A.S. Kahnt, E. la Buscató, S. Ulrich, Y. Tanrikulu, J. Achenbach, F. Rörsch, S. Grösch, G. Schneider, J. Cinatl, E. Proschak, D. Steinhilber, and B. Hofmann Molecular characterization of EP6 - a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor Biochem. Pharmacol. 83 2012 228 240
11. N.C. Gilbert, S.G. Bartlett, M.T. Waight, D.B. Neau, W.E. Boeglin, A.R. Brash, and M.E. Newcomer The structure of human 5-lipoxygenase Science 331 2011 217 219
12. J.C. Boyington, B.J. Gaffney, and L.M. Amzel The three-dimensional structure of an arachidonic acid 15-lipoxygenase Science 260 1993 1482 1486 (Pubitemid 23273261)
13. C.E. Naylor, M. Jepson, D.T. Crane, R.W. Titball, J. Miller, A.K. Basak, and B. Bolgiano Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin J. Mol. Biol. 294 1999 757 770
14. T. Hammarberg, P. Provost, B. Persson, and O. Rådmark The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity J. Biol. Chem. 275 2000 38787 38793 (Pubitemid 32009215)
15. S. Kulkarni, S. Das, C.D. Funk, D. Murray, and W. Cho Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase J. Biol. Chem. 277 2002 13167 13174 (Pubitemid 34952687)
16. J. Esser, M. Rakonjac, B. Hofmann, L. Fischer, P. Provost, G. Schneider, D. Steinhilber, B. Samuelsson, and O. Rådmark Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102 Biochem. J. 425 2010 265 274
17. V. Dincbas-Renqvist, G. Pépin, M. Rakonjac, I. Plante, D.L. Ouellet, A. Hermansson, I. Goulet, J. Doucet, B. Samuelsson, O. Rådmark, and P. Provost Human Dicer C-terminus functions as a 5-lipoxygenase binding domain Biochim. Biophys. Acta 1789 2009 99 108
18. Y.Y. Zhang, T. Hammarberg, O. Rådmark, B. Samuelsson, C.F. Ng, C.D. Funk, and J. Loscalzo Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences Biochem. J. 351 2000 697 707
19. C. Hörnig, D. Albert, L. Fischer, M. Hörnig, O. Rådmark, D. Steinhilber, and O. Werz 1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain J. Biol. Chem. 280 2005 26913 26921 (Pubitemid 41040726)
20. E.R. Sailer, S. Schweizer, S.E. Boden, H.P. Ammon, and H. Safayhi Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling Eur. J. Biochem. 256 1998 364 368 (Pubitemid 28404800)
21. A. Wong, M.N. Cook, J.J. Foley, H.M. Sarau, P. Marshall, and S.M. Hwang Influx of extracellular calcium is required for the membrane translocation of 5-lipoxygenase and leukotriene synthesis Biochemistry 30 1991 9346 9354
22. M.D. Percival, D. Denis, D. Riendeau, and M.J. Gresser Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions Eur. J. Biochem. 210 1992 109 117
23. M. Noguchi, M. Miyano, T. Matsumoto, and M. Noma Human 5-lipoxygenase associates with phosphatidylcholine liposomes and modulates LTA4 synthetase activity Biochim. Biophys. Acta 1215 1994 300 306
24. K.I. Skorey, and M.J. Gresser Calcium is not required for 5-lipoxygenase activity at high phosphatidyl choline vesicle concentrations Biochemistry 37 1998 8027 8034 (Pubitemid 28307063)
25. T. Hammarberg, and O. Rådmark 5-Lipoxygenase binds calcium Biochemistry 38 1999 4441 4447
26. M. Rakonjac, L. Fischer, P. Provost, O. Werz, D. Steinhilber, B. Samuelsson, and O. Rådmark Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production Proc. Natl. Acad. Sci. U. S. A. 103 2006 13150 13155 (Pubitemid 44338931)
27. P. Provost, J. Doucet, A. Stock, G. Gerisch, B. Samuelsson, and O. Rådmark Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75 Biochem. J. 359 2001 255 263 (Pubitemid 32999769)
28. P. Provost, J. Doucet, T. Hammarberg, G. Gerisch, B. Samuelsson, and O. Rådmark 5-Lipoxygenase interacts with coactosin-like protein J. Biol. Chem. 276 2001 16520 16527
29. E. Bernstein, A.A. Caudy, S.M. Hammond, and G.J. Hannon Role for a bidentate ribonuclease in the initiation step of RNA interference Nature 409 2001 363 366 (Pubitemid 32151243)
30. P. Provost, D. Dishart, J. Doucet, D. Frendewey, B. Samuelsson, and O. Rådmark Ribonuclease activity and RNA binding of recombinant human Dicer EMBO J. 21 2002 5864 5874 (Pubitemid 35315284)
31. P. Provost, B. Samuelsson, and O. Rådmark Interaction of 5-lipoxygenase with cellular proteins Proc. Natl. Acad. Sci. U. S. A. 96 1999 1881 1885 (Pubitemid 29117836)
32. Y.Y. Zhang, O. Rådmark, and B. Samuelsson Mutagenesis of some conserved residues in human 5-lipoxygenase: effects on enzyme activity Proc. Natl. Acad. Sci. U. S. A. 89 1992 485 489
33. A.A.Y. Michel, D. Steinhilber, and O. Werz Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase Protein Expr. Purif. 59 2008 110 116
34. C. Papworth, J.C. Bauer, and J. Braman Site-directed mutagenesis in one day with > 80% efficiency Strategies 9 1996 3 4
35. M. Brungs, O. Rådmark, B. Samuelsson, and D. Steinhilber Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D3 Proc. Natl. Acad. Sci. U. S. A. 92 1995 107 111
36. A.-K. Häfner, M. Cernescu, B. Hofmann, M. Ermisch, M. Hörnig, J. Metzner, G. Schneider, B. Brutschy, and D. Steinhilber Dimerization of human 5-lipoxygenase Biol. Chem. 392 2011 1097 1111
37. E. Liepinsh, M. Rakonjac, V. Boissonneault, and P. Provost NMR structure of human coactosin-like protein J. Biomol. NMR 30 2004 353 356
38. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
39. P. Eek, R. Järving, I. Järving, N.C. Gilbert, M.E. Newcomer, and N. Samel Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2 + regulation J. Biol. Chem. 287 2012 22377 22386
40. F. He, S. Hogan, R.F. Latypov, L.O. Narhi, and V.I. Razinkov High throughput thermostability screening of monoclonal antibody formulations J. Pharm. Sci. 99 2010 1707 1720
41. A.O. Pedersen, and J. Jacobsen Reactivity of the thiol group in human and bovine albumin at pH 3-9, as measured by exchange with 2,2′- dithiodipyridine Eur. J. Biochem. 106 1980 291 295
42. A.H. Pande, S. Qin, and S.A. Tatulian Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase Biophys. J. 88 2005 4084 4094 (Pubitemid 40991120)
43. M. Hammel, M. Walther, R. Prassl, and H. Kühn Structural flexibility of the N-terminal beta-barrel domain of 15-lipoxygenase-1 probed by small angle X-ray scattering. Functional consequences for activity regulation and membrane binding J. Mol. Biol. 343 2004 917 929 (Pubitemid 39345953)
44. W. Shang, I. Ivanov, D.I. Svergun, O.Y. Borbulevych, A.M. Aleem, S. Stehling, J. Jankun, H. Kühn, and E. Skrzypczak-Jankun Probing dimerization and structural flexibility of mammalian lipoxygenases by small-angle X-ray scattering J. Mol. Biol. 409 2011 654 668
45. A.M. Aleem, J. Jankun, J.D. Dignam, M. Walther, H. Kühn, D.I. Svergun, and E. Skrzypczak-Jankun Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure J. Mol. Biol. 376 2008 193 209
46. L. Fischer, D. Szellas, O. Rådmark, D. Steinhilber, and O. Werz Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors FASEB J. 17 2003 949 951
47. O. Werz, D. Szellas, M. Henseler, and D. Steinhilber Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity Mol. Pharmacol. 54 1998 445 451 (Pubitemid 28368835)
48. R.M. McMillan, and E.R. Walker Designing therapeutically effective 5-lipoxygenase inhibitors Trends Pharmacol. Sci. 13 1992 323 330
49. D. Steinhilber 5-Lipoxygenase: a target for antiinflammatory drugs revisited Curr. Med. Chem. 6 1999 71 85 (Pubitemid 29068270)
50. H. Safayhi, T. Mack, J. Sabieraj, M.I. Anazodo, L.R. Subramanian, and H.P. Ammon Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase J. Pharmacol. Exp. Ther. 261 1992 1143 1146
51. H. Safayhi, E.R. Sailer, and H.P. Ammon Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid Mol. Pharmacol. 47 1995 1212 1216
52. M.-C. Lo, A. Aulabaugh, G. Jin, R. Cowling, J. Bard, M. Malamas, and G. Ellestad Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery Anal. Biochem. 332 2004 153 159 (Pubitemid 39099482)
53. M.W. Pantoliano, E.C. Petrella, J.D. Kwasnoski, V.S. Lobanov, J. Myslik, E. Graf, T. Carver, E. Asel, B.A. Springer, P. Lane, and F.R. Salemme High-density miniaturized thermal shift assays as a general strategy for drug discovery J. Biomol. Screen. 6 2001 429 440 (Pubitemid 34052847)
54. D. Takeshita, S. Zenno, W.C. Lee, K. Nagata, K. Saigo, and M. Tanokura Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer J. Mol. Biol. 374 2007 106 120 (Pubitemid 47600229)