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Volumn 37, Issue 12, 1996, Pages 2650-2661

Oxidation of LDL by recombinant human 15-lipoxygenase: Evidence for α-tocopherol-dependent oxidation of esterified core and surface lipids

Author keywords

Antioxidants; Atherosclerosis; Lipid peroxidation; Reactive oxygen species; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ARACHIDONATE 15 LIPOXYGENASE;

EID: 0030462774     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 0024603895 scopus 로고
    • Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
    • Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum. 1989. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320: 915-924.
    • (1989) N. Engl. J. Med. , vol.320 , pp. 915-924
    • Steinberg, D.1    Parthasarathy, S.2    Carew, T.E.3    Khoo, J.C.4    Witztum, J.L.5
  • 2
    • 0025897282 scopus 로고
    • Gene expression in macrophage-rich human atherosclerotic lesions. 15-Lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts
    • Ylä-Herttuala, S., M. E. Rosenfeld, S. Parthasarathy, E. Sigal, T. Sarkioja, J. L. Witztum, and D. Steinberg. 1991. Gene expression in macrophage-rich human atherosclerotic lesions. 15-Lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts. J. Clin. Invest. 87: 1146-1152.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1146-1152
    • Ylä-Herttuala, S.1    Rosenfeld, M.E.2    Parthasarathy, S.3    Sigal, E.4    Sarkioja, T.5    Witztum, J.L.6    Steinberg, D.7
  • 3
    • 0027519515 scopus 로고
    • Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein[a]
    • Jürgens, G., Q. Chen, H. Esterbauer, S. Mair, G. Ledinski, and H. P. Dinges. 1993. Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein[a]. Arterioscler. Thromb. 13: 1689-1699.
    • (1993) Arterioscler. Thromb. , vol.13 , pp. 1689-1699
    • Jürgens, G.1    Chen, Q.2    Esterbauer, H.3    Mair, S.4    Ledinski, G.5    Dinges, H.P.6
  • 4
    • 0028321941 scopus 로고
    • A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions. Complex formation of oxidized phosphatidylcholines and polypeptides
    • Itabe, H., E. Takeshima, H. Iwasaki, J. Kimura, Y. Yoshida, T. Imanaka, and T. Takano. 1994. A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions. Complex formation of oxidized phosphatidylcholines and polypeptides. J. Biol. Chem. 269: 15274-15279.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15274-15279
    • Itabe, H.1    Takeshima, E.2    Iwasaki, H.3    Kimura, J.4    Yoshida, Y.5    Imanaka, T.6    Takano, T.7
  • 6
    • 0029932445 scopus 로고    scopus 로고
    • Presence of hypochlorite-modified proteins in human atherosclerotic lesions
    • Hazell, L. J., L. Arnold, D. Flowers, G. Waeg, E. Malle, and R. Stocker. 1996. Presence of hypochlorite-modified proteins in human atherosclerotic lesions. J. Clin. Invest. 97: 1535-1544.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1535-1544
    • Hazell, L.J.1    Arnold, L.2    Flowers, D.3    Waeg, G.4    Malle, E.5    Stocker, R.6
  • 8
  • 9
    • 0029111439 scopus 로고
    • Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques
    • Folcik, V. A., R. A. Nivar-Aristy, L. P. Krajewski, and M. K. Cathcart. 1995. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques. J. Clin. Invest. 96: 504-510.
    • (1995) J. Clin. Invest. , vol.96 , pp. 504-510
    • Folcik, V.A.1    Nivar-Aristy, R.A.2    Krajewski, L.P.3    Cathcart, M.K.4
  • 10
    • 0028292033 scopus 로고
    • Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions
    • Daugherty, A., J. L. Dunn, D. L. Rateri, and J. W. Heinecke. 1994. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J. Clin. Invest. 94: 437-444.
    • (1994) J. Clin. Invest. , vol.94 , pp. 437-444
    • Daugherty, A.1    Dunn, J.L.2    Rateri, D.L.3    Heinecke, J.W.4
  • 11
    • 0025076921 scopus 로고
    • Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions
    • Ylä-Herttuala, S., M. E. Rosenfeld, S. Parthasarathy, C. K. Glass, E. Sigal, J. L. Witztum, and D. Steinberg. 1990. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc. Natl. Acad. Sci. USA. 87: 6959-6963.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6959-6963
    • Ylä-Herttuala, S.1    Rosenfeld, M.E.2    Parthasarathy, S.3    Glass, C.K.4    Sigal, E.5    Witztum, J.L.6    Steinberg, D.7
  • 13
    • 0029151215 scopus 로고
    • Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase
    • Ezaki, M., J. L. Witztum, and D. Steinberg. 1995. Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase. J. Lipid Res. 36: 1996-2004.
    • (1995) J. Lipid Res. , vol.36 , pp. 1996-2004
    • Ezaki, M.1    Witztum, J.L.2    Steinberg, D.3
  • 14
    • 0029013214 scopus 로고
    • Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein
    • Ylä-Herttuala, S., J. Luoma, H. Viita, T. Hiltunen, T. Sisto, and T. Nikkari. 1995. Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein. J. Clin. Invest. 95: 2692-2698.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2692-2698
    • Ylä-Herttuala, S.1    Luoma, J.2    Viita, H.3    Hiltunen, T.4    Sisto, T.5    Nikkari, T.6
  • 15
    • 0011172276 scopus 로고
    • A role for endothelial cell lipoxygenase in the oxidative modification of low-density lipoprotein
    • Parthasarathy, S., E. Wieland, and D. Steinberg. 1989. A role for endothelial cell lipoxygenase in the oxidative modification of low-density lipoprotein. Proc. Natl. Acad. Sci. USA. 86: 1046-1050.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1046-1050
    • Parthasarathy, S.1    Wieland, E.2    Steinberg, D.3
  • 18
    • 0028076349 scopus 로고
    • Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities
    • Kühn, H., J. Belkner, H. Suzuki, and S. Yamamoto. 1994. Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities. J. Lipid Res. 35: 1749-1759.
    • (1994) J. Lipid Res. , vol.35 , pp. 1749-1759
    • Kühn, H.1    Belkner, J.2    Suzuki, H.3    Yamamoto, S.4
  • 20
    • 0025084538 scopus 로고
    • Oxygenation of biological membranes by the pure reticulocyte lipoxygenase
    • Kühn, H., J. Belkner, R. Wiesner, and A. R. Brash. 1990. Oxygenation of biological membranes by the pure reticulocyte lipoxygenase. J. Biol. Chem. 265: 18351-18361.
    • (1990) J. Biol. Chem. , vol.265 , pp. 18351-18361
    • Kühn, H.1    Belkner, J.2    Wiesner, R.3    Brash, A.R.4
  • 21
    • 0026017421 scopus 로고
    • The oxygenation of cholesterol esters by the reticulocyte lipoxygenase
    • Belkner J., R. Wiesner, H. Kühn, and V. Z. Lankin. 1991. The oxygenation of cholesterol esters by the reticulocyte lipoxygenase. FEBS Lett. 279: 110-114.
    • (1991) FEBS Lett. , vol.279 , pp. 110-114
    • Belkner, J.1    Wiesner, R.2    Kühn, H.3    Lankin, V.Z.4
  • 22
    • 0026460826 scopus 로고
    • Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant
    • Bowry, V. W., K. U. Ingold, and R. Stocker. 1992. Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant. Biochem. J. 288: 341-344.
    • (1992) Biochem. J. , vol.288 , pp. 341-344
    • Bowry, V.W.1    Ingold, K.U.2    Stocker, R.3
  • 23
    • 0027213625 scopus 로고
    • Tocopherol-mediated peroxidation. The pro-oxidant effect of vitamin e on the radical-initiated oxidation of human low-density lipoprotein
    • Bowry, V. W., and R. Stocker. 1993. Tocopherol-mediated peroxidation. The pro-oxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein. J. Am. Chem. Soc. 115: 6029-6040.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 6029-6040
    • Bowry, V.W.1    Stocker, R.2
  • 24
    • 0028791912 scopus 로고
    • Inverse deuterium kinetic isotope effect for peroxidation in human low-density lipoprotein (LDL): A simple test for tocopherol-mediated peroxidation of LDL lipids
    • Witting, P. K., V. W. Bowry, and R. Stocker. 1995. Inverse deuterium kinetic isotope effect for peroxidation in human low-density lipoprotein (LDL): a simple test for tocopherol-mediated peroxidation of LDL lipids. FEBS Lett. 375: 45-49.
    • (1995) FEBS Lett. , vol.375 , pp. 45-49
    • Witting, P.K.1    Bowry, V.W.2    Stocker, R.3
  • 25
    • 0029878284 scopus 로고    scopus 로고
    • Co-supplementation with coenzyme Q prevents the pro-oxidant effect of α-tocopherol and increases the resistance of LDL towards transition metal-dependent oxidation initiation
    • Thomas, S. R., J. Neuzil, and R. Stocker. 1996. Co-supplementation with coenzyme Q prevents the pro-oxidant effect of α-tocopherol and increases the resistance of LDL towards transition metal-dependent oxidation initiation. Arterioscl. Thromb. Vasc. Biol. 16: 687-696.
    • (1996) Arterioscl. Thromb. Vasc. Biol. , vol.16 , pp. 687-696
    • Thomas, S.R.1    Neuzil, J.2    Stocker, R.3
  • 26
    • 0028915679 scopus 로고
    • Prevention of tocopherol-mediated peroxidation of ubiquinol-10-free human low density lipoprotein
    • Bowry, V. W., D. Mohr, J. Cleary, and R. Stocker. 1995. Prevention of tocopherol-mediated peroxidation of ubiquinol-10-free human low density lipoprotein. J. Biol. Chem. 270: 5756-5763.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5756-5763
    • Bowry, V.W.1    Mohr, D.2    Cleary, J.3    Stocker, R.4
  • 28
    • 0020510516 scopus 로고
    • Controlled synthesis of monohydroperoxides by α-tocopherol inhibited autoxidation of polyunsaturated lipids
    • Peers, K. E., and D. T. Coxon. 1983. Controlled synthesis of monohydroperoxides by α-tocopherol inhibited autoxidation of polyunsaturated lipids. Chem. Phys. Lipids 32: 49-56.
    • (1983) Chem. Phys. Lipids , vol.32 , pp. 49-56
    • Peers, K.E.1    Coxon, D.T.2
  • 29
    • 0028239166 scopus 로고
    • Rapid isolation of lipoproteins and assessment of their peroxidation by HPLC postcolumn chemiluminescence
    • Sattler, W., D. Mohr, and R. Stocker. 1994. Rapid isolation of lipoproteins and assessment of their peroxidation by HPLC postcolumn chemiluminescence. Methods Enzymol. 233: 469-489.
    • (1994) Methods Enzymol. , vol.233 , pp. 469-489
    • Sattler, W.1    Mohr, D.2    Stocker, R.3
  • 31
    • 0027464942 scopus 로고
    • Impaired discrimination between stereoisomers of alpha-tocopherol in patients with familial isolated vitamin e deficiency
    • Traber, M. G., R. J. Sokol, A. Kohlschütter, T. Yokota, D. P. Muller, R. Dufour, and H. J. Kayden. 1993. Impaired discrimination between stereoisomers of alpha-tocopherol in patients with familial isolated vitamin E deficiency. J. Lipid Res. 34: 201-210.
    • (1993) J. Lipid Res. , vol.34 , pp. 201-210
    • Traber, M.G.1    Sokol, R.J.2    Kohlschütter, A.3    Yokota, T.4    Muller, D.P.5    Dufour, R.6    Kayden, H.J.7
  • 32
    • 0028120302 scopus 로고
    • Human plasma LDL cryopreserved with sucrose maintains in vivo kinetics indistinguishable from freshly isolated human LDL in cynomolgus monkeys
    • Rumsey, S. C., A. F. Stucchi, R. J. Nicolosi, H. N. Ginsberg, R. Ramakrishnan, and R. J. Deckelbaum. 1994. Human plasma LDL cryopreserved with sucrose maintains in vivo kinetics indistinguishable from freshly isolated human LDL in cynomolgus monkeys. J. Lipid Res. 35: 1592-1598.
    • (1994) J. Lipid Res. , vol.35 , pp. 1592-1598
    • Rumsey, S.C.1    Stucchi, A.F.2    Nicolosi, R.J.3    Ginsberg, H.N.4    Ramakrishnan, R.5    Deckelbaum, R.J.6
  • 33
    • 0030641128 scopus 로고    scopus 로고
    • Requirement for, promotion, or inhibition of radical-induced initiation of plasma lipoprotein lipid peroxidation
    • In press
    • Neuzil, J., S. R. Thomas, and R. Stocker. 1996. Requirement for, promotion, or inhibition of radical-induced initiation of plasma lipoprotein lipid peroxidation. Free Radical Biol. Med. In press.
    • (1996) Free Radical Biol. Med.
    • Neuzil, J.1    Thomas, S.R.2    Stocker, R.3
  • 35
    • 0023112020 scopus 로고
    • Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography
    • Yamamoto, Y., M. H. Brodsky, J. C. Baker, and B. N. Ames. 1987. Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography. Anal. Biochem. 160: 7-13.
    • (1987) Anal. Biochem. , vol.160 , pp. 7-13
    • Yamamoto, Y.1    Brodsky, M.H.2    Baker, J.C.3    Ames, B.N.4
  • 36
    • 0029129908 scopus 로고
    • Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of α-tocopherol and ascorbate
    • Suarna, C., R. T. Dean, J. May, and R. Stocker. 1995. Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of α-tocopherol and ascorbate. Arterioscler. Thromb. Vasc. Biol. 15: 1616-1624.
    • (1995) Arterioscler. Thromb. Vasc. Biol. , vol.15 , pp. 1616-1624
    • Suarna, C.1    Dean, R.T.2    May, J.3    Stocker, R.4
  • 37
    • 0028293275 scopus 로고
    • Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells
    • Thomas, C. E., R. L. Jackson, D. F. Ohlweiler, and G. Ku. 1994. Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells. J. Lipid Res. 35: 417-427.
    • (1994) J. Lipid Res. , vol.35 , pp. 417-427
    • Thomas, C.E.1    Jackson, R.L.2    Ohlweiler, D.F.3    Ku, G.4
  • 38
    • 0026657363 scopus 로고
    • The role of lipid peroxidation and antioxidants in oxidative modification of LDL
    • Esterbauer, H., J. Gebicki, H. Puhl, and G. Jürgens. 1992. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radical Biol. Med. 13: 341-390.
    • (1992) Free Radical Biol. Med. , vol.13 , pp. 341-390
    • Esterbauer, H.1    Gebicki, J.2    Puhl, H.3    Jürgens, G.4
  • 39
    • 9544238226 scopus 로고    scopus 로고
    • Radical-initiated lipid peroxidation in low density lipoproteins: Insights obtained from kinetic modeling
    • Waldeck, A. R., and R. Stocker. 1996. Radical-initiated lipid peroxidation in low density lipoproteins: insights obtained from kinetic modeling. Chem. Res. Toxicol. 9: 954-964.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 954-964
    • Waldeck, A.R.1    Stocker, R.2
  • 40
    • 0025219139 scopus 로고
    • Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related
    • Sigal, E., D. Grunberger, E. Highland, C. Gross, R. A. F. Dixon, and C. S. Craik. 1990. Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related. J. Biol. Chem. 265: 5113-5120.
    • (1990) J. Biol. Chem. , vol.265 , pp. 5113-5120
    • Sigal, E.1    Grunberger, D.2    Highland, E.3    Gross, C.4    Dixon, R.A.F.5    Craik, C.S.6
  • 41
    • 0023701424 scopus 로고
    • The influence of the triglyceride content of low density lipoprotein on the interaction of apolipoprotein B-100 with cells
    • Aviram, M., S. Lund-Katz, M. C. Phillips, and A. Chait. 1988. The influence of the triglyceride content of low density lipoprotein on the interaction of apolipoprotein B-100 with cells. J. Biol. Chem. 263: 16842-16848.
    • (1988) J. Biol. Chem. , vol.263 , pp. 16842-16848
    • Aviram, M.1    Lund-Katz, S.2    Phillips, M.C.3    Chait, A.4
  • 44
    • 0022503366 scopus 로고
    • Enzymology and physiology of reticulocyte lipoxygenase: Comparison with other lipoxygenases
    • Schewe, T., S. M. Rapoport, and H. Kühn. 1986. Enzymology and physiology of reticulocyte lipoxygenase: comparison with other lipoxygenases. Adv. Enzymol. Rel. Areas Mol. Biol. 58: 191-272.
    • (1986) Adv. Enzymol. Rel. Areas Mol. Biol. , vol.58 , pp. 191-272
    • Schewe, T.1    Rapoport, S.M.2    Kühn, H.3
  • 45
    • 0027246677 scopus 로고
    • The three-dimensional structure of an arachidonic acid 15-lipoxygenase
    • Boyington, J. C., B. J. Gaffney, and L. M. Amzel. 1993. The three-dimensional structure of an arachidonic acid 15-lipoxygenase. Science. 260: 1482-1486.
    • (1993) Science , vol.260 , pp. 1482-1486
    • Boyington, J.C.1    Gaffney, B.J.2    Amzel, L.M.3
  • 46
    • 33847084963 scopus 로고
    • Autoxidation of polyunsaturated lipids. Factors controlling the stereochemistry of product hydroperoxides
    • Porter, N. A., B. A. Weber, H. Weenen, and J. A. Khan. 1980. Autoxidation of polyunsaturated lipids. Factors controlling the stereochemistry of product hydroperoxides. J. Am. Chem. Soc. 102: 5597-5601.
    • (1980) J. Am. Chem. Soc. , vol.102 , pp. 5597-5601
    • Porter, N.A.1    Weber, B.A.2    Weenen, H.3    Khan, J.A.4
  • 47
    • 0030008434 scopus 로고    scopus 로고
    • Identification and quantification of the regioisomeric cholesteryl linoleate hydroperoxides in oxidized human low density lipoprotein and high density lipoprotein
    • Kenar, J. A., C. M. Havrilla, N. A. Porter, J. R. Guyton, S. A. Brown, K. F. Klemp, and E. Selinger. 1996. Identification and quantification of the regioisomeric cholesteryl linoleate hydroperoxides in oxidized human low density lipoprotein and high density lipoprotein. Chem. Res. Toxicol. 9: 737-744.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 737-744
    • Kenar, J.A.1    Havrilla, C.M.2    Porter, N.A.3    Guyton, J.R.4    Brown, S.A.5    Klemp, K.F.6    Selinger, E.7
  • 48
    • 0024820007 scopus 로고
    • Lipid peroxyl radical intermediates in the peroxidation of polyunsaturated fatty acids by lipoxygenase. Direct electron spin resonance investigations
    • Chamulitrat, W., and R. P. Mason. 1989. Lipid peroxyl radical intermediates in the peroxidation of polyunsaturated fatty acids by lipoxygenase. Direct electron spin resonance investigations. J. Biol. Chem. 264: 20968-20973.
    • (1989) J. Biol. Chem. , vol.264 , pp. 20968-20973
    • Chamulitrat, W.1    Mason, R.P.2
  • 49
    • 0023369326 scopus 로고
    • Studies on the metalion and lipoxygenase-catalysed breakdown of hydroperoxides using electron-spin-resonance spectroscopy
    • Davies, M. J., and T. F. Slater. 1987. Studies on the metalion and lipoxygenase-catalysed breakdown of hydroperoxides using electron-spin-resonance spectroscopy. Biochem. J. 245: 167-173.
    • (1987) Biochem. J. , vol.245 , pp. 167-173
    • Davies, M.J.1    Slater, T.F.2
  • 50
    • 0029985683 scopus 로고    scopus 로고
    • A rapid and simple screening test for potential inhibitors of tocopherol-mediated peroxidation of LDL lipids
    • Witting, P. K., C. Westerlund, and R. Stocker. 1996. A rapid and simple screening test for potential inhibitors of tocopherol-mediated peroxidation of LDL lipids. J. Lipid Res. 37: 853-867.
    • (1996) J. Lipid Res. , vol.37 , pp. 853-867
    • Witting, P.K.1    Westerlund, C.2    Stocker, R.3


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