Transient experimental anemia in cholesterol-fed rabbits induces systemic overexpression of the reticulocyte-type 15-lipoxygenase and protects from aortic lipid deposition

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 67, Issue 6, 2002, Pages 419-428

  Trebus, F ^a   Heydeck, D ^a   Schimke, I ^a   Gerth, C ^a   Kühn, Hartmut ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; CHOLESTEROL;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; AORTA WALL; ARTICLE; ATHEROGENESIS; CHOLESTEROL INTAKE; CONTROLLED STUDY; GENE OVEREXPRESSION; LIPID STORAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETICULOCYTE; ANIMAL; AORTA; BLOOD; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; FEMALE; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; METABOLISM; MONOCYTE; RABBIT;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ANEMIA; ANIMALS; AORTA; ARACHIDONATE 15-LIPOXYGENASE; CHOLESTEROL, DIETARY; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; FEMALE; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; MONOCYTES; RABBITS;

EID: 0036893747     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1054/plef.2002.0452     Document Type: Article

References (31)

1. Holvoet P., Collen C. Oxidized lipoproteins in atherosclerosis and thrombosis. FASEB J 1994; 8: 1284-1297.
2. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997; 272: 20963-20966.
3. Chisolm G. M., Steinberg D. The oxidative modification hypothesis of atherogenesis: An overview. Free Radic Biol Med 2000; 28: 1815-1826.
4. Steinberg D. At last direct evidence that lipoxygenases play a role in atherogenesis. J Clin Invest 1999; 103: 1487-1488.
5. Kühn H., Chan L. The role of 15-lipoxygenase in atherogenesis. Pro- and/or anti-atherogenic action. Curr Opin Lipidol 1997; 8: 111-117.
6. Cathcart M. K., Folcik V. A. Lipoxygenases and atherogenesis: Protection versus pathogenesis. Free Rad Biol Med 2000; 28: 1726-1734.
7. Henriksson P., Hamberg M., Diczfalusy U. Formtion of 15-HETE as a major hydroxeicosatetraenoic acid in the atherosclerotic vessel wall. Biochim Biophys Acta 1985; 834: 272-274.
8. Yla-Herttuala S., Rosenfeld M. E., Parthasarathy S., Glass C. K., Sigal E., Witztum J. T., Steinberg D. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc Natl Acad Sci USA 1990; 87: 6959-6963.
9. Hugou I., Blin P., Henri J., Daret D. Larrue J. 15-lipoxygenase expression in smooth muscle cells from atherosclerotic rabbit aorta. Atherosclerosis 1995; 113: 189-195.
10. Hiltunen Z, Luoma J., Nikkari T., Ylä-Herttuala S. Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions. Circulation 1995; 92: 3297-3303.
11. Ylä-Herttuala S., Luoma L., Viita H., Hiltunen T., Nikkari T. Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearence of oxidation-specific lipid protein adducts characteristic of oxidized low density lipoprotein. J Clin Invest 1995; 95: 2692-2698.
12. Sendobry S. M., Cornicelli J. A., Welch K., Bocan T., Tait B., Trivedi B. K., Colbry N., Dyer R. D., Feinmark S. J., Daugherty A. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol 1997; 20: 1199-1206.
13. Kühn H. Belkner J., Zaiss S., Fährenklemper T., Wohlfeil S. Involvement of 15-lipoxygenase in early stages of atherogenesis. J Exp Med 1994; 179: 1903-1911.
14. Sun D., Funk C. D. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. J Biol Chem 1996; 271: 24055-24062.
15. Cyrus T., Witztum J. L., Rader D. J., Tangirala R., Fazio S., Linton M. F., Funk C .D. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice. J Clin Invest 1999; 103: 1597-1604.
16. Cyrus T., Pratico D., Zhao L., Witztum J. L., Rader D. J., Rokach J., FitzGerald G. A., Funk C. D. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation 2001; 103: 2277-2282.
17. George J., Afek A., Shaish A., Levkovitz H., Bloom N., Cyrus T., Zhao L., Funk C. D., Sigal E., Harats D. 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice. Circulation 2001; 104: 1646-1650.
18. Harats D., Kurihara H., Belloni P., Oakley H., Zoiber A., Ackley D., Cain G., Kurihara Y., Lawn R., Sigal E. Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promotor. J Clin Invest 1995; 95: 1335-1344.
19. Harats D., Kurihara H., Levkovitz H., Shaish A. S., Sigal E. 15-lipoxygenase overexpression induces atherosclerosis in LDL receptor deficient mice. Atherosclerosis 1997; 134: 279.
20. Shen J., Kühn H., Petho-Schramm A., Chan L. Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promotor: Macrophage-specific expression and variable positional specificity of the transgenic enzyme. FASEB J 1995; 9: 1623-1631.
21. Shen J., Herderick E., Cornhill F., Zsigmond E., Kim H. S., Kühn H., Guevara N. V., Chan L. Macrophage-mediated 15-lipoxygernase expression protects against atherosclerosis development. J Clin Invest 1996; 98: 2201-2208.
22. Conrad D. J., Kühn H., Mulkins M., Highland E., Sigal E. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc Natl Acad Sci USA 1992; 89: 217-221.
23. Bligh E. G., Dyer W. J. A rapid method of total lipid extraction and purification. Can J Biochem Biophysiol 1959; 37: 911-917.
24. Berger M., Schwarz K., Thiele H., Reimann I., Huth A., Borngräber S., Kühn H., Thiele B. J. Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits. J Mol Biol 1998; 278: 933-946.
25. Rapoport S. M., Schewe T., Wiesner R., Halangk W., Ludwig P., Janicke-Höhne M., Tannert C., Hiebsch C., Klatt D. The lipoxygenase of reticulocytes. Purification, characterization and biologial dynamics of the lipoxygenase, its identity with the respiratory inhibitors of reticulocytes. Eur J Biochem 1979; 96: 545-561.
26. Belkner J., Stender H., Kühn H. The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E. J Biol Chem 1998; 273: 23225-23232.
27. Schaefer A., Magocsi M., Marquardt H. Signalling mechanisms in erythropoiesis: The enigmatic role of calcium. Cell Signal 1997; 9: 483-495.
28. Folcik V. A., Nivar-Aristy R. A., Krajewski L. P., Cathcardt M. K. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques. J Clin Invest 1995; 96: 504-510.
29. Kühn H., Heydeck D., Hugou I., Gniwotta C. The in vivo action of 15-lipoxygenase in early stages of human atherogenesis. J Clin Invest 1997; 99: 888-893.
30. Paul A., Calleja L., Vilella E., Martinez R., Osada J., Jove J. Reduced progression of atherosclerosis in apolipoprotein-e deficient mice with phenylhydrazine-induced anemia. Atherosclerosis 1999; 147: 61-68.
31. Kinuta M., Matteson J. L., Itano H. A. Difference in rates of the reaction of various mammalian oxyhemoglobins with phenylhydrazine. Arch Toxicol 1995; 69: 212-214.