Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 33, 2007, Pages 13319-13324

  Saam, Jan ^a   Ivanov, Igor ^a   Walther, Matthias ^a   Holzhütter, Hermann Georg ^a   Kuhn, Hartmut ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Free energy; Lipid peroxidation; Oxygen channel; Oxygen diffusion; Oxygenases

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; OXYGEN;

ARTICLE; CATALYSIS; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME MECHANISM; HYDROGEN BOND; LIPID PEROXIDATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; OXYGEN DIFFUSION; PRIORITY JOURNAL; REACTION ANALYSIS; SITE DIRECTED MUTAGENESIS;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONIC ACID; BINDING SITES; CATALYTIC DOMAIN; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; OXYGEN; RABBITS;

EID: 34548060346     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702401104     Document Type: Article

References (32)

1. Calhoun DB, Vanderkooi JM, Woodrow III GW, Englander SW (1983) Biochemistry 22:1526-1532.
2. Lario PI, Sampson N, Vrielink A (2003) J Mol Biol 326:1635-1650.
3. Koutsoupakis K, Stavrakis S, Soulimane T, Varotsis C (2003) J Biol Chem 278:14893-14896.
4. Brunori M, Cutruzzola F, Savino C, Travaglini-Allocatelli C, Vallone B, Gibson QH (1999) Biophys J 76:1259-1269.
5. Tilton RF, Kuntz ID, Petsko G (1984) Biol Cyber 23:2849-2857.
6. Cohen J, Arkhipov A, Braun R, Schulten K (2006) Biophys J 91:1844-1857.
7. Brash AR (1999) J Biol Chem 274:23679-23682.
8. Feussner I, Wasternack K (2002) Annu Rev Plant Biol 53:275-297.
9. Funk CD (2001) Science 294:1871-1875.
10. van Leyen K, Duvoisin RM, Engelhardt H, Wiedmann M (1998) Nature 395:392-395.
11. Kuhn H, Römisch I, Belkner J (2005) Mol Nutr Food Res 49:1014-1029.
12. Kuhn H, O'Donnel V (2006) Prog Lipid Res 45:334-356.
13. Boyington JC, Gaffney BC, Amzel LM (1993) Science 260:1482-1486.
14. Minor W, Steczko J, Stec B, Otwinowski Z, Bolin JT, Walter R, Axelrod B (1996) Biochemistry 35:10687-10701.
15. Knapp MJ, Seebeck FP, Klinman JP (2001) J Am Chem Soc 123:2931-2932.
16. Knapp MJ, Klinman JP (2003) Biochemistry 42:11466-11475.
17. Gillmor SA, Villasenor A, Fletterick R, Sigal E, Browner MF (1997) Nat Struct Biol 4:1003-1009.
18. Nelson MJ, Seitz SP (1994) Curr Opin Struct Biol 4:878-884.
19. Schneider C, Pratt DA, Porter NA, Brash AR (2007) Chem Biol 14:473-488.
20. Juranek I, Suzuki H, Yamamoto S (1999) Biochim Biophys Acta 1436:509-518.
21. Furse KE, Pratt DA, Schneider C, Brash AR, Porter NA, Lybrand TP (2006) Biochemistry 45:3206-3218.
22. Egmond MR, Veldinkand GA, Vliegenthart JF, Boldingh J (1973) Biochem Biophys Res Commun 54:1178-1184.
23. Li R, Klinman JP, Matthews FS (1998) Structure (London) 6:293-307.
24. Coulombe R, Yue KQ, Ghisla S, Vrielink A (2001) J Biol Chem 276:30435-30441.
25. Riistama S, Puustinen A, García-Horsman A, Iwata S, Michel H, Wikström M (1996) Biochim Biophys Acta 1275:1-4.
26. Hofacker I, Schulten K (1998) Proteins Struct Funct Gen 30:100-107.
27. Humphrey W, Dalke A, Schulten K (1996) J Mol Graphics 14:33-38.
28. Kuhn H, Saam J, Eibach S, Holzhütter HG, Ivanov I, Walther M (2005) Biochem Biophys Res Commun 338:93-101.
29. Gan QF, Browner MF, Sloane DL, Sigal E (1996) J Biol Chem 271:25412-25418.
30. Kale L, Skeel R, Bhandarkar M, Brunner R, Gursoy A, Krawetz N, Phillips J, Shinozaki A, Varadarajan K, Schulten K (1999) J Comp Phys 151:283-312.
31. MacKerell AD, Jr, Bashford D, Bellott M, Dunbrack RL, Jr, Evanseck JD, Field MJ, Fischer S, Gao J, Guo H, Ha S, et al. (1998) J Phys Chem B 102:3586-3616.
32. Ivanov I, Saam J, Kuhn H, Holzhütter H (2005) FEBS J 272:2523-2535.