-
1
-
-
33847250395
-
Mouse and rat BDNF gene structure and expression revisited
-
Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T (2007) Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85:525-535
-
(2007)
J Neurosci Res
, vol.85
, pp. 525-535
-
-
Aid, T.1
Kazantseva, A.2
Piirsoo, M.3
Palm, K.4
Timmusk, T.5
-
2
-
-
84879867061
-
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome
-
Aiuti A, Biasco L, Scaramuzza S, Ferrua F, Cicalese MP, Baricordi C, Dionisio F, Calabria A, Giannelli S, Castiello MC, Bosticardo M, Evangelio C, Assanelli A, Casiraghi M, Di Nunzio S, Callegaro L, Benati C, Rizzardi P, Pellin D, Di Serio C, Schmidt M, Von Kalle C, Gardner J, Mehta N, Neduva V, Dow DJ, Galy A, Miniero R, Finocchi A, Metin A, Banerjee PP, Orange JS, Galimberti S, Valsecchi MG, Biffi A, Montini E, Villa A, Ciceri F, Roncarolo MG, Naldini L (2013) Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science 341(6148):1233151
-
(2013)
Science
, vol.341
, Issue.6148
, pp. 1233151
-
-
Aiuti, A.1
Biasco, L.2
Scaramuzza, S.3
Ferrua, F.4
Cicalese, M.P.5
Baricordi, C.6
Dionisio, F.7
Calabria, A.8
Giannelli, S.9
Castiello, M.C.10
Bosticardo, M.11
Evangelio, C.12
Assanelli, A.13
Casiraghi, M.14
Di Nunzio, S.15
Callegaro, L.16
Benati, C.17
Rizzardi, P.18
Pellin, D.19
Di Serio, C.20
Schmidt, M.21
Von Kalle, C.22
Gardner, J.23
Mehta, N.24
Neduva, V.25
Dow, D.J.26
Galy, A.27
Miniero, R.28
Finocchi, A.29
Metin, A.30
Banerjee, P.P.31
Orange, J.S.32
Galimberti, S.33
Valsecchi, M.G.34
Biffi, A.35
Montini, E.36
Villa, A.37
Ciceri, F.38
Roncarolo, M.G.39
Naldini, L.40
more..
-
3
-
-
25444453003
-
Association between BDNF Val66Met polymorphism and age at onset in Huntington disease
-
Alberch J, Lopez M, Badenas C, Carrasco JL, Mila M, Munoz E, Canals JM (2005) Association between BDNF Val66Met polymorphism and age at onset in Huntington disease. Neurology 65:964-965
-
(2005)
Neurology
, vol.65
, pp. 964-965
-
-
Alberch, J.1
Lopez, M.2
Badenas, C.3
Carrasco, J.L.4
Mila, M.5
Munoz, E.6
Canals, J.M.7
-
4
-
-
77949351649
-
Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS
-
Alcala-Barraza SR, Lee MS, Hanson LR, McDonald AA, Frey WH 2nd, McLoon LK (2010) Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS. J Drug Target 18:179-190
-
(2010)
J Drug Target
, vol.18
, pp. 179-190
-
-
Alcala-Barraza, S.R.1
Lee, M.S.2
Hanson, L.R.3
McDonald, A.A.4
Frey, W.H.5
McLoon, L.K.6
-
5
-
-
1842334441
-
Anterograde transport of brain-derived neurotrophic factor and its role in the brain
-
Altar CA, Cai N, Bliven T, Juhasz M, Conner JM, Acheson AL, Lindsay RM, Wiegand SJ (1997) Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 389:856-860
-
(1997)
Nature
, vol.389
, pp. 856-860
-
-
Altar, C.A.1
Cai, N.2
Bliven, T.3
Juhasz, M.4
Conner, J.M.5
Acheson, A.L.6
Lindsay, R.M.7
Wiegand, S.J.8
-
6
-
-
49549088134
-
CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice
-
Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S, Cattaneo E, Marsh JL, Thompson LM (2008) CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice. Mol Cell Neurosci 39:8-20
-
(2008)
Mol Cell Neurosci
, vol.39
, pp. 8-20
-
-
Apostol, B.L.1
Simmons, D.A.2
Zuccato, C.3
Illes, K.4
Pallos, J.5
Casale, M.6
Conforti, P.7
Ramos, C.8
Roarke, M.9
Kathuria, S.10
Cattaneo, E.11
Marsh, J.L.12
Thompson, L.M.13
-
7
-
-
13244279859
-
Tissue transglutaminase contributes to disease progression in the R6/2 Huntington’s disease mouse model via aggregate-independent mechanisms
-
Bailey CD, Johnson GV (2005) Tissue transglutaminase contributes to disease progression in the R6/2 Huntington’s disease mouse model via aggregate-independent mechanisms. J Neurochem 92:83-92
-
(2005)
J Neurochem
, vol.92
, pp. 83-92
-
-
Bailey, C.D.1
Johnson, G.V.2
-
8
-
-
2442506955
-
Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor
-
Baquet ZC, Gorski JA, Jones KR (2004) Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. J Neurosci 24:4250-4258
-
(2004)
J Neurosci
, vol.24
, pp. 4250-4258
-
-
Baquet, Z.C.1
Gorski, J.A.2
Jones, K.R.3
-
9
-
-
84864321286
-
BDNF control of adult SVZ neurogenesis
-
Bath KG, Akins MR, Lee FS (2012) BDNF control of adult SVZ neurogenesis. Dev Psychobiol 54 (6):578-589. doi:10.1002/dev.20546
-
(2012)
Dev Psychobiol
, vol.54
, Issue.6
, pp. 578-589
-
-
Bath, K.G.1
Akins, M.R.2
Lee, F.S.3
-
10
-
-
4544335687
-
The N-methyl-D-aspartate antagonist memantine retards progression of Huntington’s disease
-
Beister A, Kraus P, Kuhn W, Dose M, Weindl A, Gerlach M (2004) The N-methyl-D-aspartate antagonist memantine retards progression of Huntington’s disease. J Neural Transm Suppl (68):117-22
-
(2004)
J Neural Transm Suppl
, Issue.68
, pp. 117-122
-
-
Beister, A.1
Kraus, P.2
Kuhn, W.3
Dose, M.4
Weindl, A.5
Gerlach, M.6
-
11
-
-
0033544840
-
Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington’s disease, as demonstrated by adenoviral gene transfer
-
Bemelmans AP, Horellou P, Pradier L, Brunet I, Colin P, Mallet J (1999) Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington’s disease, as demonstrated by adenoviral gene transfer. Hum Gene Ther 10:2987-2997
-
(1999)
Hum Gene Ther
, vol.10
, pp. 2987-2997
-
-
Bemelmans, A.P.1
Horellou, P.2
Pradier, L.3
Brunet, I.4
Colin, P.5
Mallet, J.6
-
12
-
-
84877740982
-
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis
-
Ben M’Barek K, Pla P, Orvoen S, Benstaali C, Godin JD, Gardier AM, Saudou F, David DJ, Humbert S (2013) Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis. J Neurosci 33:8608-8620
-
(2013)
J Neurosci
, vol.33
, pp. 8608-8620
-
-
Ben M’Barek, K.1
Pla, P.2
Orvoen, S.3
Benstaali, C.4
Godin, J.D.5
Gardier, A.M.6
Saudou, F.7
David, D.J.8
Humbert, S.9
-
13
-
-
84878847875
-
Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington’s disease
-
Benraiss A, Toner MJ, Xu Q, Bruel-Jungerman E, Rogers EH, Wang F, Economides AN, Davidson BL, Kageyama R, Nedergaard M, Goldman SA (2013) Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington’s disease. Cell Stem Cell 12:787-799
-
(2013)
Cell Stem Cell
, vol.12
, pp. 787-799
-
-
Benraiss, A.1
Toner, M.J.2
Xu, Q.3
Bruel-Jungerman, E.4
Rogers, E.H.5
Wang, F.6
Economides, A.N.7
Davidson, B.L.8
Kageyama, R.9
Nedergaard, M.10
Goldman, S.A.11
-
14
-
-
84879873039
-
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy
-
Biffi A, Montini E, Lorioli L, Cesani M, Fumagalli F, Plati T, Baldoli C, Martino S, Calabria A, Canale S, Benedicenti F, Vallanti G, Biasco L, Leo S, Kabbara N, Zanetti G, Rizzo WB, Mehta NA, Cicalese MP, Casiraghi M, Boelens JJ, Del Carro U, Dow DJ, Schmidt M, Assanelli A, Neduva V, Di Serio C, Stupka E, Gardner J, von Kalle C, Bordignon C, Ciceri F, Rovelli A, Roncarolo MG, Aiuti A, Sessa M, Naldini L (2013) Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy. Science 341(6148):1233158
-
(2013)
Science
, vol.341
, Issue.6148
, pp. 1233158
-
-
Biffi, A.1
Montini, E.2
Lorioli, L.3
Cesani, M.4
Fumagalli, F.5
Plati, T.6
Baldoli, C.7
Martino, S.8
Calabria, A.9
Canale, S.10
Benedicenti, F.11
Vallanti, G.12
Biasco, L.13
Leo, S.14
Kabbara, N.15
Zanetti, G.16
Rizzo, W.B.17
Mehta, N.A.18
Cicalese, M.P.19
Casiraghi, M.20
Boelens, J.J.21
Del Carro, U.22
Dow, D.J.23
Schmidt, M.24
Assanelli, A.25
Neduva, V.26
Di Serio, C.27
Stupka, E.28
Gardner, J.29
Von Kalle, C.30
Bordignon, C.31
Ciceri, F.32
Rovelli, A.33
Roncarolo, M.G.34
Aiuti, A.35
Sessa, M.36
Naldini, L.37
more..
-
15
-
-
26644436945
-
Gene therapy of storage disorders by retroviral and lentiviral vectors
-
Biffi A, Naldini L (2005) Gene therapy of storage disorders by retroviral and lentiviral vectors. Hum Gene Ther 16:1133-1142
-
(2005)
Hum Gene Ther
, vol.16
, pp. 1133-1142
-
-
Biffi, A.1
Naldini, L.2
-
16
-
-
0030878098
-
Fast transport and retrograde movement of huntingtin and HAP 1 in axons
-
Block-Galarza J, Chase KO, Sapp E, Vaughn KT, Vallee RB, DiFiglia M, Aronin N (1997) Fast transport and retrograde movement of huntingtin and HAP 1 in axons. Neuroreport 8:2247-2251
-
(1997)
Neuroreport
, vol.8
, pp. 2247-2251
-
-
Block-Galarza, J.1
Chase, K.O.2
Sapp, E.3
Vaughn, K.T.4
Vallee, R.B.5
Difiglia, M.6
Aronin, N.7
-
17
-
-
33646421164
-
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
-
Borrell-Pages M, Canals JM, Cordelieres FP, Parker JA, Pineda JR, Grange G, Bryson EA, Guillermier M, Hirsch E, Hantraye P, Cheetham ME, Neri C, Alberch J, Brouillet E, Saudou F, Humbert S (2006) Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J Clin Invest 116:1410-1424
-
(2006)
J Clin Invest
, vol.116
, pp. 1410-1424
-
-
Borrell-Pages, M.1
Canals, J.M.2
Cordelieres, F.P.3
Parker, J.A.4
Pineda, J.R.5
Grange, G.6
Bryson, E.A.7
Guillermier, M.8
Hirsch, E.9
Hantraye, P.10
Cheetham, M.E.11
Neri, C.12
Alberch, J.13
Brouillet, E.14
Saudou, F.15
Humbert, S.16
-
18
-
-
77956320467
-
Cystamine metabolism and brain transport properties: Clinical implications for neurodegenerative diseases
-
Bousquet M, Gibrat C, Ouellet M, Rouillard C, Calon F, Cicchetti F (2010) Cystamine metabolism and brain transport properties: clinical implications for neurodegenerative diseases. J Neurochem 114:1651-1658
-
(2010)
J Neurochem
, vol.114
, pp. 1651-1658
-
-
Bousquet, M.1
Gibrat, C.2
Ouellet, M.3
Rouillard, C.4
Calon, F.5
Cicchetti, F.6
-
19
-
-
0000337980
-
The BDNF Trial Group (1995) A PhaseI/II study of recombinant human brain-derived neurotrophic factor in patients with amyotrophic lateral sclerosis
-
Bradley WG, Miami FL, The BDNF Trial Group (1995) A PhaseI/II study of recombinant human brain-derived neurotrophic factor in patients with amyotrophic lateral sclerosis. Ann Neurol 38:971
-
Ann Neurol
, vol.38
, pp. 971
-
-
Bradley, W.G.1
Miami, F.L.2
-
20
-
-
3142764484
-
Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes
-
Bruce AW, Donaldson IJ, Wood IC, Yerbury SA, Sadowski MI, Chapman M, Gottgens B, Buckley NJ (2004) Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci USA 101:10458-10463
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10458-10463
-
-
Bruce, A.W.1
Donaldson, I.J.2
Wood, I.C.3
Yerbury, S.A.4
Sadowski, M.I.5
Chapman, M.6
Gottgens, B.7
Buckley, N.J.8
-
21
-
-
0032925851
-
Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults
-
Bruce-Keller AJ, Umberger G, McFall R, Mattson MP (1999) Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol 45:8-15
-
(1999)
Ann Neurol
, vol.45
, pp. 8-15
-
-
Bruce-Keller, A.J.1
Umberger, G.2
McFall, R.3
Mattson, M.P.4
-
22
-
-
4444350918
-
Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington’s disease
-
Canals JM, Pineda JR, Torres-Peraza JF, Bosch M, Martin-Ibanez R, Munoz MT, Mengod G, Ernfors P, Alberch J (2004) Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington’s disease. J Neurosci 24:7727-7739
-
(2004)
J Neurosci
, vol.24
, pp. 7727-7739
-
-
Canals, J.M.1
Pineda, J.R.2
Torres-Peraza, J.F.3
Bosch, M.4
Martin-Ibanez, R.5
Munoz, M.T.6
Mengod, G.7
Ernfors, P.8
Alberch, J.9
-
23
-
-
0037072807
-
Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington’s disease mutation
-
Carmichael J, Sugars KL, Bao YP, Rubinsztein DC (2002) Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington’s disease mutation. J Biol Chem 277:33791-33798
-
(2002)
J Biol Chem
, vol.277
, pp. 33791-33798
-
-
Carmichael, J.1
Sugars, K.L.2
Bao, Y.P.3
Rubinsztein, D.C.4
-
24
-
-
0035282594
-
Loss of normal huntingtin function: New developments in Huntington’s disease research
-
Cattaneo E, Rigamonti D, Goffredo D, Zuccato C, Squitieri F, Sipione S (2001) Loss of normal huntingtin function: new developments in Huntington’s disease research. Trends Neurosci 24:182-188
-
(2001)
Trends Neurosci
, vol.24
, pp. 182-188
-
-
Cattaneo, E.1
Rigamonti, D.2
Goffredo, D.3
Zuccato, C.4
Squitieri, F.5
Sipione, S.6
-
25
-
-
28644433087
-
Normal huntingtin function: An alternative approach to Huntington’s disease
-
Cattaneo E, Zuccato C, Tartari M (2005) Normal huntingtin function: an alternative approach to Huntington’s disease. Nat Rev Neurosci 6:919-930
-
(2005)
Nat Rev Neurosci
, vol.6
, pp. 919-930
-
-
Cattaneo, E.1
Zuccato, C.2
Tartari, M.3
-
26
-
-
84885158161
-
High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes
-
Charbord J, Poydenot P, Bonnefond C, Feyeux M, Casagrande F, Brinon B, Francelle L, Auregan G, Guillermier M, Cailleret M, Viegas P, Nicoleau C, Martinat C, Brouillet E, Cattaneo E, Peschanski M, Lechuga M, Perrier AL (2013) High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem Cells 31:1816-1828
-
(2013)
Stem Cells
, vol.31
, pp. 1816-1828
-
-
Charbord, J.1
Poydenot, P.2
Bonnefond, C.3
Feyeux, M.4
Casagrande, F.5
Brinon, B.6
Francelle, L.7
Auregan, G.8
Guillermier, M.9
Cailleret, M.10
Viegas, P.11
Nicoleau, C.12
Martinat, C.13
Brouillet, E.14
Cattaneo, E.15
Peschanski, M.16
Lechuga, M.17
Perrier, A.L.18
-
27
-
-
33646136884
-
Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons
-
Chang DT, Rintoul GL, Pandipati S, Reynolds IJ (2006) Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons. Neurobiol Dis 22:388-400
-
(2006)
Neurobiol Dis
, vol.22
, pp. 388-400
-
-
Chang, D.T.1
Rintoul, G.L.2
Pandipati, S.3
Reynolds, I.J.4
-
28
-
-
0037248718
-
Fluoxetine-induced exacerbation of chorea in Huntington’s disease? A case report
-
Chari S, Quraishi SH, Jainer AK (2003) Fluoxetine-induced exacerbation of chorea in Huntington’s disease? A case report. Pharmacopsychiatry 36:41-43
-
(2003)
Pharmacopsychiatry
, vol.36
, pp. 41-43
-
-
Chari, S.1
Quraishi, S.H.2
Jainer, A.K.3
-
29
-
-
0029807385
-
Inhibition of hsc70-catalysed clathrin uncoating by HSJ1 proteins
-
Cheetham ME, Anderton BH, Jackson AP (1996) Inhibition of hsc70-catalysed clathrin uncoating by HSJ1 proteins. Biochem J 319(1):103-108
-
(1996)
Biochem J
, vol.319
, Issue.1
, pp. 103-108
-
-
Cheetham, M.E.1
Erton, B.H.2
Jackson, A.P.3
-
30
-
-
0345269738
-
Upstream stimulatory factors are mediators of Ca2+_responsive transcription in neurons
-
Chen WG, West AE, Tao X, Corfas G, Szentirmay MN, Sawadogo M, Vinson C, Greenberg ME (2003a) Upstream stimulatory factors are mediators of Ca2+_responsive transcription in neurons. J Neurosci 23:2572-2581
-
(2003)
J Neurosci
, vol.23
, pp. 2572-2581
-
-
Chen, W.G.1
West, A.E.2
Tao, X.3
Corfas, G.4
Szentirmay, M.N.5
Sawadogo, M.6
Vinson, C.7
Greenberg, M.E.8
-
31
-
-
0242332183
-
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
-
Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, Jaenisch R, Greenberg ME (2003b) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302:885-889
-
(2003)
Science
, vol.302
, pp. 885-889
-
-
Chen, W.G.1
Chang, Q.2
Lin, Y.3
Meissner, A.4
West, A.E.5
Griffith, E.C.6
Jaenisch, R.7
Greenberg, M.E.8
-
32
-
-
2342550552
-
Variant brainderived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activitydependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
-
Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS (2004) Variant brainderived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activitydependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24:4401-4411
-
(2004)
J Neurosci
, vol.24
, pp. 4401-4411
-
-
Chen, Z.Y.1
Patel, P.D.2
Sant, G.3
Meng, C.X.4
Teng, K.K.5
Hempstead, B.L.6
Lee, F.S.7
-
33
-
-
80054772539
-
Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington’s disease
-
Chiu CT, Liu G, Leeds P, Chuang DM (2011) Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington’s disease. Neuropsychopharmacology 36:2406-2421
-
(2011)
Neuropsychopharmacology
, vol.36
, pp. 2406-2421
-
-
Chiu, C.T.1
Liu, G.2
Leeds, P.3
Chuang, D.M.4
-
34
-
-
34948855498
-
Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease
-
Cho SR, Benraiss A, Chmielnicki E, Samdani A, Economides A, Goldman SA (2007) Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. J Clin Invest 117:2889-2902
-
(2007)
J Clin Invest
, vol.117
, pp. 2889-2902
-
-
Cho, S.R.1
Benraiss, A.2
Chmielnicki, E.3
Samdani, A.4
Economides, A.5
Goldman, S.A.6
-
35
-
-
34250867453
-
Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington’s disease patients
-
Ciammola A, Sassone J, Cannella M, Calza S, Poletti B, Frati L, Squitieri F, Silani V (2007) Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington’s disease patients. Am J Med Genet B Neuropsychiatr Genet 144:574-577
-
(2007)
Am J Med Genet B Neuropsychiatr Genet
, vol.144
, pp. 574-577
-
-
Ciammola, A.1
Sassone, J.2
Cannella, M.3
Calza, S.4
Poletti, B.5
Frati, L.6
Squitieri, F.7
Silani, V.8
-
36
-
-
49149112606
-
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
-
Colin E, Zala D, Liot G, Rangone H, Borrell-Pages M, Li XJ, Saudou F, Humbert S (2008) Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J 27:2124-2134
-
(2008)
EMBO J
, vol.27
, pp. 2124-2134
-
-
Colin, E.1
Zala, D.2
Liot, G.3
Rangone, H.4
Borrell-Pages, M.5
Li, X.J.6
Saudou, F.7
Humbert, S.8
-
37
-
-
16744362352
-
A controlled trial of fluoxetine in nondepressed patients with Huntington’s disease
-
Como PG, Rubin AJ, O’Brien CF, Lawler K, Hickey C, Rubin AE, Henderson R, McDermott MP, McDermott M, Steinberg K, Shoulson I (1997) A controlled trial of fluoxetine in nondepressed patients with Huntington’s disease. Mov Disord 12:397-401
-
(1997)
Mov Disord
, vol.12
, pp. 397-401
-
-
Como, P.G.1
Rubin, A.J.2
O’Brien, C.F.3
Lawler, K.4
Hickey, C.5
Rubin, A.E.6
Henderson, R.7
McDermott, M.P.8
McDermott, M.9
Steinberg, K.10
Shoulson, I.11
-
38
-
-
49549109150
-
Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington’s disease: Restoration by the neuroprotective compound CEP-1347
-
Conforti P, Ramos C, Apostol BL, Simmons DA, Nguyen HP, Riess O, Thompson LM, Zuccato C, Cattaneo E (2008) Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington’s disease: restoration by the neuroprotective compound CEP-1347. Mol Cell Neurosci 39:1-7
-
(2008)
Mol Cell Neurosci
, vol.39
, pp. 1-7
-
-
Conforti, P.1
Ramos, C.2
Apostol, B.L.3
Simmons, D.A.4
Nguyen, H.P.5
Riess, O.6
Thompson, L.M.7
Zuccato, C.8
Cattaneo, E.9
-
39
-
-
84882239332
-
In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice
-
Conforti P, Mas Monteys A, Zuccato C, Buckley NJ, Davidson B, Cattaneo E (2012) In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice. Gene Ther 20:678-685
-
(2012)
Gene Ther
, vol.20
, pp. 678-685
-
-
Conforti, P.1
Mas Monteys, A.2
Zuccato, C.3
Buckley, N.J.4
Davidson, B.5
Cattaneo, E.6
-
40
-
-
84884906692
-
Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington’s disease models
-
Conforti P, Zuccato C, Gaudenzi G, Ieraci A, Camnasio S, Buckley NJ, Mutti C, Cotelli F, Contini A, Cattaneo E (2013) Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington’s disease models. J Neurochem 127:22-35
-
(2013)
J Neurochem
, vol.127
, pp. 22-35
-
-
Conforti, P.1
Zuccato, C.2
Gaudenzi, G.3
Ieraci, A.4
Camnasio, S.5
Buckley, N.J.6
Mutti, C.7
Cotelli, F.8
Contini, A.9
Cattaneo, E.10
-
41
-
-
77249144782
-
Neural stem cell systems: Physiological players or in vitro entities?
-
Conti L, Cattaneo E (2010) Neural stem cell systems: physiological players or in vitro entities? Nat Rev Neurosci 11:176-187
-
(2010)
Nat Rev Neurosci
, vol.11
, pp. 176-187
-
-
Conti, L.1
Cattaneo, E.2
-
42
-
-
0032765275
-
Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex
-
Croll SD, Suri C, Compton DL, Simmons MV, Yancopoulos GD, Lindsay RM, Wiegand SJ, Rudge JS, Scharfman HE (1999) Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 93:1491-1506
-
(1999)
Neuroscience
, vol.93
, pp. 1491-1506
-
-
Croll, S.D.1
Suri, C.2
Compton, D.L.3
Simmons, M.V.4
Yancopoulos, G.D.5
Lindsay, R.M.6
Wiegand, S.J.7
Rudge, J.S.8
Scharfman, H.E.9
-
43
-
-
84855393915
-
A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington’s disease
-
Cummings DM, Alaghband Y, Hickey MA, Joshi PR, Hong SC, Zhu C, Ando TK, Andre´ VM, Cepeda C, Watson JB, Levine MS (2012) A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington’s disease. J Neurophysiol 107:677-691
-
(2012)
J Neurophysiol
, vol.107
, pp. 677-691
-
-
Cummings, D.M.1
Alaghband, Y.2
Hickey, M.A.3
Joshi, P.R.4
Hong, S.C.5
Zhu, C.6
Ando, T.K.7
Re´, V.M.8
Cepeda, C.9
Watson, J.B.10
Levine, M.S.11
-
44
-
-
0033600124
-
The length of polyglutamine tract, its level of expression, the rate of degradation, and the transglutaminase activity influence the formation of intracellular aggregates
-
de Cristofaro T, Affaitati A, Cariello L, Avvedimento EV, Varrone S (1999) The length of polyglutamine tract, its level of expression, the rate of degradation, and the transglutaminase activity influence the formation of intracellular aggregates. Biochem Biophys Res Commun 260:150-158
-
(1999)
Biochem Biophys Res Commun
, vol.260
, pp. 150-158
-
-
De Cristofaro, T.1
Affaitati, A.2
Cariello, L.3
Avvedimento, E.V.4
Varrone, S.5
-
45
-
-
0037109665
-
Therapeutic effects of cystamine in a murine model of Huntington’s disease
-
Dedeoglu A, Kubilus JK, Jeitner TM, Matson SA, Bogdanov M, Kowall NW, Matson WR, Cooper AJ, Ratan RR, Beal MF, Hersch SM, Ferrante RJ (2002) Therapeutic effects of cystamine in a murine model of Huntington’s disease. J Neurosci 22:8942-8950
-
(2002)
J Neurosci
, vol.22
, pp. 8942-8950
-
-
Dedeoglu, A.1
Kubilus, J.K.2
Jeitner, T.M.3
Matson, S.A.4
Bogdanov, M.5
Kowall, N.W.6
Matson, W.R.7
Cooper, A.J.8
Ratan, R.R.9
Beal, M.F.10
Hersch, S.M.11
Ferrante, R.J.12
-
46
-
-
33845381075
-
Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism
-
del Toro D, Canals JM, Gines S, Kojima M, Egea G, Alberch J (2006) Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism. J Neurosci 26:12748-12757
-
(2006)
J Neurosci
, vol.26
, pp. 12748-12757
-
-
Del Toro, D.1
Canals, J.M.2
Gines, S.3
Kojima, M.4
Egea, G.5
Alberch, J.6
-
47
-
-
33750209146
-
No evidence of association between BDNF gene variants and age-at-onset of Huntington’s disease
-
Di Maria E, Marasco A, Tartari M, Ciotti P, Abbruzzese G, Novelli G, Bellone E, Cattaneo E, Mandich P (2006) No evidence of association between BDNF gene variants and age-at-onset of Huntington’s disease. Neurobiol Dis 24:274-279
-
(2006)
Neurobiol Dis
, vol.24
, pp. 274-279
-
-
Di Maria, E.1
Marasco, A.2
Tartari, M.3
Ciotti, P.4
Abbruzzese, G.5
Novelli, G.6
Bellone, E.7
Cattaneo, E.8
Mandich, P.9
-
48
-
-
59649109467
-
Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish
-
Diekmann H, Anichtchik O, Fleming A, Futter M, Goldsmith P, Roach A, Rubinsztein DC (2009) Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish. J Neurosci 29:1343-1349
-
(2009)
J Neurosci
, vol.29
, pp. 1343-1349
-
-
Diekmann, H.1
Anichtchik, O.2
Fleming, A.3
Futter, M.4
Goldsmith, P.5
Roach, A.6
Rubinsztein, D.C.7
-
49
-
-
0028989602
-
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
-
DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, Young C, Martin E, Vonsattel JP, Carraway R, Reeves SA et al (1995) Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14:1075-1081
-
(1995)
Neuron
, vol.14
, pp. 1075-1081
-
-
Difiglia, M.1
Sapp, E.2
Chase, K.3
Schwarz, C.4
Meloni, A.5
Young, C.6
Martin, E.7
Vonsattel, J.P.8
Carraway, R.9
Reeves, S.A.10
-
50
-
-
0033757718
-
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
-
Dragatsis I, Levine MS, Zeitlin S (2000) Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat Genet 26:300-306
-
(2000)
Nat Genet
, vol.26
, pp. 300-306
-
-
Dragatsis, I.1
Levine, M.S.2
Zeitlin, S.3
-
51
-
-
60849109193
-
CAG repeat lengths > or ¼335 attenuate the phenotype in the R6/2 Huntington’s disease transgenic mouse
-
Dragatsis I, Goldowitz D, Del Mar N, Deng YP, Meade CA, Liu L, Sun Z, Dietrich P, Yue J, Reiner A (2009) CAG repeat lengths > or ¼335 attenuate the phenotype in the R6/2 Huntington’s disease transgenic mouse. Neurobiol Dis 33:315-330
-
(2009)
Neurobiol Dis
, vol.33
, pp. 315-330
-
-
Dragatsis, I.1
Goldowitz, D.2
Del Mar, N.3
Deng, Y.P.4
Meade, C.A.5
Liu, L.6
Sun, Z.7
Dietrich, P.8
Yue, J.9
Reiner, A.10
-
52
-
-
0035030699
-
Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury
-
Duan W, Lee J, Guo Z, Mattson MP (2001a) Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. J Mol Neurosci 16:1-12
-
(2001)
J Mol Neurosci
, vol.16
, pp. 1-12
-
-
Duan, W.1
Lee, J.2
Guo, Z.3
Mattson, M.P.4
-
53
-
-
0035145760
-
Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice
-
Duan W, Guo Z, Mattson MP (2001b) Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice. J Neurochem 76:619-626
-
(2001)
J Neurochem
, vol.76
, pp. 619-626
-
-
Duan, W.1
Guo, Z.2
Mattson, M.P.3
-
54
-
-
0037418339
-
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
-
Duan W, Guo Z, Jiang H, Ware M, Li XJ, Mattson MP (2003) Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci USA 100:2911-2916
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2911-2916
-
-
Duan, W.1
Guo, Z.2
Jiang, H.3
Ware, M.4
Li, X.J.5
Mattson, M.P.6
-
55
-
-
1642406567
-
Paroxetine retards disease onset and progression in Huntingtin mutant mice
-
Duan W, Guo Z, Jiang H, Ladenheim B, Xu X, Cadet JL, Mattson MP (2004) Paroxetine retards disease onset and progression in Huntingtin mutant mice. Ann Neurol 55:590-594
-
(2004)
Ann Neurol
, vol.55
, pp. 590-594
-
-
Duan, W.1
Guo, Z.2
Jiang, H.3
Ladenheim, B.4
Xu, X.5
Cadet, J.L.6
Mattson, M.P.7
-
56
-
-
43649106471
-
Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington’s disease
-
Duan W, Peng Q, Masuda N, Ford E, Tryggestad E, Ladenheim B, Zhao M, Cadet JL, Wong J, Ross CA (2008) Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington’s disease. Neurobiol Dis 30:312-322
-
(2008)
Neurobiol Dis
, vol.30
, pp. 312-322
-
-
Duan, W.1
Peng, Q.2
Masuda, N.3
Ford, E.4
Tryggestad, E.5
Ladenheim, B.6
Zhao, M.7
Cadet, J.L.8
Wong, J.9
Ross, C.A.10
-
57
-
-
0030249761
-
Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse
-
Dubey A, Forster MJ, Lal H, Sohal RS (1996) Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch Biochem Biophys 333:189-197
-
(1996)
Arch Biochem Biophys
, vol.333
, pp. 189-197
-
-
Dubey, A.1
Forster, M.J.2
Lal, H.3
Sohal, R.S.4
-
58
-
-
0037150687
-
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington’s disease
-
Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, Krainc D (2002) Sp1 and TAFII130 transcriptional activity disrupted in early Huntington’s disease. Science 296:2238-2243
-
(2002)
Science
, vol.296
, pp. 2238-2243
-
-
Dunah, A.W.1
Jeong, H.2
Griffin, A.3
Kim, Y.M.4
Standaert, D.G.5
Hersch, S.M.6
Mouradian, M.M.7
Young, A.B.8
Tanese, N.9
Krainc, D.10
-
59
-
-
0037462449
-
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
-
Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269
-
(2003)
Cell
, vol.112
, pp. 257-269
-
-
Egan, M.F.1
Kojima, M.2
Callicott, J.H.3
Goldberg, T.E.4
Kolachana, B.S.5
Bertolino, A.6
Zaitsev, E.7
Gold, B.8
Goldman, D.9
Dean, M.10
Lu, B.11
Weinberger, D.R.12
-
60
-
-
0030906578
-
Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington’s disease
-
Emerich DF, Winn SR, Hantraye PM, Peschanski M, Chen EY, Chu Y, McDermott P, Baetge EE, Kordower JH (1997) Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington’s disease. Nature 386:395-399
-
(1997)
Nature
, vol.386
, pp. 395-399
-
-
Emerich, D.F.1
Winn, S.R.2
Hantraye, P.M.3
Peschanski, M.4
Chen, E.Y.5
Chu, Y.6
McDermott, P.7
Baetge, E.E.8
Kordower, J.H.9
-
61
-
-
0030726894
-
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin
-
Engelender S, Sharp AH, Colomer V, Tokito MK, Lanahan A, Worley P, Holzbaur EL, Ross CA (1997) Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum Mol Genet 6:2205-2212
-
(1997)
Hum Mol Genet
, vol.6
, pp. 2205-2212
-
-
Engelender, S.1
Sharp, A.H.2
Colomer, V.3
Tokito, M.K.4
Lanahan, A.5
Worley, P.6
Holzbaur, E.L.7
Ross, C.A.8
-
62
-
-
0026589752
-
Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment
-
Falkenberg T, Mohammed AK, Henriksson B, Persson H, Winblad B, Lindefors N (1992) Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment. Neurosci Lett 138:153-156
-
(1992)
Neurosci Lett
, vol.138
, pp. 153-156
-
-
Falkenberg, T.1
Mohammed, A.K.2
Henriksson, B.3
Persson, H.4
Winblad, B.5
Lindefors, N.6
-
63
-
-
0034595722
-
Brain-derived neurotrophic factor in Huntington disease
-
Ferrer I, Goutan E, Marin C, Rey MJ, Ribalta T (2000) Brain-derived neurotrophic factor in Huntington disease. Brain Res 866:257-261
-
(2000)
Brain Res
, vol.866
, pp. 257-261
-
-
Ferrer, I.1
Goutan, E.2
Marin, C.3
Rey, M.J.4
Ribalta, T.5
-
64
-
-
5444229092
-
Cystamine increases L-cysteine levels in Huntington’s disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation
-
Fox JH, Barber DS, Singh B, Zucker B, Swindell MK, Norflus F, Buzescu R, Chopra R, Ferrante RJ, Kazantsev A, Hersch SM (2004) Cystamine increases L-cysteine levels in Huntington’s disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation. J Neurochem 91:413-422
-
(2004)
J Neurochem
, vol.91
, pp. 413-422
-
-
Fox, J.H.1
Barber, D.S.2
Singh, B.3
Zucker, B.4
Swindell, M.K.5
Norflus, F.6
Buzescu, R.7
Chopra, R.8
Ferrante, R.J.9
Kazantsev, A.10
Hersch, S.M.11
-
65
-
-
0027468487
-
Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions
-
Frim DM, Uhler TA, Short MP, Ezzedine ZD, Klagsbrun M, Breakefield XO, Isacson O (1993) Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions. Neuroreport 4:367-370
-
(1993)
Neuroreport
, vol.4
, pp. 367-370
-
-
Frim, D.M.1
Uhler, T.A.2
Short, M.P.3
Ezzedine, Z.D.4
Klagsbrun, M.5
Breakefield, X.O.6
Isacson, O.7
-
66
-
-
0036214689
-
Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation
-
Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi J, Sun B, Tandon NN (2002) Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 87:728-734
-
(2002)
Thromb Haemost
, vol.87
, pp. 728-734
-
-
Fujimura, H.1
Altar, C.A.2
Chen, R.3
Nakamura, T.4
Nakahashi, T.5
Kambayashi, J.6
Sun, B.7
Tandon, N.N.8
-
67
-
-
0034795827
-
Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain
-
Fukumoto T, Morinobu S, Okamoto Y, Kagaya A, Yamawaki S (2001) Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmacology (Berl) 158:100-106
-
(2001)
Psychopharmacology (Berl)
, vol.158
, pp. 100-106
-
-
Fukumoto, T.1
Morinobu, S.2
Okamoto, Y.3
Kagaya, A.4
Yamawaki, S.5
-
68
-
-
0033557661
-
Cellular localization of huntingtin in striatal and cortical neurons in rats: Lack of correlation with neuronal vulnerability in Huntington’s disease
-
Fusco FR, Chen Q, Lamoreaux WJ, Figueredo-Cardenas G, Jiao Y, Coffman JA, Surmeier DJ, Honig MG, Carlock LR, Reiner A (1999) Cellular localization of huntingtin in striatal and cortical neurons in rats: lack of correlation with neuronal vulnerability in Huntington’s disease. J Neurosci 19:1189-1202
-
(1999)
J Neurosci
, vol.19
, pp. 1189-1202
-
-
Fusco, F.R.1
Chen, Q.2
Lamoreaux, W.J.3
Figueredo-Cardenas, G.4
Jiao, Y.5
Coffman, J.A.6
Surmeier, D.J.7
Honig, M.G.8
Carlock, L.R.9
Reiner, A.10
-
69
-
-
0141725601
-
Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain
-
Fusco FR, Zuccato C, Tartari M, Martorana A, De March Z, Giampa C, Cattaneo E, Bernardi G (2003) Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain. Eur J Neurosci 18:1093-1102
-
(2003)
Eur J Neurosci
, vol.18
, pp. 1093-1102
-
-
Fusco, F.R.1
Zuccato, C.2
Tartari, M.3
Martorana, A.4
De March, Z.5
Giampa, C.6
Cattaneo, E.7
Bernardi, G.8
-
70
-
-
70449529637
-
Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
-
Gabathuler R (2010) Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol Dis 37:48-57
-
(2010)
Neurobiol Dis
, vol.37
, pp. 48-57
-
-
Gabathuler, R.1
-
71
-
-
3142636768
-
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
-
Gauthier LR, Charrin BC, Borrell-Pages M, Dompierre JP, Rangone H, Cordelieres FP, De Mey J, MacDonald ME, Lessmann V, Humbert S, Saudou F (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118:127-138
-
(2004)
Cell
, vol.118
, pp. 127-138
-
-
Gauthier, L.R.1
Charrin, B.C.2
Borrell-Pages, M.3
Dompierre, J.P.4
Rangone, H.5
Cordelieres, F.P.6
De Mey, J.7
Macdonald, M.E.8
Lessmann, V.9
Humbert, S.10
Saudou, F.11
-
73
-
-
84875020639
-
From molecular to nanotechnology strategies for delivery of neurotrophins: Emphasis on brain-derived neurotrophic factor (BDNF)
-
Geral C, Angelova A, Lesieur S (2013) From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF). Pharmaceutics 5:127-167
-
(2013)
Pharmaceutics
, vol.5
, pp. 127-167
-
-
Geral, C.1
Angelova, A.2
Lesieur, S.3
-
74
-
-
41749083721
-
Brain-derived neurotrophic factor overexpression in the forebrain ameliorates Huntington’s disease phenotypes in mice
-
Gharami K, Xie Y, An JJ, Tonegawa S, Xu B (2008) Brain-derived neurotrophic factor overexpression in the forebrain ameliorates Huntington’s disease phenotypes in mice. J Neurochem 105:369-379
-
(2008)
J Neurochem
, vol.105
, pp. 369-379
-
-
Gharami, K.1
Xie, Y.2
An, J.J.3
Tonegawa, S.4
Xu, B.5
-
75
-
-
33644956493
-
Striatal modulation of cAMP-response-element-binding protein (CREB) after excitotoxic lesions: Implications with neuronal vulnerability in Huntington’s disease
-
Giampa C, DeMarch Z, D’Angelo V, Morello M, Martorana A, Sancesario G, Bernardi G, Fusco FR (2006) Striatal modulation of cAMP-response-element-binding protein (CREB) after excitotoxic lesions: implications with neuronal vulnerability in Huntington’s disease. Eur J Neurosci 23:11-20
-
(2006)
Eur J Neurosci
, vol.23
, pp. 11-20
-
-
Giampa, C.1
Demarch, Z.2
D’Angelo, V.3
Morello, M.4
Martorana, A.5
Sancesario, G.6
Bernardi, G.7
Fusco, F.R.8
-
76
-
-
84877905808
-
Systemic delivery of recombinant brain derived neurotrophic factor (BDNF) in the R6/2 mouse model of Huntington’s disease
-
Giampa C, Montagna E, Dato C, Melone MA, Bernardi G, Fusco FR (2013) Systemic delivery of recombinant brain derived neurotrophic factor (BDNF) in the R6/2 mouse model of Huntington’s disease. PLoS One 8(5):64037
-
(2013)
Plos One
, vol.8
, Issue.5
, pp. 64037
-
-
Giampa, C.1
Montagna, E.2
Dato, C.3
Melone, M.A.4
Bernardi, G.5
Fusco, F.R.6
-
77
-
-
79952898732
-
Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases
-
Gibrat C, Cicchetti F (2011) Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases. Prog Neuropsychopharmacol Biol Psychiatry 35:380-389
-
(2011)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.35
, pp. 380-389
-
-
Gibrat, C.1
Cicchetti, F.2
-
78
-
-
27644485740
-
Reduced hippocampal neurogenesis in R6/2 transgenic Huntington’s disease mice
-
Gil JM, Mohapel P, Araujo IM, Popovic N, Li JY, Brundin P, Petersen A (2005) Reduced hippocampal neurogenesis in R6/2 transgenic Huntington’s disease mice. Neurobiol Dis 20:744-751
-
(2005)
Neurobiol Dis
, vol.20
, pp. 744-751
-
-
Gil, J.M.1
Mohapel, P.2
Araujo, I.M.3
Popovic, N.4
Li, J.Y.5
Brundin, P.6
Petersen, A.7
-
79
-
-
0038249170
-
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
-
Gill SS, Patel NK, Hotton GR, O’Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN, Heywood P (2003) Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 9:589-595
-
(2003)
Nat Med
, vol.9
, pp. 589-595
-
-
Gill, S.S.1
Patel, N.K.2
Hotton, G.R.3
O’Sullivan, K.4
McCarter, R.5
Bunnage, M.6
Brooks, D.J.7
Svendsen, C.N.8
Heywood, P.9
-
80
-
-
0037335074
-
Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington’s disease knock-in mice
-
Gines S, Seong IS, Fossale E, Ivanova E, Trettel F, Gusella JF, Wheeler VC, Persichetti F, MacDonald ME (2003) Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington’s disease knock-in mice. Hum Mol Genet 12:497-508
-
(2003)
Hum Mol Genet
, vol.12
, pp. 497-508
-
-
Gines, S.1
Seong, I.S.2
Fossale, E.3
Ivanova, E.4
Trettel, F.5
Gusella, J.F.6
Wheeler, V.C.7
Persichetti, F.8
Macdonald, M.E.9
-
81
-
-
33644956205
-
Reduced expression of the TrkB receptor in Huntington’s disease mouse models and in human brain
-
Gines S, Bosch M, Marco S, Gavalda N, Diaz-Hernandez M, Lucas JJ, Canals JM, Alberch J (2006) Reduced expression of the TrkB receptor in Huntington’s disease mouse models and in human brain. Eur J Neurosci 23:649-658
-
(2006)
Eur J Neurosci
, vol.23
, pp. 649-658
-
-
Gines, S.1
Bosch, M.2
Marco, S.3
Gavalda, N.4
Diaz-Hernandez, M.5
Lucas, J.J.6
Canals, J.M.7
Alberch, J.8
-
82
-
-
80053613635
-
Conditional BDNF release under pathological conditions improves Huntington’s disease pathology by delaying neuronal dysfunction
-
Giralt A, Carreton O, Lao-Peregrin C, Martın ED, Alberch J (2011) Conditional BDNF release under pathological conditions improves Huntington’s disease pathology by delaying neuronal dysfunction. Mol Neurodegener 6:71
-
(2011)
Mol Neurodegener
, vol.6
, pp. 71
-
-
Giralt, A.1
Carreton, O.2
Lao-Peregrin, C.3
Martın, E.D.4
Alberch, J.5
-
83
-
-
60349130539
-
Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: Involvement of phospholipaseCgamma activity and glutamate receptor expression
-
Giralt A, Rodrigo T, Martin ED, Gonzalez JR, Mila M, Cena V, Dierssen M, Canals JM, Alberch J (2009) Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression. Neuroscience 158:1234-1250
-
(2009)
Neuroscience
, vol.158
, pp. 1234-1250
-
-
Giralt, A.1
Rodrigo, T.2
Martin, E.D.3
Gonzalez, J.R.4
Mila, M.5
Cena, V.6
Dierssen, M.7
Canals, J.M.8
Alberch, J.9
-
84
-
-
77957999730
-
BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington’s disease
-
Giralt A, Friedman HC, Caneda-Ferron B, Urban N, Moreno E, Rubio N, Blanco J, Peterson A, Canals JM, Alberch J (2010) BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington’s disease. Gene Ther 17:1294-1308
-
(2010)
Gene Ther
, vol.17
, pp. 1294-1308
-
-
Giralt, A.1
Friedman, H.C.2
Caneda-Ferron, B.3
Urban, N.4
Moreno, E.5
Rubio, N.6
Blanco, J.7
Peterson, A.8
Canals, J.M.9
Alberch, J.10
-
85
-
-
2442717709
-
Domains of the TGN: Coats, tethers and G proteins
-
Gleeson PA, Lock JG, Luke MR, Stow JL (2004) Domains of the TGN: coats, tethers and G proteins. Traffic 5:315-326
-
(2004)
Traffic
, vol.5
, pp. 315-326
-
-
Gleeson, P.A.1
Lock, J.G.2
Luke, M.R.3
Stow, J.L.4
-
86
-
-
46749157501
-
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
-
Gray M, Shirasaki DI, Cepeda C, Andre VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW (2008) Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci 28:6182-6195
-
(2008)
J Neurosci
, vol.28
, pp. 6182-6195
-
-
Gray, M.1
Shirasaki, D.I.2
Cepeda, C.3
Re, V.M.4
Wilburn, B.5
Lu, X.H.6
Tao, J.7
Yamazaki, I.8
Li, S.H.9
Sun, Y.E.10
Li, X.J.11
Levine, M.S.12
Yang, X.W.13
-
87
-
-
27644524469
-
Cognitive disorders and neurogenesis deficits in Huntington’s disease mice are rescued by fluoxetine
-
Grote HE, Bull ND, Howard ML, van Dellen A, Blakemore C, Bartlett PF, Hannan AJ (2005) Cognitive disorders and neurogenesis deficits in Huntington’s disease mice are rescued by fluoxetine. Eur J Neurosci 22:2081-2088
-
(2005)
Eur J Neurosci
, vol.22
, pp. 2081-2088
-
-
Grote, H.E.1
Bull, N.D.2
Howard, M.L.3
Van Dellen, A.4
Blakemore, C.5
Bartlett, P.F.6
Hannan, A.J.7
-
88
-
-
12144280807
-
Polyglutamine diseases and transport problems: Deadly traffic jams on neuronal highways
-
Gunawardena S, Goldstein LS (2005) Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Arch Neurol 62:46-51
-
(2005)
Arch Neurol
, vol.62
, pp. 46-51
-
-
Gunawardena, S.1
Goldstein, L.S.2
-
89
-
-
0141750470
-
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila
-
Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein LS (2003) Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 40:25-40
-
(2003)
Neuron
, vol.40
, pp. 25-40
-
-
Gunawardena, S.1
Her, L.S.2
Brusch, R.G.3
Laymon, R.A.4
Niesman, I.R.5
Gordesky-Gold, B.6
Sintasath, L.7
Bonini, N.M.8
Goldstein, L.S.9
-
90
-
-
0034088054
-
Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: Preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid
-
Guo Z, Ersoz A, Butterfield DA, Mattson MP (2000) Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid. J Neurochem 75:314-320
-
(2000)
J Neurochem
, vol.75
, pp. 314-320
-
-
Guo, Z.1
Ersoz, A.2
Butterfield, D.A.3
Mattson, M.P.4
-
91
-
-
51349090473
-
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
-
Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, Morillon E, Clappier E, Caccavelli L, Delabesse E, Beldjord K, Asnafi V, MacIntyre E, Dal Cortivo L, Radford I, Brousse N, Sigaux F, Moshous D, Hauer J, Borkhardt A, Belohradsky BH, Wintergerst U, Velez MC, Leiva L, Sorensen R, Wulffraat N, Blanche S, Bushman FD, Fischer A, Cavazzana- Calvo M (2008) Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 118:3132-3142
-
(2008)
J Clin Invest
, vol.118
, pp. 3132-3142
-
-
Hacein-Bey-Abina, S.1
Garrigue, A.2
Wang, G.P.3
Soulier, J.4
Lim, A.5
Morillon, E.6
Clappier, E.7
Caccavelli, L.8
Delabesse, E.9
Beldjord, K.10
Asnafi, V.11
Macintyre, E.12
Dal Cortivo, L.13
Radford, I.14
Brousse, N.15
Sigaux, F.16
Moshous, D.17
Hauer, J.18
Borkhardt, A.19
Belohradsky, B.H.20
Wintergerst, U.21
Velez, M.C.22
Leiva, L.23
Sorensen, R.24
Wulffraat, N.25
Blanche, S.26
Bushman, F.D.27
Fischer, A.28
Cavazzana- Calvo, M.29
more..
-
92
-
-
33645896451
-
Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by exon IV promoter
-
Hansson AC, Sommer WH, Metsis M, Stromberg I, Agnati LF, Fuxe K (2006) Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by exon IV promoter. J Neuroendocrinol 18:104-114
-
(2006)
J Neuroendocrinol
, vol.18
, pp. 104-114
-
-
Hansson, A.C.1
Sommer, W.H.2
Metsis, M.3
Stromberg, I.4
Agnati, L.F.5
Fuxe, K.6
-
93
-
-
65649083752
-
Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF
-
Hara D, Fukuchi M, Miyashita T, Tabuchi A, Takasaki I, Naruse Y, Mori N, Kondo T, Tsuda M (2009) Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF. Biochem Biophys Res Commun 384:506-511
-
(2009)
Biochem Biophys Res Commun
, vol.384
, pp. 506-511
-
-
Hara, D.1
Fukuchi, M.2
Miyashita, T.3
Tabuchi, A.4
Takasaki, I.5
Naruse, Y.6
Mori, N.7
Kondo, T.8
Tsuda, M.9
-
94
-
-
0043135252
-
Brain-derived neurotrophic factor val66met polymorphism affects human memoryrelated hippocampal activity and predicts memory performance
-
Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR (2003) Brain-derived neurotrophic factor val66met polymorphism affects human memoryrelated hippocampal activity and predicts memory performance. J Neurosci 23:6690-6694
-
(2003)
J Neurosci
, vol.23
, pp. 6690-6694
-
-
Hariri, A.R.1
Goldberg, T.E.2
Mattay, V.S.3
Kolachana, B.S.4
Callicott, J.H.5
Egan, M.F.6
Weinberger, D.R.7
-
95
-
-
78349291479
-
Nicotinamide improves motor deficits and upregulates PGC-1alpha and BDNF gene expression in a mouse model of Huntington’s disease
-
Hathorn T, Snyder-Keller A, Messer A (2011) Nicotinamide improves motor deficits and upregulates PGC-1alpha and BDNF gene expression in a mouse model of Huntington’s disease. Neurobiol Dis 41:43-50
-
(2011)
Neurobiol Dis
, vol.41
, pp. 43-50
-
-
Hathorn, T.1
Snyder-Keller, A.2
Messer, A.3
-
96
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes
-
HDCRG
-
HDCRG (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72:971-983
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
97
-
-
70450189083
-
Selective neuronal requirement for huntingtin in the developing zebrafish
-
Henshall TL, Tucker B, Lumsden AL, Nornes S, Lardelli MT, Richards RI (2009) Selective neuronal requirement for huntingtin in the developing zebrafish. Hum Mol Genet 18:4830-4842
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4830-4842
-
-
Henshall, T.L.1
Tucker, B.2
Lumsden, A.L.3
Nornes, S.4
Lardelli, M.T.5
Richards, R.I.6
-
98
-
-
58149385090
-
Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin
-
Her LS, Goldstein LS (2008) Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci 28:13662-13672
-
(2008)
J Neurosci
, vol.28
, pp. 13662-13672
-
-
Her, L.S.1
Goldstein, L.S.2
-
99
-
-
11144357398
-
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington’s disease
-
Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM (2004) Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington’s disease. Cell Death Differ 11:424-438
-
(2004)
Cell Death Differ
, vol.11
, pp. 424-438
-
-
Hermel, E.1
Gafni, J.2
Propp, S.S.3
Leavitt, B.R.4
Wellington, C.L.5
Young, J.E.6
Hackam, A.S.7
Logvinova, A.V.8
Peel, A.L.9
Chen, S.F.10
Hook, V.11
Singaraja, R.12
Krajewski, S.13
Goldsmith, P.C.14
Ellerby, H.M.15
Hayden, M.R.16
Bredesen, D.E.17
Ellerby, L.M.18
-
100
-
-
37349121771
-
Stem cells and neurological diseases
-
Hess DC, Borlongan CV (2008) Stem cells and neurological diseases. Cell Prolif 41(1):94-114
-
(2008)
Cell Prolif
, vol.41
, Issue.1
, pp. 94-114
-
-
Hess, D.C.1
Borlongan, C.V.2
-
101
-
-
0036152343
-
Environmental enrichment slows disease progression in R6/2 Huntington’s disease mice
-
Hockly E, Cordery PM, Woodman B, Mahal A, van Dellen A, Blakemore C, Lewis CM, Hannan AJ, Bates GP (2002) Environmental enrichment slows disease progression in R6/2 Huntington’s disease mice. Ann Neurol 51:235-242
-
(2002)
Ann Neurol
, vol.51
, pp. 235-242
-
-
Hockly, E.1
Cordery, P.M.2
Woodman, B.3
Mahal, A.4
Van Dellen, A.5
Blakemore, C.6
Lewis, C.M.7
Hannan, A.J.8
Bates, G.P.9
-
102
-
-
33644783812
-
Regional and cellular gene expression changes in human Huntington’s disease brain
-
Hodges A, Strand AD, Aragaki AK, Kuhn A, Sengstag T, Hughes G, Elliston LA, Hartog C, Goldstein DR, Thu D, Hollingsworth ZR, Collin F, Synek B, Holmans PA, Young AB, Wexler NS, Delorenzi M, Kooperberg C, Augood SJ, Faull RL, Olson JM, Jones L, Luthi-Carter R (2006) Regional and cellular gene expression changes in human Huntington’s disease brain. Hum Mol Genet 15:965-977
-
(2006)
Hum Mol Genet
, vol.15
, pp. 965-977
-
-
Hodges, A.1
Strand, A.D.2
Aragaki, A.K.3
Kuhn, A.4
Sengstag, T.5
Hughes, G.6
Elliston, L.A.7
Hartog, C.8
Goldstein, D.R.9
Thu, D.10
Hollingsworth, Z.R.11
Collin, F.12
Synek, B.13
Holmans, P.A.14
Young, A.B.15
Wexler, N.S.16
Delorenzi, M.17
Kooperberg, C.18
Augood, S.J.19
Faull, R.L.20
Olson, J.M.21
Jones, L.22
Luthi-Carter, R.23
more..
-
103
-
-
0033136692
-
A YAC mouse model for Huntington’s disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
-
Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, Phillips AG, Rubin EM, Hersch SM, Hayden MR (1999) A YAC mouse model for Huntington’s disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron 23:181-192
-
(1999)
Neuron
, vol.23
, pp. 181-192
-
-
Hodgson, J.G.1
Agopyan, N.2
Gutekunst, C.A.3
Leavitt, B.R.4
Lepiane, F.5
Singaraja, R.6
Smith, D.J.7
Bissada, N.8
McCutcheon, K.9
Nasir, J.10
Jamot, L.11
Li, X.J.12
Stevens, M.E.13
Rosemond, E.14
Roder, J.C.15
Phillips, A.G.16
Rubin, E.M.17
Hersch, S.M.18
Hayden, M.R.19
-
104
-
-
21344434592
-
Transglutaminase and diseases of the central nervous system
-
Hoffner G, Djian P (2005) Transglutaminase and diseases of the central nervous system. Front Biosci 10:3078-3092
-
(2005)
Front Biosci
, vol.10
, pp. 3078-3092
-
-
Hoffner, G.1
Djian, P.2
-
105
-
-
0345600893
-
Dosage effects of riluzole in Huntington’s disease: A multicenter placebo-controlled study
-
HSG
-
HSG (2003) Dosage effects of riluzole in Huntington’s disease: a multicenter placebo-controlled study. Neurology 61:1551-1556
-
(2003)
Neurology
, vol.61
, pp. 1551-1556
-
-
-
106
-
-
0141869789
-
Cystamine inhibits transglutaminase and caspase-3 cleavage in glutamate-exposed astroglial cells
-
Ientile R, Campisi A, Raciti G, Caccamo D, Curro M, Cannavo G, Li Volti G, Macaione S, Vanella A (2003) Cystamine inhibits transglutaminase and caspase-3 cleavage in glutamate-exposed astroglial cells. J Neurosci Res 74:52-59
-
(2003)
J Neurosci Res
, vol.74
, pp. 52-59
-
-
Ientile, R.1
Campisi, A.2
Raciti, G.3
Caccamo, D.4
Curro, M.5
Cannavo, G.6
Li Volti, G.7
Macaione, S.8
Vanella, A.9
-
107
-
-
17344362229
-
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch
-
Igarashi S, Koide R, Shimohata T, Yamada M, Hayashi Y, Takano H, Date H, Oyake M, Sato T, Sato A, Egawa S, Ikeuchi T, Tanaka H, Nakano R, Tanaka K, Hozumi I, Inuzuka T, Takahashi H, Tsuji S (1998) Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch. Nat Genet 18:111-117
-
(1998)
Nat Genet
, vol.18
, pp. 111-117
-
-
Igarashi, S.1
Koide, R.2
Shimohata, T.3
Yamada, M.4
Hayashi, Y.5
Takano, H.6
Date, H.7
Oyake, M.8
Sato, T.9
Sato, A.10
Egawa, S.11
Ikeuchi, T.12
Tanaka, H.13
Nakano, R.14
Tanaka, K.15
Hozumi, I.16
Inuzuka, T.17
Takahashi, H.18
Tsuji, S.19
-
108
-
-
0033168977
-
Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro
-
Ivkovic S, Ehrlich ME (1999) Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro. J Neurosci 19:5409-5419
-
(1999)
J Neurosci
, vol.19
, pp. 5409-5419
-
-
Ivkovic, S.1
Ehrlich, M.E.2
-
109
-
-
78650748359
-
Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats
-
Jiang Y, Wei N, Lu T, Zhu J, Xu G, Liu X (2011) Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 172:398-405
-
(2011)
Neuroscience
, vol.172
, pp. 398-405
-
-
Jiang, Y.1
Wei, N.2
Lu, T.3
Zhu, J.4
Xu, G.5
Liu, X.6
-
110
-
-
70350142444
-
Gene dysregulation in Huntington’s disease: REST, microRNAs and beyond
-
Johnson R, Buckley NJ (2009) Gene dysregulation in Huntington’s disease: REST, microRNAs and beyond. Neuromolecular Med 11:183-199
-
(2009)
Neuromolecular Med
, vol.11
, pp. 183-199
-
-
Johnson, R.1
Buckley, N.J.2
-
111
-
-
39649092720
-
A microRNA-based gene dysregulation pathway in Huntington’s disease
-
Johnson R, Zuccato C, Belyaev ND, Guest DJ, Cattaneo E, Buckley NJ (2008) A microRNA-based gene dysregulation pathway in Huntington’s disease. Neurobiol Dis 29:438-445
-
(2008)
Neurobiol Dis
, vol.29
, pp. 438-445
-
-
Johnson, R.1
Zuccato, C.2
Belyaev, N.D.3
Guest, D.J.4
Cattaneo, E.5
Buckley, N.J.6
-
112
-
-
78649352832
-
Mesenchymal stem cells for the treatment of neurodegenerative disease
-
Joyce N, Annett G, Wirthlin L, Olson S, Bauer G, Nolta JA (2010) Mesenchymal stem cells for the treatment of neurodegenerative disease. Regen Med 5:933-946
-
(2010)
Regen Med
, vol.5
, pp. 933-946
-
-
Joyce, N.1
Annett, G.2
Wirthlin, L.3
Olson, S.4
Bauer, G.5
Nolta, J.A.6
-
113
-
-
0036172346
-
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
-
Karpuj MV, Becher MW, Springer JE, Chabas D, Youssef S, Pedotti R, Mitchell D, Steinman L (2002) Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine. Nat Med 8:143-149
-
(2002)
Nat Med
, vol.8
, pp. 143-149
-
-
Karpuj, M.V.1
Becher, M.W.2
Springer, J.E.3
Chabas, D.4
Youssef, S.5
Pedotti, R.6
Mitchell, D.7
Steinman, L.8
-
114
-
-
0036676160
-
Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus
-
Katoh-Semba R, Asano T, Ueda H, Morishita R, Takeuchi IK, Inaguma Y, Kato K (2002) Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus. FASEB J 16:1328-1330
-
(2002)
FASEB J
, vol.16
, pp. 1328-1330
-
-
Katoh-Semba, R.1
Asano, T.2
Ueda, H.3
Morishita, R.4
Takeuchi, I.K.5
Inaguma, Y.6
Kato, K.7
-
115
-
-
2442702838
-
AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease
-
Kells AP, Fong DM, Dragunow M, During MJ, Young D, Connor B (2004) AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease. Mol Ther 9:682-688
-
(2004)
Mol Ther
, vol.9
, pp. 682-688
-
-
Kells, A.P.1
Fong, D.M.2
Dragunow, M.3
During, M.J.4
Young, D.5
Connor, B.6
-
116
-
-
45749153812
-
AAV-BDNF mediated attenuation of quinolinic acidinduced neuropathology and motor function impairment
-
Kells AP, Henry RA, Connor B (2008) AAV-BDNF mediated attenuation of quinolinic acidinduced neuropathology and motor function impairment. Gene Ther 15:966-977
-
(2008)
Gene Ther
, vol.15
, pp. 966-977
-
-
Kells, A.P.1
Henry, R.A.2
Connor, B.3
-
117
-
-
2942616850
-
Gene expression profiling in the intact and injured brain following environmental enrichment
-
Keyvani K, Sachser N, Witte OW, Paulus W (2004) Gene expression profiling in the intact and injured brain following environmental enrichment. J Neuropathol Exp Neurol 63:598-609
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 598-609
-
-
Keyvani, K.1
Sachser, N.2
Witte, O.W.3
Paulus, W.4
-
118
-
-
33749988016
-
Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington’s disease
-
Kishikawa S, Li JL, Gillis T, Hakky MM, Warby S, Hayden M, MacDonald ME, Myers RH, Gusella JF (2006) Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington’s disease. Neurobiol Dis 24:280-285
-
(2006)
Neurobiol Dis
, vol.24
, pp. 280-285
-
-
Kishikawa, S.1
Li, J.L.2
Gillis, T.3
Hakky, M.M.4
Warby, S.5
Hayden, M.6
Macdonald, M.E.7
Myers, R.H.8
Gusella, J.F.9
-
119
-
-
79956017788
-
Blood BDNF concentrations reflect brain-tissue BDNF levels across species
-
Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M, Knudsen GM, Aznar S (2011) Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol 14:347-353
-
(2011)
Int J Neuropsychopharmacol
, vol.14
, pp. 347-353
-
-
Klein, A.B.1
Williamson, R.2
Santini, M.A.3
Clemmensen, C.4
Ettrup, A.5
Rios, M.6
Knudsen, G.M.7
Aznar, S.8
-
120
-
-
0033304705
-
Promoter-specific regulation of the brain-derived neurotropic factor gene by thyroid hormone in the developing rat cerebellum
-
Koibuchi N, Fukuda H, Chin WW (1999) Promoter-specific regulation of the brain-derived neurotropic factor gene by thyroid hormone in the developing rat cerebellum. Endocrinology 140:3955-3961
-
(1999)
Endocrinology
, vol.140
, pp. 3955-3961
-
-
Koibuchi, N.1
Fukuda, H.2
Chin, W.W.3
-
121
-
-
34948838383
-
Riluzole in Huntington’s disease: A 3-year, randomized controlled study
-
Landwehrmeyer GB, Dubois B, de Yebenes JG, Kremer B, Gaus W, Kraus PH, Przuntek H, Dib M, Doble A, Fischer W, Ludolph AC (2007) Riluzole in Huntington’s disease: a 3-year, randomized controlled study. Ann Neurol 62:262-272
-
(2007)
Ann Neurol
, vol.62
, pp. 262-272
-
-
Landwehrmeyer, G.B.1
Dubois, B.2
De Yebenes, J.G.3
Kremer, B.4
Gaus, W.5
Kraus, P.H.6
Przuntek, H.7
Dib, M.8
Doble, A.9
Fischer, W.10
Ludolph, A.C.11
-
122
-
-
1842608950
-
Decreased hippocampal cell proliferation in R6/1 Huntington’s mice
-
Lazic SE, Grote H, Armstrong RJ, Blakemore C, Hannan AJ, van Dellen A, Barker RA (2004) Decreased hippocampal cell proliferation in R6/1 Huntington’s mice. Neuroreport 15:811-813
-
(2004)
Neuroreport
, vol.15
, pp. 811-813
-
-
Lazic, S.E.1
Grote, H.2
Armstrong, R.J.3
Blakemore, C.4
Hannan, A.J.5
Van Dellen, A.6
Barker, R.A.7
-
123
-
-
0036488190
-
Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice
-
Lee J, Seroogy KB, Mattson MP (2002) Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem 80:539-547
-
(2002)
J Neurochem
, vol.80
, pp. 539-547
-
-
Lee, J.1
Seroogy, K.B.2
Mattson, M.P.3
-
124
-
-
43749108844
-
SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington’s disease
-
Leone S, Mutti C, Kazantsev A, Sturlese M, Moro S, Cattaneo E, Rigamonti D, Contini A (2008) SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington’s disease. Bioorg Med Chem 16:5695-5703
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 5695-5703
-
-
Leone, S.1
Mutti, C.2
Kazantsev, A.3
Sturlese, M.4
Moro, S.5
Cattaneo, E.6
Rigamonti, D.7
Contini, A.8
-
125
-
-
0037423204
-
Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders
-
Lesort M, Lee M, Tucholski J, Johnson GV (2003) Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. J Biol Chem 278:3825-3830
-
(2003)
J Biol Chem
, vol.278
, pp. 3825-3830
-
-
Lesort, M.1
Lee, M.2
Tucholski, J.3
Johnson, G.V.4
-
126
-
-
0028803757
-
A huntingtin-associated protein enriched in brain with implications for pathology
-
Li XJ, Li SH, Sharp AH, Nucifora FC Jr, Schilling G, Lanahan A, Worley P, Snyder SH, Ross CA (1995) A huntingtin-associated protein enriched in brain with implications for pathology. Nature 378:398-402
-
(1995)
Nature
, vol.378
, pp. 398-402
-
-
Li, X.J.1
Li, S.H.2
Sharp, A.H.3
Nucifora, F.C.4
Schilling, G.5
Lanahan, A.6
Worley, P.7
Snyder, S.H.8
Ross, C.A.9
-
127
-
-
0032519646
-
Interaction of huntingtin-associated protein with dynactin P150Glued
-
Li SH, Gutekunst CA, Hersch SM, Li XJ (1998) Interaction of huntingtin-associated protein with dynactin P150Glued. J Neurosci 18:1261-1269
-
(1998)
J Neurosci
, vol.18
, pp. 1261-1269
-
-
Li, S.H.1
Gutekunst, C.A.2
Hersch, S.M.3
Li, X.J.4
-
128
-
-
0036173896
-
Interaction of Huntington disease protein with transcriptional activator Sp1
-
Li SH, Cheng AL, Zhou H, Lam S, Rao M, Li H, Li XJ (2002) Interaction of Huntington disease protein with transcriptional activator Sp1. Mol Cell Biol 22:1277-1287
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1277-1287
-
-
Li, S.H.1
Cheng, A.L.2
Zhou, H.3
Lam, S.4
Rao, M.5
Li, H.6
Li, X.J.7
-
129
-
-
84875509193
-
Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites
-
Liot G, Zala D, Pla P, Mottet G, Piel M, Saudou F (2013) Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites. J Neurosci 33:6298-6309
-
(2013)
J Neurosci
, vol.33
, pp. 6298-6309
-
-
Liot, G.1
Zala, D.2
Pla, P.3
Mottet, G.4
Piel, M.5
Saudou, F.6
-
130
-
-
31144467231
-
Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
-
Liu QR, Lu L, Zhu XG, Gong JP, Shaham Y, Uhl GR (2006) Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res 1067:1-12
-
(2006)
Brain Res
, pp. 1-12
-
-
Liu, Q.R.1
Lu, L.2
Zhu, X.G.3
Gong, J.P.4
Shaham, Y.5
Uhl, G.R.6
-
131
-
-
37049012118
-
Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer’s disease mechanisms
-
Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM (2007) Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer’s disease mechanisms. Curr Alzheimer Res 4:503-506
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 503-506
-
-
Longo, F.M.1
Yang, T.2
Knowles, J.K.3
Xie, Y.4
Moore, L.A.5
Massa, S.M.6
-
132
-
-
0037101835
-
Dysregulation of gene expression in the R6/2 model of polyglutamine disease: Parallel changes in muscle and brain
-
Luthi-Carter R, Hanson SA, Strand AD, Bergstrom DA, Chun W, Peters NL, Woods AM, Chan EY, Kooperberg C, Krainc D, Young AB, Tapscott SJ, Olson JM (2002) Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain. Hum Mol Genet 11:1911-1926
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1911-1926
-
-
Luthi-Carter, R.1
Hanson, S.A.2
Strand, A.D.3
Bergstrom, D.A.4
Chun, W.5
Peters, N.L.6
Woods, A.M.7
Chan, E.Y.8
Kooperberg, C.9
Krainc, D.10
Young, A.B.11
Tapscott, S.J.12
Olson, J.M.13
-
133
-
-
34247402598
-
Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington’s disease
-
Lynch G, Kramar EA, Rex CS, Jia Y, Chappas D, Gall CM, Simmons DA (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington’s disease. J Neurosci 27:4424-4434
-
(2007)
J Neurosci
, vol.27
, pp. 4424-4434
-
-
Lynch, G.1
Kramar, E.A.2
Rex, C.S.3
Jia, Y.4
Chappas, D.5
Gall, C.M.6
Simmons, D.A.7
-
134
-
-
84866253260
-
Members of the myocyte enhancer factor 2 transcription factor family differentially regulate Bdnf transcription in response to neuronal depolarization
-
Lyons MR, Schwarz CM, West AE (2012) Members of the myocyte enhancer factor 2 transcription factor family differentially regulate Bdnf transcription in response to neuronal depolarization. J Neurosci 32:12780-12785
-
(2012)
J Neurosci
, vol.32
, pp. 12780-12785
-
-
Lyons, M.R.1
Schwarz, C.M.2
West, A.E.3
-
135
-
-
33751227840
-
No association between polymorphisms in the BDNF gene and age at onset in Huntington disease
-
Mai M, Akkad AD, Wieczorek S, Saft C, Andrich J, Kraus PH, Epplen JT, Arning L (2006) No association between polymorphisms in the BDNF gene and age at onset in Huntington disease. BMC Med Genet 7:79
-
(2006)
BMC Med Genet
, vol.7
, pp. 79
-
-
Mai, M.1
Akkad, A.D.2
Wieczorek, S.3
Saft, C.4
Rich, J.5
Kraus, P.H.6
Epplen, J.T.7
Arning, L.8
-
136
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87:493-506
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
Bates, G.P.11
-
137
-
-
0029905329
-
Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells
-
Martinez-Serrano A, Bjorklund A (1996) Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells. J Neurosci 16:4604-4616
-
(1996)
J Neurosci
, vol.16
, pp. 4604-4616
-
-
Martinez-Serrano, A.1
Bjorklund, A.2
-
138
-
-
0242300612
-
DNA methylationrelated chromatin remodeling in activity-dependent BDNF gene regulation
-
Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE (2003) DNA methylationrelated chromatin remodeling in activity-dependent BDNF gene regulation. Science 302:890-893
-
(2003)
Science
, vol.302
, pp. 890-893
-
-
Martinowich, K.1
Hattori, D.2
Wu, H.3
Fouse, S.4
He, F.5
Hu, Y.6
Fan, G.7
Sun, Y.E.8
-
139
-
-
77649302072
-
Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data
-
Marullo M, Zuccato C, Mariotti C, Lahiri N, Tabrizi SJ, Di Donato S, Cattaneo E (2010) Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data. Genome Biol 11: 9
-
(2010)
Genome Biol
, vol.11
, pp. 9
-
-
Marullo, M.1
Zuccato, C.2
Mariotti, C.3
Lahiri, N.4
Tabrizi, S.J.5
Di Donato, S.6
Cattaneo, E.7
-
140
-
-
0034764208
-
The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain
-
Marvanova M, Lakso M, Pirhonen J, Nawa H, Wong G, Castren E (2001) The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain. Mol Cell Neurosci 18:247-258
-
(2001)
Mol Cell Neurosci
, vol.18
, pp. 247-258
-
-
Marvanova, M.1
Lakso, M.2
Pirhonen, J.3
Nawa, H.4
Wong, G.5
Castren, E.6
-
141
-
-
77951855933
-
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
-
Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM (2010) Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest 120:1774-1785
-
(2010)
J Clin Invest
, vol.120
, pp. 1774-1785
-
-
Massa, S.M.1
Yang, T.2
Xie, Y.3
Shi, J.4
Bilgen, M.5
Joyce, J.N.6
Nehama, D.7
Rajadas, J.8
Longo, F.M.9
-
142
-
-
0037314445
-
Meal size and frequency affect neuronal plasticity and vulnerability to disease: Cellular and molecular mechanisms
-
Mattson MP, Duan W, Guo Z (2003) Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J Neurochem 84:417-431
-
(2003)
J Neurochem
, vol.84
, pp. 417-431
-
-
Mattson, M.P.1
Duan, W.2
Guo, Z.3
-
143
-
-
0034285017
-
CREB-binding protein sequestration by expanded polyglutamine
-
McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH (2000) CREB-binding protein sequestration by expanded polyglutamine. Hum Mol Genet 9:2197-2202
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2197-2202
-
-
McCampbell, A.1
Taylor, J.P.2
Taye, A.A.3
Robitschek, J.4
Li, M.5
Walcott, J.6
Merry, D.7
Chai, Y.8
Paulson, H.9
Sobue, G.10
Fischbeck, K.H.11
-
144
-
-
33645642673
-
Interaction of Huntingtin-associated protein-1 with kinesin light chain: Implications in intracellular trafficking in neurons
-
McGuire JR, Rong J, Li SH, Li XJ (2006) Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. J Biol Chem 281:3552-3559
-
(2006)
J Biol Chem
, vol.281
, pp. 3552-3559
-
-
McGuire, J.R.1
Rong, J.2
Li, S.H.3
Li, X.J.4
-
145
-
-
0027359034
-
Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation
-
Metsis M, Timmusk T, Arenas E, Persson H (1993) Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc Natl Acad Sci USA 90:8802-8806
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8802-8806
-
-
Metsis, M.1
Timmusk, T.2
Arenas, E.3
Persson, H.4
-
146
-
-
33746961204
-
Genetic analysis of candidate genes modifying the age-at-onset in Huntington’s disease
-
Metzger S, Bauer P, Tomiuk J, Laccone F, Didonato S, Gellera C, Mariotti C, Lange HW, Weirich-Schwaiger H, Wenning GK, Seppi K, Melegh B, Havasi V, Baliko L, Wieczorek S, Zaremba J, Hoffman-Zacharska D, Sulek A, Basak AN, Soydan E, Zidovska J, Kebrdlova V, Pandolfo M, Ribai P, Kadasi L, Kvasnicova M, Weber BH, Kreuz F, Dose M, Stuhrmann M, Riess O (2006) Genetic analysis of candidate genes modifying the age-at-onset in Huntington’s disease. Hum Genet 120:285-292
-
(2006)
Hum Genet
, vol.120
, pp. 285-292
-
-
Metzger, S.1
Bauer, P.2
Tomiuk, J.3
Laccone, F.4
Didonato, S.5
Gellera, C.6
Mariotti, C.7
Lange, H.W.8
Weirich-Schwaiger, H.9
Wenning, G.K.10
Seppi, K.11
Melegh, B.12
Havasi, V.13
Baliko, L.14
Wieczorek, S.15
Zaremba, J.16
Hoffman-Zacharska, D.17
Sulek, A.18
Basak, A.N.19
Soydan, E.20
Zidovska, J.21
Kebrdlova, V.22
Pandolfo, M.23
Ribai, P.24
Kadasi, L.25
Kvasnicova, M.26
Weber, B.H.27
Kreuz, F.28
Dose, M.29
Stuhrmann, M.30
Riess, O.31
more..
-
147
-
-
82155182012
-
SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington’s disease
-
Mielcarek M, Benn CL, Franklin SA, Smith DL, Woodman B, Marks PA, Bates GP (2011) SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington’s disease. PLoS One 6(11):27746
-
(2011)
Plos One
, vol.6
, Issue.11
, pp. 27746
-
-
Mielcarek, M.1
Benn, C.L.2
Franklin, S.A.3
Smith, D.L.4
Woodman, B.5
Marks, P.A.6
Bates, G.P.7
-
148
-
-
74549181538
-
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington’s disease mice
-
Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, Ko RW, Vasuta OC, Graham RK, Hayden MR, Murphy TH, Raymond LA (2010) Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington’s disease mice. Neuron 65:178-190
-
(2010)
Neuron
, vol.65
, pp. 178-190
-
-
Milnerwood, A.J.1
Gladding, C.M.2
Pouladi, M.A.3
Kaufman, A.M.4
Hines, R.M.5
Boyd, J.D.6
Ko, R.W.7
Vasuta, O.C.8
Graham, R.K.9
Hayden, M.R.10
Murphy, T.H.11
Raymond, L.A.12
-
149
-
-
0035860435
-
Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes
-
Mizuta I, Ohta M, Ohta K, Nishimura M, Mizuta E, Kuno S (2001) Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes. Neurosci Lett 310:117-120
-
(2001)
Neurosci Lett
, vol.310
, pp. 117-120
-
-
Mizuta, I.1
Ohta, M.2
Ohta, K.3
Nishimura, M.4
Mizuta, E.5
Kuno, S.6
-
150
-
-
0036135090
-
Association studies of multiple candidate genes for Parkinson’s disease using single nucleotide polymorphisms
-
Momose Y, Murata M, Kobayashi K, Tachikawa M, Nakabayashi Y, Kanazawa I, Toda T (2002) Association studies of multiple candidate genes for Parkinson’s disease using single nucleotide polymorphisms. Ann Neurol 51:133-136
-
(2002)
Ann Neurol
, vol.51
, pp. 133-136
-
-
Momose, Y.1
Murata, M.2
Kobayashi, K.3
Tachikawa, M.4
Nakabayashi, Y.5
Kanazawa, I.6
Toda, T.7
-
151
-
-
60849120450
-
Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice
-
Morton AJ, Glynn D, Leavens W, Zheng Z, Faull RL, Skepper JN, Wight JM (2009) Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice. Neurobiol Dis 33:331-341
-
(2009)
Neurobiol Dis
, vol.33
, pp. 331-341
-
-
Morton, A.J.1
Glynn, D.2
Leavens, W.3
Zheng, Z.4
Faull, R.L.5
Skepper, J.N.6
Wight, J.M.7
-
152
-
-
44049085489
-
Therapeutic potential of fluoxetine in neurological disorders
-
Mostert JP, Koch MW, Heerings M, Heersema DJ, De Keyser J (2008) Therapeutic potential of fluoxetine in neurological disorders. CNS Neurosci Ther 14:153-164
-
(2008)
CNS Neurosci Ther
, vol.14
, pp. 153-164
-
-
Mostert, J.P.1
Koch, M.W.2
Heerings, M.3
Heersema, D.J.4
De Keyser, J.5
-
153
-
-
0036724341
-
The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a familybased association study
-
Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy JL (2002) The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a familybased association study. Am J Hum Genet 71:651-655
-
(2002)
Am J Hum Genet
, vol.71
, pp. 651-655
-
-
Neves-Pereira, M.1
Mundo, E.2
Muglia, P.3
King, N.4
Macciardi, F.5
Kennedy, J.L.6
-
154
-
-
19944430730
-
BDNF gene is a risk factor for schizophrenia in a Scottish population
-
Neves-Pereira M, Cheung JK, Pasdar A, Zhang F, Breen G, Yates P, Sinclair M, Crombie C, Walker N, St Clair DM (2005) BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 10:208-212
-
(2005)
Mol Psychiatry
, vol.10
, pp. 208-212
-
-
Neves-Pereira, M.1
Cheung, J.K.2
Pasdar, A.3
Zhang, F.4
Breen, G.5
Yates, P.6
Sinclair, M.7
Crombie, C.8
Walker, N.9
St Clair, D.M.10
-
155
-
-
0035937523
-
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
-
Nucifora FC Jr, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson TM, Ross CA (2001) Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 291:2423-2428
-
(2001)
Science
, vol.291
, pp. 2423-2428
-
-
Nucifora, F.C.1
Sasaki, M.2
Peters, M.F.3
Huang, H.4
Cooper, J.K.5
Yamada, M.6
Takahashi, H.7
Tsuji, S.8
Troncoso, J.9
Dawson, V.L.10
Dawson, T.M.11
Ross, C.A.12
-
156
-
-
0034208461
-
A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis
-
Ochs G, Penn RD, York M, Giess R, Beck M, Tonn J, Haigh J, Malta E, Traub M, Sendtner M, Toyka KV (2000) A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1:201-206
-
(2000)
Amyotroph Lateral Scler Other Motor Neuron Disord
, vol.1
, pp. 201-206
-
-
Ochs, G.1
Penn, R.D.2
York, M.3
Giess, R.4
Beck, M.5
Tonn, J.6
Haigh, J.7
Malta, E.8
Traub, M.9
Sendtner, M.10
Toyka, K.V.11
-
157
-
-
71549143207
-
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
-
Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA (2009) Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med 15:1407-1413
-
(2009)
Nat Med
, vol.15
, pp. 1407-1413
-
-
Okamoto, S.1
Pouladi, M.A.2
Talantova, M.3
Yao, D.4
Xia, P.5
Ehrnhoefer, D.E.6
Zaidi, R.7
Clemente, A.8
Kaul, M.9
Graham, R.K.10
Zhang, D.11
Vincent Chen, H.S.12
Tong, G.13
Hayden, M.R.14
Lipton, S.A.15
-
158
-
-
84856742161
-
Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington’s disease
-
Olson SD, Pollock K, Kambal A, Cary W, Mitchell GM, Tempkin J, Stewart H, McGee J, Bauer G, Kim HS, Tempkin T, Wheelock V, Annett G, Dunbar G, Nolta JA (2012) Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington’s disease. Mol Neurobiol 45:87-98
-
(2012)
Mol Neurobiol
, vol.45
, pp. 87-98
-
-
Olson, S.D.1
Pollock, K.2
Kambal, A.3
Cary, W.4
Mitchell, G.M.5
Tempkin, J.6
Stewart, H.7
McGee, J.8
Bauer, G.9
Kim, H.S.10
Tempkin, T.11
Wheelock, V.12
Annett, G.13
Dunbar, G.14
Nolta, J.A.15
-
159
-
-
34250767817
-
Chromatin crosstalk in development and disease: Lessons from REST
-
Ooi L, Wood IC (2007) Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet 8:544-554
-
(2007)
Nat Rev Genet
, vol.8
, pp. 544-554
-
-
Ooi, L.1
Wood, I.C.2
-
160
-
-
40849147435
-
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking
-
Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ (2008) N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. J Neurosci 28:2783-2792
-
(2008)
J Neurosci
, vol.28
, pp. 2783-2792
-
-
Orr, A.L.1
Li, S.2
Wang, C.E.3
Li, H.4
Wang, J.5
Rong, J.6
Xu, X.7
Mastroberardino, P.G.8
Greenamyre, J.T.9
Li, X.J.10
-
161
-
-
0033526178
-
Penetration of neurotrophins and cytokines across the blood-brain/ blood-spinal cord barrier
-
Pan W, Kastin AJ (1999) Penetration of neurotrophins and cytokines across the blood-brain/ blood-spinal cord barrier. Adv Drug Deliv Rev 36:291-298
-
(1999)
Adv Drug Deliv Rev
, vol.36
, pp. 291-298
-
-
Pan, W.1
Kastin, A.J.2
-
162
-
-
0032404127
-
Transport of brain-derived neurotrophic factor across the blood-brain barrier
-
Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553-1561
-
(1998)
Neuropharmacology
, vol.37
, pp. 1553-1561
-
-
Pan, W.1
Banks, W.A.2
Fasold, M.B.3
Bluth, J.4
Kastin, A.J.5
-
163
-
-
33745979171
-
Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington’s disease transgenic mice
-
Pang TY, Stam NC, Nithianantharajah J, Howard ML, Hannan AJ (2006) Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington’s disease transgenic mice. Neuroscience 141:569-584
-
(2006)
Neuroscience
, vol.141
, pp. 569-584
-
-
Pang, T.Y.1
Stam, N.C.2
Nithianantharajah, J.3
Howard, M.L.4
Hannan, A.J.5
-
164
-
-
33748452503
-
Molecular Trojan horses for blood-brain barrier drug delivery
-
Pardridge WM (2006) Molecular Trojan horses for blood-brain barrier drug delivery. Curr Opin Pharmacol 6:494-500
-
(2006)
Curr Opin Pharmacol
, vol.6
, pp. 494-500
-
-
Pardridge, W.M.1
-
165
-
-
14644390283
-
Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo
-
Pattabiraman PP, Tropea D, Chiaruttini C, Tongiorgi E, Cattaneo A, Domenici L (2005) Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. Mol Cell Neurosci 28:556-570
-
(2005)
Mol Cell Neurosci
, vol.28
, pp. 556-570
-
-
Pattabiraman, P.P.1
Tropea, D.2
Chiaruttini, C.3
Tongiorgi, E.4
Cattaneo, A.5
Domenici, L.6
-
166
-
-
39249084415
-
The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington’s disease mouse model
-
Peng Q, Masuda N, Jiang M, Li Q, Zhao M, Ross CA, Duan W (2008) The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington’s disease mouse model. Exp Neurol 210:154-163
-
(2008)
Exp Neurol
, vol.210
, pp. 154-163
-
-
Peng, Q.1
Masuda, N.2
Jiang, M.3
Li, Q.4
Zhao, M.5
Ross, C.A.6
Duan, W.7
-
167
-
-
0345517258
-
Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivo
-
Perez-Navarro E, Alberch J, Neveu I, Arenas E (1999) Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivo. Neuroscience 91:1257-1264
-
(1999)
Neuroscience
, vol.91
, pp. 1257-1264
-
-
Perez-Navarro, E.1
Alberch, J.2
Neveu, I.3
Arenas, E.4
-
168
-
-
0033789409
-
Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington’s disease
-
Perez-Navarro E, Canudas AM, Akerund P, Alberch J, Arenas E (2000) Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington’s disease. J Neurochem 75:2190-2199
-
(2000)
J Neurochem
, vol.75
, pp. 2190-2199
-
-
Perez-Navarro, E.1
Canudas, A.M.2
Akerund, P.3
Alberch, J.4
Arenas, E.5
-
169
-
-
0032862062
-
Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year
-
Pham TM, Ickes B, Albeck D, Soderstrom S, Granholm AC, Mohammed AH (1999a) Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year. Neuroscience 94:279-286
-
(1999)
Neuroscience
, vol.94
, pp. 279-286
-
-
Pham, T.M.1
Ickes, B.2
Albeck, D.3
Soderstrom, S.4
Granholm, A.C.5
Mohammed, A.H.6
-
170
-
-
0344200106
-
Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats
-
Pham TM, Soderstrom S, Winblad B, Mohammed AH (1999b) Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats. Behav Brain Res 103:63-70
-
(1999)
Behav Brain Res
, vol.103
, pp. 63-70
-
-
Pham, T.M.1
Soderstrom, S.2
Winblad, B.3
Mohammed, A.H.4
-
171
-
-
72949098095
-
Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington’s disease
-
Pineda JR, Pardo R, Zala D, Yu H, Humbert S, Saudou F (2009) Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington’s disease. Mol Brain 2:33
-
(2009)
Mol Brain
, vol.2
, pp. 33
-
-
Pineda, J.R.1
Pardo, R.2
Zala, D.3
Yu, H.4
Humbert, S.5
Saudou, F.6
-
172
-
-
84866612250
-
NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
-
Pouladi MA, Brillaud E, Xie Y, Conforti P, Graham RK, Ehrnhoefer DE, Franciosi S, Zhang W, Poucheret P, Compte E, Maurel JC, Zuccato C, Cattaneo E, Neri C, Hayden MR (2012) NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease. Neurobiol Dis 48:282-289
-
(2012)
Neurobiol Dis
, vol.48
, pp. 282-289
-
-
Pouladi, M.A.1
Brillaud, E.2
Xie, Y.3
Conforti, P.4
Graham, R.K.5
Ehrnhoefer, D.E.6
Franciosi, S.7
Zhang, W.8
Poucheret, P.9
Compte, E.10
Maurel, J.C.11
Zuccato, C.12
Cattaneo, E.13
Neri, C.14
Hayden, M.R.15
-
173
-
-
34547499702
-
Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters
-
Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T (2007) Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 90:397-406
-
(2007)
Genomics
, vol.90
, pp. 397-406
-
-
Pruunsild, P.1
Kazantseva, A.2
Aid, T.3
Palm, K.4
Timmusk, T.5
-
174
-
-
79952255488
-
Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene
-
Pruunsild P, Sepp M, Orav E, Koppel I, Timmusk T (2011) Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene. J Neurosci 31:3295-3308
-
(2011)
J Neurosci
, vol.31
, pp. 3295-3308
-
-
Pruunsild, P.1
Sepp, M.2
Orav, E.3
Koppel, I.4
Timmusk, T.5
-
175
-
-
0030062891
-
Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay
-
Radka SF, Holst PA, Fritsche M, Altar CA (1996) Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res 709:122-301
-
(1996)
Brain Res
, vol.709
, pp. 122-301
-
-
Radka, S.F.1
Holst, P.A.2
Fritsche, M.3
Altar, C.A.4
-
176
-
-
0033756390
-
Genetic analysis of learning behavior-induced structural plasticity
-
Rampon C, Tsien JZ (2000) Genetic analysis of learning behavior-induced structural plasticity. Hippocampus 10:605-609
-
(2000)
Hippocampus
, vol.10
, pp. 605-609
-
-
Rampon, C.1
Tsien, J.Z.2
-
178
-
-
70349254437
-
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
-
Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, Secher NH, Pedersen BK, Pilegaard H (2009) Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol 94:1062-1069
-
(2009)
Exp Physiol
, vol.94
, pp. 1062-1069
-
-
Rasmussen, P.1
Brassard, P.2
Adser, H.3
Pedersen, M.V.4
Leick, L.5
Hart, E.6
Secher, N.H.7
Pedersen, B.K.8
Pilegaard, H.9
-
179
-
-
76149121821
-
Global deprivation of brainderived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth
-
Rauskolb S, Zagrebelsky M, Dreznjak A, Deogracias R, Matsumoto T, Wiese S, Erne B, Sendtner M, Schaeren-Wiemers N, Korte M, Barde YA (2010) Global deprivation of brainderived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J Neurosci 30:1739-1749
-
(2010)
J Neurosci
, vol.30
, pp. 1739-1749
-
-
Rauskolb, S.1
Zagrebelsky, M.2
Dreznjak, A.3
Deogracias, R.4
Matsumoto, T.5
Wiese, S.6
Erne, B.7
Sendtner, M.8
Schaeren-Wiemers, N.9
Korte, M.10
Barde, Y.A.11
-
180
-
-
0001589776
-
Differential loss of striatal projection neurons in Huntington disease
-
Reiner A, Albin RL, Anderson KD, D’Amato CJ, Penney JB, Young AB (1988) Differential loss of striatal projection neurons in Huntington disease. Proc Natl Acad Sci USA 85:5733-5737
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 5733-5737
-
-
Reiner, A.1
Albin, R.L.2
Erson, K.D.3
D’Amato, C.J.4
Penney, J.B.5
Young, A.B.6
-
181
-
-
0034657112
-
Wild-type huntingtin protects from apoptosis upstream of caspase-3
-
Rigamonti D, Bauer JH, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, Cooper JK, Ross CA, Govoni S, Vincenz C, Cattaneo E (2000) Wild-type huntingtin protects from apoptosis upstream of caspase-3. J Neurosci 20:3705-3713
-
(2000)
J Neurosci
, vol.20
, pp. 3705-3713
-
-
Rigamonti, D.1
Bauer, J.H.2
De-Fraja, C.3
Conti, L.4
Sipione, S.5
Sciorati, C.6
Clementi, E.7
Hackam, A.8
Hayden, M.R.9
Li, Y.10
Cooper, J.K.11
Ross, C.A.12
Govoni, S.13
Vincenz, C.14
Cattaneo, E.15
-
182
-
-
34548302039
-
Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators
-
Rigamonti D, Bolognini D, Mutti C, Zuccato C, Tartari M, Sola F, Valenza M, Kazantsev AG, Cattaneo E (2007) Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators. J Biol Chem 282:24554-24562
-
(2007)
J Biol Chem
, vol.282
, pp. 24554-24562
-
-
Rigamonti, D.1
Bolognini, D.2
Mutti, C.3
Zuccato, C.4
Tartari, M.5
Sola, F.6
Valenza, M.7
Kazantsev, A.G.8
Cattaneo, E.9
-
183
-
-
70649102209
-
Turning REST/NRSF dysfunction in Huntington’s disease into a pharmaceutical target
-
Rigamonti D, Mutti C, Zuccato C, Cattaneo E, Contini A (2009) Turning REST/NRSF dysfunction in Huntington’s disease into a pharmaceutical target. Curr Pharm Des 15:3958-3967
-
(2009)
Curr Pharm Des
, vol.15
, pp. 3958-3967
-
-
Rigamonti, D.1
Mutti, C.2
Zuccato, C.3
Cattaneo, E.4
Contini, A.5
-
184
-
-
41849133159
-
Cerebral cortex and the clinical expression of Huntington’s disease: Complexity and heterogeneity
-
Rosas HD, Salat DH, Lee SY, Zaleta AK, Pappu V, Fischl B, Greve D, Hevelone N, Hersch SM (2008) Cerebral cortex and the clinical expression of Huntington’s disease: complexity and heterogeneity. Brain 131:1057-1068
-
(2008)
Brain
, vol.131
, pp. 1057-1068
-
-
Rosas, H.D.1
Salat, D.H.2
Lee, S.Y.3
Zaleta, A.K.4
Pappu, V.5
Fischl, B.6
Greve, D.7
Hevelone, N.8
Hersch, S.M.9
-
185
-
-
0036581270
-
Opinion: Neural stem cell therapy for neurological diseases: Dreams and reality
-
Rossi F, Cattaneo E (2002) Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci 3:401-409
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 401-409
-
-
Rossi, F.1
Cattaneo, E.2
-
186
-
-
2342562572
-
Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease
-
Ryu JK, Kim J, Cho SJ, Hatori K, Nagai A, Choi HB, Lee MC, McLarnon JG, Kim SU (2004) Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease. Neurobiol Dis 16:68-77
-
(2004)
Neurobiol Dis
, vol.16
, pp. 68-77
-
-
Ryu, J.K.1
Kim, J.2
Cho, S.J.3
Hatori, K.4
Nagai, A.5
Choi, H.B.6
Lee, M.C.7
McLarnon, J.G.8
Kim, S.U.9
-
187
-
-
84858004648
-
Sox11 modulates brain-derived neurotrophic factor expression in an exon promoter-specific manner
-
Salerno KM, Jing X, Diges CM, Cornuet PK, Glorioso JC, Albers KM (2012) Sox11 modulates brain-derived neurotrophic factor expression in an exon promoter-specific manner. J Neurosci Res 90:1011-1019
-
(2012)
J Neurosci Res
, vol.90
, pp. 1011-1019
-
-
Salerno, K.M.1
Jing, X.2
Diges, C.M.3
Cornuet, P.K.4
Glorioso, J.C.5
Albers, K.M.6
-
188
-
-
37849042536
-
A rational mechanism for combination treatment of Huntington’s disease using lithium and rapamycin
-
Sarkar S, Krishna G, Imarisio S, Saiki S, O’Kane CJ, Rubinsztein DC (2008) A rational mechanism for combination treatment of Huntington’s disease using lithium and rapamycin. Hum Mol Genet 17:170-178
-
(2008)
Hum Mol Genet
, vol.17
, pp. 170-178
-
-
Sarkar, S.1
Krishna, G.2
Imarisio, S.3
Saiki, S.4
O’Kane, C.J.5
Rubinsztein, D.C.6
-
189
-
-
0032475931
-
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
-
Saudou F, Finkbeiner S, Devys D, Greenberg ME (1998) Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95:55-66
-
(1998)
Cell
, vol.95
, pp. 55-66
-
-
Saudou, F.1
Finkbeiner, S.2
Devys, D.3
Greenberg, M.E.4
-
190
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA, Slunt HH, Ratovitski T, Cooper JK, Jenkins NA, Copeland NG, Price DL, Ross CA, Borchelt DR (1999) Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet 8:397-407
-
(1999)
Hum Mol Genet
, vol.8
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
Kotzuk, J.A.6
Slunt, H.H.7
Ratovitski, T.8
Cooper, J.K.9
Jenkins, N.A.10
Copeland, N.G.11
Price, D.L.12
Ross, C.A.13
Borchelt, D.R.14
-
191
-
-
11144358364
-
Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice
-
Schilling G, Savonenko AV, Coonfield ML, Morton JL, Vorovich E, Gale A, Neslon C, Chan N, Eaton M, Fromholt D, Ross CA, Borchelt DR (2004) Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice. Exp Neurol 187:137-149
-
(2004)
Exp Neurol
, vol.187
, pp. 137-149
-
-
Schilling, G.1
Savonenko, A.V.2
Coonfield, M.L.3
Morton, J.L.4
Vorovich, E.5
Gale, A.6
Neslon, C.7
Chan, N.8
Eaton, M.9
Fromholt, D.10
Ross, C.A.11
Borchelt, D.R.12
-
192
-
-
0036861726
-
Cognitive procedural learning in patients with fronto-striatal lesions
-
Schmidtke K, Manner H, Kaufmann R, Schmolck H (2002) Cognitive procedural learning in patients with fronto-striatal lesions. Learn Mem 9:419-429
-
(2002)
Learn Mem
, vol.9
, pp. 419-429
-
-
Schmidtke, K.1
Manner, H.2
Kaufmann, R.3
Schmolck, H.4
-
193
-
-
0037310231
-
A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression
-
Sen S, Nesse RM, Stoltenberg SF, Li S, Gleiberman L, Chakravarti A, Weder AB, Burmeister M (2003) A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 28:397-401
-
(2003)
Neuropsychopharmacology
, vol.28
, pp. 397-401
-
-
Sen, S.1
Nesse, R.M.2
Stoltenberg, S.F.3
Li, S.4
Gleiberman, L.5
Chakravarti, A.6
Weder, A.B.7
Burmeister, M.8
-
194
-
-
2042512984
-
Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington’s disease
-
Senatorov VV, Ren M, Kanai H, Wei H, Chuang DM (2004) Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington’s disease. Mol Psychiatry 9:371-385
-
(2004)
Mol Psychiatry
, vol.9
, pp. 371-385
-
-
Senatorov, V.V.1
Ren, M.2
Kanai, H.3
Wei, H.4
Chuang, D.M.5
-
195
-
-
0034796483
-
Riluzole in Huntington’s disease (HD): An open label study with one year follow up
-
Seppi K, Mueller J, Bodner T, Brandauer E, Benke T, Weirich-Schwaiger H, Poewe W, Wenning GK (2001) Riluzole in Huntington’s disease (HD): an open label study with one year follow up. J Neurol 248:866-869
-
(2001)
J Neurol
, vol.248
, pp. 866-869
-
-
Seppi, K.1
Mueller, J.2
Bodner, T.3
Brandauer, E.4
Benke, T.5
Weirich-Schwaiger, H.6
Poewe, W.7
Wenning, G.K.8
-
196
-
-
0032055648
-
Identification of a signaling pathway involved in calcium regulation of BDNF expression
-
Shieh PB, Hu SC, Bobb K, Timmusk T, Ghosh A (1998) Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 20:727-740
-
(1998)
Neuron
, vol.20
, pp. 727-740
-
-
Shieh, P.B.1
Hu, S.C.2
Bobb, K.3
Timmusk, T.4
Ghosh, A.5
-
197
-
-
58049197863
-
Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/ NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued
-
Shimojo M (2008) Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/ NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued. J Biol Chem 283:34880-34886
-
(2008)
J Biol Chem
, vol.283
, pp. 34880-34886
-
-
Shimojo, M.1
-
198
-
-
63849151219
-
Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington’s disease knockin mice
-
Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G (2009) Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington’s disease knockin mice. Proc Natl Acad Sci USA 106:4906-4911
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4906-4911
-
-
Simmons, D.A.1
Rex, C.S.2
Palmer, L.3
Pandyarajan, V.4
Fedulov, V.5
Gall, C.M.6
Lynch, G.7
-
199
-
-
78650599933
-
Brief ampakine treatments slow the progression of Huntington’s disease phenotypes in R6/2 mice
-
Simmons DA, Mehta RA, Lauterborn JC, Gall CM, Lynch G (2011) Brief ampakine treatments slow the progression of Huntington’s disease phenotypes in R6/2 mice. Neurobiol Dis 41:436-444
-
(2011)
Neurobiol Dis
, vol.41
, pp. 436-444
-
-
Simmons, D.A.1
Mehta, R.A.2
Lauterborn, J.C.3
Gall, C.M.4
Lynch, G.5
-
200
-
-
84888242805
-
A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington’s disease
-
Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM (2013) A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington’s disease. J Neurosci 33:18712-18727
-
(2013)
J Neurosci
, vol.33
, pp. 18712-18727
-
-
Simmons, D.A.1
Belichenko, N.P.2
Yang, T.3
Condon, C.4
Monbureau, M.5
Shamloo, M.6
Jing, D.7
Massa, S.M.8
Longo, F.M.9
-
201
-
-
0036347948
-
Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor
-
Sklar P, Gabriel SB, McInnis MG, Bennett P, Lim YM, Tsan G, Schaffner S, Kirov G, Jones I, Owen M, Craddock N, DePaulo JR, Lander ES (2002) Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry 7:579-593
-
(2002)
Mol Psychiatry
, vol.7
, pp. 579-593
-
-
Sklar, P.1
Gabriel, S.B.2
McInnis, M.G.3
Bennett, P.4
Lim, Y.M.5
Tsan, G.6
Schaffner, S.7
Kirov, G.8
Jones, I.9
Owen, M.10
Craddock, N.11
Depaulo, J.R.12
Lander, E.S.13
-
202
-
-
10744227174
-
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
-
Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR (2003) Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet 12:1555-1567
-
(2003)
Hum Mol Genet
, vol.12
, pp. 1555-1567
-
-
Slow, E.J.1
Van Raamsdonk, J.2
Rogers, D.3
Coleman, S.H.4
Graham, R.K.5
Deng, Y.6
Oh, R.7
Bissada, N.8
Hossain, S.M.9
Yang, Y.Z.10
Li, X.J.11
Simpson, E.M.12
Gutekunst, C.A.13
Leavitt, B.R.14
Hayden, M.R.15
-
203
-
-
78651318398
-
Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington’s disease
-
Soldati C, Bithell A, Conforti P, Cattaneo E, Buckley NJ (2011) Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington’s disease. J Neurochem 116:415-425
-
(2011)
J Neurochem
, vol.116
, pp. 415-425
-
-
Soldati, C.1
Bithell, A.2
Conforti, P.3
Cattaneo, E.4
Buckley, N.J.5
-
204
-
-
84872056224
-
Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington’s disease
-
Soldati C, Bithell A, Johnston C, Wong KY, Stanton LW, Buckley NJ (2013) Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington’s disease. J Neurochem 124:418-430
-
(2013)
J Neurochem
, vol.124
, pp. 418-430
-
-
Soldati, C.1
Bithell, A.2
Johnston, C.3
Wong, K.Y.4
Stanton, L.W.5
Buckley, N.J.6
-
205
-
-
77957751719
-
Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: Implications for cell-based therapies in Parkinson’s disease
-
Somoza R, Juri C, Baes M, Wyneken U, Rubio FJ (2010) Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson’s disease. Biol Blood Marrow Transplant 16:1530-1540
-
(2010)
Biol Blood Marrow Transplant
, vol.16
, pp. 1530-1540
-
-
Somoza, R.1
Juri, C.2
Baes, M.3
Wyneken, U.4
Rubio, F.J.5
-
206
-
-
1542286877
-
Environmental enrichment rescues protein deficits in a mouse model of Huntington’s disease, indicating a possible disease mechanism
-
Spires TL, Grote HE, Varshney NK, Cordery PM, van Dellen A, Blakemore C, Hannan AJ (2004) Environmental enrichment rescues protein deficits in a mouse model of Huntington’s disease, indicating a possible disease mechanism. J Neurosci 24:2270-2276
-
(2004)
J Neurosci
, vol.24
, pp. 2270-2276
-
-
Spires, T.L.1
Grote, H.E.2
Varshney, N.K.3
Cordery, P.M.4
Van Dellen, A.5
Blakemore, C.6
Hannan, A.J.7
-
207
-
-
67349146480
-
Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins
-
Squitieri F, Orobello S, Cannella M, Martino T, Romanelli P, Giovacchini G, Frati L, Mansi L, Ciarmiello A (2009) Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins. Eur J Nucl Med Mol Imaging 36:1113-1120
-
(2009)
Eur J Nucl Med Mol Imaging
, vol.36
, pp. 1113-1120
-
-
Squitieri, F.1
Orobello, S.2
Cannella, M.3
Martino, T.4
Romanelli, P.5
Giovacchini, G.6
Frati, L.7
Mansi, L.8
Ciarmiello, A.9
-
208
-
-
0035909330
-
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
-
Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413:739-743
-
(2001)
Nature
, vol.413
, pp. 739-743
-
-
Steffan, J.S.1
Bodai, L.2
Pallos, J.3
Poelman, M.4
McCampbell, A.5
Apostol, B.L.6
Kazantsev, A.7
Schmidt, E.8
Zhu, Y.Z.9
Greenwald, M.10
Kurokawa, R.11
Housman, D.E.12
Jackson, G.R.13
Marsh, J.L.14
Thompson, L.M.15
-
209
-
-
35548937443
-
Expression profiling of Huntington’s disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration
-
Strand AD, Baquet ZC, Aragaki AK, Holmans P, Yang L, Cleren C, Beal MF, Jones L, Kooperberg C, Olson JM, Jones KR (2007) Expression profiling of Huntington’s disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neurosci 27:11758-11768
-
(2007)
J Neurosci
, vol.27
, pp. 11758-11768
-
-
Strand, A.D.1
Baquet, Z.C.2
Aragaki, A.K.3
Holmans, P.4
Yang, L.5
Cleren, C.6
Beal, M.F.7
Jones, L.8
Kooperberg, C.9
Olson, J.M.10
Jones, K.R.11
-
210
-
-
0037408279
-
Transcriptional abnormalities in Huntington disease
-
Sugars KL, Rubinsztein DC (2003) Transcriptional abnormalities in Huntington disease. Trends Genet 19:233-238
-
(2003)
Trends Genet
, vol.19
, pp. 233-238
-
-
Sugars, K.L.1
Rubinsztein, D.C.2
-
211
-
-
1042289730
-
Decreased cAMP response element-mediated transcription: An early event in exon 1 and full-length cell models of Huntington’s disease that contributes to polyglutamine pathogenesis
-
Sugars KL, Brown R, Cook LJ, Swartz J, Rubinsztein DC (2004) Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington’s disease that contributes to polyglutamine pathogenesis. J Biol Chem 279:4988-4999
-
(2004)
J Biol Chem
, vol.279
, pp. 4988-4999
-
-
Sugars, K.L.1
Brown, R.2
Cook, L.J.3
Swartz, J.4
Rubinsztein, D.C.5
-
213
-
-
0034625450
-
Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels
-
Tabuchi A, Nakaoka R, Amano K, Yukimine M, Andoh T, Kuraishi Y, Tsuda M (2000) Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels. J Biol Chem 275:17269-17275
-
(2000)
J Biol Chem
, vol.275
, pp. 17269-17275
-
-
Tabuchi, A.1
Nakaoka, R.2
Amano, K.3
Yukimine, M.4
Oh, T.5
Kuraishi, Y.6
Tsuda, M.7
-
214
-
-
0037183985
-
Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I
-
Tabuchi A, Sakaya H, Kisukeda T, Fushiki H, Tsuda M (2002) Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. J Biol Chem 277:35920-35931
-
(2002)
J Biol Chem
, vol.277
, pp. 35920-35931
-
-
Tabuchi, A.1
Sakaya, H.2
Kisukeda, T.3
Fushiki, H.4
Tsuda, M.5
-
215
-
-
0034007739
-
Increase of brain-derived neurotrophic factor gene expression in NG108-15 cells by the nuclear isoforms of Ca2+/ calmodulin-dependent protein kinase II
-
Takeuchi Y, Yamamoto H, Miyakawa T, Miyamoto E (2000) Increase of brain-derived neurotrophic factor gene expression in NG108-15 cells by the nuclear isoforms of Ca2+/ calmodulin-dependent protein kinase II. J Neurochem 74:1913-1922
-
(2000)
J Neurochem
, vol.74
, pp. 1913-1922
-
-
Takeuchi, Y.1
Yamamoto, H.2
Miyakawa, T.3
Miyamoto, E.4
-
216
-
-
0036788187
-
Analysis on the promoter region of exon IV brainderived neurotrophic factor in NG108-15 cells
-
Takeuchi Y, Miyamoto E, Fukunaga K (2002) Analysis on the promoter region of exon IV brainderived neurotrophic factor in NG108-15 cells. J Neurochem 83:67-79
-
(2002)
J Neurochem
, vol.83
, pp. 67-79
-
-
Takeuchi, Y.1
Miyamoto, E.2
Fukunaga, K.3
-
217
-
-
0032034262
-
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
-
Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME (1998) Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20:709-726
-
(1998)
Neuron
, vol.20
, pp. 709-726
-
-
Tao, X.1
Finkbeiner, S.2
Arnold, D.B.3
Shaywitz, A.J.4
Greenberg, M.E.5
-
218
-
-
33644596087
-
Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: A critical overview
-
Tardito D, Perez J, Tiraboschi E, Musazzi L, Racagni G, Popoli M (2006) Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol Rev 58:115-134
-
(2006)
Pharmacol Rev
, vol.58
, pp. 115-134
-
-
Tardito, D.1
Perez, J.2
Tiraboschi, E.3
Musazzi, L.4
Racagni, G.5
Popoli, M.6
-
219
-
-
0344076149
-
A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)
-
The BSG
-
The BSG (1999) A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III). Neurology 52:1427-1433
-
(1999)
Neurology
, vol.52
, pp. 1427-1433
-
-
-
220
-
-
0027402152
-
Multiple promoters direct tissue-specific expression of the rat BDNF gene
-
Timmusk T, Palm K, Metsis M, Reintam T, Paalme V, Saarma M, Persson H (1993) Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10:475-489
-
(1993)
Neuron
, vol.10
, pp. 475-489
-
-
Timmusk, T.1
Palm, K.2
Metsis, M.3
Reintam, T.4
Paalme, V.5
Saarma, M.6
Persson, H.7
-
221
-
-
0028891189
-
Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice
-
Timmusk T, Lendahl U, Funakoshi H, Arenas E, Persson H, Metsis M (1995) Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice. J Cell Biol 128:185-199
-
(1995)
J Cell Biol
, vol.128
, pp. 185-199
-
-
Timmusk, T.1
Lendahl, U.2
Funakoshi, H.3
Arenas, E.4
Persson, H.5
Metsis, M.6
-
222
-
-
0033534468
-
Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element
-
Timmusk T, Palm K, Lendahl U, Metsis M (1999) Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J Biol Chem 274:1078-1084
-
(1999)
J Biol Chem
, vol.274
, pp. 1078-1084
-
-
Timmusk, T.1
Palm, K.2
Lendahl, U.3
Metsis, M.4
-
223
-
-
0034703869
-
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells
-
Trettel F, Rigamonti D, Hilditch-Maguire P, Wheeler VC, Sharp AH, Persichetti F, Cattaneo E, MacDonald ME (2000) Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum Mol Genet 9:2799-2809
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2799-2809
-
-
Trettel, F.1
Rigamonti, D.2
Hilditch-Maguire, P.3
Wheeler, V.C.4
Sharp, A.H.5
Persichetti, F.6
Cattaneo, E.7
Macdonald, M.E.8
-
224
-
-
4444316194
-
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
-
Trushina E, Dyer RB, Badger JD, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT (2004) Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol 24:8195-8209
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8195-8209
-
-
Trushina, E.1
Dyer, R.B.2
Badger, J.D.3
Ure, D.4
Eide, L.5
Tran, D.D.6
Vrieze, B.T.7
Legendre-Guillemin, V.8
McPherson, P.S.9
Mandavilli, B.S.10
Van Houten, B.11
Zeitlin, S.12
McNiven, M.13
Aebersold, R.14
Hayden, M.15
Parisi, J.E.16
Seeberg, E.17
Dragatsis, I.18
Doyle, K.19
Bender, A.20
Chacko, C.21
McMurray, C.T.22
more..
-
225
-
-
0034643362
-
Delaying the onset of Huntington’s in mice
-
van Dellen A, Blakemore C, Deacon R, York D, Hannan AJ (2000) Delaying the onset of Huntington’s in mice. Nature 404:721-722
-
(2000)
Nature
, vol.404
, pp. 721-722
-
-
Van Dellen, A.1
Blakemore, C.2
Deacon, R.3
York, D.4
Hannan, A.J.5
-
226
-
-
23644455243
-
Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington’s disease
-
van Dellen A, Grote HE, Hannan AJ (2005) Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington’s disease. Clin Exp Pharmacol Physiol 32:1007-1019
-
(2005)
Clin Exp Pharmacol Physiol
, vol.32
, pp. 1007-1019
-
-
Van Dellen, A.1
Grote, H.E.2
Hannan, A.J.3
-
227
-
-
25644445315
-
Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease
-
Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR (2005) Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease. J Neurochem 95:210-220
-
(2005)
J Neurochem
, vol.95
, pp. 210-220
-
-
Van Raamsdonk, J.M.1
Pearson, J.2
Bailey, C.D.3
Rogers, D.A.4
Johnson, G.V.5
Hayden, M.R.6
Leavitt, B.R.7
-
228
-
-
85047700298
-
Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer’s disease
-
Ventriglia M, Bocchio Chiavetto L, Benussi L, Binetti G, Zanetti O, Riva MA, Gennarelli M (2002) Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer’s disease. Mol Psychiatry 7:136-137
-
(2002)
Mol Psychiatry
, vol.7
, pp. 136-137
-
-
Ventriglia, M.1
Bocchio Chiavetto, L.2
Benussi, L.3
Binetti, G.4
Zanetti, O.5
Riva, M.A.6
Gennarelli, M.7
-
229
-
-
20444448900
-
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo
-
Warby SC, Chan EY, Metzler M, Gan L, Singaraja RR, Crocker SF, Robertson HA, Hayden MR (2005) Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo. Hum Mol Genet 14:1569-1577
-
(2005)
Hum Mol Genet
, vol.14
, pp. 1569-1577
-
-
Warby, S.C.1
Chan, E.Y.2
Metzler, M.3
Gan, L.4
Singaraja, R.R.5
Crocker, S.F.6
Robertson, H.A.7
Hayden, M.R.8
-
230
-
-
0035960005
-
Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington’s disease
-
Wei H, Qin ZH, Senatorov VV, Wei W, Wang Y, Qian Y, Chuang DM (2001) Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington’s disease. Neuroscience 106:603-612
-
(2001)
Neuroscience
, vol.106
, pp. 603-612
-
-
Wei, H.1
Qin, Z.H.2
Senatorov, V.V.3
Wei, W.4
Wang, Y.5
Qian, Y.6
Chuang, D.M.7
-
231
-
-
0032938295
-
Length-dependent gametic CAG repeat instability in the Huntington’s disease knock-in mouse
-
Wheeler VC, Auerbach W, White JK, Srinidhi J, Auerbach A, Ryan A, Duyao MP, Vrbanac V, Weaver M, Gusella JF, Joyner AL, MacDonald ME (1999) Length-dependent gametic CAG repeat instability in the Huntington’s disease knock-in mouse. Hum Mol Genet 8:115-122
-
(1999)
Hum Mol Genet
, vol.8
, pp. 115-122
-
-
Wheeler, V.C.1
Auerbach, W.2
White, J.K.3
Srinidhi, J.4
Auerbach, A.5
Ryan, A.6
Duyao, M.P.7
Vrbanac, V.8
Weaver, M.9
Gusella, J.F.10
Joyner, A.L.11
Macdonald, M.E.12
-
232
-
-
0042666901
-
Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington’s disease mutation
-
Wood NI, Morton AJ (2003) Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington’s disease mutation. Brain Res Bull 61:375-383
-
(2003)
Brain Res Bull
, vol.61
, pp. 375-383
-
-
Wood, N.I.1
Morton, A.J.2
-
233
-
-
77949317804
-
Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release
-
Wu LL, Fan Y, Li S, Li XJ, Zhou XF (2010) Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem 285:5614-5623
-
(2010)
J Biol Chem
, vol.285
, pp. 5614-5623
-
-
Wu, L.L.1
Fan, Y.2
Li, S.3
Li, X.J.4
Zhou, X.F.5
-
234
-
-
78049525220
-
BDNF overexpression in the forebrain rescues Huntington’s disease phenotypes in YAC128 mice
-
Xie Y, Hayden MR, Xu B (2010) BDNF overexpression in the forebrain rescues Huntington’s disease phenotypes in YAC128 mice. J Neurosci 30:14708-14718
-
(2010)
J Neurosci
, vol.30
, pp. 14708-14718
-
-
Xie, Y.1
Hayden, M.R.2
Xu, B.3
-
235
-
-
33644822908
-
Effective gene therapy with nonintegrating lentiviral vectors
-
Yanez-Munoz RJ, Balaggan KS, MacNeil A, Howe SJ, Schmidt M, Smith AJ, Buch P, MacLaren RE, Anderson PN, Barker SE, Duran Y, Bartholomae C, von Kalle C, Heckenlively JR, Kinnon C, Ali RR, Thrasher AJ (2006) Effective gene therapy with nonintegrating lentiviral vectors. Nat Med 12:348-353
-
(2006)
Nat Med
, vol.12
, pp. 348-353
-
-
Yanez-Munoz, R.J.1
Balaggan, K.S.2
Macneil, A.3
Howe, S.J.4
Schmidt, M.5
Smith, A.J.6
Buch, P.7
Maclaren, R.E.8
Erson, P.N.9
Barker, S.E.10
Duran, Y.11
Bartholomae, C.12
Von Kalle, C.13
Heckenlively, J.R.14
Kinnon, C.15
Ali, R.R.16
Thrasher, A.J.17
-
236
-
-
0032957382
-
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
-
Young D, Lawlor PA, Leone P, Dragunow M, During MJ (1999) Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med 5:448-453
-
(1999)
Nat Med
, vol.5
, pp. 448-453
-
-
Young, D.1
Lawlor, P.A.2
Leone, P.3
Dragunow, M.4
During, M.J.5
-
237
-
-
0001611514
-
Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism
-
Yu ZF, Mattson MP (1999) Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J Neurosci Res 57:830-839
-
(1999)
J Neurosci Res
, vol.57
, pp. 830-839
-
-
Yu, Z.F.1
Mattson, M.P.2
-
238
-
-
0037090927
-
Huntingtin inclusions do not deplete polyglutaminecontaining transcription factors in HD mice
-
Yu ZX, Li SH, Nguyen HP, Li XJ (2002) Huntingtin inclusions do not deplete polyglutaminecontaining transcription factors in HD mice. Hum Mol Genet 11:905-914
-
(2002)
Hum Mol Genet
, vol.11
, pp. 905-914
-
-
Yu, Z.X.1
Li, S.H.2
Nguyen, H.P.3
Li, X.J.4
-
239
-
-
0025084077
-
Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors
-
Zafra F, Hengerer B, Leibrock J, Thoenen H, Lindholm D (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 9:3545-3550
-
(1990)
EMBO J
, vol.9
, pp. 3545-3550
-
-
Zafra, F.1
Hengerer, B.2
Leibrock, J.3
Thoenen, H.4
Lindholm, D.5
-
240
-
-
13244253858
-
Mutant huntingtin protein: A substrate for transglutaminase 1, 2, and 3
-
Zainelli GM, Dudek NL, Ross CA, Kim SY, Muma NA (2005) Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3. J Neuropathol Exp Neurol 64:58-65
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 58-65
-
-
Zainelli, G.M.1
Dudek, N.L.2
Ross, C.A.3
Kim, S.Y.4
Muma, N.A.5
-
241
-
-
77951579326
-
Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington’s disease mice
-
Zajac MS, Pang TY, Wong N, Weinrich B, Leang LS, Craig JM, Saffery R, Hannan AJ (2010) Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington’s disease mice. Hippocampus 20:621-636
-
(2010)
Hippocampus
, vol.20
, pp. 621-636
-
-
Zajac, M.S.1
Pang, T.Y.2
Wong, N.3
Weinrich, B.4
Leang, L.S.5
Craig, J.M.6
Saffery, R.7
Hannan, A.J.8
-
242
-
-
57049184027
-
Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons
-
Zala D, Colin E, Rangone H, Liot G, Humbert S, Saudou F (2008) Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum Mol Genet 17:3837-3846
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3837-3846
-
-
Zala, D.1
Colin, E.2
Rangone, H.3
Liot, G.4
Humbert, S.5
Saudou, F.6
-
243
-
-
0141531987
-
Depletion of wild-type huntingtin in mouse models of neurologic diseases
-
Zhang Y, Li M, Drozda M, Chen M, Ren S, Mejia Sanchez RO, Leavitt BR, Cattaneo E, Ferrante RJ, Hayden MR, Friedlander RM (2003) Depletion of wild-type huntingtin in mouse models of neurologic diseases. J Neurochem 87:101-106
-
(2003)
J Neurochem
, vol.87
, pp. 101-106
-
-
Zhang, Y.1
Li, M.2
Drozda, M.3
Chen, M.4
Ren, S.5
Mejia Sanchez, R.O.6
Leavitt, B.R.7
Cattaneo, E.8
Ferrante, R.J.9
Hayden, M.R.10
Friedlander, R.M.11
-
244
-
-
78649687889
-
The effect of physical activity on the brain derived neurotrophic factor: From animal to human studies
-
Zoladz JA, Pilc A (2010) The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol 61:533-541
-
(2010)
J Physiol Pharmacol
, vol.61
, pp. 533-541
-
-
Zoladz, J.A.1
Pilc, A.2
-
245
-
-
34047130812
-
Role of brain-derived neurotrophic factor in Huntington’s disease
-
Zuccato C, Cattaneo E (2007) Role of brain-derived neurotrophic factor in Huntington’s disease. Prog Neurobiol 81:294-330
-
(2007)
Prog Neurobiol
, vol.81
, pp. 294-330
-
-
Zuccato, C.1
Cattaneo, E.2
-
246
-
-
68849083063
-
Brain-derived neurotrophic factor in neurodegenerative diseases
-
Zuccato C, Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5:311-322
-
(2009)
Nat Rev Neurol
, vol.5
, pp. 311-322
-
-
Zuccato, C.1
Cattaneo, E.2
-
247
-
-
0035919701
-
Loss of huntingtin-mediated BDNF gene transcription in Huntington’s disease
-
Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington’s disease. Science 293:493-498
-
(2001)
Science
, vol.293
, pp. 493-498
-
-
Zuccato, C.1
Ciammola, A.2
Rigamonti, D.3
Leavitt, B.R.4
Goffredo, D.5
Conti, L.6
Macdonald, M.E.7
Friedlander, R.M.8
Silani, V.9
Hayden, M.R.10
Timmusk, T.11
Sipione, S.12
Cattaneo, E.13
-
248
-
-
0041353535
-
Huntingtin interacts with REST/ NRSF to modulate the transcription of NRSE-controlled neuronal genes
-
Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, Cataudella T, Leavitt BR, Hayden MR, Timmusk T, Rigamonti D, Cattaneo E (2003) Huntingtin interacts with REST/ NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet 35:76-83
-
(2003)
Nat Genet
, vol.35
, pp. 76-83
-
-
Zuccato, C.1
Tartari, M.2
Crotti, A.3
Goffredo, D.4
Valenza, M.5
Conti, L.6
Cataudella, T.7
Leavitt, B.R.8
Hayden, M.R.9
Timmusk, T.10
Rigamonti, D.11
Cattaneo, E.12
-
249
-
-
20444456571
-
Progressive loss of BDNF in a mouse model of Huntington’s disease and rescue by BDNF delivery
-
Zuccato C, Liber D, Ramos C, Tarditi A, Rigamonti D, Tartari M, Valenza M, Cattaneo E (2005) Progressive loss of BDNF in a mouse model of Huntington’s disease and rescue by BDNF delivery. Pharmacol Res 52:133-139
-
(2005)
Pharmacol Res
, vol.52
, pp. 133-139
-
-
Zuccato, C.1
Liber, D.2
Ramos, C.3
Tarditi, A.4
Rigamonti, D.5
Tartari, M.6
Valenza, M.7
Cattaneo, E.8
-
250
-
-
34347364706
-
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington’s disease
-
Zuccato C, Belyaev N, Conforti P, Ooi L, Tartari M, Papadimou E, MacDonald M, Fossale E, Zeitlin S, Buckley N, Cattaneo E (2007) Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington’s disease. J Neurosci 27:6972-6983
-
(2007)
J Neurosci
, vol.27
, pp. 6972-6983
-
-
Zuccato, C.1
Belyaev, N.2
Conforti, P.3
Ooi, L.4
Tartari, M.5
Papadimou, E.6
Macdonald, M.7
Fossale, E.8
Zeitlin, S.9
Buckley, N.10
Cattaneo, E.11
-
251
-
-
41149120252
-
Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington’s disease
-
Zuccato C, Marullo M, Conforti P, MacDonald ME, Tartari M, Cattaneo E (2008) Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington’s disease. Brain Pathol 18:225-238
-
(2008)
Brain Pathol
, vol.18
, pp. 225-238
-
-
Zuccato, C.1
Marullo, M.2
Conforti, P.3
Macdonald, M.E.4
Tartari, M.5
Cattaneo, E.6
-
252
-
-
77955643169
-
Molecular mechanisms and potential therapeutical targets in Huntington’s disease
-
Zuccato C, Valenza M, Cattaneo E (2010) Molecular mechanisms and potential therapeutical targets in Huntington’s disease. Physiol Rev 90:905-981
-
(2010)
Physiol Rev
, vol.90
, pp. 905-981
-
-
Zuccato, C.1
Valenza, M.2
Cattaneo, E.3
-
253
-
-
80051623323
-
Brain-derived neurotrophic factor in patients with Huntington’s disease
-
Zuccato C, Marullo M, Vitali B, Tarditi A, Mariotti C, Valenza M, Lahiri N, Wild EJ, Sassone J, Ciammola A, Bachoud-Levi AC, Tabrizi SJ, Di Donato S, Cattaneo E (2011) Brain-derived neurotrophic factor in patients with Huntington’s disease. PLoS One 6(8):22966
-
(2011)
Plos One
, vol.6
, Issue.8
, pp. 22966
-
-
Zuccato, C.1
Marullo, M.2
Vitali, B.3
Tarditi, A.4
Mariotti, C.5
Valenza, M.6
Lahiri, N.7
Wild, E.J.8
Sassone, J.9
Ciammola, A.10
Bachoud-Levi, A.C.11
Tabrizi, S.J.12
Di Donato, S.13
Cattaneo, E.14
|