Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

Journal of Clinical Investigation

Volumn 120, Issue 5, 2010, Pages 1774-1785

  Massa, Stephen M ^a   Yang, Tao ^b,c   Xie, Youmei ^b   Shi, Jian ^a   Bilgen, Mehmet ^d   Joyce, Jeffrey N ^e   Nehama, Dean ^c   Rajadas, Jayakumar ^c   Longo, Frank M ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2,7 BIS[[(2 HYDROXYETHYL)AMINO]SULFONYL] 9H FLUOREN 9 YLIDENE] HYDRAZINECARBOXAMIDE; 5 OXO PROLYL HISTIDYL TRYPTOPHAN METHYL ESTER; ACETAMIDE DERIVATIVE; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; N [4 [2 [5 AMINO 4 CYANO 1 (2 HYDROXYETHYL) 1H PYRAZOL 3 YL] 2 CYANOETHENYL]PHENYL] ACETAMIDE; N,N',N'' TRIS(2 HYDROXYETHYL) 1,3,5 BENZENETRICARBOXAMIDE; NEUROTROPHIC FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; FETUS; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; KINETICS; LEARNING; MALE; MOUSE; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN DOMAIN; RODENT; SCREENING TEST; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; HIPPOCAMPUS; KINETICS; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; NEURONS; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB; SIGNAL TRANSDUCTION;

EID: 77951855933     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI41356     Document Type: Article

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