Huntingtin-associated protein 1 (HAP1) interacts with the p150(Glued) subunit of dynactin

Human Molecular Genetics

Volumn 6, Issue 13, 1997, Pages 2205-2212

  Engelender, Simone ^a   Sharp, Alan H ^a   Colomer, Veronica ^a   Tokito, Mariko K ^b   Lanahan, Anthony ^a   Worley, Paul ^a   Holzbaur, Erika L F ^b   Ross, Christopher A ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CHROMOSOME PROTEIN; CYTOSKELETON PROTEIN; DYNACTIN; HUNTINGTIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN; CELL STRAIN; CENTRIOLE; CONFOCAL MICROSCOPY; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IMMUNOFLUORESCENCE; NERVE CELL; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT;

EID: 0030726894     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/6.13.2205     Document Type: Article

References (62)

1. Harper,P.S. (1996) Major Problems in Neurology, Vol. 31. Huntington's Disease. W.B.Saunders, London, UK.
2. Folstein,S.F. (1989) Huntington's Disease, A Disorder of Families. Johns Hopkins University Press, Baltimore, MD.
3. HD Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell, 72, 971-983.
4. Duyao,M., Ambrose,C., Myers,R., Novelletto,A., Persichetti,F., Frontali,M., Folstein,S., Ross,C., Franz,M., Abbott,M., Gray,J., Conneally,P., Young,A., Penney,J., Hollingsworth,Z., Shoulson,I., Lazzarini,A., Falek,A., Koroshetz,W., Sax,D., Bird,E., Vonsattel,J., Bonilla,E., Alvir,J., Conde,B., Cha,J.-H., Dure,L., Gomez,F., Ramos,M., Sanchez-Ramos,J., Snodgrass,S., de Young,M., Wexler,N., Moscowitz,C., Penchaszadeh,G., MacFarlane,H., Anderson,M., Jenkins,B., Srinidhi,J., Barnes,G., Gusella,J. and MacDonald,M. (1993) Trinucleotide repeat length instability and age of onset in Huntington's disease. Nature Genet., 4, 387-392.
5. Stine,O.C., Pleasant,N., Franz,M.L., Abbott,M.H., Folstein,S.E. and Ross.C.A. (1993) Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15. Hum. Mol. Genet., 2, 1547-1549.
6. n repeats in IT-15 in parent-offspring pairs with Huntington's disease. Am. J. Hum. Genet., 57, 593-602.
7. Sharp,A.H., Loev,S.J., Schilling,G., Li,S.-H., Li,X.-J., Bao,J., Wagster,M.V., Kotzuk,J.A., Steiner,J.P., Lo,A., Hedreen,J., Sisodia,S., Snyder,S.H., Dawson,T.M., Ryugo,D.K. and Ross,C.A. (1995) Widespread expression of Huntington's disease gene (IT15) protein product. Neuron, 14, 1065-1074.
8. DiFiglia,M., Sapp,E., Chase,K., Schwarz,C., Meloni,A., Young,C., Martin,E., Vonsattel,J.P., Carraway,R., Reeves,S.A., Boyce,F.M. and Aronin,N. (1995) Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron, 14, 1075-1081.
9. Trottier,Y., Devys,D., Imbert,G., Saudou,F., An,I., Lutz,Y., Weber,C., Agid,Y., Hirsch,E.C. and Mandel,J.-L. (1995) Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form. Nature Genet., 10, 104-110.
10. Gutekunst,C.-A., Level,A.I., Heilman,C.J., Whaley,W.L., Yi,H., Nash,N.R., Rees,H.D., Madden,J.J. and Hersch,S.M. (1995) Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc. Natl. Acad. Sci. USA, 92, 8710-8714.
11. Li,X.-J., Li,S.-H., Sharp,A.H., Nucifora,F.C., Schilling,G., Lanahan,A., Worley,P., Snyder,S.H. and Ross,C.A. (1995) A huntingtin-associated protein enriched in brain with implications for pathology. Nature, 378, 398-402.
12. Wanker,E.E., Rovira,C., Scherzinger,E., Hasenbank,R., WSlter,S., Tait,D., Colicelli,J. and Lehrach,H. (1997) HIP-1: a huntingtin interacting protein isolated by the yeast two-hybrid system. Hum. Mol. Genet., 6, 487-495.
13. Kalchman,M.A., Graham,R.K., Xia,G., Koide,H.B., Hodges,J.G., Graham,K.C., Goldberg,Y.P., Gietz,R.D., Pickart,C.M. and Hayden,M.R. (1996) Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J. Biol. Chem., 271, 19385-19394.
14. Kalchman,M.A., Koide,H.B., McCutcheon,K., Graham,R.K., Nichol,K., Nishiyama,K., Kazemi-Esfarjani,P., Lynn,F.C., Wellington,C., Metzler,M., Goldberg,Y.P., Kanazawa,I., Gietz,R.D. and Hayden,M.R. (1997) HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. Nature Genet., 16, 44-53.
15. Burke,J.R., Enghild,J.J., Martin,M.E., Jou,Y.S., Myers,R.M., Roses,A.D., Vance,J.M. and Strittmatter,W.J. (1996) Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Med., 2, 347-350.
16. Li,X.-J., Sharp,A.H., Li,S.-H., Dawson,T.M., Snyder,S.H. and Ross,C.A. (1996) Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble nitric oxide synthase. Proc. Natl. Acad. Sci. USA, 93, 4839-4844.
17. Colomer,V., Engelender,E., Sharp,A.H., Duan,K., Cooper,J.K., Lanahan,A., Lyford,G., Worley,P. and Ross,C.A. (1997) Huntingtin-associated protein 1 (HAP1) binds to a trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Hum. Mol. Genet., 6, 1519-1525.
18. Holzbaur,E.L., Hammarback,J.A., Paschal,B.M., Kravit,N.G., Pfister,K.K. and Vallee,R.B. (1991) Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued. Nature, 351, 579-583.
19. Gill,S.R., Schroer,T.A., Szilak,I., Steuer,E.R., Sheetz,M.P. and Cleveland,D.W. (1991) Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J. Cell Biol., 6, 1639-1650.
20. Tokito,M.K., Howland,D.S., Lee,V.M.-Y. and Holzbaur,E.L.F̀. (1996) Functionally distinct isoforms of dynactin are expressed in human neurons. Mol. Biol. Cell, 7, 1167-1180.
21. Balczon,R., Bao,L. and Zimmer,W.E. (1994) PCM-1, a 228-kD centrosome autoantigen with a distinct cell cycle distribution. J. Cell Biol., 124, 783-794.
22. Myers,M.W., Lazzarini,R.A., Lee,V.M., Schlaepfer,W.W. and Nelson,D.L. (1987) The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family. EMBO J., 6, 1617-1626.
23. Schnapp,B.J. (1997) Retroactive motors. Neuron, 18, 523-526.
24. Karpinski,B.A., Morle,G.D., Huggenvik,J., Uhler,M.D. and Leiden,J.M. (1992) Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc. Natl. Acad. Sci. USA, 89, 4820-4824.
25. Friedman,J.R., Fredericks,W.J., Jensen,D.E., Speicher,D.W., Huang,X.-P., Neilson,E.G. and Rauscher,F.J. (1996) KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Der., 10, 2067-2078.
26. Moosman,P., Georgiev,O., Le Douarin,B., Bourquin,J.-P. and Schaffner,W. (1996) Transcriptional repression by RING finger protein TIF1β that interacts with the KRAB repressor domain of KOX1. Nucleic Acids Res., 24, 4859-4867.
27. Lupas,A. (1996) Prediction and analysis of coiled-coil structures. Methods Enzymol., 266, 513-525.
28. Berger,B., Wilson,D.B., Wolf,E., Tonchev,T., Milla,M. and Kim,P.S. (1995) Predicting coiled coils by use of pairwise residue correlations. Proc. Natl. Acad. Sci. USA, 92, 8259-8263.
29. Lupas,A. (1996) Coiled coils: new structures and new functions. Trends Biochem. Sci., 21, 357-406.
30. Jaffrey,S.R. and Snyder,S.H. (1996) PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science, 274, 774-777.
31. Glued component of the dynactin complex in developing and adult rat brain. J. Comp. Neurol, 357, 15-24.
32. Holleran,E.A., Tokito,M.K., Karki,S. and Holzbaur,E.L.F. (1996) Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. J. Cell Biol., 135, 1815-1829.
33. Huttner,W.B., Schiebler,W., Greengard,P. and Camilli,P. (1983) Synapsin (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J. Cell Biol., 96, 1374-1388.
34. Jahn,R., Schiebler,W., Ouimet,C. and Greengard,P. (1985) A 30,000-dalton membrane protein (p38) present in synaptic vesicles. Proc. Natl. Acad. Sci. USA, 82, 4137-4141.
35. Matthew,W.D., Tsaveler,L. and Reichardt,L.F. (1981) Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. J. Cell Biol., 91, 257-269.
36. Green,L.A. and Tischler,A.S. (1976) Establishment of noradrenergic clonal line of rat adrenal pheocromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA, 73, 2424-2428.
37. O'Shea,E.K., Klemm,J.D., Kim,P.S. and Alber,T. (1991) X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science, 254, 539-544.
38. Schafer,D.A., Gill,S.R., Cooper,J.A., Heuser,J.E. and Schroer,T.A. (1994) Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin. J. Cell Biol., 126, 403-412.
39. Sweeney,H.L. and Holzbaur,E.L.F. (1996) Mutational analysis of motor proteins. Annu. Rev. Physiol., 58, 751-792.
40. Glued binds directly to both the microtubule and centractin. Proc. Natl. Acad. Sci. USA, 92, 1634-1638.
41. Karki,S. and Holzbaur,E.L.F. (1995) Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J. Biol. Chem., 270, 28806-28811.
42. Glued. J. Cell Biol., 131, 1507-1516.
43. Waterman-Storer,C.M., Kuznetsov,S., Karki,S., Tabb,J.S., Weiss,D.G., Langford,G.M. and Holzbaur,E.L.F. (1997) The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport. Proc. Natl. Acad. Sci. USA, in press.
44. Harte,P.J., Kankel,D.R. (1982) Genetic analysis of mutations at the Glued locus and interacting loci in Drosophila melanogaster. Genetics, 101, 477-501.
45. Garen,S.H. and Kankel,D.R. (1983) Golgi and genetic mosaic analyses of visual system mutants in Drosophila melanogaster. Dev. Biol., 96, 445-466.
46. Corthésy-Theulaz,I., Pauloin,A. and Pfeffer,S.R. (1992) Cytoplasmic dynein participates in the centrosomal localization of the Golgi complex. J. Cell Biol., 118, 1333-1345.
47. Fath,K.R., Trimbur,G.M. and Burgess,D.R. (1994) Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells. J. Cell Biol., 126, 661-675.
48. Alam,M.R., Caldwell,B.D., Johnson,R.C., Darlington,D.N., Mains,R.E. and Eipper,B.A. (1996) Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide processing enzyme. J. Biol. Chem., 271, 28636-28640.
49. Alam,M.R., Johnson,R.C., Darlington,D.N., Hand,T.A., Mains,R.E. and Eipper,B.A. (1997) Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine α-amidating monooxygenase, an integral membrane peptide-processing enzyme. J. Biol. Chem., 272, 12667-12675.
50. Milgram,S.L., Mains,R.E. and Eipper,B.A. (1996) Identification of routing determinants in the cytosolic domain of a secretory granule-associated integral membrane protein. J. Biol. Chem., 271, 17526-17535.
51. Pearlman,J.A., Powaser,P.A., Elledge,S.J. and Caskey,C.T. (1994) Troponin T is capable of binding dystrophin via leucine zipper. FEBS Lett., 354, 183-186.
52. Kumar,J., Yu,H. and Sheetz,M.P. (1995) Kinectin, an essential anchor for kinesin-driven vesicle motility. Science, 267, 1834-1837.
53. Vallee,R.B. and Sheetz,M.P. (1996) Targeting of motor proteins. Science, 271, 1539-1544.
54. Balczon,R. and West,K. (1991) The identification of mammalian centrosomal antigens using human autoimmune anticentrosome antisera. Cell Motil. Cytoskeleton, 20, 121-135.
55. Graveland,G.A., Williams,R.S. and DiFiglia,M. (1985) Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease. Science, 227, 770-773.
56. Sotrel,A., Williams,R.S., Kaufmann,W.E. and Myers,R.H. (1993) Evidence for neuronal degeneration and dendritic plasticity of pyramidal neurons of Huntington's disease: a quantitative Golgi study. Neurology, 43, 2088-2096.
57. Sapp,E., Schwarz,C., Chase,K., Bhide,P., Young,A.B., Penney,J., Vonsattel,J.P., Aronin,N. and DiFiglia,M. (1997) Altered neuronal expression and intracellular trafficking of huntingtin in the Huntington's disease brain. Soc. Neurosci. Abstr., 22, 226.
58. Velier,J., Schwarz,C., Young,C., Fallon,J., Hyman,B., Martin,E.J., Hughes,S., Vallee,R., Aronin,N., DiFiglia,M. (1996) Wild-type and mutant huntingtin localize to the golgi complex and to vesicles in the peripheral cytoplasm in fibroblasts of control and HD patients. Soc. Neurosci. Abstr., 22, 226.
59. Chevray,P.M. and Nathans,D. (1992) Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc. Natl. Acad. Sci. USA, 89, 5789-5793.
60. Fields,S. and Sternglanz,R. (1994) The two-hybrid system: an assay for protein-protein interactions. Trends Genet., 10, 286-292.
61. Sambrook,J., Fritsch,E.F. and Maniatis,T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 16.30 and 16.32.
62. Green,L.A., Aletta,J.M., Rukenstein,A. and Green,S.H. (1987) PC12 pheocromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation. Methods Enzymol., 147B, 207-216.