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Volumn 95, Issue 1, 1998, Pages 55-66

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN;

EID: 0032475931     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81782-1     Document Type: Article
Times cited : (1405)

References (38)
  • 1
    • 0025040233 scopus 로고
    • Suppression of human colorectal carcinoma cell growth by wild type p53
    • Baker, S.J., Markowitz, S., Fearon, E.R., Wilson, J.K., and Vogelstein, B. (1990). Suppression of human colorectal carcinoma cell growth by wild type p53. Science 249, 912-915.
    • (1990) Science , vol.249 , pp. 912-915
    • Baker, S.J.1    Markowitz, S.2    Fearon, E.R.3    Wilson, J.K.4    Vogelstein, B.5
  • 2
    • 0031918640 scopus 로고    scopus 로고
    • Intranuclear neuronal inclusions in Huntington's disease and Dentatorubral and Pallidoluysian atrophy - Correlation between the density of inclusions and IT-15 CAG triplet repeat length
    • Becher, M.W., Kotzuk, J.A., Sharp, A.M., Davies, S.W., Bates, G.P., Price, D.L., and Ross, C.A. (1998). Intranuclear neuronal inclusions in Huntington's disease and Dentatorubral and Pallidoluysian atrophy - correlation between the density of inclusions and IT-15 CAG triplet repeat length. Neurobiol. Dis. 4, 387-397.
    • (1998) Neurobiol. Dis. , vol.4 , pp. 387-397
    • Becher, M.W.1    Kotzuk, J.A.2    Sharp, A.M.3    Davies, S.W.4    Bates, G.P.5    Price, D.L.6    Ross, C.A.7
  • 3
    • 0029085920 scopus 로고
    • The identification of a functional nuclear localization signal in the Huntington disease protein
    • Bessert, D.A., Gutridge, K.L., Dunbar, J.C., and Carlock, L.R. (1995). The identification of a functional nuclear localization signal in the Huntington disease protein. Brain Res. Mol. Brain Res. 33, 165-173.
    • (1995) Brain Res. Mol. Brain Res. , vol.33 , pp. 165-173
    • Bessert, D.A.1    Gutridge, K.L.2    Dunbar, J.C.3    Carlock, L.R.4
  • 6
    • 0032501740 scopus 로고    scopus 로고
    • Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?
    • Davies, S.W., Beardsall, K., Turmaine, M., DiFiglia, M., Aronin, N., and Bates, G.P. (1998). Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions? Lancet 351, 131-133.
    • (1998) Lancet , vol.351 , pp. 131-133
    • Davies, S.W.1    Beardsall, K.2    Turmaine, M.3    Difiglia, M.4    Aronin, N.5    Bates, G.P.6
  • 7
    • 0029816724 scopus 로고    scopus 로고
    • Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation
    • De Rooij, K.E., Dorsman, J.C., Smoor, M.A., Den Dunnen, J.T., and Van Ommen, G.J. (1996). Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation. Hum. Mol. Genet. 5, 1093-1099.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1093-1099
    • De Rooij, K.E.1    Dorsman, J.C.2    Smoor, M.A.3    Den Dunnen, J.T.4    Van Ommen, G.J.5
  • 9
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.P., and Aronin, N. (1997). Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990-1993.
    • (1997) Science , vol.277 , pp. 1990-1993
    • Difiglia, M.1    Sapp, E.2    Chase, K.O.3    Davies, S.W.4    Bates, G.P.5    Vonsattel, J.P.6    Aronin, N.7
  • 10
    • 0029040355 scopus 로고
    • In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
    • Dragunow, M., Faull, R.L., Lawlor, P., Beilharz, E.J., Singleton, K., Walker, E.B., and Mee, E. (1995). In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport 6, 1053-1057.
    • (1995) Neuroreport , vol.6 , pp. 1053-1057
    • Dragunow, M.1    Faull, R.L.2    Lawlor, P.3    Beilharz, E.J.4    Singleton, K.5    Walker, E.B.6    Mee, E.7
  • 13
    • 23444458415 scopus 로고
    • Transcriptional activation modulated by homopolymeric glutamine and proline stretches
    • Gerber, H.-P., Seipel, K., Georgiev, O., Hoefferer, M., Hug, M., Rusconi, S., and Schaffner, W. (1994). Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science 263, 808-811.
    • (1994) Science , vol.263 , pp. 808-811
    • Gerber, H.-P.1    Seipel, K.2    Georgiev, O.3    Hoefferer, M.4    Hug, M.5    Rusconi, S.6    Schaffner, W.7
  • 15
    • 0021982117 scopus 로고
    • Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease
    • Graveland, G.A., Williams, R.S., and DiFiglia, M. (1985). Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease. Science 227, 770-773.
    • (1985) Science , vol.227 , pp. 770-773
    • Graveland, G.A.1    Williams, R.S.2    Difiglia, M.3
  • 16
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Group THDCR (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 19
    • 0028799793 scopus 로고
    • Early loss of neostriatal striosome neurons in Huntington's disease
    • Hedreen, J.C., and Folstein, S.E. (1995). Early loss of neostriatal striosome neurons in Huntington's disease. J. Neuropathol. Exp. Neurol. 54, 105-120.
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 105-120
    • Hedreen, J.C.1    Folstein, S.E.2
  • 20
    • 0032475941 scopus 로고    scopus 로고
    • Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
    • this issue
    • Klement, I.A., Skinner, P.J., Kaytor, M.D., Yi, H., Hersch, S.M., Clark, H.B., Zoghbi, H.Y., and Orr, H.T. (1998). Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 95, this issue, 41-53.
    • (1998) Cell , vol.95 , pp. 41-53
    • Klement, I.A.1    Skinner, P.J.2    Kaytor, M.D.3    Yi, H.4    Hersch, S.M.5    Clark, H.B.6    Zoghbi, H.Y.7    Orr, H.T.8
  • 21
    • 0030701840 scopus 로고    scopus 로고
    • Molecular cloning and cell cycle-dependent expression of mammalian crm1, a protein involved in nuclear export of proteins
    • Kudo, N., Khochbin, S., Nishi, K., Kitano, K., Yanagida, M., Yoshida, M., and Horinouchi, S. (1997). Molecular cloning and cell cycle-dependent expression of mammalian crm1, a protein involved in nuclear export of proteins. J. Biol. Chem. 272, 29742-29745.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29742-29745
    • Kudo, N.1    Khochbin, S.2    Nishi, K.3    Kitano, K.4    Yanagida, M.5    Yoshida, M.6    Horinouchi, S.7
  • 22
    • 0031945025 scopus 로고    scopus 로고
    • Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats
    • Li, S.-H., and Li, X.-J. (1998). Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats. Hum. Mol. Genet. 7, 777-782.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 777-782
    • Li, S.-H.1    Li, X.-J.2
  • 24
    • 0022876328 scopus 로고
    • Huntington's disease: Pathogenesis and management
    • Martin, J.B., and Gusella, J.F. (1986). Huntington's disease: pathogenesis and management. N. Engl. J. Med. 315, 1267-1276.
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1267-1276
    • Martin, J.B.1    Gusella, J.F.2
  • 26
    • 0028318159 scopus 로고
    • Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression
    • Nishi, K., Yoshida, M., Fujiwara, D., Nishikawa, M., Horinouchi, S., and Beppu, T. (1994). Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J. Biol. Chem. 269, 6320-6324.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6320-6324
    • Nishi, K.1    Yoshida, M.2    Fujiwara, D.3    Nishikawa, M.4    Horinouchi, S.5    Beppu, T.6
  • 27
  • 28
    • 0029072690 scopus 로고
    • Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
    • Portera-Cailliau, C., Hedreen, J.C., Price, D.L., and Koliatsos, V.E. (1995). Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J. Neurosci. 15, 3775-3787.
    • (1995) J. Neurosci. , vol.15 , pp. 3775-3787
    • Portera-Cailliau, C.1    Hedreen, J.C.2    Price, D.L.3    Koliatsos, V.E.4
  • 30
    • 0031446233 scopus 로고    scopus 로고
    • Intranuclear neuronal inclusions: A common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?
    • Ross, C.A. (1997). Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases? Neuron 19, 1147-1150.
    • (1997) Neuron , vol.19 , pp. 1147-1150
    • Ross, C.A.1
  • 31
    • 0028873186 scopus 로고
    • Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis
    • Sapp, E., Ge, P., Aizawa, H., Bird, E., Penney, J., Young, A.B., Vonsattel, J.P., and DiFiglia, M. (1995). Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis. Neuroscience 64, 397-404.
    • (1995) Neuroscience , vol.64 , pp. 397-404
    • Sapp, E.1    Ge, P.2    Aizawa, H.3    Bird, E.4    Penney, J.5    Young, A.B.6    Vonsattel, J.P.7    Difiglia, M.8
  • 34
    • 0028972448 scopus 로고
    • Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias
    • Trottier, Y., Lutz, Y., Stevanin, G., Imbert, G., Devys, D., Cancel, G., Saudou, F., Weber, C., David, G., and Tora, L. (1995a). Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias. Nature 378, 403-406.
    • (1995) Nature , vol.378 , pp. 403-406
    • Trottier, Y.1    Lutz, Y.2    Stevanin, G.3    Imbert, G.4    Devys, D.5    Cancel, G.6    Saudou, F.7    Weber, C.8    David, G.9    Tora, L.10
  • 37
    • 0029130168 scopus 로고
    • Identification of a signal for rapid export of proteins from the nucleus
    • Wen, W., Meinkoth, J.L., Tsien, R.Y., and Taylor, S.S. (1995). Identification of a signal for rapid export of proteins from the nucleus. Cell 82, 463-473.
    • (1995) Cell , vol.82 , pp. 463-473
    • Wen, W.1    Meinkoth, J.L.2    Tsien, R.Y.3    Taylor, S.S.4
  • 38
    • 0030812809 scopus 로고    scopus 로고
    • Proteolysis and DNA replication: The Cdc34 requirement in the xenopus egg cell cycle
    • Yew, P.R., and Kirschner M.W. (1997). Proteolysis and DNA replication: the Cdc34 requirement in the xenopus egg cell cycle. Science 277, 1672-1676.
    • (1997) Science , vol.277 , pp. 1672-1676
    • Yew, P.R.1    Kirschner, M.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.