Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models

Journal of Neurochemistry

Volumn 127, Issue 1, 2013, Pages 22-35

  Conforti, Paola ^a   Zuccato, Chiara ^a   Gaudenzi, Germano ^a   Ieraci, Alessandro ^a   Camnasio, Stefano ^a   Buckley, Noel J ^b   Mutti, Cesare ^a   Cotelli, Franco ^a   Contini, Alessandro ^a   Cattaneo, Elena ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

BDNF; Huntington's disease (HD); protein protein interaction; REST NRSF; virtual drug screening

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; COMPOUND 91; MESSENGER RNA; MUSCARINIC M4 RECEPTOR; PHOSPHATIDATE PHOSPHATASE; PROENKEPHALIN; QUINOLONE; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; SYNAPSIN I; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SIN3B; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CELL SURVIVAL; CELL VIABILITY; CHRM4 GENE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; EMBRYO; GENE; GENE EXPRESSION REGULATION; GENE LOCUS; GENE SILENCING; GENETIC SCREENING; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DOCKING; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROENKEPHALIN GENE; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SNAP25 GENE; SYN1 GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ZEBRA FISH;

BDNF; HUNTINGTON'S DISEASE (HD); PROTEIN-PROTEIN INTERACTION; REST/NRSF; VIRTUAL DRUG SCREENING;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; EMBRYO, NONMAMMALIAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; LUCIFERASES; MICROINJECTIONS; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; TRANSFECTION; ZEBRAFISH;

DANIO RERIO;

EID: 84884906692     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12348     Document Type: Article

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