Exon I of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Cell

Volumn 87, Issue 3, 1996, Pages 493-506

  Mangiarini, Laura ^a   Sathasivam, Kirupa ^a   Seller, Mary ^a   Cozens, Barbara ^f   Harper, Alex ^b   Hetherington, Colin ^c   Lawton, Martin ^a   Trottier, Yvon ^d   Lehrach, Hans ^e   Davies, Stephen W ^f   Bates, Gillian P ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^e MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; TRINUCLEOTIDE; HD PROTEIN, HUMAN; HDH PROTEIN, MOUSE; NERVE PROTEIN; NUCLEAR PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; EMBRYO; EXON; FEMALE; GENE EXPRESSION; HUNTINGTON CHOREA; MALE; MOTOR DYSFUNCTION; NEWBORN; NONHUMAN; NUCLEOTIDE REPEAT; PHENOTYPE; PRIORITY JOURNAL; SEIZURE; STEREOTYPY; TRANSGENIC MOUSE; TREMOR; ANIMAL; BRAIN; DISEASE MODEL; GENETICS; HUMAN; MOUSE; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SPINAL CORD; TRANSGENE; TRINUCLEOTIDE REPEAT;

ANIMALIA; MUS MUSCULUS;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; EXONS; FEMALE; HUMANS; HUNTINGTON DISEASE; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; SPINAL CORD; TRANSGENES; TRINUCLEOTIDE REPEATS;

EID: 16044373842     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81369-0     Document Type: Article

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