Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats

Neuroscience

Volumn 172, Issue , 2011, Pages 398-405

  Jiang, Y ^a   Wei, N ^a   Lu, T ^a   Zhu, J ^a   Xu, G ^a   Liu, X ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

BDNF; Cytokines; Inflammation; Intranasal delivery; Microglia; Stroke

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; MESSENGER RNA; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; IMMUNOFLUORESCENCE; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MORPHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78650748359     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.10.054     Document Type: Article

References (33)

1. Alcala-Barraza S.R., Lee M.S., Hanson L.R., McDonald A.A., Frey W.H., McLoon L.K. Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS. J Drug Target 2010, 18:179-190.
2. Danielyan L., Schafer R., von Ameln-Mayerhofer A., Buadze M., Geisler J., Klopfer T., Burkhardt U., Proksch B., Verleysdonk S., Ayturan M., Buniatian G.H., Gleiter C.H., Frey W.H. Intranasal delivery of cells to the brain. Eur J Cell Biol 2009, 88:315-324.
3. de Bilbao F., Arsenijevic D., Moll T., Garcia-Gabay I., Vallet P., Langhans W., Giannakopoulos P. In vivo over-expression of interleukin-10 increases resistance to focal brain ischemia in mice. J Neurochem 2009, 110:12-22.
4. Denes A., Vidyasagar R., Feng J., Narvainen J., McColl B.W., Kauppinen R.A., Allan S.M. Proliferating resident microglia after focal cerebral ischaemia in mice. J Cereb Blood Flow Metab 2007, 27:1941-1953.
5. Dziewulska D., Mossakowski M.J. Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke. Clin Neuropathol 2003, 22:35-40.
6. + T cells. J Immunol 2003, 171:6549-6555.
7. Hallenbeck J.M. The many faces of tumor necrosis factor in stroke. Nat Med 2002, 8:1363-1368.
8. Hill W.D., Hess D.C., Carroll J.E., Wakade C.G., Howard E.F., Chen Q., Cheng C., Martin-Studdard A., Waller J.L., Beswick R.A. The NF-kappaB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia. Brain Res Bull 2001, 55:375-386.
9. Jang S.W., Liu X., Yepes M., Shepherd K.R., Miller G.W., Liu Y., Wilson W.D., Xiao G., Blanchi B., Sun Y.E., Ye K. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A 2010, 107:2687-2692.
10. Jin R., Yang G., Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 2010, 87:779-789.
11. Kajiya M., Shiba H., Fujita T., Takeda K., Uchida Y., Kawaguchi H., Kitagawa M., Takata T., Kurihara H. Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death. J Cell Physiol 2009, 221:696-706.
12. Liu X.F., Fawcett J.R., Thorne R.G., DeFor T.A., Frey W.H. Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage. J Neurol Sci 2001, 187:91-97.
13. Lloyd-Jones D., et al. Executive summary: heart disease and stroke statistics2010 update: a report from the American Heart Association. Circulation 2010, 121:948-954.
14. Lu B., Pang P.T., Woo N.H. The yin and yang of neurotrophin action. Nat Rev Neurosci 2005, 6:603-614.
15. Ma M., Ma Y., Yi X., Guo R., Zhu W., Fan X., Xu G., Frey W.H., Liu X. Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone. BMC Neurosci 2008, 9:117.
16. Makar T.K., Bever C.T., Singh I.S., Royal W., Sahu S.N., Sura T.P., Sultana S., Sura K.T., Patel N., Dhib-Jalbut S., Trisler D. Brain-derived neurotrophic factor gene delivery in an animal model of multiple sclerosis using bone marrow stem cells as a vehicle. J Neuroimmunol 2009, 210:40-51.
17. McCoy M.K., Tansey M.G. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation 2008, 5:45.
18. Migliore M.M., Vyas T.K., Campbell R.B., Amiji M.M., Waszczak B.L. Brain delivery of proteins by the intranasal route of administration: a comparison of cationic liposomes versus aqueous solution formulations. J Pharm Sci 2010, 99:1745-1761.
19. Mizoguchi Y., Monji A., Kato T., Seki Y., Gotoh L., Horikawa H., Suzuki S.O., Iwaki T., Yonaha M., Hashioka S., Kanba S. Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia. J Immunol 2009, 183:7778-7786.
20. Mowla S.J., Farhadi H.F., Pareek S., Atwal J.K., Morris S.J., Seidah N.G., Murphy R.A. Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 2001, 276:12660-12666.
21. Neumann J., Gunzer M., Gutzeit H.O., Ullrich O., Reymann K.G., Dinkel K. Microglia provide neuroprotection after ischemia. FASEB J 2006, 20:714-716.
22. Ooboshi H., Ibayashi S., Shichita T., Kumai Y., Takada J., Ago T., Arakawa S., Sugimori H., Kamouchi M., Kitazono T., Iida M. Postischemic gene transfer of interleukin-10 protects against both focal and global brain ischemia. Circulation 2005, 111:913-919.
23. Pun P.B., Lu J., Moochhala S. Involvement of ROS in BBB dysfunction. Free Radic Res 2009, 43:348-364.
24. Schabitz W.R., Steigleder T., Cooper-Kuhn C.M., Schwab S., Sommer C., Schneider A., Kuhn H.G. Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke 2007, 38:2165-2172.
25. Sehara Y., Hayashi T., Deguchi K., Zhang H., Tsuchiya A., Yamashita T., Lukic V., Nagai M., Kamiya T., Abe K. Decreased focal inflammatory response by G-CSF may improve stroke outcome after transient middle cerebral artery occlusion in rats. J Neurosci Res 2007, 85:2167-2174.
26. Shi Q., Zhang P., Zhang J., Chen X., Lu H., Tian Y., Parker T.L., Liu Y. Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice. Neurosci Lett 2009, 465:220-225.
27. Sniderhan L.F., Garcia-Bates T.M., Burgart M., Bernstein S.H., Phipps R.P., Maggirwar S.B. Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma. Exp Hematol 2009, 37:1295-1309.
28. Swanson R.A., Morton M.T., Tsao-Wu G., Savalos R.A., Davidson C., Sharp F.R. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 1990, 10:290-293.
29. Ulmann L., Hatcher J.P., Hughes J.P., Chaumont S., Green P.J., Conquet F., Buell G.N., Reeve A.J., Chessell I.P., Rassendren F. Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci 2008, 28:11263-11268.
30. Valerio A., Dossena M., Bertolotti P., Boroni F., Sarnico I., Faraco G., Chiarugi A., Frontini A., Giordano A., Liou H.C., De Simoni M.G., Spano P., Carruba M.O., Pizzi M., Nisoli E. Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-kappaB/c-Rel-dependent transcription. Stroke 2009, 40:610-617.
31. Yeiser E.C., Rutkoski N.J., Naito A., Inoue J., Carter B.D. Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice. J Neurosci 2004, 24:10521-10529.
32. Yenari M.A., Xu L., Tang X.N., Qiao Y., Giffard R.G. Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro. Stroke 2006, 37:1087-1093.
33. Zhang J., Geula C., Lu C., Koziel H., Hatcher L.M., Roisen F.J. Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro. Exp Neurol 2003, 183:469-481.