High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes

Stem Cells

Volumn 31, Issue 9, 2013, Pages 1816-1828

  Charbord, Jérémie ^a   Poydenot, Pauline ^a   Bonnefond, Caroline ^a   Feyeux, Maxime ^a   Casagrande, Fabrice ^a   Brinon, Benjamin ^a   Francelle, Laetitia ^b,c   Aurégan, Gwenaelle ^b,c   Guillermier, Martine ^b,c   Cailleret, Michel ^a   Viegas, Pedro ^a   Nicoleau, Camille ^a   Martinat, Cécile ^a   Brouillet, Emmanuel ^b,c   Cattaneo, Elena ^d   Peschanski, Marc ^a   Lechuga, Marc ^a   Perrier, Anselme L ^a  

^a I Stem   (France)

^b Molecular Imaging Research Center   (France)

^c CNRS   (France)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

High throughput screening; Human embryonic stem cells; Neural stem cells; Neuron restrictive silencer factor; Repressor element 1 silencing transcription factor

Indexed keywords

BENZOIMIDAZOLE 5 CARBOXAMIDE DERIVATIVE; BRAIN DERIVED NEUROTROPHIC FACTOR; IMIDAZOLE DERIVATIVE; QUINOLINIC ACID; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTOME; UNCLASSIFIED DRUG; X 38207; X 38210; X 5050; X 5917;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE SEQUENCE; GENE SILENCING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MALE; MOUSE; NERVE CELL; NEURAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PREFRONTAL CORTEX; PROTEIN DEGRADATION; REPRESSOR GENE; TRANSCRIPTOMICS; UPREGULATION;

HIGH THROUGHPUT SCREENING; HUMAN EMBRYONIC STEM CELLS; NEURAL STEM CELLS; NEURON RESTRICTIVE SILENCER FACTOR; REPRESSOR ELEMENT-1 SILENCING TRANSCRIPTION FACTOR;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HUNTINGTON DISEASE; LUCIFERASES; MALE; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; NEURONS; REPRESSOR PROTEINS; SMALL MOLECULE LIBRARIES; TRANSCRIPTOME;

EID: 84885158161     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1430     Document Type: Article

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