Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration

Journal of Neuroscience

Volumn 27, Issue 43, 2007, Pages 11758-11768

  Strand, Andrew D ^a   Baquet, Zachary C ^b,f   Aragaki, Aaron K ^a   Holmans, Peter ^c   Yang, Lichuan ^d   Cleren, Carine ^e   Beal, M Flint ^d   Jones, Lesley ^c   Kooperberg, Charles ^a   Olson, James M ^a   Jones, Kevin R ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e UNIVERSITÉ CÔTE D'AZUR   (France)

^f ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

BDNF; Huntington's disease; Microarray; Neurodegeneration; Neurotrophin; Polyglutamine; Striatum

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3 NITROPROPIONIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; HUNTINGTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN CELL; BRAIN DEGENERATION; CONTROLLED STUDY; FOREBRAIN; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC MODEL; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; MITOCHONDRION; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SYNTHESIS; RAT; STATISTICAL SIGNIFICANCE; STRIATE CORTEX; TRANSGENIC MOUSE;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; HUMANS; HUNTINGTON DISEASE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE DEGENERATION; RATS; RATS, INBRED LEW;

EID: 35548937443     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2461-07.2007     Document Type: Article

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