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Volumn 30, Issue 44, 2010, Pages 14708-14718

BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; DOPAMINE 2 RECEPTOR; ENKEPHALIN;

EID: 78049525220     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1637-10.2010     Document Type: Article
Times cited : (210)

References (58)
  • 1
    • 0000429264 scopus 로고    scopus 로고
    • Neurotrophin trafficking by anterograde transport
    • Altar CA, DiStefano PS (1998) Neurotrophin trafficking by anterograde transport. Trends Neurosci 21:433-437.
    • (1998) Trends Neurosci , vol.21 , pp. 433-437
    • Altar, C.A.1    DiStefano, P.S.2
  • 4
    • 17844372504 scopus 로고    scopus 로고
    • From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome
    • Bagni C, Greenough WT (2005) From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat Rev Neurosci 6:376-387.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 376-387
    • Bagni, C.1    Greenough, W.T.2
  • 5
    • 2442506955 scopus 로고    scopus 로고
    • Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor
    • Baquet ZC, Gorski JA, Jones KR (2004) Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. J Neurosci 24:4250-4258.
    • (2004) J Neurosci , vol.24 , pp. 4250-4258
    • Baquet, Z.C.1    Gorski, J.A.2    Jones, K.R.3
  • 6
    • 27744573047 scopus 로고    scopus 로고
    • The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice
    • Barton ME, Shannon HE (2005) The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice. Neuroscience 136:563-569.
    • (2005) Neuroscience , vol.136 , pp. 563-569
    • Barton, M.E.1    Shannon, H.E.2
  • 7
    • 34250171705 scopus 로고    scopus 로고
    • Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease
    • Benn CL, Slow EJ, Farrell LA, Graham R, Deng Y, Hayden MR, Cha JH (2007) Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease. Neuroscience 147:354-372.
    • (2007) Neuroscience , vol.147 , pp. 354-372
    • Benn, C.L.1    Slow, E.J.2    Farrell, L.A.3    Graham, R.4    Deng, Y.5    Hayden, M.R.6    Cha, J.H.7
  • 8
    • 4444350918 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
    • Canals JM, Pineda JR, Torres-Peraza JF, Bosch M, Martín- Ibañez R, Muñoz MT, Mengod G, Ernfors P, Alberch J (2004) Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease. J Neurosci 24:7727-7739.
    • (2004) J Neurosci , vol.24 , pp. 7727-7739
    • Canals, J.M.1    Pineda, J.R.2    Torres-Peraza, J.F.3    Bosch, M.4    Martín- Ibañez, R.5    Muñoz, M.T.6    Mengod, G.7    Ernfors, P.8    Alberch, J.9
  • 9
    • 34948855498 scopus 로고    scopus 로고
    • Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease
    • Cho SR, Benraiss A, Chmielnicki E, Samdani A, Economides A, Goldman SA (2007) Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. J Clin Invest 117:2889-2902.
    • (2007) J Clin Invest , vol.117 , pp. 2889-2902
    • Cho, S.R.1    Benraiss, A.2    Chmielnicki, E.3    Samdani, A.4    Economides, A.5    Goldman, S.A.6
  • 11
    • 0032765275 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex
    • Croll SD, Suri C, Compton DL, Simmons MV, Yancopoulos GD, Lindsay RM, Wiegand SJ, Rudge JS, Scharfman HE (1999) Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 93:1491-1506.
    • (1999) Neuroscience , vol.93 , pp. 1491-1506
    • Croll, S.D.1    Suri, C.2    Compton, D.L.3    Simmons, M.V.4    Yancopoulos, G.D.5    Lindsay, R.M.6    Wiegand, S.J.7    Rudge, J.S.8    Scharfman, H.E.9
  • 13
    • 0026320986 scopus 로고
    • Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: A combined study using the section-Golgi method and calbindin D28k immunocytochemistry
    • Ferrante RJ, Kowall NW, Richardson EP Jr (1991) Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry. J Neurosci 11:3877-3887.
    • (1991) J Neurosci , vol.11 , pp. 3877-3887
    • Ferrante, R.J.1    Kowall, N.W.2    Richardson Jr., E.P.3
  • 14
    • 0034595722 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in Huntington disease
    • Ferrer I, Goutan E, Marín C, Rey MJ, Ribalta T (2000) Brain-derived neurotrophic factor in Huntington disease. Brain Res 866:257-261.
    • (2000) Brain Res , vol.866 , pp. 257-261
    • Ferrer, I.1    Goutan, E.2    Marín, C.3    Rey, M.J.4    Ribalta, T.5
  • 15
    • 0030967339 scopus 로고    scopus 로고
    • Intact mirror-tracing and impaired rotary-pursuit skill learning in patients with Huntington's disease: Evidence for dissociable memory systems in skill learning
    • Gabrieli JD, Stebbins GT, Singh J, Willingham DB, Goetz CG (1997) Intact mirror-tracing and impaired rotary-pursuit skill learning in patients with Huntington's disease: evidence for dissociable memory systems in skill learning. Neuropsychology 11:272-281.
    • (1997) Neuropsychology , vol.11 , pp. 272-281
    • Gabrieli, J.D.1    Stebbins, G.T.2    Singh, J.3    Willingham, D.B.4    Goetz, C.G.5
  • 17
    • 41749083721 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor overexpression in the forebrain ameliorates Huntington's disease phenotypes in mice
    • Gharami K, Xie Y, An JJ, Tonegawa S, Xu B (2008) Brain-derived neurotrophic factor overexpression in the forebrain ameliorates Huntington's disease phenotypes in mice. J Neurochem 105:369-379.
    • (2008) J Neurochem , vol.105 , pp. 369-379
    • Gharami, K.1    Xie, Y.2    An, J.J.3    Tonegawa, S.4    Xu, B.5
  • 18
    • 0346749473 scopus 로고    scopus 로고
    • Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells
    • Gines S, Ivanova E, Seong IS, Saura CA, MacDonald ME (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278:50514-50522.
    • (2003) J Biol Chem , vol.278 , pp. 50514-50522
    • Gines, S.1    Ivanova, E.2    Seong, I.S.3    Saura, C.A.4    MacDonald, M.E.5
  • 19
    • 60349130539 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: Involvement of phospholipase C gamma activity and glutamate receptor expression
    • Giralt A, Rodrigo T, Martin ED, Gonzalez JR, Milà M, Ceña V, Dierssen M, Canals JM, Alberch J (2009) Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipase C gamma activity and glutamate receptor expression. Neuroscience 158:1234-1250.
    • (2009) Neuroscience , vol.158 , pp. 1234-1250
    • Giralt, A.1    Rodrigo, T.2    Martin, E.D.3    Gonzalez, J.R.4    Milà, M.5    Ceña, V.6    Dierssen, M.7    Canals, J.M.8    Alberch, J.9
  • 20
    • 0021982117 scopus 로고
    • Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease
    • Graveland GA, Williams RS, DiFiglia M (1985) Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease. Science 227:770-773.
    • (1985) Science , vol.227 , pp. 770-773
    • Graveland, G.A.1    Williams, R.S.2    DiFiglia, M.3
  • 21
    • 0024503945 scopus 로고
    • Neuropsychological evidence for multiple implicit memory systems: A comparison of Alzheimer's, Huntington's, and Parkinson's disease patients
    • Heindel WC, Salmon DP, Shults CW, Walicke PA, Butters N (1989) Neuropsychological evidence for multiple implicit memory systems: a comparison of Alzheimer's, Huntington's, and Parkinson's disease patients. J Neurosci 9:582-587.
    • (1989) J Neurosci , vol.9 , pp. 582-587
    • Heindel, W.C.1    Salmon, D.P.2    Shults, C.W.3    Walicke, P.A.4    Butters, N.5
  • 22
    • 58149385090 scopus 로고    scopus 로고
    • Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin
    • Her LS, Goldstein LS (2008) Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci 28:13662-13672.
    • (2008) J Neurosci , vol.28 , pp. 13662-13672
    • Her, L.S.1    Goldstein, L.S.2
  • 24
    • 0033168977 scopus 로고    scopus 로고
    • Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro
    • Ivkovic S, Ehrlich ME (1999) Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro. J Neurosci 19:5409-5419.
    • (1999) J Neurosci , vol.19 , pp. 5409-5419
    • Ivkovic, S.1    Ehrlich, M.E.2
  • 25
    • 13244279632 scopus 로고    scopus 로고
    • Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons
    • Ji Y, Pang PT, Feng L, Lu B (2005) Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat Neurosci 8:164-172.
    • (2005) Nat Neurosci , vol.8 , pp. 164-172
    • Ji, Y.1    Pang, P.T.2    Feng, L.3    Lu, B.4
  • 26
    • 0025727341 scopus 로고
    • Procedural learning is impaired in Huntington's disease: Evidence from the serial reaction time task
    • Knopman D, Nissen MJ (1991) Procedural learning is impaired in Huntington's disease: evidence from the serial reaction time task. Neuropsychologia 29:245-254.
    • (1991) Neuropsychologia , vol.29 , pp. 245-254
    • Knopman, D.1    Nissen, M.J.2
  • 31
    • 38649128208 scopus 로고    scopus 로고
    • Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
    • Matsumoto T, Rauskolb S, Polack M, Klose J, Kolbeck R, Korte M, Barde YA (2008) Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci 11:131-133.
    • (2008) Nat Neurosci , vol.11 , pp. 131-133
    • Matsumoto, T.1    Rauskolb, S.2    Polack, M.3    Klose, J.4    Kolbeck, R.5    Korte, M.6    Barde, Y.A.7
  • 32
    • 0028040712 scopus 로고
    • Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons
    • Mizuno K, Carnahan J, Nawa H (1994) Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons. Dev Biol 165:243-256.
    • (1994) Dev Biol , vol.165 , pp. 243-256
    • Mizuno, K.1    Carnahan, J.2    Nawa, H.3
  • 33
    • 33745979171 scopus 로고    scopus 로고
    • Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice
    • Pang TY, Stam NC, Nithianantharajah J, Howard ML, Hannan AJ (2006) Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice. Neuroscience 141:569-584.
    • (2006) Neuroscience , vol.141 , pp. 569-584
    • Pang, T.Y.1    Stam, N.C.2    Nithianantharajah, J.3    Howard, M.L.4    Hannan, A.J.5
  • 34
    • 39249084415 scopus 로고    scopus 로고
    • The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
    • Peng Q, Masuda N, Jiang M, Li Q, Zhao M, Ross CA, Duan W (2008) The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model. Exp Neurol 210:154-163.
    • (2008) Exp Neurol , vol.210 , pp. 154-163
    • Peng, Q.1    Masuda, N.2    Jiang, M.3    Li, Q.4    Zhao, M.5    Ross, C.A.6    Duan, W.7
  • 35
    • 20144379127 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    • Pineda JR, Canals JM, Bosch M, Adell A, Mengod G, Artigas F, Ernfors P, Alberch J (2005) Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease. J Neurochem 93:1057-1068.
    • (2005) J Neurochem , vol.93 , pp. 1057-1068
    • Pineda, J.R.1    Canals, J.M.2    Bosch, M.3    Adell, A.4    Mengod, G.5    Artigas, F.6    Ernfors, P.7    Alberch, J.8
  • 36
    • 33749010358 scopus 로고    scopus 로고
    • Neurotrophin-regulated signalling pathways
    • Reichardt LF (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361:1545-1564.
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1545-1564
    • Reichardt, L.F.1
  • 39
    • 0036861726 scopus 로고    scopus 로고
    • Cognitive procedural learning in patients with fronto-striatal lesions
    • Schmidtke K, Manner H, Kaufmann R, Schmolck H (2002) Cognitive procedural learning in patients with fronto-striatal lesions. Learn Mem 9:419-429.
    • (2002) Learn Mem , vol.9 , pp. 419-429
    • Schmidtke, K.1    Manner, H.2    Kaufmann, R.3    Schmolck, H.4
  • 40
    • 53349101055 scopus 로고    scopus 로고
    • Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients
    • Seo H, Kim W, Isacson O (2008) Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. Hum Mol Genet 17:3144-3153.
    • (2008) Hum Mol Genet , vol.17 , pp. 3144-3153
    • Seo, H.1    Kim, W.2    Isacson, O.3
  • 41
    • 63849151219 scopus 로고    scopus 로고
    • Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice
    • Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G (2009) Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc Natl Acad Sci 106:4906-4911.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 4906-4911
    • Simmons, D.A.1    Rex, C.S.2    Palmer, L.3    Pandyarajan, V.4    Fedulov, V.5    Gall, C.M.6    Lynch, G.7
  • 43
    • 1542286877 scopus 로고    scopus 로고
    • Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    • Spires TL, Grote HE, Varshney NK, Cordery PM, van Dellen A, Blakemore C, Hannan AJ (2004a) Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. J Neurosci 24:2270-2276.
    • (2004) J Neurosci , vol.24 , pp. 2270-2276
    • Spires, T.L.1    Grote, H.E.2    Varshney, N.K.3    Cordery, P.M.4    Van Dellen, A.5    Blakemore, C.6    Hannan, A.J.7
  • 44
    • 2942620844 scopus 로고    scopus 로고
    • Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    • Spires TL, Grote HE, Garry S, Cordery PM, Van Dellen A, Blakemore C, Hannan AJ (2004b) Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice. Eur J Neurosci 19:2799-2807.
    • (2004) Eur J Neurosci , vol.19 , pp. 2799-2807
    • Spires, T.L.1    Grote, H.E.2    Garry, S.3    Cordery, P.M.4    Van Dellen, A.5    Blakemore, C.6    Hannan, A.J.7
  • 48
    • 17644368893 scopus 로고    scopus 로고
    • Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease
    • DOI 10.1523/JNEUROSCI.0590-05.2005
    • Van Raamsdonk JM, Pearson J, Slow EJ, Hossain SM, Leavitt BR, Hayden MR (2005) Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease. J Neurosci 25:4169-4180. (Pubitemid 40563393)
    • (2005) Journal of Neuroscience , vol.25 , Issue.16 , pp. 4169-4180
    • Van Raamsdonk, J.M.1    Pearson, J.2    Slow, E.J.3    Hossain, S.M.4    Leavitt, B.R.5    Hayden, M.R.6
  • 49
    • 33846576161 scopus 로고    scopus 로고
    • Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease
    • Van Raamsdonk JM, Pearson J, Murphy Z, Hayden MR, Leavitt BR (2006) Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease. BMC Neurosci 7:80.
    • (2006) BMC Neurosci , vol.7 , pp. 80
    • Van Raamsdonk, J.M.1    Pearson, J.2    Murphy, Z.3    Hayden, M.R.4    Leavitt, B.R.5
  • 51
    • 0028800803 scopus 로고
    • The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro
    • Ventimiglia R, Mather PE, Jones BE, Lindsay RM (1995) The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro. Eur J Neurosci 7:213-222.
    • (1995) Eur J Neurosci , vol.7 , pp. 213-222
    • Ventimiglia, R.1    Mather, P.E.2    Jones, B.E.3    Lindsay, R.M.4
  • 54
    • 0033710349 scopus 로고    scopus 로고
    • Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB
    • Xu B, Zang K, Ruff NL, Zhang YA, McConnell SK, Stryker MP, Reichardt LF (2000) Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron 26:233-245.
    • (2000) Neuron , vol.26 , pp. 233-245
    • Xu, B.1    Zang, K.2    Ruff, N.L.3    Zhang, Y.A.4    McConnell, S.K.5    Stryker, M.P.6    Reichardt, L.F.7


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