SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5695-5703

  Leone, Samantha ^a   Mutti, Cesare ^b   Kazantsev, Aleksey ^c   Sturlese, Mattia ^d   Moro, Stefano ^d   Cattaneo, Elena ^a   Rigamonti, Dorotea ^b   Contini, Alessandro ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Dialectica Srl   (Italy)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

2 Aminothiazoles; 3D QSAR; Huntington's disease; Pharmacophore; Structure activity relationship

Indexed keywords

2 AMINOTHIAZOLE DERIVATIVE;

ARTICLE; DRUG SCREENING; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUNTINGTON CHOREA; MOLECULAR MODEL; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION;

GENE EXPRESSION REGULATION; GENE LIBRARY; GENE SILENCING; HUNTINGTON DISEASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRESSOR PROTEINS; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRANSCRIPTION, GENETIC;

EID: 43749108844     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.067     Document Type: Article

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